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Creation of bioactive compounds by activation and engineering of microbial secondary metabolite biosynthetic genes

Research Project

Project/Area Number 15H02445
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Bioorganic chemistry
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Osada Hiroyuki  国立研究開発法人理化学研究所, 環境資源科学研究センター, 副センター長 (80160836)

Co-Investigator(Kenkyū-buntansha) 加藤 直樹  国立研究開発法人理化学研究所, 環境資源科学研究センター, 研究員 (90442946)
Co-Investigator(Renkei-kenkyūsha) TAKAHASHI Shunji  国立研究開発法人理化学研究所, 環境資源科学研究センター, ユニットリーダー (30311608)
FUTAMURA Yushi  国立研究開発法人理化学研究所, 環境資源科学研究センター, 研究員 (70525857)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥42,250,000 (Direct Cost: ¥32,500,000、Indirect Cost: ¥9,750,000)
Fiscal Year 2017: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
Fiscal Year 2016: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
Fiscal Year 2015: ¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Keywords生物活性物質 / ケミカルバイオロジー / 二次代謝産物
Outline of Final Research Achievements

Natural products that possess structural diversity and show a wide range of specific biological activities have been an important resource for the development of pharmaceutical drugs and agrochemicals. In this project, we focused on secondary metabolites produced by microorganisms to establish a methodology for the discovery of new bioactive compounds by means of new chemical biology research tools constructed by ourselves, such as NPPlot, MorphoBase, ChemProteoBase, and photoaffinity beads. A number of new microbial metabolites were isolated by genetic engineering and manipulation of regulatory systems, and evaluated their biological activities, leading to a creation of seeds for the drug discovery.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (180 results)

All 2018 2017 2016 2015

All Journal Article (45 results) (of which Int'l Joint Research: 16 results,  Peer Reviewed: 45 results,  Open Access: 14 results,  Acknowledgement Compliant: 7 results) Presentation (134 results) (of which Int'l Joint Research: 52 results,  Invited: 27 results) Book (1 results)

  • [Journal Article] Biosynthesis and structure activity relationship studies of okaramines that target insect glutamate-gated chloride channels2018

    • Author(s)
      Kato Naoki、Furutani Shogo、Otaka Junnosuke、Noguchi Akira、Kinugasa Kiyomi、Kai Kenji、Hayashi Hideo、Ihara Makoto、Takahashi Shunji、Matsuda Kazuhiko、Osada Hiroyuki
    • Journal Title

      ACS Chemical Biology

      Volume: 13 Issue: 3 Pages: 561-566

    • DOI

      10.1021/acschembio.7b00878

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a small-molecule ligand of β-arrestin1 as an inhibitor of stromal fibroblast cell migration accelerated by cancer cells2018

    • Author(s)
      Suvarna K, Honda K, Kondoh Y, Osada H, Watanabe N.
    • Journal Title

      Cancer Med

      Volume: 7 Issue: 3 Pages: 883-893

    • DOI

      10.1002/cam4.1339

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of cytotoxic, glutathione-reactive moieties inducing accumulation of reactive oxygen species via glutathione depletion2018

    • Author(s)
      Wilke J, Kawamura T, Watanabe N, Osada H, Ziegler S, Waldmann H.
    • Journal Title

      Bioorg Med Chem

      Volume: 26 Issue: 8 Pages: 1453-1461

    • DOI

      10.1016/j.bmc.2017.11.009

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Wakodecalines A and B, new decaline metabolites isolated from a fungus Pyrenochaetopsis sp. RK10-F0582018

    • Author(s)
      Nogawa T, Kato N, Shimizu T, Okano A, Futamura Y, Takahahi S, Osada H
    • Journal Title

      The Journal of Antibiotica

      Volume: 71 Issue: 1 Pages: 123-128

    • DOI

      10.1038/ja.2017.103

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a terpenoid-production platform in Streptomyces reveromyceticus SN-5932017

    • Author(s)
      Khalid A、Takagi H、Panthee S、Muroi M、Chappell J、Osada H、Takahashi S
    • Journal Title

      ACS Synthetic Biology

      Volume: 6 Issue: 12 Pages: 2339-2349

    • DOI

      10.1021/acssynbio.7b00249

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Regulatory mechanism of mycotoxin tenuazonic acid production in Pyricularia oryzae2017

    • Author(s)
      Yun CS, Motoyama T, Osada H
    • Journal Title

      ACS Chem Biol

      Volume: 12 Issue: 9 Pages: 2270-2274

    • DOI

      10.1021/acschembio.7b00353

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a gene cluster for telomestatin biosynthesis and heterologous expression using a specific promoter in a clean host.2017

    • Author(s)
      4.Amagai, K., Ikeda, H., Hashimoto, J., Kozone, I., Izumikawa, M., Kudo, F., Eguchi, T., Nakamura, T., Osada, H., Takahashi, S., Shin-ya
    • Journal Title

      Sci. Rep.

      Volume: 7 Issue: 1 Pages: 3382-3382

    • DOI

      10.1038/s41598-017-03308-5

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Functional annotation of chemical libraries across diverse biological processes.2017

    • Author(s)
      Piotrowski JS, Li SC, Deshpande R.......Shirahige K,......Boone C.
    • Journal Title

      Nat Chem Biol.

      Volume: 13 Issue: 9 Pages: 982-993

    • DOI

      10.1038/nchembio.2436

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Hitoyol A and B, Two Norsesquiterpenoids from the Basidiomycete Coprinopsis cinerea2017

    • Author(s)
      Otaka Junnosuke、Hashizume Daisuke、Masumoto Yui、Muranaka Atsuya、Uchiyama Masanobu、Koshino Hiroyuki、Futamura Yushi、Osada Hiroyuki
    • Journal Title

      Organic Letters

      Volume: 19 Issue: 15 Pages: 4030-4033

    • DOI

      10.1021/acs.orglett.7b01784

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a trichothecene production inhibitor by chemical array and library screening using trichodiene synthase as a target protein.2017

    • Author(s)
      3.Maeda K., Nakajima Y., Motoyama T., Kondoh Y., Kawamura T., Kanamaru K., Ohsato S., Nishiuchi T., Yoshida M., Osada H., Kobayashi T., Kimura M.
    • Journal Title

      Pestic. Biochem. Physiol

      Volume: 138 Pages: 1-7

    • DOI

      10.1016/j.pestbp.2017.03.006

    • NAID

      120006523682

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure-activity relationships of terpendole E and its natural derivatives.2017

    • Author(s)
      Nagumo Y, Hayashi T, Hirota H, Aono H, Kawatani M, Osada H, Usui T
    • Journal Title

      ChemistrySelect

      Volume: 2 Issue: 4 Pages: 1533-1536

    • DOI

      10.1002/slct.201602015

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Trachyspic acid 19-butyl ester, a new inhibitor of Plk1 polo box domain-dependent recognition from uncharacterized fungus RKGS-F2684.2017

    • Author(s)
      Nogawa T, Ogita N, Futamura Y, Negishi S, Watanabe N, Osada H
    • Journal Title

      J Antibiot

      Volume: 70 Issue: 5 Pages: 705-707

    • DOI

      10.1038/ja.2016.167

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Octaminomycins A and B, Cyclic Octadepsipeptides Active against Plasmodium falciparum.2017

    • Author(s)
      Jang JP, Nogawa T, Futamura Y, Shimizu T, Hashizume D, Takahashi S, Jang JH, Ahn JS, Osada H
    • Journal Title

      J Nat Prod

      Volume: 80 Issue: 1 Pages: 134-140

    • DOI

      10.1021/acs.jnatprod.6b00758

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Opantimycin A, a new metabolite isolated from Streptomyces sp. RK88-1355.2017

    • Author(s)
      Nogawa T, Okano A, Lim CL, Futamura Y, Shimizu T, Takahashi S, Ibrahim D, Osada H
    • Journal Title

