Elucidation and manipulation of regeneration potential of cortical neurons by artificial scaffold creation
| Project/Area Number |
15H03019
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
AJIOKA Itsuki 東京医科歯科大学, 統合研究機構, 准教授 (10348790)
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| Research Collaborator |
SAWAMOTO Kazunobu
MURAOKA Takahiro
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2017: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2016: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2015: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
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| Keywords | 細胞足場 / 血管新生 / 細胞周期 / 脳損傷 / 脳梗塞 / 人工足場 / 発生・分化 / 生体材料 / 脳神経疾患 / 再生医学 / 脳再生 / バイオマテリアル / 大脳皮質 / VEGF / ニューロン |
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| Outline of Final Research Achievements |
Our brain is thought not to regenerate after severely damaged. For example, limb paralysis caused by stroke hardly recovers with natural healing. However, recent developments in neurobiology research have revealed that our brain has regenerative potential. In this study, we elucidated the regenerative potency of neurons and developed biomaterials for injured brain regeneration.
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| Academic Significance and Societal Importance of the Research Achievements |
ニューロンが細胞分裂しない事実はよく知られているが、そのメカニズムはほとんど知られていなかった。本研究において、ニューロンの細胞分裂保護機構の一端を明らかにした点を学術的意義として強調する。また、本研究で開発した人工足場材料が脳卒中などの損傷脳再生への応用展開が期待されるという点を社会的意義として強調する。
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Report
(4 results)
Research Products
(20 results)
