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Cancer fluid biopsy for childhood malignancies using one cell analysis

Research Project

Project/Area Number 15H02567
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatric surgery
Research InstitutionHiroshima University

Principal Investigator

Hiyama Eiso  広島大学, 自然科学研究支援開発センター, 教授 (00218744)

Co-Investigator(Kenkyū-buntansha) 金輪 真佐美 (福永真佐美)  広島大学, 自然科学研究支援開発センター, 助教 (00284208)
栗原 將  広島大学, 医歯薬保健学研究科(医), 助教 (40724894)
上田 祐華  広島大学, 病院(医), 病院助教 (70624641)
外丸 祐介  広島大学, 自然科学研究支援開発センター, 教授 (90309352)
Co-Investigator(Renkei-kenkyūsha) MASUJIMA TSUTOMU  理化学研究所, 生命システム研究センター, チームリーダー (10136054)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥42,380,000 (Direct Cost: ¥32,600,000、Indirect Cost: ¥9,780,000)
Fiscal Year 2017: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2016: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2015: ¥27,170,000 (Direct Cost: ¥20,900,000、Indirect Cost: ¥6,270,000)
Keywords癌 / 細胞 / 組織 / 核酸 / バイオテクノロジー / 臨床 / 細胞、組織
Outline of Final Research Achievements

Cancer liquid biopsy was performed on primary cultured cells, frozen specimens and plasma of pediatric tumors preserved in Hiroshima University Hospital and circulating tumor cells collected with magnetic beads cell concentrators. In single cell mass spectrometry (cellomics), anaerobic glycolysis was enhanced in cancer stem cells, and in single cell genomic mutations were detectable. Prognosis-related microRNAs were isolated from exosomes as a biomarker search in culture supernatant and plasma. Furthermore, it was also possible to detect gene mutations such as MYC gene amplification and β catenin mutation by the next generation sequencing and digital PCR using cell free DNA. It was considered to be a useful tool for minimally invasive diagnosis, drug susceptibility and monitoring of recurrence.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (60 results)

All 2018 2017 2016 2015

All Journal Article (25 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 25 results,  Open Access: 17 results,  Acknowledgement Compliant: 3 results) Presentation (32 results) (of which Int'l Joint Research: 12 results,  Invited: 1 results) Book (3 results)

  • [Journal Article] Differentiated embryo chondrocyte plays a crucial role in DNA damage response via transcriptional regulation under hypoxic conditions2018

    • Author(s)
      Nakamura Hideaki、Bono Hidemasa、Hiyama Keiko、Kawamoto Takeshi、Kato Yukio、Nakanishi Takeshi、Nishiyama Masahiko、Hiyama Eiso、Hirohashi Nobuyuki、Sueoka Eisaburo、Poellinger Lorenz、Tanimoto Keiji
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 2 Pages: e0192136-e0192136

    • DOI

      10.1371/journal.pone.0192136

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Sodium Thiosulfate Protection of Cisplatin-Induced Ototoxicity2018

    • Author(s)
      Brock PR, Maibach R, Childs M, Rajput K, Roebuck D, Sullivan MJ, Laithier V, Ronghe M, Dall'Igna P, Hiyama E, Brichard B, Skeen J, Mateos ME, Capra M, Rangaswami AA, Ansari M, Rechnitzer C, Veal GJ, Covezzoli A, Brugieres L, Perilongo G, Czauderna P, Morland B, Neuwelt EA
    • Journal Title

      New Eng. J. Med

      Volume: in press

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Transgenic mice specifically expressing amphiregulin in white adipose tissue showed less adipose tissue mass.2018

    • Author(s)
      Yang B, Kumoto T, Arima T, Nakamura M, Sanada Y, Kumrungsee T, Sotomaru Y, Shimada M, Yanaka N.
    • Journal Title

      Genes Cells

      Volume: 23 Issue: 3 Pages: 136-145

    • DOI

      10.1111/gtc.12558

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inflammatory myofibroblastic tumors of the lung carrying a chimeric A2M-ALK gene: report of 2 infantile cases and review of the differential diagnosis of infantile pulmonary lesions2017

