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Neural mechanisms of interaction between the extended body and environment.

Research Project

Project/Area Number 15H03126
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Basic / Social brain science
Research InstitutionDokkyo Medical University (2018)
National Rehabilitation Center for Persons with Disabilities (2015-2017)

Principal Investigator

KANSAKU KENJI  獨協医科大学, 医学部, 教授 (60399318)

Co-Investigator(Kenkyū-buntansha) 高野 弘二  国立障害者リハビリテーションセンター(研究所), 研究所 脳機能系障害研究部, 研究員 (00510588)
Research Collaborator KAWASE Toshihiro  
SATO Yuki  
OKAHARA Yoji  
HAYASHI Nana  
HALDER Sebastian  
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2018: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Keywords自己 / 身体 / 環境 / BMI / コミュニケーション
Outline of Final Research Achievements

In this study we first investigated the incorporation of prosthetic arms in amputees using the crossed hands illusion, in which successive somatosensory stimuli are delivered, one to each arm, at intervals of 300ms or less. The induced reversal illusion was greater with a prosthetic limb than without in amputees, which suggested that somatosensory signals were referred to the spatial location of the tips of the prosthetic arm. We then applied a robotic arm using myoelectric control in the rubber hand illusion. The sense of ownership and agency in able-bodied participants and amputees was extended to the robotic arm when the wrists of the real and robotic arms were flexed/extended synchronously, which suggested that incorporation of the prosthesis was induced. We also prepared a rubber tail and used the rubber tail to induce illusion in mice, like the rubber hand illusion. Our results suggested that our experimental setting allows us to investigate body ownership in mice.

Academic Significance and Societal Importance of the Research Achievements

切断者を対象とした一連の実験の結果は、義手や自身で操作できる運動補助装置に身体性が拡張していることを示唆するものであり、自分の身体の一部となる義手の開発などに向け、有用な知見となり得る。また、マウスの尾に対するラバーハンド錯覚と類似した錯覚は、これまでヒトやサルのみで報告されていた現象をはじめてマウスで報告したものであり、身体に関する脳内表現をニューロンレベルで明らかとするために貢献し得る。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (53 results)

All 2019 2018 2017 2016 2015 Other

All Int'l Joint Research (4 results) Journal Article (13 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 12 results,  Open Access: 9 results,  Acknowledgement Compliant: 4 results) Presentation (36 results) (of which Int'l Joint Research: 21 results,  Invited: 5 results)

  • [Int'l Joint Research] オックスフォード大学(英国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] テュービンゲン大学(ドイツ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] オスロ大学(ノルウェー)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] オックスフォード大学(英国)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Long-term use of a neural prosthesis in progressive paralysis.2018

    • Author(s)
      Okahara, Y., Takano, K., Nagao, M., Kondo, K., Iwadate, Y., Birbaumer, N., Kansaku, K.
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 16787-16787

    • DOI

      10.1038/s41598-018-35211-y

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comparison of four control methods for a five-choice assistive technology2018

    • Author(s)
      Halder, S., Takano, T., Kansaku, K.
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 12 Pages: 228-228

    • DOI

      10.3389/fnhum.2018.00228

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Body ownership and agency altered by an electromyographically-controlled robotic arm.2018

    • Author(s)
      Sato, Y., Kawase, T., Takano, K., Spence, C, Kansaku, K.
    • Journal Title

      Royal Society Open Science,

      Volume: 5(5) Issue: 5 Pages: 172170-172170

    • DOI

      10.1098/rsos.172170

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Operation of a P300-based brain-computer interface in patients with Duchenne muscular dystrophy.2018

    • Author(s)
      Utsumi, K., Takano, K., Okahara, Y., Komori, T., Onodera, O., Kansaku, K.
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 1753-1753

    • DOI

      10.1038/s41598-018-20125-6

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Incorporation of prosthetic limbs into the body representation of amputees: Evidence from the crossed hands temporal order illusion.2017

    • Author(s)
      Sato, Y., Kawase, T., Takano, K., Spence, C., Kansaku, K.
    • Journal Title

      Progress in Brain Research

      Volume: 236 Pages: 225-241

    • DOI

      10.1016/bs.pbr.2017.08.003

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Affective stimuli for an auditory P300 brain-computer interface.2017

    • Author(s)
      Onishi, A., Takano, K., Kawase, T., Ora, H., Kansaku, K.
    • Journal Title

