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Recovery of lower limb function by hybrid-rehabilitation combining DC stimulation and gait: Physiologic study

Research Project

Project/Area Number 15H03044
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionRitsumeikan University

Principal Investigator

Mima Tatsuya  立命館大学, 先端総合学術研究科, 教授 (20324618)

Co-Investigator(Kenkyū-buntansha) 野嶌 一平  名古屋大学, 医学系研究科(保健), 助教 (20646286)
植木 美乃  名古屋市立大学, 大学院医学研究科, 講師 (40467478)
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2016: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2015: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Keywordsリハビリテーション / 非侵襲的脳刺激法 / 経頭蓋的直流刺激法
Outline of Final Research Achievements

We developed a new hybrid rehabilitation method by combining brain stimulation, peripheral electrical stimulation and repetitive movement for lower limb function reconstruction. After studies in healthy individuals, the affected M1 foot area was given rhythmic transcranial direct current stimulation synchronized with the walking rhythm of each individual for chronic poststroke patients. After repeated interventions in chronic stroke patients, their gait function improved. This suggests that brain stimulation synchronized with gait rhythm is a promising approach for inducing gait recovery (in submission). After developing the new method of lower extremity rehabilitation as originally intended, we performed the study in healthy people, and extended it to clinical application.

Academic Significance and Societal Importance of the Research Achievements

慢性期脳卒中患者での下肢機能の再建を実現することができれば、車いす生活となっている多くの患者にとってのADL,QOLの著明な改善に繋がることが期待される。また、車いす就労は制限されているため、下肢機能の改善を可能とする技術開発は、高齢社会の日本において生産人口の増加という点でも寄与できる。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (41 results)

All 2019 2018 2017 2016 2015 Other

All Int'l Joint Research (2 results) Journal Article (21 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 20 results,  Open Access: 15 results,  Acknowledgement Compliant: 4 results) Presentation (17 results) (of which Int'l Joint Research: 4 results,  Invited: 1 results) Remarks (1 results)

  • [Int'l Joint Research] 国立対麻痺病院(スペイン)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] オスロ大学(ノルウェー)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] A Potential Therapeutic Approach for Ataxia with Non-invasive Cerebellar Stimulation2019

    • Author(s)
      小金丸聡子
    • Journal Title

      The Japanese Journal of Rehabilitation Medicine

      Volume: 56 Issue: 2 Pages: 122-129

    • DOI

      10.2490/jjrmc.56.122

    • NAID

      130007623488

    • ISSN
      1881-3526, 1881-8560
    • Year and Date
      2019-02-18
    • Related Report
      2018 Annual Research Report
  • [Journal Article] Transcranial static magnetic stimulation over the primary motor cortex alters sequential implicit motor learning2019

    • Author(s)
      Nojima I, Watanabe T, Goyda T, Sugata H, Ikeda T, Mima T.
    • Journal Title

      Neurosci Lett

      Volume: 696 Pages: 33-37

    • DOI

      10.1016/j.neulet.2018.12.010

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anodal transcranial patterned stimulation of the motor cortex during gait can induce activity-dependent corticospinal plasticity to alter human gait.2018

    • Author(s)
      Koganemaru S, Mikami Y, Maezawa H, Matsuhashi M, Ikeda S, Ikoma K, Mima T
    • Journal Title

      PLoS One.

      Volume: 13 Issue: 12 Pages: 1-19

    • DOI

      10.1371/journal.pone.0208691

    • NAID

      120006644054

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neurofeedback Control of the Human GABAergic System Using Non-invasive Brain Stimulation.2018

    • Author(s)
      Koganemaru S, Mikami Y, Maezawa H, Ikeda S, Ikoma K, Mima T
    • Journal Title

      Neuroscience.

      Volume: 380 Pages: 38-48

    • DOI

      10.1016/j.neuroscience.2018.03.051

    • NAID

      120006636173

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Body ownership and agency altered by an electromyographically-controlled robotic arm.2018

    • Author(s)
      Sato, Y., Kawase, T., Takano, K., Spence, C, Kansaku, K.
    • Journal Title

      Royal Society Open Science,

      Volume: 5(5) Issue: 5 Pages: 172170-172170

    • DOI

      10.1098/rsos.172170

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Transcranial Direct Current Stimulation Improves Pusher Phenomenon2018

    • Author(s)
      Yamaguchi T, Satow T, Komuro T, Mima T.
    • Journal Title

      Case Rep Neurol

      Volume: 11 Issue: 1 Pages: 61-65

    • DOI

      10.1159/000497284

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Voluntary control of forward leaning posture relates to low-frequency neural inputs to the medial gastrocnemius muscle2018

    • Author(s)
      Watanabe T, Nojima I, Sugiura H, Yacoubi B, Christou EA
    • Journal Title

      Gait & Posture

      Volume: 68 Pages: 187-192

    • DOI

      10.1016/j.gaitpost.2018.11.026

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fatigue-induced decline in low-frequency common input to bilateral and unilateral plantar flexors during quiet standing2018