    • Author(s)
      Tanaka Mio、Kohashi Kenichi、Kushitani Kei、Yoshida Misa、Kurihara Sho、Kawashima Masumi、Ueda Yuka、Souzaki Ryota、Kinoshita Yoshiaki、Oda Yoshinao、Takeshima Yukio、Hiyama Eiso、Taguchi Tomoaki、Tanaka Yukichi
    • Journal Title

      Human Pathology

      Volume: 66 Pages: 177-182

    • DOI

      10.1016/j.humpath.2017.06.013

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Risk-stratified staging in paediatric hepatoblastoma: a unified analysis from the Children's Hepatic tumors International Collaboration.2017

    • Author(s)
      Meyers RL, Maibach R, Hiyama E, Harberle B, Krailo M, Rangaswami A, Aronson DC, Malogolowkin MH, Perilongo G, von Schweinitz D, Ansari M, Lopez-Terrada D, Tanaka Y, Alaggio R, Leuschner I, Hishiki T, Schmid I, Watanabe K, Yoshimura K, Feng Y, Rinaldi E, Saraceno D, Derosa M, Czauderna P.
    • Journal Title

      Lancet Oncol.

      Volume: 18 Issue: 1 Pages: 122-131

    • DOI

      10.1016/s1470-2045(16)30598-8

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The role of pulmonary metastasectomy for hepatoblastoma in children with metastasis at diagnosis: Results from the JPLT-2 study2017

    • Author(s)
      Hishiki T, Watanabe K, Ida K, Hoshino K, Iehara T, Aoki Y, Kazama T, Kihira K, Takama Y, Taguchi T, Fujimura J, Honda S, Matsumoto K, Mori M, Yano M, Yokoi A, Tanaka Y, Fuji H, Miyazaki O, Yoshimura K, Takimoto T, Hiyama E
    • Journal Title

      Journal of Pediatric Surgery

      Volume: 52 Issue: 12 Pages: 2051

    • DOI

      10.1016/j.jpedsurg.2017.08.031

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of microRNAs from the Gtl2-Rian locus contributes to postnatal death in mice.2017

    • Author(s)
      Kumamoto S, Takahashi N, Nomura K, Fujiwara M, Kijioka M, Uno Y, Matsuda Y, Sotomaru Y, Kono T.
    • Journal Title

      Hum Mol Genet

      Volume: 26 Issue: 19 Pages: 3653-3662

    • DOI

      10.1093/hmg/ddx223

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 小児肝腫瘍の最近の話題:グローバル試験へ向けて2016

    • Author(s)
      檜山 英三, 上田 祐華, 栗原 将, 河島 茉澄
    • Journal Title

      小児外科

      Volume: 48 Pages: 1192-1195

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical prognostic value of DNA methylation in hepatoblastoma: Four novel tumor suppressor candidates2016

    • Author(s)
      Honda S, Minato M, Suzuki H, Fujiyoshi M, Miyagi H, Haruta M, Kaneko Y, Hatanaka KC, Hiyama E, Kamijo T, Okada T, Taketomi A
    • Journal Title

      Cancer Science

      Volume: in press Issue: 6 Pages: 812-819

    • DOI

      10.1111/cas.12928

    • NAID

      120005828475

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognostic value of circulating tumour DNA in patients undergoing curative resection for pancreatic cancer.2016

    • Author(s)
      Hadano N, Murakami Y, Uemura K, Hashimoto Y, Kondo N, Nakagawa N, Sueda T, Hiyama E.
    • Journal Title

      Br J Cancer

      Volume: 175 Issue: 1 Pages: 69-75

    • DOI

      10.1038/bjc.2016.175

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum-Based Quantification of MYCN Gene Amplification in Young Patients with Neuroblastoma: Potential Utility as a Surrogate Biomarker for Neuroblastoma.2016

    • Author(s)
      4.Yagyu S, Iehara T, et al.
    • Journal Title

      PLoS One.

