• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Synthesis and Virus/Bacteria Capturing of Self-Propelled Protein Microtubes

Research Project

Project/Area Number 15H03533
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Nanomaterials chemistry
Research InstitutionChuo University

Principal Investigator

KOMATSU TERUYUKI  中央大学, 理工学部, 教授 (30298187)

Co-Investigator(Kenkyū-buntansha) 森田 能次  中央大学, 理工学部, 助教 (40795308)
秋山 元英  中央大学, 理工学部, 助教 (90467697)
Co-Investigator(Renkei-kenkyūsha) ISHII Makoto  慶応義塾大学, 医学部, 講師 (30317333)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2017: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Keywordsナノ・マイクロ機能材料 / 蛋白質 / マイクロチューブ / 交互積層 / 白金ナノ粒子 / 大腸菌 / ウイルス / 生体機能材料 / バクテリア
Outline of Final Research Achievements

We prepared self-propelled protein microtubes with oxygen bubble ejecting ability on the inner pore wall, and clarified that the swimming tubes function as a unique microcylinder capable of capturing Escherichia coli efficiently in aqueous medium. Furthermore, we successfully synthesized microtubes with selective molecular capture ability, nanotubes to trap influenza virus, microtube reactors with enzymatic activity, and elucidated the correlation between multilayered structure and function. Self-propelled microtubes have been highlighted in the Chemistry World (Royal Society of Chemistry) and are attracted considerable attention.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (34 results)

All 2018 2017 2016 2015 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (22 results) (of which Int'l Joint Research: 9 results,  Invited: 2 results) Remarks (9 results)

  • [Journal Article] Self-Propelled Soft Protein Microtubes with a Pt Nanoparticle Interior Surface2017

    • Author(s)
      S. Kobayakawa, Y. Nakai, M. Akiyama, T. Komatsu
    • Journal Title

      Chem. Eur. J.

      Volume: 23 Pages: 5044-5050

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glycoprotein Nanotube Traps Influenza Virus2017

    • Author(s)
      S. Yuge, M. Akiyama, M. Ishii, H. Namkoong, K. Yagi, Y. Nakai, R. Adachi, T. Komatsu
    • Journal Title

      Chem. Lett.

      Volume: 46 Issue: 1 Pages: 95-97

    • DOI

      10.1246/cl.160805

    • NAID

      130005308379

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nanotube Reactor with a Lipase Wall Interior for Enzymatic Ring-opening Oligomerization of Lactone2015

    • Author(s)
      Y. Amano, T. Komatsu
    • Journal Title

      Chemistry Letters

      Volume: 44 Issue: 12 Pages: 1646-1648

    • DOI

      10.1246/cl.150789

    • NAID

      130005112536

    • ISSN
      0366-7022, 1348-0715
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 自走するカタラーゼマイクロチューブの合成とその速度制御2018

    • Author(s)
      菅井夏穂、中井葉子、森田能次、小松晃之
    • Organizer
      日本化学会第98春季年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] リポソームを内包した金ナノ粒子ナノチューブの 合成と薬物放出2018

    • Author(s)
      榎本由人、森田能次、小松晃之
    • Organizer
      日本化学会第98春季年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Self-Propelled Protein Microtube and its E.coli Capturing Ability2017

    • Author(s)
      Y. Nakai, M. Akiyama, Y. Morita, T. Komatsu
    • Organizer
      IUPAC 17th International Symposium on MacroMolecular Complexes (MMC-17)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Protein Nano- and Micro-tubes as Functional Biomaterials2017

    • Author(s)
      T. Komatsu
    • Organizer
      14th International Conference on Polymers for Advanced Technologies (PAT-2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Self-Propelled Protein Microtubes with an Interior Surface Composed of Pt Nanoparticles2017

    • Author(s)
      Y. Nakai, Y. Morita, T. Komatsu
    • Organizer
      14th International Conference on Polymers for Advanced Technologies (PAT-2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] リポソームを内孔表面に固定した金ナノ粒子ナノチューブの合成2017

    • Author(s)
      榎本由人、森田能次、小松晃之
    • Organizer
      第66回高分子討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Protein-Based Smart Nano- and Micro-tubes2017

    • Author(s)
      T. Komatsu
    • Organizer
      IUPAC 13th International Conference on Novel Materials and their Synthesis (NMS-XIII)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 自走方向を制御できる蛋白質マイクロチューブの合成と大腸菌捕捉2016

    • Author(s)
      中井葉子、秋山元英、小松晃之
    • Organizer
      第6回CSJ化学フェスタ2016
    • Place of Presentation
      タワーホール船堀(東京)
    • Year and Date
      2016-11-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] 鋳型内交互積層法によるDNAナノチューブの合成とその 応用2016

    • Author(s)
      秋山元英、山田知佳、小松晃之
    • Organizer
      第10回バイオ関連化学シンポジウム
    • Place of Presentation
      石川県立音楽堂(金沢)
    • Year and Date
      2016-09-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] DNAナノチューブの薬物送達システムへの応用2016

    • Author(s)
      山田知佳、秋山元英、小松晃之
    • Organizer
      第10回バイオ関連化学シンポジウム
    • Place of Presentation
      石川県立音楽堂(金沢)
    • Year and Date
      2016-09-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] グルコースオキシダーゼマイクロチューブの酵素活性2016

    • Author(s)
      安達 諒、秋山元英、小松晃之
    • Organizer
      第10回バイオ関連化学シンポジウム
    • Place of Presentation
      石川県立音楽堂(金沢)
    • Year and Date
      2016-09-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] 自走する蛋白質マイクロチューブの大腸菌捕捉能2016