      J Antibiot

      Volume: 70 Issue: 2 Pages: 222-225

    • DOI

      10.1038/ja.2016.113

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] RK-144171, a new benadrostin derivative produced by Streptomyces sp. RK88-1441.2017

    • Author(s)
      Jang JP, Takahashi S, Futamura Y, Nogawa T, Jang JH, Ahn JS, Osada H
    • Journal Title

      J Antibiot

      Volume: 70 Issue: 1 Pages: 102-104

    • DOI

      10.1038/ja.2016.65

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Identification and structure-activity relationship of purine derivatives as novel MTH1 inhibitors.2016

    • Author(s)
      Kumar A, Kawamura T, Kawatani M, Osada H, Zhang KY
    • Journal Title

      Chem Biol Drug Des

      Volume: - Issue: 6 Pages: 862-869

    • DOI

      10.1111/cbdd.12909

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Proteomic profiling reveals that collismycin A is an iron chelator.2016

    • Author(s)
      Kawatani M, Muroi M, Wada A, Inoue G, Futamura Y, Aono H, Shimizu K, Shimizu T, Igarashi Y, Takahashi-Ando N, Osada H
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 38385-38385

    • DOI

      10.1038/srep38385

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Stachybotrysin, an Osteoclast Differentiation Inhibitor from the Marine-Derived Fungus Stachybotrys sp. KCB13F013.2016

    • Author(s)
      Kim JW, Ko SK, Kim HM, Kim GH, Son S, Kim GS, Hwang GJ, Jeon ES, Shin KS, Ryoo IJ, Hong YS, Oh H, Lee KH, Soung NK, Hashizume D, Nogawa T, Takahashi S, Kim BY, Osada H, Jang JH, Ahn JS
    • Journal Title

      J Nat Prod

      Volume: 79 Issue: 10 Pages: 2703-2708

    • DOI

      10.1021/acs.jnatprod.6b00641

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Identification of a novel sesquiterpene biosynthetic machinery involved in astellolide biosynthesis.2016

    • Author(s)
      Shinohara Y, Takahashi S, Osada H, Koyama Y
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 32865-32865

    • DOI

      10.1038/srep32865

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparative chemical array screening for p38γ/δ MAPK inhibitors using a single gatekeeper residue difference between p38α/β and p38γ/δ.2016

    • Author(s)
      Kondoh Y, Honda K, Hiranuma S, Hayashi T, Shimizu T, Watanabe N, Osada H
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 29881-29881

    • DOI

      10.1038/srep29881

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] High-throughput screening identifies artesunate as selective inhibitor of cancer stemness: Involvement of mitochondrial metabolism.2016

    • Author(s)
      Subedi A, Futamura Y, Nishi M, Ryo A, Watanabe N, Osada H
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 477 Issue: 4 Pages: 737-742

    • DOI

      10.1016/j.bbrc.2016.06.128

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Discovery of novel selenium derivatives as Pin1 inhibitors by high-throughput screening.2016

    • Author(s)
      Subedi A, Shimizu T, Ryo A, Sanada E, Watanabe N, Osada H
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 474 Issue: 3 Pages: 528-533

    • DOI

      10.1016/j.bbrc.2016.04.124

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival.2016

    • Author(s)
      Kawamura T, Kawatani M, Muroi M, Kondoh Y, Futamura Y, Aono H, Tanaka M, Honda K, Osada H
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 26521-26521

    • DOI

      10.1038/srep26521

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Unantimycin A, a new neoantimycin analog isolated from a microbial metabolite fraction library2016

    • Author(s)
      Lim CL., Nogawa T., Okano A., Futamura Y., Kawatani M., Takahashi S. Ibrahim D., Osada H.
    • Journal Title

      The Journal of Antibiotics

      Volume: AOP Issue: 6 Pages: 456-458

    • DOI

      10.1038/ja.2015.124

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Identification of a novel compound that inhibits osteoclastogenesis by suppressing nucleoside transporters.2016

    • Author(s)
      S. Katsuyama, K. Sugino, Y. Sasazawa, Y. Nakano, H. Aono, K. Morishita, M. Kawatani, K. Umezawa, H. Osada and S. Simizu
    • Journal Title

      FEBS Letters

      Volume: 590 Issue: 8 Pages: 1152-1162

    • DOI

      10.1002/1873-3468.12146

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biosynthetic approaches to creating bioactive fungal metabolites: Pathway engineering and activation of secondary metabolism.2016

    • Author(s)
      Motoyama T, Osada H
    • Journal Title

      Bioorg Med Chem Lett

      Volume: 26 Issue: 24 Pages: 5843-5850

    • DOI

      10.1016/j.bmcl.2016.11.013

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemical and biological studies of reveromycin A.2016

    • Author(s)
      Osada H
    • Journal Title

      J Antibiot

      Volume: 69 Issue: 10 Pages: 723-730

    • DOI

      10.1038/ja.2016.57

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells by Inhibition of Casein Kinase 12016

    • Author(s)
      Ursu A, Illich DJ, Takemoto Y, Porfetye AT, Zhang M, Brockmeyer A, Janning P, Watanabe N, Osada H, Vetter IR, Ziegler S, Schöler HR, Waldmann H
    • Journal Title

      Cell Chem Biol

      Volume: 23 Issue: 4 Pages: 494-507

    • DOI

      10.1016/j.chembiol.2016.02.015

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] New Cyclic Lipopeptides of the Iturin Class Produced by Saltern-Derived Bacillus sp. KCB14S0062016

    • Author(s)
      Son S, Ko SK, Jang M, Kim JW, Kim GS, Lee JK, Jeon ES, Futamura Y, Ryoo IJ, Lee JS, Oh H, Hong YS, Kim BY, Takahashi S, Osada H, Jang JH, Ahn JS.
    • Journal Title

      Mar Drugs

      Volume: 14 Issue: 4 Pages: 72-72

    • DOI

      10.3390/md14040072

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Small molecules that target phosphorylation dependent protein-protein interaction2016

    • Author(s)
      Watanabe N, Osada H
    • Journal Title

      Bioorg Med Chem

      Volume: 印刷中 Issue: 15 Pages: 30171-30177

    • DOI

      10.1016/j.bmc.2016.03.023

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Integrated profiling methods for identifying the targets of bioactive compounds: MorphoBase and ChemProteoBase2016

    • Author(s)
      Muroi M, Futamura Y, Osada H
    • Journal Title

      Nat Prod Rep

      Volume: 33 Issue: 5 Pages: 621-625

    • DOI

      10.1039/c5np00106d

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Structures and biological activities of azaphilones produced by Penicillium sp. KCB11A109 from a ginseng field2016

    • Author(s)
      Son S, Ko SK, Kim JW, Lee JK, Jang M, Ryoo IJ, Hwang GJ, Kwon MC, Shin KS, Futamura Y, Hong YS, Oh H, Kim BY, Ueki M, Takahashi S, Osada H, Jang JH, Ahn JS.
    • Journal Title

      Phytochemistry

      Volume: 122 Pages: 154-164

    • DOI

      10.1016/j.phytochem.2015.12.008

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] RQN-18690A (18-deoxyherboxidiene) targets SF3b, a spliceosome component, and inhibits angiogenesis2016

    • Author(s)
      Kakeya, H., Kaida, D., Sekiya, H., Nagai, K., Yoshida, M., and Osada, H.
    • Journal Title

      J. Antibiot. (Tokyo)

      Volume: 69 Issue: 2 Pages: 121-123

    • DOI

      10.1038/ja.2015.94

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] An overproduction of astellolides induced by genetic disruption of chromatin-remodeling factors in Aspergillus oryzae2016

    • Author(s)
      Shinohara Y, Kawatani M, Futamura Y, Osada H, Koyama Y
    • Journal Title