      Volume: 11(8) Issue: 8 Pages: e0161039-e0161039

    • DOI

      10.1371/journal.pone.0161039

    • NAID

      120005997753

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Resectability and tumor response after preoperative chemotherapy in hepatoblastoma treated by the Japanese Study Group for Pediatric Liver Tumor (JPLT)-2 protocol2016

    • Author(s)
      Hiyama E, Hishiki T, Watanabe K, Ida K, Yano M, Oue T, Iehara T, Hoshino K, Koh K, Tanaka Y, Kurihara S, Ueda Y, Onitake Y.
    • Journal Title

      J Pediatr Surg.

      Volume: 51 Issue: 12 Pages: 2053

    • DOI

      10.1016/j.jpedsurg.2016.09.038

    • URL

      https://pure.teikyo.jp/en/publications/0fe5c4dd-a3bf-403e-9e9e-6cc3508f6fa0

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Telomere biology including TERT rearrangements in neuroblastoma: a useful indicator for surgical treatments2016

    • Author(s)
      Kawashima Masumi、Kojima Masato、Ueda Yuka、Kurihara Sho、Hiyama Eiso
    • Journal Title

      Journal of Pediatric Surgery

      Volume: 51 Issue: 12 Pages: 2080-2085

    • DOI

      10.1016/j.jpedsurg.2016.09.042

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcriptional regulator Bhlhe40 works as a cofactor of T-bet in the regulation of IFN-γ production in iNKT cell2016

    • Author(s)
      Kanda M, Yamanaka H, Kojo S, Usui Y, Honda H, Sotomaru Y, Harada M, Taniguchi M, Suzuki N, Atsumi T, Wada H, Bagdadi M, Seino, K
    • Journal Title

      Proceedings of the National Academy of Sciences of the USA

      Volume: 14: 113(24) Issue: 24

    • DOI

      10.1073/pnas.1604178113

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] KRAS mutation leads to decreased expression of regulator of calcineurin 2, resulting in tumor proliferation in colorectal cancer.2016

    • Author(s)
      Niitsu H, Hinoi T, Kawaguchi Y, Sentani K, Yuge R, Kitadai Y, Sotomaru Y, Adachi T, Saito Y, Miguchi M, Kochi M, Sada H, Shimomura M, Oue N, Yasui W, Ohdan H.
    • Journal Title

      Oncogenesis.

      Volume: 5 Issue: 8 Pages: 8-8

    • DOI

      10.1038/oncsis.2016.47

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Gasdermin C Is Upregulated by Inactivation of Transforming Growth Factor β Receptor Type II in the Presence of Mutated Apc, Promoting Colorectal Cancer Proliferation2016

    • Author(s)
      Miguchi M, Hinoi T, Shimomura M et al
    • Journal Title

      PloS One

      Volume: 11 Issue: 11 Pages: 0166422-0166422

    • DOI

      10.1371/journal.pone.0166422

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] DEC2 is a negative regulator for the proliferation and differentiation of chondrocyte lineage-committed mesenchymal stem cells2016

    • Author(s)
      Sasamoto, T., Fujimoto, K., Kanawa, M., Kimura, J., Takeuchi, J., Harada, N., Goto, N., Kawamoto, T., Noshiro, M., Suardita, K., Tanne, K., Kato, Y.
    • Journal Title

      Int. J. Mol. Med

      Volume: 印刷中 Issue: 3 Pages: 876-884

    • DOI

      10.3892/ijmm.2016.2660

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] High glucose promotes TGF-β1 production by inducing FOS expression in human peritoneal mesothelial cells2016

    • Author(s)
      Kokoroishi K, Nakashima A, Doi S, Ueno T, Doi T, Yokoyama Y, Honda K, Kanawa M, Kato Y, Kohno N, Masaki T.
    • Journal Title

      Clin Exp Nephrol.