      Frontiers in Neuroscience

      Volume: 11 Pages: 522-522

    • DOI

      10.3389/fnins.2017.00522

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Operation of a P300-based brain-computer interface by patients with spinocerebellar ataxia.2017

    • Author(s)
      Okahara, Y., Takano, K., Komori, T., Nagao, M., Iwadate, Y., Kansaku, K.
    • Journal Title

      Clinical Neurophysiology Practice

      Volume: 2 Pages: 147-153

    • DOI

      10.1016/j.cnp.2017.06.004

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A hybrid BMI-based exoskeleton for paresis: EMG control for assisting arm movements.2017

    • Author(s)
      Kawase T, Sakurada T, Koike Y, Kansaku K.
    • Journal Title

      Journal of Neural Engineering

      Volume: 14(1) Issue: 1 Pages: 016015-016015

    • DOI

      10.1088/1741-2552/aa525f

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The rubber tail illusion as evidence of body ownership in mice.2016

    • Author(s)
      Wada, M., Takano, K., Ora, H., Ide, M., Kansaku, K.
    • Journal Title

      The Journal of Neuroscience

      Volume: 36 Issue: 43 Pages: 11133-11137

    • DOI

      10.1523/jneurosci.3006-15.2016

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Arm crossing updates brain functional connectivity of the left posterior parietal cortex.2016

    • Author(s)
      Ora H, Wada M, Salat D, Kansaku K.
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 28105-28105

    • DOI

      10.1038/srep28105

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] An evaluation of training with an auditory P300 brain-computer interface for the Japanese Hiragana syllabary.2016

    • Author(s)
      Halder S, Takano T, Ora H, Onishi A, Utsumi K, Kansaku K.
    • Journal Title

      Frontiers in Neuroscience

      Volume: 10 Pages: 446-446

    • DOI

      10.3389/fnins.2016.00446

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] ブレイン-マシン・インターフェイス技術によるコミュニケーション支援2016

    • Author(s)
      神作憲司
    • Journal Title

      ノーマライゼーション-障害者の福祉

      Volume: 36 Pages: 16-19

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Use of high-frequency visual stimuli above the critical flicker frequency in a SSVEP-based BMI.2015

    • Author(s)
      Sakurada, T., Kawase, T., Komatsu, T., Kansaku, K.
    • Journal Title

      Clinical Neurophysiology

      Volume: 126 Issue: 10 Pages: 1972-1978

    • DOI

      10.1016/j.clinph.2014.12.010

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Presentation] Decoder construction for MEG signals in a subitizing task.2019

    • Author(s)
      Takano, K., Kansaku, K.
    • Organizer
      The 96th Annual Meeting of the Physiological Society of Japan
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Body ownership and agency altered by a robotic arm controlled by electromyography of elbow muscles.2019

    • Author(s)
      Kawase, T., Kono, K., Cho, K., Kato, E., Kansaku, K.
    • Organizer
      The 96th Annual Meeting of the Physiological Society of Japan
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Lower C-Fos expressions in the posterior parietal cortex during rubber tail task in Caps2 KO mice.2019

    • Author(s)
      Wada, M., Ide, M., Atsumi, T., Takano, K., Sano, Y., Shinoda, Y, Kansaku, K.
    • Organizer
      The 96th Annual Meeting of the Physiological Society of Japan
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 高周波点滅視覚刺激を用いたSSVEP型-BMIアシストロボットの実装.2018

    • Author(s)
      櫻田武、神作憲司.
    • Organizer
      第5回脳神経外科BMI懇話会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Utility of peripheral visual field in the SSVEP-based brain-computer interface.2018

    • Author(s)
      Takano, K., Morita-Hayashi, N., Kansaku, K.
    • Organizer
      The 48th Annual Meeting of the Society for Neuroscience
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] EMG-controlled robotic arm intended to be incorporated into body representation.2018

    • Author(s)
      Kawase, T., Sato, Y., Kansaku, K.
    • Organizer
      The 41st Annual Meeting of Japan Neuroscience Society
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Operation of a SSVEP-based BMI in a patient who progressed to the completely locked-in state.2018

    • Author(s)
      Okahara, Y., Takano, K., Nagao, M., Iwadate, Y., Kansaku, K.
    • Organizer
      The 41st Annual Meeting of Japan Neuroscience Society
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 脳情報の解析と利用2018

    • Author(s)
      神作憲司
    • Organizer
      第48回千葉大学脳神経外科医会研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 脳からの情報を利用する:神経生理学に何が出来るか?2018

