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Development of next-generation technologies for bone-cartilage regeneration on the basis of Raman profiling for regenerated bones and cartilages

Research Project

Project/Area Number 15H03021
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionTohoku University (2017)
Kyoto University (2015-2016)

Principal Investigator

Yamamoto Masaya  東北大学, 工学研究科, 教授 (10332735)

Co-Investigator(Kenkyū-buntansha) 田畑 泰彦  京都大学, ウイルス・再生医科学研究所, 教授 (50211371)
吉本 敬太郎  東京大学, 大学院総合文化研究科, 准教授 (60392172)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2017: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Keywords再生医療 / 生体材料 / 分析科学
Outline of Final Research Achievements

The objective of this study is to develop an analysis technique on the basis of Raman spectroscopy to discriminate the type of cartilage tissues regenerated by emerging new technologies to be applied for regenerative medicine, such as mesenchymal stem cell aggregates, iPS cell aggregates, developing osteochondral tissue of embryos, decellularized cartilages. We found that Raman spectroscopy can be applied for the regenerated bones and cartilages. In addition, several researches have been carried out to develop biofunctional hydrogels that allows us to induce efficient osteoblastic differentiation of mesenchymal stem cells in culture.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (19 results)

All 2017 2016 2015

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (17 results) (of which Int'l Joint Research: 7 results,  Invited: 4 results)

  • [Journal Article] Effect of hydrogel elasticity and ephrinB2-immobilized manner on Runx2 expression of human mesenchymal stem cells.2017

    • Author(s)
      H. Toda, M. Yamamoto, H. Uyama, Y. Tabata
    • Journal Title

      Acta Biomater

      Volume: 印刷中 Pages: 312-322

    • DOI

      10.1016/j.actbio.2017.03.016

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fabrication of hydrogels with elasticity changed by alkaline phosphatase for stem cell culture.2016

    • Author(s)
      H. Toda, M. Yamamoto, H. Uyama, Y. Tabata
    • Journal Title

      Acta Biomater

      Volume: 29 Pages: 215-227

    • DOI

      10.1016/j.actbio.2015.10.036

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Presentation] 軟骨組織のタイプ判別法としてのラマン分光法に関する研究2017

    • Author(s)
      山本雅哉、田畑泰彦
    • Organizer
      第16回日本再生医療学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] ラマン分光を利用した軟骨組織タイプ判別の試み2017

    • Author(s)
      山本雅哉、西本高明、田畑泰彦
    • Organizer
      第37回日本骨形態計測学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Raman spectroscopic tissue characterization of rabbit cartilages with different tissue types2017

    • Author(s)
      Masaya Yamamoto, Taka-aki Nishimoto, Yasuhiko Tabata
    • Organizer
      TERMIS-AP 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 再生医療・疾患研究のための生体機能性ハイドロゲルの設計2017

    • Author(s)
      山本雅哉
    • Organizer
      バイオマテリアル研究 東北地区交流会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ラマン分光を利用した部位特異的軟骨組織の判別2016

    • Author(s)
      山本雅哉、田畑泰彦
    • Organizer
      日本バイオマテリアル学会シンポジウム2016
    • Place of Presentation
      福岡
    • Year and Date
      2016-11-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] Sandwich culture of human mesenchymal stem cells with ephrinB2 oriented-immobilized polyacrylamide hydrogels2016

    • Author(s)
      M. Yamamoto, H. Toda, Y. Tabata
    • Organizer
      Biointerfaces International 2016
    • Place of Presentation
      Zurich, Switzerland
    • Year and Date
      2016-08-23
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Design for in vitro cellular microenvironments by using bio-functional hydrogels2016

    • Author(s)
      M. Yamamoto
    • Organizer
      AUSBME
    • Place of Presentation
      Beijing, China
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Sandwich culture of mesenchymal stem cells between bio-functional hydrogels as a novel 3-D culture method for regulating their osteoblastic differentiation2016

    • Author(s)
      M. Yamamoto, H. Toda, Y. Tabata
    • Organizer
      10th World Biomaterials Congress
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2016-05-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 三次元培養法としての生体機能性ハイドロゲルを用いたサンドイッチ培養による間葉系幹細胞の骨分化促進2015

    • Author(s)
      山本雅哉、戸田裕之、田畑泰彦
    • Organizer
      第25回日本MRS年次大会
    • Place of Presentation
      横浜
    • Year and Date
      2015-12-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] 生体機能性ハイドロゲルを用いた三次元細胞培養環境の設計2015

    • Author(s)
      山本雅哉、戸田裕之、田畑泰彦
    • Organizer
      第147回ポバール会
    • Place of Presentation
      京都
    • Year and Date
      2015-12-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] 生体機能性ハイドロゲルを用いた三次元細胞培養環境の評価2015

    • Author(s)
      戸田裕之、山本雅哉、田畑泰彦
    • Organizer
      第37回日本バイオマテリアル学会大会
    • Place of Presentation
      京都
    • Year and Date
      2015-11-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] Sandwich culture with bio-functional hydrogels as a three-dimensional culture technique to induce osteoblastic differentiation of mesenchymal stem cells.2015

    • Author(s)
      M. Yamamoto, H. Toda, Y. Tabata
    • Organizer
      TERMIS world congress 2015
    • Place of Presentation
      Boston, USA
    • Year and Date
      2015-09-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Design of functional hydrogels for creating artificial extracellular microenvironments in vitro2015

    • Author(s)
      M. Yamamoto
    • Organizer
      International Symposium on Nanoarchitectonics for Mechanobiology
    • Place of Presentation
      つくば
    • Year and Date
      2015-07-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 生体機能性ハイドロゲルを用いた三次元培養環境の構築2015

    • Author(s)
      戸田裕之、山本雅哉、田畑泰彦
    • Organizer
      第44回医用高分子シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2015-07-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] Novel 3-D culture technique based on sandwich culture between bio-functional hydrogels for enhancing osteoblastic differentiation of mesenchymal stem cells.2015

    • Author(s)
      M. Yamamoto, H. Toda, Y. Tabata
    • Organizer
      International Conference on Regenerative Biomedical Materials (ICRBM) 2015
    • Place of Presentation
      Wuhan, China
    • Year and Date
      2015-06-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 生体機能性ハイドロゲルサンドイッチ培養による三次元培養環境の構築2015

    • Author(s)
      戸田裕之、山本雅哉、田畑泰彦
    • Organizer
      第64回高分子学会年次大会
    • Place of Presentation
      札幌
    • Year and Date
      2015-05-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] Sandwich culture with bio-functional hydrogels as a three-dimensional culture technique to induce osteoblastic differentiation of mesenchymal stem cells.2015

    • Author(s)
      M. Yamamoto, H. Toda, Y. Tabata
    • Organizer
      The 5th Asian Biomaterials Congress
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2015-05-07
    • Related Report
      2015 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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