      Volume: 20 Issue: 1 Pages: 30-38

    • DOI

      10.1007/s10157-015-1128-9

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chlorinated Water Modulates the Development of Colorectal Tumors with Chromosomal Instability and Gut Microbiota in Apc-Deficient Mice.2015

    • Author(s)
      Sasada T, Hinoi T, Saito Y, Adachi T, Takakura Y, Kawaguchi Y, Sotomaru Y, Sentani K, Oue N, Yasui W, Ohdan H.
    • Journal Title

      PLoS One.

      Volume: 10 Issue: 7 Pages: e0132435-e0132435

    • DOI

      10.1371/journal.pone.0132435

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Characteristic expression of MSX1, MSX2, TBX2 and ENTPD1 in dental pulp cells2015

    • Author(s)
      Fujii S, Fujimoto K, Goto N, Kanawa M, Kawamoto T, Pan H, Srivatanakul P, Rakdang W, Pornprasitwech J, Saskianti T, Suardita K, Nishimura F, Kato Y.
    • Journal Title

      Free PMC Article

      Volume: 3 Pages: 566-572

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Circulating free DNA as non-invasive diagnostic biomarker for childhood solid tumors2015

    • Author(s)
      Kurihara S, Ueda Y, Onitake Y, Sueda T, Ohta E, Morihara N, Hirano S, Irisuna F, Hiyama E
    • Journal Title

      Journal of Pediatric Surgery

      Volume: 50 Issue: 12 Pages: 2094-2097

    • DOI

      10.1016/j.jpedsurg.2015.08.033

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mortality and morbidity in primarily resected hepatoblastomas in Japan: Experience of the JPLT (Japanese Study Group for Pediatric Liver Tumor) trials2015

    • Author(s)
      Hiyama E, Hishiki T, Watanabe K, Ida K, Yano M, Oue T, Iehara T, Hoshino K, Koh K, Tanaka Y, Kurihara S, Ueda Y, Onitake Y
    • Journal Title

      Journal of Pediatric Surgery

      Volume: 50 Issue: 12 Pages: 2098

    • DOI

      10.1016/j.jpedsurg.2015.08.035

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Direct Lipido-Metabolomics of Single Floating Cells for Analysis of Circulating Tumor Cells by Live Single-cell Mass Spectrometry2015

    • Author(s)
      Hiyama E, Ali A, Amer S, Harada T, Shimamoto K, Furushima R, Abouleila Y, Emara S, Masujima T
    • Journal Title

      Analytical Sciences

      Volume: 31 Issue: 12 Pages: 1215-1217

    • DOI

      10.2116/analsci.31.1215

    • NAID

      130005129718

    • ISSN
      0910-6340, 1348-2246
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Children's Hepatic tumors International Collaboration (CHIC): Novel global rare tumor database yields new prognostic factors in hepatoblastoma and becomes a research model2015

    • Author(s)
      Czauderna P, Haeberle B, Hiyama E, Rangaswami A, Krailo M, Maibach R, Rinaldi E, Feng Y, Aronson D, Malogolowkin M, Yoshimura K, Leuschner I, Lopez-Terrada D, Hishiki T, Perilongo G, von Schweinitz D, Schmid I, Watanabe K, Derosa M, Meyers R
    • Journal Title

      European Journal of Cancer

      Volume: 1 Pages: 92-101

    • DOI

      10.1016/j.ejca.2015.09.023

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Nerve Growth Factor Expression Is Not Associated with Perineural Invasion in Extrahepatic Cholangiocarcinoma2015

    • Author(s)
      Urabe K, Murakami Y, Kondo N, Uemura K, Hashimoto Y, Nakagawa N, Sasaki H, Hiyama E, Takahashi S, Sueda T.
    • Journal Title