    • Author(s)
      神作憲司
    • Organizer
      北海道大学大学院医学研究院・第129回ニューロサイエンス談話会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 神経難病領域における脳情報利用の試み2018

    • Author(s)
      神作憲司
    • Organizer
      日本難病看護学会・企画セミナー/箱根病院・箱根で学ぶ神経難病看護シリーズ
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] C-Fos expressions in the cerebral cortex during rubber tail task in mice.2018

    • Author(s)
      Wada, M., Ide, M., Atsumi, T., Takano, K., Ora, H., Kansaku, K.
    • Organizer
      The 95th Annual Meeting of the Physiological Society of Japan.
    • Related Report
      2017 Annual Research Report
  • [Presentation] 神経難病へのブレイン-マシン・インターフェイス(BMI)の応用.2017

    • Author(s)
      神作憲司.
    • Organizer
      第7回神経難病リハビリテーション研究会.
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ブレイン-マシン・インタフェースによるコミュニケーションと運動の補助.2017

    • Author(s)
      神作憲司.
    • Organizer
      第109回 ロボット工学セミナー・臨床応用から理解するリハビリテーション・ロボティクス
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 上肢アシストスーツに対する脳波筋電ハイブリッド制御2017

    • Author(s)
      川瀬利弘、小池康晴、神作憲司.
    • Organizer
      LIFE2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] Effect of vision of arm posture on a crossed hands illusion task in an amputee.2017

    • Author(s)
      Sato, Y., Kawase, T., Takano, K., Kansaku, K.
    • Organizer
      The 47th Annual Meeting of the Society for Neuroscience.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of synchronous movement of an EMG controlled robotic arm on robot hand illusion in amputees.2017

    • Author(s)
      Sato, Y., Kawase, T., Takano, K., Kansaku, K.
    • Organizer
      The 40th Annual Meeting of Japan Neuroscience Society
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A BMI-based robotic exoskeleton for neurorehabilitation and daily actions: hybrid control based on EMG and SSVEP for elbow and wrist.2017

    • Author(s)
      Kawase, T., Koike, Y., Kansaku, K.
    • Organizer
      The 40th Annual Meeting of Japan Neuroscience Society
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] P300-based brain-machine interface applied to patients with Duchenne muscular dystrophy.2017

    • Author(s)
      Utsumi, K., Okahara, Y., Takano, K., Komori, T., Onodera, O., Kansaku, K.
    • Organizer
      Real-time functional imaging and neurofeedback conference 2017.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of oxytocin on a rubber tail task in CAPS2 KO mice: an initial study2017

    • Author(s)
      Wada, M., Atsumi, T., Ide, M., Sano, Y., Shinoda, Y., Furuichi, T., Kansaku, K.
    • Organizer
      The 77th Annual Meeting of the Japanese Society for Animal Psychology.
    • Related Report
      2017 Annual Research Report
  • [Presentation] 脳波によるBMI技術:社会への実装に向けて2017

    • Author(s)
      神作憲司
    • Organizer
      第19回日本ヒト脳機能マッピング学会・シンポジウム
    • Place of Presentation
      京都, 京都大学百周年時計台記念館
    • Related Report
      2016 Annual Research Report
  • [Presentation] EEG evaluation of relative change of subjective sleepiness.2017

    • Author(s)
      Utsumi, K., Takano, K., Onodera, O., Kansaku, K.
    • Organizer
      The 94th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      浜松, アクトシティ浜松
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Comparison between response in real tail grasping and rubber tail illusion in mice.2017

    • Author(s)
      Wada, M., Ide, M., Takano, K., Ora, H., Kansaku, K.
    • Organizer
      The 94th Annual Meeting of the Physiological Society of Japan.
    • Place of Presentation
      浜松, アクトシティ浜松
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] C-Fos and Arc expression during a rubber tail task in mice: an initial study.2016

    • Author(s)
      Wada, M., Ide, M., Ora, H., Kansaku, K.
    • Organizer
      The 93rd Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      札幌, コンベンションセンター
    • Year and Date
      2016-03-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] A rubber tail task in CAPS2 KO mice: second report.2016