    • Author(s)
      Watanabe Tatsunori、Saito Kotaro、Ishida Kazuto、Tanabe Shigeo、Nojima Ippei
    • Journal Title

      Neuroscience Letters

      Volume: 686 Pages: 193-197

    • DOI

      10.1016/j.neulet.2018.09.019

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Age-Related Declines in the Ability to Modulate Common Input to Bilateral and Unilateral Plantar Flexors During Forward Postural Lean2018

    • Author(s)
      Watanabe T, Saito K, Ishida K, Tanabe S, Nojima I
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 12 Pages: 1-9

    • DOI

      10.3389/fnhum.2018.00254

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of auditory stimulus on executive function and execution time during cognitively demanding stepping task in patients with Parkinson's disease.2018

    • Author(s)
      Watanabe T, Saito K, Ishida K, Tanabe S, Horiba M, Itamoto S, Ueki Y, Wada I, Nojima I.
    • Journal Title

      Neurosci Lett

      Volume: 674 Pages: 101-105

    • DOI

      10.1016/j.neulet.2018.03.032

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Trading of dynamic interaural time and level difference cues and its effect on the auditory motion-onset response measured with electroencephalography.2017

    • Author(s)
      Altmann, C. F., Ueda, R., Bucher, B., Furukawa, S., Ono, K., Kashino, M., Mima, T., Fukuyama, H.
    • Journal Title

      NeuroImage

      Volume: 159 Pages: 185-194

    • DOI

      10.1016/j.neuroimage.2017.07.055

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Facilitation of Function and Manipulation Knowledge of Tools Using Transcranial Direct Current Stimulation (tDCS)2017

    • Author(s)
      Ishibashi, R., Mima, T., Fukuyama, H., Pobric, G
    • Journal Title

      Frontiers in Integrative Neuroscience

      Volume: 11 Pages: 37-37

    • DOI

      10.3389/fnint.2017.00037

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of vestibular rehabilitation combined with transcranial cerebellar direct current stimulation in patients with chronic dizziness: An exploratory study.2017

    • Author(s)
      Koganemaru S, Goto F, Arai M, Toshikuni K, Hosoya M, Wakabayashi T, Yamamoto N, Minami S, Ikeda S, Ikoma K, Mima T.
    • Journal Title

      Brain Stimulation

      Volume: - Issue: 3 Pages: 576-578

    • DOI

      10.1016/j.brs.2017.02.005

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Neural pattern similarity between contra- and ipsilateral movements in high-frequency band of human electrocorticograms2017

    • Author(s)
      Fujiwara Y, Matsumoto R, Nakae T, Usami K, Matsuhashi M, Kikuchi T, Yoshida K, Kunieda T, Miyamoto S, Mima T, Ikeda A, Osu R
    • Journal Title

      Neuroimage

      Volume: 15 Pages: 302-313

    • DOI

      10.1016/j.neuroimage.2016.11.058

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Spatiotemporal Organization and Cross-Frequency Coupling of Sleep Spindles in Primate Cerebral Cortex.2016

    • Author(s)
      Takeuchi, S., R. Murai, H. Shimazu, Y. Isomura, T. Mima and T. Tsujimoto
    • Journal Title

      Sleep

      Volume: 39(9) Issue: 9 Pages: 1719-1735

    • DOI

      10.5665/sleep.6100

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Combination of Static Magnetic Fields and Peripheral Nerve Stimulation Can Alter Focal Cortical Excitability.2016

    • Author(s)
      Nojima, I., S. Koganemaru and T. Mima
    • Journal Title

      Front Hum Neurosci

      Volume: 10 Pages: 598-598

    • DOI

      10.3389/fnhum.2016.00598

    • NAID

      120005980908

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Current Stimulation and Neuromuscular Electrical Stimulation Improves Gait Ability in a Patient in Chronic Stage of Stroke2016

    • Author(s)
      Hosaka R, Nakajima T, Aihara K, Yamaguchi Y, Mushiake H.
    • Journal Title

      Case Rep Neurol

      Volume: 8 Issue: 1 Pages: 39-46

    • DOI

      10.1159/000444167

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Motion-induced disturbance of auditory-motor synchronization and its modulation by transcranial direct current stimulation (tDCS)2016

    • Author(s)
      Ono, K., Mikami, Y., Fukuyama, H. and Mima, T.
    • Journal Title

      Eur J Neurosci.

      Volume: 43 Issue: 4 Pages: 509-515

    • DOI

      10.1111/ejn.13135

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cortico-muscular synchronization by proprioceptive afferents from the tongue muscles during isometric tongue protrusion.2016

    • Author(s)
      Maezawa H, Mima T, Yazawa S, Matsuhashi M, Shiraishi H, Funahashi M
    • Journal Title

      Neuroimage

      Volume: 128 Pages: 284-92

    • DOI

      10.1016/j.neuroimage.2015.12.058

    • NAID

      120005906988

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two is More Than One: How to Combine Brain Stimulation Rehabilitative Training for Functional Recovery?2016

    • Author(s)
      Koganemaru S, Fukuyama H, Mima T.
    • Journal Title

      Front Syst Neurosci.