      Digestive Diseases and Sciences

      Volume: 61 Issue: 3 Pages: 774-784

    • DOI

      10.1007/s10620-015-3953-9

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] PULMONARY METASTASECTOMY IN HEPATOBLASTOMA-JPLT-2 EXPEROENCE2017

    • Author(s)
      Hishiki T, Watanabe K, Ida K, Hoshuno K, Iehara T, Aoki Y, Kazama T, Kihira K, Takama Y, Taguchi T, Fujimura J, Honda S, Matsumoto K, Mori M, Yano M, Yokoi A, Tanaka Y, Fuji H, Miyazaki O, Yoshimura K, Takimoto T,  Hiyama E
    • Organizer
      SIOPEL SPRING MEETING 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 肝芽腫の包括的メチル化解析で明らかとなった予後不良に関連するメチル化サブタイプと癌特異的エンハンサー2017

    • Author(s)
      永江 玄太, 山本 尚吾, 辰野 健二, Claire Renard-Guillet, 梅田 高呂, 堤 修一, 藤田 征志, 中川 英刀, 檜山 英三, 油谷 浩幸
    • Organizer
      第76回日本癌学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 肝芽腫におけるシスプラチン耐性関連遺伝子の異常高メチル化の同定2017

    • Author(s)
      藤好, 直, 本多 昌平, 湊 雅嗣, 鈴木 拓, 檜山 英三, 武冨 紹信
    • Organizer
      第76回日本癌学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] DHRS3 とNR0B1 は神経芽腫細胞株の分化と増殖抑制を誘導する2017

    • Author(s)
      山岡 絵美, 久保 陽子, 檜山 英三
    • Organizer
      第76回日本癌学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Integrated Genetic and Epigenetic Analysis novel Molecular Subgroups in Hepatoblastoma2017

    • Author(s)
      Hiyama E, Kurihara S, Hirano S, Irisuna F, Ueda Y, Kawashima M
    • Organizer
      The 49th Congress of the International Society of Paediatric Oncology (SIOP2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The probability of liquid biopsy as non-invasive diagnostic tool for childhood solid tumors2017

    • Author(s)
      Kurihara S, Hiyama E, Ueda Y
    • Organizer
      第59回日本小児血液・がん学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 両側多発性腎腫瘍の一例2017

    • Author(s)
      野間 康輔, 望月 慎史, 江口 勇太, 小野 大地, 松村 梨沙, 土居 岳彦, 川口 浩史, 栗原 将, 檜山 英三, 小林 正夫
    • Organizer
      第59回日本小児血液・がん学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 小児肝がん細胞において高発現する膜蛋白ADAM32の意義2017

    • Author(s)
      深澤 賢宏, 谷本 圭司, 山岡 絵美, 金輪 真佐美, 廣橋 伸之, 檜山 英三
    • Organizer
      第40回日本分子生物学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Exome sequencing of hepatoblastoma identifies biological signatures and protential therapeutic targets2016

    • Author(s)
      Hiyama E
    • Organizer
      International Pediatric Liver Tumor Symposium
    • Place of Presentation
      Texas, USA.
    • Year and Date
      2016-02-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 肝芽腫において異常メチル化で発現抑制されるPARP6の機能解析2016

    • Author(s)
      本多 昌平, 宮城 久之, 檜山 英三, 武冨 紹信
    • Organizer
      第116回日本外科学会定期学術集会
    • Related Report
      2016 Annual Research Report
  • [Presentation] 膵癌患者におけるcirculating tumor DNAの検出と予後2016

    • Author(s)
      村上 義昭, 上村 健一郎, 橋本 泰司, 近藤 成, 中川 直哉, 末田 泰二郎, 檜山 英三
    • Organizer
      第116回日本外科学会定期学術集会
    • Related Report
      2016 Annual Research Report
  • [Presentation] Telomere biology in neuroblastoma: focusing on alteration of TERT promoter lesion2016

    • Author(s)
      Hiyama E, Kawashima M, Kurihara S, Ueda Y, Onitake Y, Hiyama K
    • Organizer
      Advances in Neuroblastoma Research Congress (ANR) 2016
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Incidence of stage IV neuroblastoma patients 2-5 years of age was increased after the cessation of mass screening in Japan2016

    • Author(s)
      Yoneda A, Tajiri T, Hiyama E, Iehara T, Hishiki T, Kinoshita Y, Yonekura T, Yokota I, Teramukai S
    • Organizer
      Advances in Neuroblastoma Research Congress (ANR) 2016
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 予後良好な神経芽細胞腫で発現していた3 遺伝子の機能解2016

