Development of Stereoselective Hydrofuctionalizations

• Project/Area Number: 15H03810
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Synthetic chemistry
• Research Institution: Osaka City University (2016-2018); Kyoto University (2015)
• Principal Investigator: Nishimura Takahiro 大阪市立大学, 大学院理学研究科, 教授 (50335197)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000); Fiscal Year 2017: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2016: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2015: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
• Keywords: 触媒 / 不斉合成 / イリジウム / C-H活性化 / ヒドロ官能基化 / 付加反応 / 立体選択性 / 有機化学 / 遷移金属 / 活性化 / 付加

Outline of Final Research Achievements

We have developed following atom-economical organic transformations by using iridium catalysts, which include stereoselective addition of H-X bonds (X = C, N, O) to carbon-carbon unsaturated bonds, so-called hydrofuntionalization: (1) Stereoselective addition reactions involving C-H bond activation, (2) Asymmetric intramolecular cyclization of alkenylamides, and (3) Asymmetric intramolecular cyclization of alkenylcarboxylic acids.

Academic Significance and Societal Importance of the Research Achievements

遷移金属触媒を用いた不飽和結合へのH-X結合の付加反応は，無駄となる原子のない高原子効率型反応であり，その開発は有用な有機化合物合成プロセスに必要不可欠である．本研究で開発された反応は，様々な炭素骨格やアルキルアミン，エーテル，エステル類合成の新しい手法である．さらに，不斉付加反応にも成功しており，生理活性物質や天然物など幅広い化合物の効率的な合成にも応用できる可能性を持つ．

