| Project/Area Number |
15H03091
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
MESAKI Noboru 筑波大学, 体育系(名誉教授), 名誉教授 (30010408)
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| Co-Investigator(Kenkyū-buntansha) |
佐藤 幸治 神戸大学, 人間発達環境学研究科, 准教授 (20584022)
相澤 勝治 専修大学, 文学部, 准教授 (80375477)
家光 素行 立命館大学, スポーツ健康科学部, 教授 (90375460)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2017: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Keywords | 動脈硬化 / 性ステロイドホルモン / 有酸素性運動 / 加齢 / 肥満 |
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| Outline of Final Research Achievements |
This study was aimed to clarify whether the secretion of sex steroids hormones is associated with aerobic exercise training-induced reduction of arterial stiffness. To directly evidence exercise effect by using inhibitor of sex steroid hormone synthase, Male obese type 2 diabetic rats (OLETF) were randomly divided into 4 groups; sedentary obese control, 8-week aerobic training, aerobic training with continuous infusion of 5α-reductase inhibitor, or aerobic training with continuous infusion of P450 aromatase inhibitor groups. Aerobic exercise training in OLETF significantly reduced carotid-femoral pulse wave velocity (cfPWV), an index of arterial stiffness, as compared with the sedentary obese control group, whereas the training-induced reduction of cfPWV was not suppressed by administrations of the 5α-reductase and P450 aromatase inhibitors. These results suggest that sex steroids hormones may be not associated with aerobic exercise training-induced reduction of arterial stiffness.
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