      J Antibiot

      Volume: 69 Issue: 1 Pages: 4-8

    • DOI

      10.1038/ja.2015.73

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reveromycin A Administration Prevents Alveolar Bone Loss in Osteoprotegerin Knockout Mice with Periodontal Disease2015

    • Author(s)
      Mizuno M, Miyazawa K, Tabuchi M, Tanaka M, Yoshizako M, Minamoto C, Torii Y, Tamaoka Y, Kawatani M, Osada H, Maeda H, Goto S
    • Journal Title

      Sci Rep

      Volume: 5 Issue: 1 Pages: 16510-16510

    • DOI

      10.1038/srep16510

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of middle chain fatty acyl-CoA ligase responsible for the biosynthesis of 2-alkylmalonyl-CoA for polyketide extender unit2015

    • Author(s)
      Miyazawa T., Takahashi S., Kawata A., Panthee S., Hayashi T., Shimizu T., Nogawa T., Osada H.
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 290 Issue: 45 Pages: 26994-27011

    • DOI

      10.1074/jbc.m115.677195

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Haenamindole, an unusual diketopiperazine derivative from a marine-derived Penicillium sp. KCB12F0052015

    • Author(s)
      Kim JW, Ko SK, Son S, Shin KS, Ryoo IJ, Hong YS, Oh H, Hwang BY, Hirota H, Takahashi S, Kim BY, Osada H, Jang JH, Ahn JS
    • Journal Title

      Bioorg Med Chem Lett

      Volume: 25 Issue: 22 Pages: 5398-5401

    • DOI

      10.1016/j.bmcl.2015.09.026

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Neuritogenic Activity of Tetradecyl 2,3-Dihydroxybenzoate Is Mediated through the Insulin-Like Growth Factor 1 Receptor/Phosphatidylinositol 3 Kinase/Mitogen-Activated Protein Kinase Signaling Pathway2015

    • Author(s)
      Tang R, Gao L, Kawatani M, Chen J, Cao X, Osada H, Xiang L, Qi J
    • Journal Title

      Mol Pharmacol

      Volume: 88 Issue: 2 Pages: 326-334

    • DOI

      10.1124/mol.115.097758

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Novel abscisic acid antagonists identified with chemical array screening.2015

    • Author(s)
      Ito T, Kondoh Y, Yoshida K, Umezawa T, Shimizu T, Shinozaki K, Osada H
    • Journal Title

      Chembiochem

      Volume: 16 Issue: 17 Pages: 2471-2478

    • DOI

      10.1002/cbic.201500429

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Biosynthesis of the mycotoxin tenuazonic acid by a fungal NRPS-PKS hybrid enzyme2015

    • Author(s)
      Choong-Soo Yun, Takayuki Motoyama & Hiroyuki Osada
    • Journal Title

      Nature Communications

      Volume: 6 Issue: 1 Pages: 8758-8758

    • DOI

      10.1038/ncomms9758

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Identification of matrix metalloproteinase inhibitors by chemical arrays.2015

    • Author(s)
      Kawatani M, Fukushima Y, Kondoh Y, Honda K, Sekine T, Yamaguchi Y, Taniguchi N, Osada H
    • Journal Title

      Biosci Biotechnol Biochem

      Volume: 79 Issue: 10 Pages: 1597-1602

    • DOI

      10.1080/09168451.2015.1045829

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] RK-270A-C, new oxindole derivatives isolated from a microbial metabolites fraction library of Streptomyces sp. RK85-270.2015

    • Author(s)
      Jang JP, Nogawa T, Uramoto M, Okano A, Futamura Y, Shimizu T, Takahashi S, Jang JH, Ahn JS, Osada H.
    • Journal Title

      J Antibiot (Tokyo)

      Volume: 68 Issue: 4 Pages: 293-295

    • DOI

      10.1038/ja.2014.141

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A new enzyme involved in the control of the stereochemistry in the decalin formation during equisetin biosynthesis.2015

    • Author(s)
      Kato N, Nogawa T, Hirota H, Jang JH, Takahashi S, Ahn JS, Osada H.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 460 Issue: 2 Pages: 210-215

    • DOI

      10.1016/j.bbrc.2015.03.011

    • NAID

      130007491120

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibition of malaria parasite growth by quinomycin A and its derivatives through DNA-intercalating activity.2015

    • Author(s)
      Hayase H, Watanabe N, Lim CL, Nogawa T, Komatsuya K, Kita K, Osada H.
    • Journal Title

      Biosci Biotechnol Biochem

      Volume: 79 Issue: 4 Pages: 633-635

    • DOI

      10.1080/09168451.2014.987205

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Construction and application of a photo-cross-linked chemical array.2015

    • Author(s)
      Kondoh Y, Honda K, Osada H
    • Journal Title

      Methods Mol Biol 2015;1263:29-41

      Volume: 1263 Pages: 29-41

    • DOI

      10.1007/978-1-4939-2269-7_3

    • ISBN
      9781493922680, 9781493922697
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 破骨細胞を標的とするリベロマイシンA:生物活性研究から生合成研究への展開2018

    • Author(s)
      長田裕之
    • Organizer
      日本薬学会第138回年会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 担子菌類Coprinopsis cinereaからの新規骨格を有する2種のノルセスキテルペノイド2018

    • Author(s)
      大髙潤之介、二村友史、長田裕之
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 糸状菌Pyrenochaetopsis sp. RK10-F058より単離した新規デカリン骨格含有二次代謝産物wakodecaline Cの構造2018

    • Author(s)
      野川俊彦、加藤直樹、清水猛、岡野亜紀子、二村友史、高橋俊二、長田裕之
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] がん代謝阻害剤スクリーニングと呼吸阻害作用解析2018

    • Author(s)
      室井誠、二村友史、青野晴美、川谷誠、関根朋美、野川俊彦、林田莉奈、長田裕之
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] がん代謝研究を加速するオミックス解析基盤の構築2018

    • Author(s)
      佐竹華子、二村友史、室井誠、野川俊彦、川谷誠、井本正哉、長田裕之
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Pyricularia oryzaeにおけるテヌアゾン酸生産誘導化合物の探索と作用機構解析2018

    • Author(s)
      本山高幸、田中陽子、長田裕之
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 立体選択的デカリン形成を担うFsa2ファミリーDiels-Alderaseの機能解析2018

    • Author(s)
      加藤直樹、野川俊彦、衣笠清美、高橋俊二、長田裕之
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] リベロマイシン生合成に関わるサクシニル化酵素群の機能解析2018

    • Author(s)
      鬼頭奈央子、高橋 俊二、佐藤裕美、奥村英夫、熊坂崇、長田裕之
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] テヌアゾン酸の環状骨格形成を担うケトシンターゼドメインの結晶化解析2018

    • Author(s)
      尹忠銖、西本一希、本山高幸、日野智也、永野真吾、長田裕之
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] イネいもち病菌におけるpyriculol類生合成関連aldo/keto reductase遺伝子の機能解析2018

    • Author(s)
      古山祐貴、本山高幸、野川俊彦、清田洋正、鎌倉高志、長田裕之
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Tolypocladium albumにおけるNPD938による二次代謝産物生合成遺伝子の発現誘導機構2018

    • Author(s)
      石井友彬、本山高幸、鎌倉高志、長田裕之
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] がん代謝を阻害するプレニルフラボノイドの作用機序解析2018

    • Author(s)
      二村友史、青野晴美、佐竹華子、室井誠、川谷誠、野川俊彦、井本正哉、長田裕之
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] がん細胞に活性酸素種産生を誘導する化合物のスクリーニング2018

    • Author(s)
      河村達郎、WILKE Julian、渡辺信元、ZIEGLER Slava、WALDMANN Herbert、長田裕之
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 新規アントラキノンkinanthraquinoneの同定と生物活性評価2018

    • Author(s)
      高木海、野川俊彦、二村友史、長田裕之、高橋俊二
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Candida albicansに菌糸形態を誘導する化合物RK-276Aのケミカルバイオロジー研究2018

