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A role of anandamide in the development of acute lung injury

Research Project

Project/Area Number 15590801
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionShinshu University

Principal Investigator

KOIZUMI Tomonobu  Shinshu University, School of Medicine Hospital, Associate Professor, 医学部附属病院, 講師 (20273097)

Co-Investigator(Kenkyū-buntansha) KUBO Keishi  Shinshu University, School of Medicine, Professor, 医学部, 教授 (80143965)
FUJIMOTO Keisaku  Shinshu University, School of Medicine, Associate Professor, 医学部, 助教授 (70242691)
HANAOKA Masayuki  Shinshu University, School of Medicine, Associate Professor, 医学部, 講師 (20334899)
Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2004: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2003: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywordsanadamide / endotoxin / lung injury / polymixin B / sheep
Research Abstract

We examined the role of anandamide in the acute lung injury in sheep. We prepared awake sheep with vascular monitoring and lung lymph balance. 5 mg of anandamide was infused intravenously after stable baseline over 2 hours. Pulmonary and systemic artery pressure, cardiac output and lung lymph flow were measured every 30 min. After the infusion of anandamide, there were no significant changes in these parameters. Based on the findings, anandmide seems to be independent in the pathophysiology in acute lung injury in sheep. It should be necessary to examine the dose response of anandmide.

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • Research Products

    (19 results)

All 2004 Other

All Journal Article (15 results) Publications (4 results)

  • [Journal Article] Effect of ONO1714, a specific inducible nitric oxide synthase inhibitor, on lung lymph filtration and gas exchange during endotoxemia in unanesthetized2004

    • Author(s)
      Koizumi T, 他
    • Journal Title

      Anesthesiology 101

      Pages: 59-65

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Contribution of nitric oxide to adaptation of tibetan sheep to high altitude2004

    • Author(s)
      Koizumi T 他
    • Journal Title

      Respir Physiol Neurobiol 140

      Pages: 189-196

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Comparison of pulmonary vascular response to endogenous nitric oxide inhibition in sheep and pigs living at 2,300m2004

    • Author(s)
      Ruan Z, Koizumi T 他
    • Journal Title

      J Comp Physiol [B] 174

      Pages: 549-554

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Primary malignant lymphoma in the posterior mediastinum2004

    • Author(s)
      Takamizawa A, Koizumi T 他
    • Journal Title

      Respiration 71

      Pages: 417-420

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] JTE-607, a cytokine release blocker, attenuates acid aspiration-induced lung injury in rats2004

    • Author(s)
      jian MY, Koizumi T 他
    • Journal Title

      Eur J Pharmacol 488

      Pages: 231-238

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Phase II study of weekly docetaxel combined with cisplatin in patients with advanced non-small-cell lung cancer2004

    • Author(s)
      Tsunoda T, Koizumi T, 他
    • Journal Title

      Cancer Chemother Pharmacol 54

      Pages: 173-177

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Effect of ONO1714, a specific inducible nitric oxide synthase inhibitor, on lung lymph filtration and gas exchange during endotoxemia in unanesthetized sheep2004

    • Author(s)
      Koizumi T, et al.
    • Journal Title

      Anesthesiology 101

      Pages: 59-65

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Contribution of nitric oxide to adaptation of tibetan sheep to high altitude2004

    • Author(s)
      Koizumi T, et al.
    • Journal Title

      Respir Physiol Neurobiol 140

      Pages: 189-196

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Comparison of pulmonary vascular response to endogenous nitric oxide inhibition in sheep and pigs living at 2,300 m2004

    • Author(s)
      Ruan Z, Koizumi T et al.
    • Journal Title

      J Comp Physiol [B] 174

      Pages: 549-555

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Primary malignant lymphoma in the posterior Mediastinum2004

    • Author(s)
      Takamizawa A, Koizumi T et al.
    • Journal Title

      Respiration 71

      Pages: 417-420

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] JTE-607, a cytokine release blocker, attenuates acid aspiration-induced lung injury in rats2004

    • Author(s)
      Jian MY, Koizumi T et al.
    • Journal Title

      Eur J Pharmacol 488

      Pages: 231-238

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Phase II study of weekly docetaxel combined with cisplatin in patients with advanced non-small-cell lung cancer2004

    • Author(s)
      Tsunoda T, Koizumi T, et al.
    • Journal Title

      Cancer Chemother Pharmacol 54

      Pages: 173-177

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effect of ONO1714, a specific inducible nitric oxide synthase inhibitor, on lung lymph filtration and as exchange during endotoxemia in unanesthetized2004

    • Author(s)
      Koizumi T, 他
    • Journal Title

      Anesthesiology 101

      Pages: 59-65

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Comparison of pulmonary vascular response to endogenous nitric oxide inhibition in sheep and pigs living at 2,300 m2004

    • Author(s)
      Ruan Z, Koizumi T 他
    • Journal Title

      J Comp Physiol [B] 174

      Pages: 549-554

    • Related Report
      2004 Annual Research Report
  • [Journal Article] PTE-607, a cytokine release blocker, attenuates acid aspiration-induced lung injury in rats2004

    • Author(s)
      Jian MY, Koizumi T 他
    • Journal Title

      Eur J Pharmacol 488

      Pages: 231-238

    • Related Report
      2004 Annual Research Report
  • [Publications] Ogasawara H, et al.: "Effects of a selective nitric oxide synthase inhibitor on endotoxin-induced alteration in hypoxic pulmonary vasoconstriction in sheep"J Cardiovasc Pharmacol. 42. 521-526 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sakai A, et al.: "Cardiopulmonary hemodynamics of blue-sheep, Pseudois nayaur, as high-altitude adapted mammals"Jpn J Physiol.. 53. 377-384 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ruan Z, et al.: "Nitric oxide, but not carbon monoxide, attenuates anaphylaxis-induced postsinusoidal contraction and congestion in guinea pig liver"Am J Physiol Regul.Integr Comp Physiol.. 286. R94-R100 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ishizaki T, et al.: "Blunted effect of the Kv channel inhibitor on pulmonary circulation in Tibetan sheep : A model for studying hypoxia and pulmonary artery pressure regulation"Respirology. 9. 125-129 (2004)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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