      Volume: 9 Pages: 154-154

    • DOI

      10.3389/fnsys.2015.00154

    • NAID

      120005947022

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Action observation with kinesthetic illusion can produce human motor plasticity.2015

    • Author(s)
      Nojima I, Koganemaru S, Kawamata T, Fukuyama H, Mima T.
    • Journal Title

      Eur J Neurosci.

      Volume: 41 Issue: 12 Pages: 1614-23

    • DOI

      10.1111/ejn.12921

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 静磁場刺激がタキストスコープによる線分分割課題の精度に及ぼす影響2018

    • Author(s)
      桐本光,緒方勝也,中薗寿人,鶴 大輔,美馬達哉,飛松省三
    • Organizer
      第48回日本臨床神経生理学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 静磁場刺激によるタキストスコープ線分分割課題の精度の改善2018

    • Author(s)
      桐本光,緒方勝也,中薗寿人,鶴 大輔,美馬達哉,飛松省三
    • Organizer
      第12回Motor Control研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 側頭葉に対する経頭蓋静磁場刺激によるタキストスコープ線分分割課題の精度の変化2018

    • Author(s)
      桐本光,緒方勝也,中薗寿人,鶴 大輔,美馬達哉
    • Organizer
      第12回日本作業療法研究学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 静磁場刺激はマウス神経細胞の膜興奮性を一時的に低下させる2018

    • Author(s)
      高松泰行,Adya Saran Sinha,秋田天平, 福田敦夫,美馬達哉
    • Organizer
      第33回日本生体磁気学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Static magnetic fields can temporarily alter the membrane excitability of mouse pyramidal neurons.2018

    • Author(s)
      Yasuyuki Takamatsu, Adya Saran Sinha, Tenpei Akita, Atsuo Fukuda, Tatsuya Mima
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] The effect of static magnetic fields on the membrane excitability of pyramidal neurons in mice2018

    • Author(s)
      Yasuyuki Takamatsu, Adya Saran Sinha, Tenpei Akita, Atsuo Fukuda, Tatsuya Mima
    • Organizer
      Neuroscience 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 中枢性生体磁気介入と末梢刺激のカップリングによる神経可塑性2018

    • Author(s)
      美馬達哉
    • Organizer
      第33回日本生体磁気学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ヒトにおける動的および静的経頭蓋的磁気刺激の比較2018

    • Author(s)
      美馬達哉
    • Organizer
      第1回静磁場刺激国際ワークショップ
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Recovery of balance and gait function induced by transcranial rhythmic current stimulation synchronized with gait rhythm in post-stroke patients2018

    • Author(s)
      SATOKO KOGANEMARU、RYOSUKE KITATANI、AYAKA MAEDA、MASAO MATSUHASHI、KATSUNORI IKOMA、TATSUYA MIMA
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 脊髄小脳変性症における小脳性連合性対刺激法による小脳機能の増強と運動機能の変化2018

    • Author(s)
      飛澤悠伊、小金丸聡子、仁宮慎一郎、井口大暢、西村宗一郎、美馬達哉、池田聡、生駒一憲
    • Organizer
      第2回日本リハビリテーション医学会秋季学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 自己の運動意思の認識にかかわる脳活動2018

    • Author(s)
      松橋眞生、文室知之、美馬達哉、福山秀直、池田昭夫
    • Organizer
      第48回日本臨床神経生理学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 一次運動野に対する経頭蓋的静磁場刺激が対側一次運動野に与える影響2018

    • Author(s)
      高松泰行、湯川喜裕、水口雅俊、下村亮太、美馬達哉
    • Organizer
      第48回日本臨床神経生理学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 脊髄小脳変性症患者における小脳PASによる小脳抑制(CBI)の変化2018

    • Author(s)
      汪ゆみん、小金丸聡子、飛澤悠伊、仁宮慎一郎、井口大暢、美馬達哉、池田聡、生駒一憲
    • Organizer
      第48回日本臨床神経生理学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 音楽を併用した随意運動での運動関連電位に影響を与える情動因子の検討2018

    • Author(s)
      中島淑恵、美馬達哉、梶井文子
    • Organizer
      第48回日本臨床神経生理学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Transcranial static magnetic stimulation over human primary motor cortex can modulate implicit motor learning2018

    • Author(s)
      Nojima I, Watanabe T, Hirayama M, Sugata H, Ikeda T, Mima T.
    • Organizer
      Neuroscience 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] rTMSを用いた上肢Hybrid-rehabilitationと機能特異的脳再構成2018

    • Author(s)
      小金丸 聡子
    • Organizer
      第2回日本リハビリテーション医学会秋季学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Reconsolidation task performed with untrained limb enhances motor skill acquisition2018

    • Author(s)
      Gyoda T, Ishida K, Watanabe T, Nojima I
    • Organizer
      Neuroscience 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Remarks]

    • URL

      http://research-db.ritsumei.ac.jp/Profiles/123/0012283/profile.html

    • Related Report
      2018 Annual Research Report

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Published: 2015-04-16   Modified: 2020-03-30  

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