Research Products

• [Journal Article] Iridium-Catalyzed Direct Hydroarylation of Glycals via C-H Activation: Ligand-Controlled Stereoselective Synthesis of α- and β-C-Glycosyl Arenes (2019)
  • Author(s): Sakamoto Kana、Nagai Masaki、Ebe Yusuke、Yorimitsu Hideki、Nishimura Takahiro
  • Journal Title: ACS Catalysis Volume: 9 Issue: 2 Pages: 1347-1352
  • DOI: 10.1021/acscatal.8b04686
  • NAID: 120007017946
  • Peer Reviewed
• [Journal Article] Iridium-Catalyzed Asymmetric Hydroarylation of Chromene Derivatives with Aromatic Ketones: Enantioselective Synthesis of 2-Arylchromanes (2019)
  • Author(s): Sakamoto Kana、Nishimura Takahiro
  • Journal Title: Advanced Synthesis & Catalysis Volume: 361 Issue: 9 Pages: 2124-2128
  • DOI: 10.1002/adsc.201801664
  • NAID: 120006843162
  • Peer Reviewed
• [Journal Article] Iridium-Catalyzed Hydroarylation of Conjugated Dienes via π-Allyliridium Intermediates (2018)
  • Author(s): Nagamoto Midori, Yorimitsu Hideki, Nishimura Takahiro
  • Journal Title: Organic Letters Volume: 20 Issue: 3 Pages: 828-831
  • DOI: 10.1021/acs.orglett.7b03969
  • Peer Reviewed / Open Access
• [Journal Article] Hydroxoiridium-Catalyzed sp3 C-H Alkylation of Indoline Derivatives with Terminal Alkenes (2018)
  • Author(s): Nakamura Ikumi、Yamauchi Daisuke、Nishimura Takahiro
  • Journal Title: Asian Journal of Organic Chemistry Volume: 7 Issue: 7 Pages: 1347-1350
  • DOI: 10.1002/ajoc.201800189
  • NAID: 120006712086
  • Peer Reviewed
• [Journal Article] Iridium-Catalyzed Sequential sp3 C-H Alkylation of an N-Methyl Group with Alkenes Towards the Synthesis of α-Substituted Amines (2018)
  • Author(s): Hattori Hiroshi、Nishimura Takahiro
  • Journal Title: Advanced Synthesis & Catalysis Volume: 360 Issue: 24 Pages: 4827-4831
  • DOI: 10.1002/adsc.201801131
  • NAID: 120006776858
  • Peer Reviewed
• [Journal Article] Iridium/Chiral Diene-Catalyzed Enantioselective (3+2) Annulation of Aromatic Ketimines with 1,3-Enynes via C-H Activation (2018)
  • Author(s): Nagamoto Midori, Sakamoto Kana, Nishimura Takahiro
  • Journal Title: Advanced Synthesis & Catalysis Volume: 360 Issue: 4 Pages: 791-795
  • DOI: 10.1002/adsc.201701378
  • Peer Reviewed
• [Journal Article] Iridium-Catalyzed sp3 C-H Alkylation of 3-Carbonyl-2-(alkylamino)pyridines with Alkenes (2017)
  • Author(s): Masaki Nagai, Midori Nagamoto, Takahiro Nishimura, Hideki Yorimitsu
  • Journal Title: Chemistry Letters Volume: 46 Issue: 8 Pages: 1176-1178
  • DOI: 10.1246/cl.170373
  • NAID: 130005906971
  • Peer Reviewed
• [Journal Article] Iridium-Catalyzed Asymmetric Reactions Realizing High Atom Efficiency (2017)
  • Author(s): Nagamoto Midori、Ebe Yusuke、Nishimura Takahiro
  • Journal Title: Journal of Synthetic Organic Chemistry, Japan Volume: 75 Issue: 5 Pages: 421-431
  • DOI: 10.5059/yukigoseikyokaishi.75.421
  • NAID: 130006903189
  • ISSN: 0037-9980, 1883-6526
  • Peer Reviewed
• [Journal Article] Hydroxoiridium-Catalyzed Hydroarylation of Alkynes and Bicycloalkenes with N-Sulfonylbenzamides (2017)
  • Author(s): Nagamoto Midori, Fukuda Jun-ichi, Hatano Miyuki, Yorimitsu Hideki, Nishimura Takahiro
  • Journal Title: Organic Letters Volume: 19 Issue: 21 Pages: 5952-5955
  • DOI: 10.1021/acs.orglett.7b02950
  • Peer Reviewed / Open Access
• [Journal Article] Iridium-catalyzed Cleavage of C-O Bonds Using Alcohols as Reducing Reagents (2017)
  • Author(s): Hibe Yuta、Ebe Yusuke、Nishimura Takahiro、Yorimitsu Hideki
  • Journal Title: Chemistry Letters Volume: 46 Issue: 7 Pages: 953-955
  • DOI: 10.1246/cl.170239
  • NAID: 130005709546
  • Peer Reviewed
• [Journal Article] Ir-Catalyzed Regio- and Enantioselective Hydroarylation of Alkenyl Ethers via Olefin Isomerization (2017)
  • Author(s): Yusuke Ebe, Mitsuki Onoda, Takahiro Nishimura,* Hideki Yorimitsu
  • Journal Title: Angewandte Chemie, International Edition Volume: 印刷中 Issue: 20 Pages: 5607-5611
  • DOI: 10.1002/anie.201702286
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Iridium-Catalyzed Intramolecular Oxidative Cyclization of Alkenyl Amides and Alkenoic Acids (2017)
  • Author(s): Nagamoto Midori, Nishimura Takahiro, Yorimitsu Hideki
  • Journal Title: Synthesis Volume: 49 Issue: 18 Pages: 4272-4282
  • DOI: 10.1055/s-0036-1588435
  • Peer Reviewed / Open Access
• [Journal Article] Hydroxoiridium-Catalyzed Hydroalkylation of Terminal Alkenes with Ureas by C(sp3)-H Bond Activation (2017)
  • Author(s): Yamauchi Daisuke、Nishimura Takahiro、Yorimitsu Hideki
  • Journal Title: Angewandte Chemie International Edition Volume: 56 Issue: 25 Pages: 7200-7204
  • DOI: 10.1002/anie.201702169
  • Peer Reviewed
• [Journal Article] Asymmetric Transformations under Iridium/Chiral Diene Catalysis (2017)
  • Author(s): Midori Nagamoto, Takahiro Nishimura
  • Journal Title: ACS Catalysis Volume: 7 Issue: 1 Pages: 833-847
  • DOI: 10.1021/acscatal.6b02495
  • Peer Reviewed
• [Journal Article] Regularized regression analysis of digitized molecular structures in organic reactions for quantification of steric effects (2017)
  • Author(s): Yamaguchi Shigeru, Nishimura Takahiro, Hibe Yuta, Nagai Masaki, Sato Hirofumi, Johnston Ian
  • Journal Title: Journal of Computational Chemistry Volume: 38 Issue: 21 Pages: 1825-1833