    • Author(s)
      山岡 絵美, 林 陽子, 檜山 英三
    • Organizer
      第75回日本癌学会学術総会
    • Related Report
      2016 Annual Research Report
  • [Presentation] 神経芽腫細胞株における分化誘導候補因子の解析2016

    • Author(s)
      山岡 絵美, 金輪 真佐美, 田川 浩美, 福場 郁子, 久保 陽子, 古屋敷 なぎさ, 平野 尚子, 深澤 賢宏, 檜山 英三
    • Organizer
      第39回日本分子生物学会年会
    • Related Report
      2016 Annual Research Report
  • [Presentation] Cancer Fluid Biopsy Using Circulating Tumour Cells and Circulating Free DNA in Childhood Solid Tumors2016

    • Author(s)
      Hiyama E, Kurihara S, Ueda Y, Kawashima M, Hiyama K
    • Organizer
      48th Congress of the International Society of Paediatric Oncology (SIOP)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 当院における小児腎腫瘍18例の検討2016

    • Author(s)
      兒島 正人, 河島 茉澄, 栗原 將, 上田 祐華, 檜山 英三
    • Organizer
      第58回日本小児血液・がん学会学術集会
    • Related Report
      2016 Annual Research Report
  • [Presentation] 後腹膜原発peripheral primitive neuroectodermal tumor(pPNET)の1例2016

    • Author(s)
      栗原 將, 上田 祐華, 河島 茉澄, 溝口 洋子, 今中 雄介, 下村 麻衣子, 川口 浩史, 小林 正夫, 檜山 英三
    • Organizer
      第58回日本小児血液・がん学会学術集会
    • Related Report
      2016 Annual Research Report
  • [Presentation] 様々な核の組合せにより作製したマーモセット4倍体胚の発生能について2016

    • Author(s)
      外丸祐介、信清麻子、吉岡みゆき、畠山照彦、黒滝陽子、平川玲子、佐々木えりか
    • Organizer
      日本マーモセット研究会
    • Related Report
      2016 Annual Research Report
  • [Presentation] Effect of Mesenchymal Stem Cells on Mixed Self Assembled Monolayer2016

    • Author(s)
      Hirata I, Veronica SR, Tania S, Yamauchi Y, Kanawa M, Kato Y, Kato K
    • Organizer
      The International Dental Materials Congress 2016 (Bali, Indonesia)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 予後良好な神経芽細胞腫で高発現していたDHRS3, NR0B1, CYP26A1の機能解析2015

    • Author(s)
      山岡 絵美, 金輪 真佐美, 田川 浩美, 福場 郁子, 久保-林 陽子, 古屋敷 なぎさ, 阿部 裕子, 平野 尚子, 檜山 英三
    • Organizer
      BMB2015(第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会)
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 小児肝がんに対するゲノム解析と国際共同臨床試験へのアプローチ2015

    • Author(s)
      檜山 英三
    • Organizer
      第53回日本癌治療学会学術集会
    • Place of Presentation
      京都市
    • Year and Date
      2015-10-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 霊長類受精卵のガラス化保存2015

    • Author(s)
      外丸祐介, 信清麻子, 吉岡みゆき,畠山照彦,印藤頼子,兼子明久,岡本宗裕,岡原純子,佐々木えりか
    • Organizer
      Cryopreservation Conference 2015
    • Place of Presentation
      愛知県岡崎市
    • Year and Date
      2015-10-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] シングルセル解析を目指した血中循環腫瘍細胞(CTC : Circullating Tumor Cells)の基礎的研究について2015

    • Author(s)
      島本 和美, 檜山 英三
    • Organizer
      第74回日本癌学会学術集会
    • Place of Presentation
      愛知県名古屋市
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] Integrated exome analysis in childhood hepatoblastoma: Biological approach for molecular targeting2015