    • Author(s)
      中井葉子、小早川聡志、秋山元英、小松晃之
    • Organizer
      第65回高分子学会年次大会
    • Place of Presentation
      神戸国際会議場(神戸)
    • Year and Date
      2016-05-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] グルコースオキシダーゼを階層成分として有する蛋白質マイクロチューブの合成2016

    • Author(s)
      安達 諒、秋山元英、小松晃之
    • Organizer
      日本化学会第96春季年会
    • Place of Presentation
      同志社大学(京都)
    • Year and Date
      2016-03-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] 自走する蛋白質マイクロチューブの合成とその大腸菌捕捉能2016

    • Author(s)
      中井葉子、小早川聡史、秋山元英、小松晃之
    • Organizer
      日本化学会第96春季年会
    • Place of Presentation
      同志社大学(京都)
    • Year and Date
      2016-03-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] Synthesis of Self-Propelled Protein Microtubes2015

    • Author(s)
      S. Kobayakawa, T. Komatsu
    • Organizer
      The International Chemical Congress of Pacific Basin Societies (Pacifichem 2015)
    • Place of Presentation
      Honolulu (USA)
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis of Human Serum Albumin Having a Terpyridyl Group and Its Dimer Formation by Metal Ion Coordination2015

    • Author(s)
      S. Suzuki, T. Komatsu
    • Organizer
      The International Chemical Congress of Pacific Basin Societies (Pacifichem 2015)
    • Place of Presentation
      Honolulu (USA)
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis of Porphyrin Wire Connected by Pd Coordination2015

    • Author(s)
      Y. Yagisawa, Y. Yamazawa, T. Komatsu
    • Organizer
      The International Chemical Congress of Pacific Basin Societies (Pacifichem 2015)
    • Place of Presentation
      Honolulu (USA)
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis and Anticancer Activity of Doxrobicin-Loaded DNA Nanotubes2015

    • Author(s)
      C. Yamada, M. Akiyama, T. Komatsu
    • Organizer
      The International Chemical Congress of Pacific Basin Societies (Pacifichem 2015)
    • Place of Presentation
      Honolulu (USA)
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ドキソルビシンを導入したDNAナノチューブの合成と抗がん活性2015

    • Author(s)
      山田知佳、秋山元英、小松晃之
    • Organizer
      第5回CSJ化学フェスタ2015
    • Place of Presentation
      船堀タワーホール(東京)
    • Year and Date
      2015-10-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] Pd配位で連結したポルフィリンワイヤーの合成2015

    • Author(s)
      八木澤結香、山澤幸香、秋山元英、小松晃之
    • Organizer
      錯体化学会第65回討論会
    • Place of Presentation
      奈良女子大学(奈良)
    • Year and Date
      2015-09-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] Protein Nano- and Micro-tubes as Smart Biomaterials2015

    • Author(s)
      T. Komatsu
    • Organizer
      IMS Asian International Symposium “Supramolecular Dynamics at the Interface of Chemistry and Biology
    • Place of Presentation
      分子科学研究所(岡崎)
    • Year and Date
      2015-06-11
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Preparation and Anticancer Activities of Doxorubicin-loaded DNA Nanotubes2015

    • Author(s)
      M. Akiyama, C. Yamada, T. Komatsu
    • Organizer
      第64回高分子学会年次大会
    • Place of Presentation
      札幌コンベンションセンター(札幌)
    • Year and Date
      2015-05-27
    • Related Report
      2015 Annual Research Report
  • [Remarks] 中央大学理工学部 生命分子化学研究室ホームページ(日本語版・英語版)

    • URL

      http://www.chem.chuo-u.ac.jp/~komatsu-lab/index.html

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Remarks] 論文が Chem. Eur. J. 誌の表紙を飾り、英国化学会のニュースで紹介されました

    • URL

      http://www.chuo-u.ac.jp/academics/faculties/science/departments/chemistry/news/2017/02/52740/

    • Related Report
      2017 Annual Research Report
  • [Remarks] IUPAC第17回高分子錯体国際会議においてポスター賞を受賞

    • URL

      http://www.chuo-u.ac.jp/academics/faculties/science/departments/chemistry/news/2017/08/59937/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 理工学部教授 小松晃之がDistinguished Award 2016受賞

    • URL

      http://www.chuo-u.ac.jp/academics/faculties/science/departments/chemistry/news/2016/10/48300/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 第6回CSJ化学フェスタ2016 において優秀ポスター発表賞受賞

    • URL

      http://www.chuo-u.ac.jp/academics/faculties/science/departments/chemistry/news/2016/12/50928/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 理工学部教授 小松晃之のインフルエンザに関する研究が日本経済新聞で紹介されました

    • URL

      http://www.chuo-u.ac.jp/academics/faculties/science/departments/chemistry/news/2017/02/52707/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 平成28年度 中央大学学術研究奨励賞受賞者一覧

    • URL

      http://www.chuo-u.ac.jp/research/performance/award/2016/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 中央大学理工学部 生命分子化学研究室ホームページ(日本語版)

    • URL

      http://www.chem.chuo-u.ac.jp/~komatsu-lab/index.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 中央大学理工学部 生命分子化学研究室ホームページ(英語版)

    • URL

      http://www.chem.chuo-u.ac.jp/~komatsu-lab/en/index.html

    • Related Report
      2015 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi