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Construction of screening system of food and drug for prevention/diagnosis/treatment of NASH using new biomarker

Research Project

Project/Area Number 15H02904
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Eating habits
Research InstitutionNational Institute of Advanced Industrial Science and Technology

Principal Investigator

MORITA Naoki  国立研究開発法人産業技術総合研究所, 生命工学領域, 総括研究主幹 (60371085)

Co-Investigator(Kenkyū-buntansha) 芳賀 早苗  北海道大学, 保健科学研究院, 特任講師 (60706505)
酒井 佳夫  金沢大学, 医学系, 准教授 (80401925)
野田 なつみ  北海道大学, 保健科学研究院, 助教 (30624358)
Co-Investigator(Renkei-kenkyūsha) OZAWA Takeaki  東京大学, 大学院理学系研究科, 教授 (40302806)
SAKASHITA Mami  国立研究開発法人産業技術総合研究所, 生命工学領域生物プロセス研究部門, 主任研究員 (20357099)
Research Collaborator OZAKI Michitaka  
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2017: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2016: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Keywords非アルコール性脂肪性肝炎(NASH) / 脂肪肝 / マーカー分子 / メタボリック症候群 / 機能性食品
Outline of Final Research Achievements

We tried to measure p62/SQSTM1 in blood using ELISA method, however, the ELISA method for p62/SQSTM1 using conventional antibodies remains problems to be overcome in terms of sensitivity. It seemed that it is optimal at this time to perform measurement using liver tissue for the measurement of p62/SQSTM1 with molecular biological method. In the clinical study, we confirmed the usefulness of evaluating p62/SQSTM1 expression together with antioxidant capacity by using Keap-1 molecule. This combination method would improve the specificity of diagnosis. In addition, we identified new molecular marker(s) associated with lipidification. This molecule(s) is expressed on the lipid bilayer membrane that covers the lipid droplet. It is considered that the new molecule(s) enhanced further lipidification, and promoteed liver cell injury by fatty liver, which is related to the progression of NASH pathology.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (2 results)

All 2016 2015

All Presentation (2 results)

  • [Presentation] “光”を利用した肝細胞機能制御技術の開発2016

    • Author(s)
      芳賀早苗、小澤岳昌、森田直樹、野田なつみ、尾崎倫孝
    • Organizer
      第22回肝細胞研究会
    • Place of Presentation
      米子コンベンションセンター
    • Year and Date
      2016-06-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] p62/SQSTM1 を基軸とした新たな肝臓・肝細胞保護・機能維持法の探索2015

    • Author(s)
      尾崎倫孝、芳賀早苗、森田直樹、伊敏
    • Organizer
      第42回日本臓器保存生物医学会学術集会
    • Place of Presentation
      いわて県民情報交流センター(アイーナ)
    • Year and Date
      2015-11-13
    • Related Report
      2015 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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