    • Author(s)
      Hiyama E, Kurihara S, Onitake Y, Ueda Y, Morihara N, Fukuba I, Komatsu R.
    • Organizer
      SIOP 2015
    • Place of Presentation
      Cape Town, South Africa
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] フローサイトメーターによる血中循環腫瘍細胞(CTC)の測定について(神経芽腫)2015

    • Author(s)
      島本 和美, 檜山 英三
    • Organizer
      第25回日本サイトメトリー学会学術集会
    • Place of Presentation
      東京都
    • Year and Date
      2015-07-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] Survival and late effects in the risk-stratified hepatoblastoma patients treated by JPLT-2 protocol2015

    • Author(s)
      Hiyama E, Kurihara S, Ueda Y, Hishiki T, Ida K, Iehara T, Oue T, Yano M, Watanabe K, Hoshino K, Ko K, Tanaka Y.
    • Organizer
      2015 ASCO Annual Meeting
    • Place of Presentation
      Chicago, U.S.A
    • Year and Date
      2015-05-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] コモンマーモセット凍結保存精子の運動性と体外受精能2015

    • Author(s)
      外丸祐介、畠山照彦、吉岡みゆき、信清麻子
    • Organizer
      第62回日本実験動物学会総会
    • Place of Presentation
      京都市
    • Year and Date
      2015-05-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] OCIAD2はDNAメチル化により制御される肝芽腫の新規癌抑制遺伝子である2015

    • Author(s)
      湊 雅嗣, 本多 昌平, 小林 希, 三次 早香, 鈴木 拓, 岡田 忠雄, 宮城 久之, 檜山 英三, 武冨 紹信
    • Organizer
      第52回日本小児外科学会学術集会
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2015-05-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Circulating free DNA as non-invasive diagnostic biomarker for childhood solid tumors2015

    • Author(s)
      Kurihara S, Ueda Y, Onitake Y, Sueda T, Ohta E, Morihara N, Hirano S, Irisuna F, Hiyama E.
    • Organizer
      48th Annual Meeting of the Pacific Association of Pediatric Surgeons
    • Place of Presentation
      Jeju, South Kore
    • Year and Date
      2015-05-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mortality and morbidity in primarily resected hepatoblastomas in Japan: experience of JPLT (Japanese study group for pediatric liver tumor) trials2015

    • Author(s)
      Hiyama E, Hishiki T, Watanabe K, Ida K, Yano M, Oue T, Iehara T, Hoshino K, Koh K, Tanaka Y, Kurihara S, Ueda Y, Onitake Y.
    • Organizer
      48th Annual Meeting of the Pacific Association of Pediatric Surgeons
    • Place of Presentation
      Jeju, South Kore
    • Year and Date
      2015-05-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Droplet Digital PCRを用いた膵癌KRAS遺伝子変異の研究2015

    • Author(s)
      羽田野 直人, 村上 義昭, 上村 健一郎, 橋本 泰司, 近藤 成, 中川 直哉, 佐々木 勇人, 檜山 英三, 末田 泰二郎
    • Organizer
      第115回日本外科学会定期学術集会
    • Place of Presentation
      愛知県名古屋市
    • Year and Date
      2015-04-16
    • Related Report
      2015 Annual Research Report
  • [Book] 標準小児外科学 第7版2017

    • Author(s)
      檜山 英三
    • Total Pages
      7
    • Publisher
      医学書院
    • ISBN
      4260027808
    • Related Report
      2016 Annual Research Report
  • [Book] よくわかる臨床研究~小児がん~ 小児がん臨床研究プロトコルの実際「肝腫瘍」2016

    • Author(s)
      檜山 英三
    • Total Pages
      6
    • Publisher
      医薬ジャーナル社
    • Related Report
      2016 Annual Research Report
  • [Book] 小児血液・腫瘍学2015

    • Author(s)
      檜山 英三
    • Total Pages
      585
    • Publisher
      診断と治療社
    • Related Report
      2015 Annual Research Report

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Published: 2015-04-16   Modified: 2023-03-16  

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