    • Author(s)
      山本甲斐、二村友史、清水猛、長田裕之
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 抗生物質学からケミカルバイオロジーへの展開(微生物創薬研究の温故知新)2018

    • Author(s)
      長田裕之
    • Organizer
      日本技術士会化学部会 2月度 講演会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Systematic Isolation of Microbial Metabolites and the Target Identification2018

    • Author(s)
      Hiroyuki Osada
    • Organizer
      International Symposium on Himalayan Biodiversity Bioresources
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] New approach to search and isolate novel secondary metabolites from microbes for a chemical biology study2018

    • Author(s)
      Toshihiko Nogawa and Hiroyuki Osada
    • Organizer
      International Symposium on Himalayan Biodiversity Bioresources
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Anti-osteoclastic agent, reveromycin A (biological activity and biosynthesis)2018

    • Author(s)
      Hiroyuki Osada
    • Organizer
      Department of Chemistry Bicoastal Lecture Series, The Scripps Research Institute
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Chemical Synthesis or Biosynthesis:It is the Question for Reveromycin Production2018

    • Author(s)
      Hiroyuki Osada
    • Organizer
      The Mona Symposium 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] イネいもち病菌のネクトリアピロン類の生産誘導条件の探索と大量生産株の作製2017

    • Author(s)
      本山 高幸, 田中 陽子, 長田 裕之
    • Organizer
      日本農芸化学会2017年度大会
    • Place of Presentation
      京都女子大学(京都府京都市)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] イネいもち病菌におけるピリクロール類生合成に関わるFAD依存性モノオキシゲナーゼ遺伝子の解析2017

    • Author(s)
      古山 祐貴, 本山 高幸, 鎌倉 高志, 野川 俊彦, 長田 裕之
    • Organizer
      日本農芸化学会2017年度大会
    • Place of Presentation
      京都女子大学(京都府京都市)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] じゃがいもの新規機能性成分探索に向けたフラクションライブラリーの作製2017

    • Author(s)
      野川 俊彦, 二村 友史, 岡野 亜紀子, 石原 克之, 須藤 麻里, 伊藤 政喜, 長田 裕之
    • Organizer
      日本農芸化学会2017年度大会
    • Place of Presentation
      京都女子大学(京都府京都市)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] じゃがいもフラクションライブラリーを用いた抗糖化活性の検討2017

    • Author(s)
      須藤 麻里, 吉原 潮梨, 石原 克之, 野川 俊彦, 二村 友史, 岡野 亜紀子, 長田 裕之
    • Organizer
      日本農芸化学会2017年度大会
    • Place of Presentation
      京都女子大学(京都府京都市)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] リベロマイシン生合成に関わる酸化還元酵素RevMの機能解析2017

    • Author(s)
      鬼頭 奈央子, 高橋 俊二, 宮澤 岳, 前島 希, 田中 美帆, 室井 誠. 奥村 英夫, 熊坂 崇, 長田 裕之
    • Organizer
      日本農芸化学会2017年度大会
    • Place of Presentation
      京都女子大学(京都府京都市)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] リベロマイシン生合成に関わるRevMの結晶構造解析2017

    • Author(s)
      奥村 英夫, 鬼頭 奈央子, 高橋 俊二, 宮澤 岳, 熊坂 崇, 長田 裕之
    • Organizer
      日本農芸化学会2017年度大会
    • Place of Presentation
      京都女子大学(京都府京都市)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] 化合物アレイの新たな活用法:天然物の鏡像体化合物群の活用を目指したスクリーニング法の開発2017

    • Author(s)
      近藤 恭光, 野口 太朗, 大石 真也, 本田 香織, 大野 浩章, 藤井 信孝, 長田 裕之
    • Organizer
      日本農芸化学会2017年度大会
    • Place of Presentation
      京都女子大学(京都府京都市)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] ストレプトマイセス リベロマイセティカスを用いたテルペノイド生産プラットフォームの開発2017

    • Author(s)
      AMMARA KHALID, 高木 海, SURESH PANTHEE, 長田 裕之, 高橋 俊二
    • Organizer
      日本農芸化学会2017年度大会
    • Place of Presentation
      京都女子大学(京都府京都市)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] プレニル化インドールアルカロイドokaramine生合成におけるazetidine環合成酵素の同定2017

    • Author(s)
      加藤 直樹, 大髙 潤之介, 衣笠 清美, 古谷 章悟, 高橋 俊二, 松田 一彦, 長田 裕之
    • Organizer
      日本農芸化学会2017年度大会
    • Place of Presentation
      京都女子大学(京都府京都市)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] がん細胞に誘起される繊維芽細胞遊走を阻害する小分子探索2017

    • Author(s)
      渡辺信元、Kruthi Suvarna、本田香織、近藤恭光、長田裕之
    • Organizer
      2107年度生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] がん代謝を標的とする小分子阻害剤の探索2017

    • Author(s)
      長田裕之、二村友史、室井誠
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] グルコース非依存性がん代謝機構を標的とした小分子阻害剤の探索2017

    • Author(s)
      川谷誠、青野晴美、二村友史、室井誠、長田裕之
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Exploration of small molecules targeting cancer metabolism2017

    • Author(s)
      二村友史、青野晴美、川谷誠、長田裕之
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Identification of a ligand compound of beta-arrestin as an inhibitor of metastasis of carcinoma associated fibroblasts2017

    • Author(s)
      Kruthi Suvarna, Hiroyuki Osada, Nobumoto Watanabe
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 糸状菌Pyrenochaetopsis sp. RK10-F058より単離した新規デカリン骨格含有二次代謝産物の構造2017

    • Author(s)
      野川俊彦、加藤直樹、清水猛、岡野亜紀子、二村友史、高橋俊二、長田裕之
    • Organizer
      第59回天然有機化合物討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 真菌の形態変化を指標とした抗真菌物質YO15001A、Bの単離2017

    • Author(s)
      山本甲斐、二村友史、長田裕之
    • Organizer
      第32回日本放線菌学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] リベロマイシン生合成に関わるRevMの機能解析2017

    • Author(s)
      鬼頭奈央子、高橋俊二、佐藤裕美、奥村英夫、熊坂崇、長田裕之
    • Organizer
      第32回日本放線菌学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 植物病原糸状菌の感染戦略におけるテヌアゾン酸生産の関与2017

    • Author(s)
      柏毅、本山高幸、長田裕之
    • Organizer
      平成29年度植物感染生理談話会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 破骨細胞を標的とするreveromycin Aの研究2017

    • Author(s)
      長田裕之
    • Organizer
      筑波大学WPIセミナー「有機化学・創薬化学セミナー」
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 抗生物質学からケミカルバイオロジーへの展開(微生物創薬研究の温故知新)2017

    • Author(s)
      長田裕之
    • Organizer
      ライフサイエンス技術部会・反応分科会 講演会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 的を射る難しさ2017

    • Author(s)
      長田 裕之
    • Organizer
      第52回 天然物化学談話会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] エネルギー代謝を標的とした小分子化合物の探索2017

    • Author(s)
      二村友史、川谷誠、青野晴美、長田裕之
    • Organizer
      第21回日本がん分子標的治療学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] グルコース非依存性がん代謝機構を標的とした小分子阻害剤の探索2017

    • Author(s)
      川谷誠、青野晴美、二村友史、室井誠、長田裕之
    • Organizer
      第21回日本がん分子標的治療学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] アルテスネイトはミトコンドリア障害を介して幹細胞特異的生存阻害を引き起こす2017

    • Author(s)
      渡辺信元、二村友史、長田裕之
    • Organizer
      第21回日本がん分子標的治療学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ケミカルバイオロジーの威力2017

    • Author(s)
      長田 裕之
    • Organizer
      関西学院大学化学セミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ChemProteoBase を用いた化合物のオフターゲット解析2017

    • Author(s)
      室井誠、川谷誠、河村達郎、近藤恭光、二村友史、田中美帆、青野晴美、本田香織、長田裕之
    • Organizer
      日本ケミカルバイオロジー学会 第12回年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 植物病原糸状菌が生産する二次代謝産物テヌアゾン酸は宿主の抵抗性を誘導する2017

    • Author(s)
      柏毅、本山高幸、長田裕之
    • Organizer
      平成29年度日本植物病理学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Chemical array screening, a powerful approach for exploring small molecule inhibitors against proteins2017

    • Author(s)
      Hiroyuki Osada
    • Organizer
      International Symposium “Systems Glycobiology and Beyond”
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Screening and target identification of small molecules affecting cancer metabolism2017

    • Author(s)
      Hiroyuki Osada
    • Organizer
      ICBS 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Biosynthesis and regulatory mechanism of mycotoxin tenuazonic acid in Pyricularia oryzae2017

    • Author(s)
      Choong-Soo Yun, Takayuki Motoyama, Hiroyuki Osada
    • Organizer
      3rd KRIBB-RIKEN Chemical Biology Joint Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Application of a fraction library for new metabolites search2017

    • Author(s)
      Toshihiko Nogawa, Akiko Okano, Yushi Futamura, Takeshi Shimizu, Nobumoto Watanabe, Shunji Takahashi, Hiroyuki Osada
    • Organizer
      3rd KRIBB-RIKEN Chemical Biology Joint Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Exploration of novel antifungal substances based on fungal morphological changes2017

    • Author(s)
      Kai Yamamoto, Yushi Futamura, Takeshi Shimizu, Hiroyuki Osada
    • Organizer
      3rd KRIBB-RIKEN Chemical Biology Joint Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Fsa2-family Diels-Alderases are responsible for the stereoselective decaline formation2017

    • Author(s)
      Naoki Kato, Toshihiko Nogawa, Kiyomi Kinugasa, Shunji Takahashi, Hiroyuki Osada
    • Organizer
      3rd KRIBB-RIKEN Chemical Biology Joint Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification of pyrrolizilactone biosynthetic gene cluster of the fungus RKB35642017

    • Author(s)
      Sayaka Hirosawa, Naoki Kato, Kiyomi Kinugasa, Shunji Takahashi, Hiroyuki Osada
    • Organizer
      3rd KRIBB-RIKEN Chemical Biology Joint Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] New secondary metabolites from Basidiomycete2017

    • Author(s)
      Junnosuke Otaka and Hiroyuki Osada
    • Organizer
      3rd KRIBB-RIKEN Chemical Biology Joint Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of an FAD-dependent Monooxygenase Gene Involved in Pyriculol Biosynthesis2017

    • Author(s)
      Yuki Furuyama, Takayuki Motoyama, Toshihiko Nogawa, Takashi Kamakura, Hiroyuki Osada
    • Organizer
      3rd KRIBB-RIKEN Chemical Biology Joint Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification of novel anthraquinone biosynthetic gene cluster2017

    • Author(s)
      Risa Takao, Naoko Kito, Hiroshi Takagi, Hiroyuki Osada, Shunji Takahashi
    • Organizer
      3rd KRIBB-RIKEN Chemical Biology Joint Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Inhibitor of stromal fibroblast migration accelerated by cancer cells2017

    • Author(s)
      Kruthi Suvarna, Kaori Honda, Yasumitsu Kondoh, Hiroyuki Osada, Nobumoto Watanabe
    • Organizer
      3rd KRIBB-RIKEN Chemical Biology Joint Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Pentapeptides from Streptomyces sp. RK88-1441 by using the one strain-many compounds strategy2017

    • Author(s)
      Jun-Pil Jang, Gwi Ja Hwang, Min Cheol Kwon, In-Ja Ryoo, Sung-Kyun Ko, Jae-Hyuk Jang, Hiroyuki Osada, Jong Seong Ahn
    • Organizer
      3rd KRIBB-RIKEN Chemical Biology Joint Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of lucilactaene biosynthesis gene cluster2017

    • Author(s)
      Sho Kato, Takayuki Motoyama, Hiroyuki Osada
    • Organizer
      3rd KRIBB-RIKEN Chemical Biology Joint Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Activation of the sleeping gene cluster of microbial secondary metabolites2017

    • Author(s)
      Hiroyuki Osada
    • Organizer
      9th US-Japan Seminar on the Biosynthesis of Natural Products
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Screening of Inhibitors against Cancer Stem Cells from Natural Products Depository (NPDepo)2017

    • Author(s)
      Hiroyuki Osada
    • Organizer
      18th International Symposium on the Biology of Actinomycetes (ISBA18)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Structure-activity relationship of NPD9055, a small-molecule inducer of reactive oxygen species2017

    • Author(s)
      Tatsuro Kawamura, Erchang Shang, Gernot Hahne, Sonja Sievers, Slava Ziegler, Nobumoto Watanabe, Herbert Waldmann, Hiroyuki Osada
    • Organizer
      RIKEN-Max Planck Joint Research Center for System Chemical Biology, The 6th Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Novel application of chemical array: Screening approach for drug discovery from natural product enantiomers2017

    • Author(s)
      Yasumitsu Kondoh, Kaori Honda, Taro Noguchi, Shinya Oishi, Hiroaki Ohno, Nobutaka Fujii, and Hiroyuki Osada
    • Organizer
      RIKEN-Max Planck Joint Research Center for System Chemical Biology, The 6th Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A proteomic profiling, ChemProteoBase, reveals non-proteinous target of compounds2017

    • Author(s)
      Makoto Muroi, Makoto Kawatani, Akira Wada, Miho Tanaka, and Hiroyuki Osada
    • Organizer
      RIKEN-Max Planck Joint Research Center for System Chemical Biology, The 6th Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Artesunate selectively inhibits of cancer stemness through the mitochondrial dysfunction2017

    • Author(s)
      Nobumoto Watanabe, Amit Subedi, Yushi Futamura, Akihide Ryo and Hiroyuki Osada
    • Organizer
      RIKEN-Max Planck Joint Research Center for System Chemical Biology, The 6th Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Screening of small molecule inhibitors of human pirin2017

    • Author(s)
      Hiroyuki Osada
    • Organizer
      253rd American Chemical Society National Meeting & Exposition
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Analysis of MTH1 inhibitors by ChemProteoBase, the drug-target analysis system based on proteomic profiling.2016

    • Author(s)
      Muroi M, Kawatani M, Kawamura T, Futamura Y, Osada H
    • Organizer
      The 21st JFCR-International Symposium on Cancer Chemotherapy (JFCR-ISCC)
    • Place of Presentation
      Miraikan (National Museum of Emerging Science and Innovation) (Tokyo, Japan)
    • Year and Date
      2016-12-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] アルテスネイトはミトコンドリアを標的として、肝細胞特異的にがん細胞生存を阻害する2016

    • Author(s)
      渡辺 信元, Amit Sbedi, 二村 友史, 梁明秀, 長田 裕之
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival2016

    • Author(s)
      Kawamura T, Kawatani M, Muroi M, Kondoh Y, Futamura Y, Aono H, Tanakaa M, Honda K, Osada H
    • Organizer
      28th EORTC-NCI-AACR SYMPOSIUM
    • Place of Presentation
      ICM - Internationales Congress Center Munich (Munich, Germany)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] フサリセチンAの特徴的な環構造形成を担う環化酵素の同定2016

    • Author(s)
      加藤 直樹, 衣笠 清美,Jae-Hyuk JANG,高橋 俊二,Jong Seog AHN,長田 裕之
    • Organizer
      第16回糸状菌分子生物学コンファレンス
    • Place of Presentation
      宇治おうばくプラザ(京都大学宇治キャンパス内)(京都府宇治市)
    • Year and Date
      2016-11-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] 分子標的治療薬開発の落とし穴2016

    • Author(s)
      長田 裕之
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Characterization of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival2016

    • Author(s)
      河村 達郎, 川谷 誠, 室井 誠, 青野 晴美, 二村 友史, 長田 裕之
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] エネルギー代謝プロファイリングを用いたがん代謝阻害剤の探索研究2016

    • Author(s)
      二村 友史, 青野 晴美, 川谷 誠, 室井 誠, 長田 裕之
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] 化合物アレイ法による医薬シードの探索2016

    • Author(s)
      長田 裕之
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] The role of the MTH1 enzyme in cancer gave rise to controversy2016

    • Author(s)
      Kawamura T, Kawatani M, Osada H
    • Organizer
      The First Asian 3 Roundtable Meeting on Chemical Probe Research Hub
    • Place of Presentation
      Hotel LEOPALACE Hakata (Fukuoka, Japan)
    • Year and Date
      2016-09-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 放線菌Streptomyces sp. RK88-1355より単離した新規Opantimycin Aの構造2016

    • Author(s)
      野川 俊彦, リム・チュンリャン, 岡野 亜紀子, 二村 友史, 清水 猛, 高橋 俊二, 長田 裕之
    • Organizer
      第58回天然有機化合物討論会
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2016-09-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] Activation of fungal secondary metabolism by disturbance of the two-component signal transduction system and identification of the nectriapyrone biosynthetic gene cluster2016

    • Author(s)
      Motoyama T, Tanaka Y, Osada H
    • Organizer
      9th Joint Natural Products Conference 2016
    • Place of Presentation
      Tivoli Congress Centre (Copenhagen, Denmark)
    • Year and Date
      2016-07-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Comparative chemical array screening of p38γ/δ MAPK inhibitors by focusing on a single gatekeeper residue difference between p38α/β and p38γ/δ2016

    • Author(s)
      Kondoh Y, Honda K, Hiranuma S, Shimizu T, Osada H
    • Organizer
      17th Tetrahedron Symposium
    • Place of Presentation
      MeliaSitges Hotel Congress Centre (Sitges, Barcelona, Spain)
    • Year and Date
      2016-06-30
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Stereospecific ring formation in biosynthesis of specialized microbial metabolites2016

    • Author(s)
      Osada H
    • Organizer
      17th Tetrahedron Symposium
    • Place of Presentation
      MeliaSitges Hotel Congress Centre (Sitges, Barcelona, Spain)
    • Year and Date
      2016-06-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 酸化ヌクレオチド加水分解酵素MTH1阻害剤の作用解析2016

    • Author(s)
      川谷 誠, 河村 達郎, 室井 誠, 青野 晴美, 二村 友史, 田中 美帆, 長田 裕之
    • Organizer
      第20回日本がん分子標的治療学会学術集会
    • Place of Presentation
      別府国際コンベンションセンター(大分県別府市)
    • Year and Date
      2016-05-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] エネルギー代謝プロファイリングを用いたがん代謝阻害薬の探索研究2016

    • Author(s)
      二村 友史, 川谷 誠, 青野 晴美, 室井 誠, 田中 美帆, 長田 裕之
    • Organizer
      第20回日本がん分子標的治療学会学術集会
    • Place of Presentation
      別府国際コンベンションセンター(大分県別府市)
    • Year and Date
      2016-05-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] リン酸化特異的プロリン異性化酵素Pin1の新規阻害小分子の単離2016

    • Author(s)
      渡邉 信元, 長田 裕之
    • Organizer
      第20回日本がん分子標的治療学会学術集会
    • Place of Presentation
      別府国際コンベンションセンター(大分県別府市)
    • Year and Date
      2016-05-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] Identification of MTH1inhibitors by chemical arrays2016

    • Author(s)
      Kawamura T, Kawatani M, Kondoh Y, Muroi M, Futamura Y, Aono H, Tanaka M, Honda K, Osada H
    • Organizer
      RIKEN-Max Planck Joint Research Center for Systems Chemical Biology The 5th Symposium
    • Place of Presentation
      Harnack-Haus, Tagungsstatte der Max-Planck-Gesellschaft (Berlin, Germany)
    • Year and Date
      2016-04-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Expansion of ChemProteoBase for the analysis of compounds affecting cancer metabolism2016

    • Author(s)
      Muroi M, Tanaka M, Osada H
    • Organizer
      RIKEN-Max Planck Joint Research Center for Systems Chemical Biology The 5th Symposium
    • Place of Presentation
      Harnack-Haus, Tagungsstatte der Max-Planck-Gesellschaft (Berlin, Germany)
    • Year and Date
      2016-04-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 14-3-3 protein-porotein interaction inhibitors identified by high throughput screening2016

    • Author(s)
      Watanabe N, Osada H
    • Organizer
      RIKEN-Max Planck Joint Research Center for Systems Chemical Biology The 5th Symposium
    • Place of Presentation
      Harnack-Haus, Tagungsstatte der Max-Planck-Gesellschaft (Berlin, Germany)
    • Year and Date
      2016-04-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Comparative chemical array screening for p38γ/δ MAPK inhibitors using a single gatekeeper residue difference between p38α/β and p38γ/δ2016

    • Author(s)
      Kondoh Y, Honda K, Hiranuma S, Shimizu T, Osada H
    • Organizer
      RIKEN-Max Planck Joint Research Center for Systems Chemical Biology The 5th Symposium
    • Place of Presentation
      Harnack-Haus, Tagungsstatte der Max-Planck-Gesellschaft (Berlin, Germany)
    • Year and Date
      2016-04-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Fragment arrays for early druggability assessments2016

    • Author(s)
      Jonas Aretz, Yasumitsu Kondoh, Kaori Honda, Upendra Rao Anumala, Marc Nazare, Nobumoto Watanabe, Hiroyuki Osada, Christoph Rademacher
    • Organizer
      RIKEN-Max Planck Joint Research Center for Systems Chemical Biology The 5th Symposium
    • Place of Presentation
      Harnack-Haus, Tagungsstatte der Max-Planck-Gesellschaft (Berlin, Germany)
    • Year and Date
      2016-04-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 抗生物質学のすすめ2016

    • Author(s)
      長田 裕之
    • Organizer
      第42回 農芸化学「化学と生物」シンポジウム
    • Place of Presentation
      札幌市教育文化会館 (北海道札幌市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Chemical array screening of matrix metalloproteinase inhibitors2016

    • Author(s)
      近藤 恭光, 川谷 誠, 本田 香織, 関根 朋美, 長田 裕之
    • Organizer
      日本農芸化学会 2016年度大会
    • Place of Presentation
      札幌コンベンションセンター 札幌市産業振興センター (北海道札幌市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] プレニル化インドールアルカロイドokaramineの遺伝学的手法による生合成経路解析2016

    • Author(s)
      加藤 直樹, 古谷 章悟, 大髙 潤之介, 衣笠 清美, 高橋 俊二, 松田 一彦, 長田 裕之
    • Organizer
      日本農芸化学会 2016年度大会
    • Place of Presentation
      札幌コンベンションセンター 札幌市産業振興センター (北海道札幌市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 微生物フラクションライブラリーより単離した新規ネオアンチマイシン類縁体ウナンチマイシンAの構造2016

    • Author(s)
      野川 俊彦, リム・チュンリャン, 岡野 亜紀子, 二村 友史, 川谷 誠, 高橋 俊二, ダーラ・イブラヒム, 長田裕之
    • Organizer
      日本農芸化学会 2016年度大会
    • Place of Presentation
      札幌コンベンションセンター 札幌市産業振興センター (北海道札幌市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] ChemProteoBaseによるがん代謝作用薬の解析2016

    • Author(s)
      室井 誠, 田中 美帆, 長田 裕之
    • Organizer
      日本農芸化学会 2016年度大会
    • Place of Presentation
      札幌コンベンションセンター 札幌市産業振興センター (北海道札幌市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 真菌の形態変化を指標とした抗真菌物質の探索研究2016