    • Author(s)
      Wada, M. Ide, M., Atsumi, T., Yagishita, K., Katakai, M., Shinoda, Y., Furuichi, T., Kansaku, K.
    • Organizer
      The 76th Annual Meeting of the Japanese Society for Animal Psychology.
    • Place of Presentation
      札幌, 北海道大学 学術交流会館
    • Related Report
      2016 Annual Research Report
  • [Presentation] Speech comprehension in patients with persistent vegetative state: a neuroimaging approach.2016

    • Author(s)
      Okahara, Y., Utsumi, K., Takano, K., Odaka, K., Uchino, Y., Kansaku, K.
    • Organizer
      The 46th Annual Meeting of the Society for Neuroscience.
    • Place of Presentation
      San Diego Convention Center, San Diego, USA.
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A rubber tail task in Ca2+-dependent activator protein for secretion (CAPS) 2 knockout mice.2016

    • Author(s)
      Wada, M., Ide, M., Atsumi, T., Yagishita, K., Katakai, M., Shinoda, Y., Furuichi, T., Kansaku, K.
    • Organizer
      The 46th Annual Meeting of the Society for Neuroscience.
    • Place of Presentation
      San Diego Convention Center, San Diego, USA.
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 無反応覚醒症候群における感覚性言語中枢の神経画像評価.2016

    • Author(s)
      岡原陽二、宇津見宏太、高野弘二、内野福生、岩立康男、神作憲司.
    • Organizer
      第75回 日本脳神経外科学会総会
    • Place of Presentation
      福岡, 福岡国際会議場
    • Related Report
      2016 Annual Research Report
  • [Presentation] A crossed hands illusion task in an amputee with a prosthesis.2016

    • Author(s)
      Sato, Y., Ora, H., Takano, K., Kansaku, K.
    • Organizer
      The 39th Annual Meeting of Japan Neuroscience Society
    • Place of Presentation
      横浜, パシフィコ横浜
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A BMI-based robotic exoskeleton for neurorehabilitation and daily actions: effects of hybrid BMI-based assistance on muscle activities in a stroke patient.2016

    • Author(s)
      Kawase, T., Koike, Y., Kansaku, K.
    • Organizer
      The 39th Annual Meeting of Japan Neuroscience Society
    • Place of Presentation
      横浜, パシフィコ横浜
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Affective sounds applied to auditory P300 brain-machine interface.2016

    • Author(s)
      Onishi, A., Ora, H., Kansaku, K.
    • Organizer
      The 39th Annual Meeting of Japan Neuroscience Society
    • Place of Presentation
      横浜, パシフィコ横浜
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Initial evaluation of an auditory P300 brain-computer interface for the Japanese Hiragana syllabary.2016

    • Author(s)
      Halder, S., Takano, K., Ora, H., Onishi, A., Utsumi, K., Kansaku, K.
    • Organizer
      International Brain-Computer Interface (BCI) Meeting 2016
    • Place of Presentation
      Asilomar Conference Center, Pacific Grove, USA.
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A longitudinal evaluation of SSVEP-BMI in patients with ALS.2015

    • Author(s)
      Takano. K., Komatsu. T., Nagao. M., Kondo. K., Kansaku. K.
    • Organizer
      The 45th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      米国シカゴ, マコーミックプレイス
    • Year and Date
      2015-10-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Neurofeedback training improves decoding accuracy in MEG/SSVEF.2015

    • Author(s)
      Ora, H., Kansaku, K.
    • Organizer
      The 45th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      米国シカゴ, マコーミックプレイス
    • Year and Date
      2015-10-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A rubber hand experiment using an EMG controlled robotic arm in amputee participants.2015

    • Author(s)
      Sato, Y., Kawase, T., Kansaku. K.
    • Organizer
      The 45th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      米国シカゴ, マコーミックプレイス
    • Year and Date
      2015-10-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A rubber tail task in CAPS2 KO mice: an initial study.2015

    • Author(s)
      Wada, M. Ide, M., Yagishita, K., Katakai, M., Shinoda, Y., Furuichi, T., Kansaku,
    • Organizer
      The 75th Annual Meeting of the Japanese Society for Animal Psychology
    • Place of Presentation
      東京, 日本女子大学
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] A BMI-based robotic exoskeleton for neurorehabilitation and daily actions: use of a hybrid control method based on EMG and SSVEP in a stroke patient.2015

    • Author(s)
      Kawase, T., Koike. Y., Kansaku. K.
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸, 神戸国際会議場
    • Year and Date
      2015-07-29
    • Related Report
      2015 Annual Research Report

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Published: 2015-04-16   Modified: 2022-08-26  

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