    • Author(s)
      山本 甲斐, 二村 友史, 植木 雅志, 鈴木 龍一郎, 白瀧 義明, 長田裕之
    • Organizer
      日本農芸化学会 2016年度大会
    • Place of Presentation
      札幌コンベンションセンター 札幌市産業振興センター (北海道札幌市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] イネいもち病菌のピリクロール類生合成遺伝子クラスターの同定2016

    • Author(s)
      古山 祐貴, 本山 高幸, 鎌倉 高志, 長田裕之
    • Organizer
      日本農芸化学会 2016年度大会
    • Place of Presentation
      札幌コンベンションセンター 札幌市産業振興センター (北海道札幌市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] カビ由来新規NRPS-PKS融合酵素によるカビ毒テヌアゾン酸の生合成2016

    • Author(s)
      尹 忠銖, 本山 高幸, 長田 裕之
    • Organizer
      日本農芸化学会 2016年度大会
    • Place of Presentation
      札幌コンベンションセンター 札幌市産業振興センター (北海道札幌市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] イネいもち病菌におけるカビ毒テヌアゾン酸の生合成2016

    • Author(s)
      尹 忠銖, 本山 高幸, 長田 裕之
    • Organizer
      第59回 日本放線菌学会学術講演会
    • Place of Presentation
      東京電機大学 (東京都足立区)
    • Year and Date
      2016-03-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] Screening of small molecule compounds with activity to selectively inhibit the cancer stem cell properties2016

    • Author(s)
      Hiroyuki Osada
    • Organizer
      Tenth AACR-JCA Joint Conference on Breakthroughs in Cancer Research: From Biology to Therapeutics
    • Place of Presentation
      Hyatt Regency Maui (Maui, Hawaii, USA)
    • Year and Date
      2016-02-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Discovery and analyses of 14-3-3 protein-protein interaction inhibitors identified by high throughput screening2016

    • Author(s)
      Nobumoto Watanabe, Hiroyuki Osada
    • Organizer
      Tenth AACR-JCA Joint Conference on Breakthroughs in Cancer Research: From Biology to Therapeutics
    • Place of Presentation
      Hyatt Regency Maui (Maui, Hawaii, USA)
    • Year and Date
      2016-02-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Biosynthesis of the mycotoxin tenuazonic acid by a fungal NRPS-PKS hybrid enzyme2016

    • Author(s)
      Yun CS, Motoyama T, Osada H
    • Organizer
      The 8th Korea-Japan Chemical Biology symposium
    • Place of Presentation
      Okinawa Institute of Science and Technology Graduate University (Naha, Okinawa, Japan)
    • Year and Date
      2016-01-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Characterization of middle chain fatty acyl-CoA ligase responsible for the biosynthesis of 2-alkylmalonyl-CoAs for polyketide extender unit2016

    • Author(s)
      Miyazawa H, Takahashi S, Shimizu T, Nogawa T, Osada H
    • Organizer
      The 8th Korea-Japan Chemical Biology symposium
    • Place of Presentation
      Okinawa Institute of Science and Technology Graduate University (Naha, Okinawa, Japan)
    • Year and Date
      2016-01-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Discovery of a new enzyme involved in the stereoselective decalin formation during equisetin biosynthesis2016

    • Author(s)
      Kato N, Nogawa T, Hirota H, Takahashi S, Jang JH, Ahn JS, Osada H
    • Organizer
      The 8th Korea-Japan Chemical Biology symposium
    • Place of Presentation
      Okinawa Institute of Science and Technology Graduate University (Naha, Okinawa, Japan)
    • Year and Date
      2016-01-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Bioactive compounds from Plant Roots2016

    • Author(s)
      Otaka J, Futamura Y, Osada H
    • Organizer
      The 8th Korea-Japan Chemical Biology symposium
    • Place of Presentation
      Okinawa Institute of Science and Technology Graduate University (Naha, Okinawa, Japan)
    • Year and Date
      2016-01-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Phenotypic screening of small molecules targeting cancer metabolism2016

    • Author(s)
      Futamura Y, Kawatani M, Aono H, Muroi M, Tanaka M, Osada H
    • Organizer
      The 8th Korea-Japan Chemical Biology symposium
    • Place of Presentation
      Okinawa Institute of Science and Technology Graduate University (Naha, Okinawa, Japan)
    • Year and Date
      2016-01-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 化合物アレイによる創薬シードの探索2015

    • Author(s)
      長田 裕之
    • Organizer
      日本薬学会関東支部第40回学術講演会 創薬イノベーションを支える最先端サイエンス
    • Place of Presentation
      日本薬学会長井記念館 長井記念ホール (東京都渋谷区)
    • Year and Date
      2015-12-26
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Biosynthesis study aiming at creation of an anti-osteoclast drug2015

    • Author(s)
      Hiroyuki Osada, Toshihiko Nogawa, Shunji Takahashi
    • Organizer
      The international chemical congress of pacific basin societies (Pacifichem) 2015
    • Place of Presentation
      Hawaii Convention Center 他 (Honolulu, Hawaii, USA)
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Discovery and target identification of pyrrolizilactone, a fungal metabolite2015

    • Author(s)
      Hiroyuki Osada, Yushi Futamura, Toshihiko Nogawa
    • Organizer
      The international chemical congress of pacific basin societies (Pacifichem) 2015
    • Place of Presentation
      Hawaii Convention Center 他 (Honolulu, Hawaii, USA)
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A new enzyme involved in the control of the stereochemistry in the decalin formation during equisetin biosynthesis2015

    • Author(s)
      Naoki Kato, Toshihiko Nogawa, Hiroshi Hirota, Shunji Takahashi, Jae-Hyuk Jang, Jong Seog Ahn, Hiroyuki Osada
    • Organizer
      The international chemical congress of pacific basin societies (Pacifichem) 2015
    • Place of Presentation
      Hawaii Convention Center 他 (Honolulu, Hawaii, USA)
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Iolation of new metabolites from a microbial metabolites fraction library by NPPlot screening2015

    • Author(s)
      Toshihiko Nogawa, Akiko Okano, Jang Jun-Pil, Takeshi Shimizu, Shunji Takahashi, Hiroyuki Osada
    • Organizer
      The international chemical congress of pacific basin societies (Pacifichem) 2015
    • Place of Presentation
      Hawaii Convention Center 他 (Honolulu, Hawaii, USA)
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Characterization of fatty acyl-CoA ligase for the biosynthesis of the extender unit of reveromycin A2015

    • Author(s)
      Shunji Takahashi, Takeshi Miyazawa, Hiroyuki Osada
    • Organizer
      The international chemical congress of pacific basin societies (Pacifichem) 2015
    • Place of Presentation
      Hawaii Convention Center 他 (Honolulu, Hawaii, USA)
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 抗生物質研究を起源とするケミカルバイオロジー研究2015

    • Author(s)
      長田 裕之
    • Organizer
      日本農芸化学会関東支部2015年度第2回支部例会
    • Place of Presentation
      東京大学弥生講堂 一条ホール (東京都文京区)
    • Year and Date
      2015-12-12
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 糸状菌二次代謝を標的とした農薬探索2015

    • Author(s)
      本山 高幸, 尹 忠銖, 長田 裕之
    • Organizer
      BMB2015 第38回 日本分子生物学会, 第88回 日本生物化学会大会
    • Place of Presentation
      神戸ポートアイランド (兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 新たなNRPS-PKS融合酵素によるかび毒テヌアゾン酸の生合成2015

    • Author(s)
      尹 忠銖, 本山 高幸, 長田 裕之
    • Organizer
      第15回糸状菌分子生物学コンファレンス
    • Place of Presentation
      ルミエール府中 (東京都府中市)
    • Year and Date
      2015-11-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] 昆虫制御活性物質オカラミンの生合成遺伝子クラスターの同定2015

    • Author(s)
      加藤 直樹, 古谷 章悟,衣笠 清美,高橋 俊二,松田 一彦,長田 裕之
    • Organizer
      第15回糸状菌分子生物学コンファレンス
    • Place of Presentation
      ルミエール府中 (東京都府中市)
    • Year and Date
      2015-11-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] 創農薬を志向したケミカルバイオロジー研究2015

    • Author(s)
      長田 裕之
    • Organizer
      第2回 グリーン科学技術研究所シンポジウム
    • Place of Presentation
      グリーン科学技術研究所 (静岡県静岡市)
    • Year and Date
      2015-11-17
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Chemical array screen identifies a novel MMP inhibitor NPDK-18 that suppresses tumor cell migration2015

    • Author(s)
      Makoto Kawatani, Yasumitsu Kondoh, Kaori Honda, Tomomi Sekine, Hiroyuki Osada
    • Organizer
      AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
    • Place of Presentation
      Hynes Convention Center (Boston, USA)
    • Year and Date
      2015-11-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] リベロマイシン生合成機構の解析2015

    • Author(s)
      高橋 俊二, 長田 裕之
    • Organizer
      第67回日本生物工学会大会
    • Place of Presentation
      城山観光ホテル (鹿児島県鹿児島市)
    • Year and Date
      2015-10-26
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Screening of novel antimalarial agents2015

    • Author(s)
      Hiroyuki Osada
    • Organizer
      Finding Strengthening Plan of Global Network on Science, Technology and ICT, with the OECD Ministerial Meeting Daejeon 2015
    • Place of Presentation
      Daejeon Convention Center (Daejeon, Korea)
    • Year and Date
      2015-10-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Screening of Novel Antimalarial Agents in RIKEN NPDepo2015

    • Author(s)
      Hiroyuki Osada
    • Organizer
      Finding Strengthening Plan of Global Network on Science, Technology and ICT, with the OECD Ministerial Meeting Daejeon 2015
    • Place of Presentation
      Daejeon Convention Center (Daejeon, Korea)
    • Year and Date
      2015-10-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Screening of Antimicrobial Agents in NPDepo2015

    • Author(s)
      Hiroyuki Osada
    • Organizer
      RIKEN-Academia Sinica Joint Conference on Chemical Biology
    • Place of Presentation
      Genomics Research Center, Academia Sinica (Taipei, Taiwan)
    • Year and Date
      2015-10-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cell Cycle Arrest with Small Molecule Inhibitors of Phosphorylation Dependend Protein-protein Interaction2015

    • Author(s)
      Nobumoto Watanabe
    • Organizer
      RIKEN-Academia Sinica Joint Conference on Chemical Biology
    • Place of Presentation
      Genomics Research Center, Academia Sinica (Taipei, Taiwan)
    • Year and Date
      2015-10-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Discovery of NP428 as selective tumorsphere inhibitor2015

    • Author(s)
      Subedi Amit, Nobumoto Watanabe, Mayuko Nishii, Akihide Ryo, Hiroyuki Osada
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場 (愛知県名古屋市)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] リン酸化依存タンパク質間相互作用阻害による細胞周期停止の解析2015

    • Author(s)
      渡辺 信元, Amit Subedi, 長田 裕之
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場 (愛知県名古屋市)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] エキセチン生合成における立体選択的なデカリン環形成に関わる新規酵素遺伝子fsa2の発見2015

    • Author(s)
      加藤 直樹, 野川 俊彦, 廣田 洋, 高橋 俊二, Jae-Hyuk Jang, Jong Seog Ahn, 長田 裕之
    • Organizer
      第57回天然有機化合物討論会
    • Place of Presentation
      神奈川県民ホール (神奈川県横浜市)
    • Year and Date
      2015-09-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] ポリケチド伸長単位生合成に関与する脂肪酸活性化酵素の機能解析2015

    • Author(s)
      宮澤 岳, 高橋 俊二, 長田 裕之
    • Organizer
      2015年度(第30回)日本放線菌学会大会
    • Place of Presentation
      富山国際会議場 (富山県富山市)
    • Year and Date
      2015-09-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] Streptomyces reveromyceticusにおけるテルペノイド生合成プラットフォーム2015

    • Author(s)
      シュレス パンテー, アマラ カーリッド, 高木 海, 白井 智量, 近藤 昭彦, 長田 裕之, 高橋 俊二
    • Organizer
      2015年度(第30回)日本放線菌学会大会
    • Place of Presentation
      富山国際会議場 (富山県富山市)
    • Year and Date
      2015-09-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] 遺伝子破壊実験によるテロメスタチン生合成遺伝子クラスターの同定2015

    • Author(s)
      天貝 啓太, 工藤 史貴, 江口 正, 長田 裕之, 池田 治生, 新家 一男, 高橋 俊二
    • Organizer
      2015年度(第30回)日本放線菌学会大会
    • Place of Presentation
      富山国際会議場 (富山県富山市)
    • Year and Date
      2015-09-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] 抗生物質研究からケミカルバイオロジー研究へ2015

    • Author(s)
      長田 裕之
    • Organizer
      メディカル・サイエンス セミナー(最近話題の微生物のはなし)
    • Place of Presentation
      学士会館 (東京都千代田区)
    • Year and Date
      2015-07-08
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 分子標的治療を目指したタンパク質間相互作用阻害剤の探索2015

    • Author(s)
      長田 裕之
    • Organizer
      第795回千葉県がんセンター研究所集談会
    • Place of Presentation
      千葉県がんセンター (千葉県千葉市)
    • Year and Date
      2015-07-06
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] フラクションライブラリーとスペクトルデータベースを利用した新規化合物探索2015

    • Author(s)
      野川 俊彦, Jang Jun-Pil, Lim Chung Liang, 岡野 亜紀子, 本郷 やよい, 中村 健道, 清水 猛, 高橋 俊二, 長田 裕之
    • Organizer
      第63回質量分析総合討論会
    • Place of Presentation
      つくば国際会議場エポルカつくば (茨城県つくば市)
    • Year and Date
      2015-06-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] モルフォベースを基盤とした抗がん物質探索:特異な線状構造体を誘導するNPD4152の発見2015

    • Author(s)
      二村 友史, 川谷 誠, 室井 誠, 青野 晴美, 長田 裕之
    • Organizer
      第19回日本がん分子標的治療学会学術集会
    • Place of Presentation
      松山全日空ホテル (愛媛県松山市)
    • Year and Date
      2015-06-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] MorphobaseおよびChemProteoBaseを用いたGN.9482の標的同定2015

    • Author(s)
      青野 晴美, 川谷 誠, 二村 友史, 室井 誠, 峯岸 秀充, 中村 浩之, 長田 裕之
    • Organizer
      第19回日本がん分子標的治療学会学術集会
    • Place of Presentation
      松山全日空ホテル (愛媛県松山市)
    • Year and Date
      2015-06-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] 化合物アレイを用いた新規MTH1阻害剤の探索2015

    • Author(s)
      河村 達郎, 川谷 誠, 長田 裕之
    • Organizer
      第19回日本がん分子標的治療学会学術集会
    • Place of Presentation
      松山全日空ホテル (愛媛県松山市)
    • Year and Date
      2015-06-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] がん代謝作用薬解析におけるChemProteoBaseの利用2015

    • Author(s)
      室井 誠、田中 美帆、川谷 誠、長田 裕之
    • Organizer
      第19回日本がん分子標的治療学会学術集会
    • Place of Presentation
      松山全日空ホテル (愛媛県松山市)
    • Year and Date
      2015-06-10
    • Related Report
      2015 Annual Research Report
  • [Book] Bioprobes, 2nd edition2017

    • Author(s)
      Osada H (ed)
    • Total Pages
      384
    • Publisher
      Springer
    • ISBN
      9784431565277
    • Related Report
      2017 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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