  • DOI: 10.1002/jcc.24791
  • Peer Reviewed
• [Journal Article] Asymmetric hydroarylation of vinyl ethers catalyzed by a hydroxoiridium complex: azoles as effective directing groups (2017)
  • Author(s): Yamauchi Daisuke, Nishimura Takahiro, Yorimitsu Hideki
  • Journal Title: Chemical Communications Volume: 53 Issue: 18 Pages: 2760-2763
  • DOI: 10.1039/c7cc00238f
  • Peer Reviewed
• [Journal Article] Asymmetric Cyclization of N-Sulfonyl Alkenyl Amides Catalyzed by Iridium/Chiral Diene Complexes (2016)
  • Author(s): Midori Nagamoto, Tomoyuki Yanagi, Takahiro Nishimura, Hideki Yorimitsu
  • Journal Title: Organic Letters Volume: 18 Issue: 18 Pages: 4474-4477
  • DOI: 10.1021/acs.orglett.6b01954
  • Peer Reviewed
• [Journal Article] Selective H/D Exchange at Vinyl and Methylidene Groups with D2O Catalyzed by an Iridium Complex (2016)
  • Author(s): Hatano Miyuki, Nishimura Takahiro, Yorimitsu Hideki
  • Journal Title: Organic Letters Volume: 18 Issue: 15 Pages: 3674-3677
  • DOI: 10.1021/acs.orglett.6b01721
  • Peer Reviewed
• [Journal Article] Iridium-catalyzed asymmetric [3 + 2] annulation of aromatic ketimines with alkynes via C–H activation: unexpected inversion of the enantioselectivity induced by protic acids (2016)
  • Author(s): Midori Nagamoto, Daisuke Yamauchi, Takahiro Nishimura
  • Journal Title: Chemical Communications Volume: 印刷中 Issue: 34 Pages: 5876-5879
  • DOI: 10.1039/c6cc01398h
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Rhodium-Catalyzed Enantioselective Addition of Tricyclopropylboroxin to N-Sulfonylimines (2016)
  • Author(s): Takahiro Nishimura, Tomotaka Nagai, Ryosuke Takechi, and Yusuke Ebe
  • Journal Title: Synthesis Volume: 48 Issue: 16 Pages: 2612-2618
  • DOI: 10.1055/s-0035-1561605
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Asymmetric Alkylation of N-Sulfonylbenzamides with Vinyl Ethers via C-H Bond Activation Catalyzed by Hydroxoiridium/Chiral Diene Complexes (2016)
  • Author(s): M. Hatano, Y. Ebe, T. Nishimura, and H. Yorimitsu
  • Journal Title: Journal of the American Chemical Society Volume: 138 Issue: 12 Pages: 4010-4013
  • DOI: 10.1021/jacs.6b01591
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Iridium-Catalyzed Annulation of Aromatic Imines with 1,3-Dienes via Direct Functionalization of an Aromatic C―H Bond (2015)
  • Author(s): Yusuke Ebe, Miyuki Hatano and Takahiro Nishimura
  • Journal Title: Advanced Synthesis & Catalysis Volume: 印刷中 Issue: 7 Pages: 1425-1436
  • DOI: 10.1002/adsc.201401171
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Enantioselective 1,4-addition of cyclopropylboronic acid catalyzed by rhodium/chiral diene complexes (2015)
  • Author(s): Ryosuke Takechi, Takahiro Nishimura
  • Journal Title: Chemical Communications Volume: 印刷中 Issue: 40 Pages: 8528-8531
  • DOI: 10.1039/c5cc02140e
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Iridium-Catalyzed Branch-Selective Hydroarylation of Vinyl Ethers via C-H Bond Activation (2015)
  • Author(s): Y. Ebe and T. Nishimura
  • Journal Title: Journal of the American Chemical Society Volume: 137 Issue: 18 Pages: 5899-5902
  • DOI: 10.1021/jacs.5b03099
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Formation of Carbocycles via a 1,4-Rh Shift Triggered by a Rhodium-Catalyzed Addition of Terminal Alkynes to 3,3-Diarylcyclopropenes (2015)
  • Author(s): T. Sawano, M. Hashizume, S. Nishimoto, K. Ou, and T. Nishimura
  • Journal Title: Organic Letters Volume: 17 Issue: 11 Pages: 2630-2633
  • DOI: 10.1021/acs.orglett.5b00984
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Hydroxoiridium/Chiral Diene Complexes as Effective Catalysts for Asymmetric Annulation of α-Oxo- and Iminocarboxamides with 1,3-Dienes. (2015)
  • Author(s): M. Hatano and T. Nishimura
  • Journal Title: Angewandte Chemie, International Edition Volume: 54 Issue: 37 Pages: 10949-10952
  • DOI: 10.1002/anie.201505382
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Iridium-catalyzed asymmetric cyclization of alkenoic acids leading to γ-lactones (2015)
  • Author(s): M. Nagamoto and T. Nishimura
  • Journal Title: Chemical Communications Volume: 51 Issue: 70 Pages: 13466-13469
  • DOI: 10.1039/c5cc05393e
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Iridium-Catalyzed Enantioselective Hydroarylation of Chromene Derivatives (2019)
  • Author(s): Kana Sakamoto, Takahiro Nishimura
  • Organizer: 10th OCARINA International Symposium
  • Int'l Joint Research
• [Presentation] Iridium-Catalyzed sp3 C-H bond Alkylation of Indoline Delivatives with Terminal Alkenes (2019)
  • Author(s): Ikumi Nakamura, Masaki Nagai, Takahiro Nishimura
  • Organizer: 10th OCARINA International Symposium
  • Int'l Joint Research
• [Presentation] カチオン性イリジウム触媒による分子内ヒドロアリール化反応 (2019)
  • Author(s): 坂本佳那，西村貴洋
  • Organizer: 日本化学会第99春季年会
• [Presentation] イリジウム触媒を用いたN-スルホニルアクリルアミドの電子不足共役ジエンによるC-Hアルキル化反応とそれに続く環化反応 (2019)
  • Author(s): 村上琴音，永本翠，西村貴洋
  • Organizer: 日本化学会第99春季年会
• [Presentation] イリジウム触媒を用いたN-メチルC－H結合の1,1-二置換アルケンへの付加反応 (2019)
  • Author(s): 中村威久海，永井将貴，西村貴洋
  • Organizer: 日本化学会第99春季年会
• [Presentation] ロジウム触媒を用いたアリールボロン酸の2H-クロメンへの不斉付加反応 (2019)
  • Author(s): 梅田萌子，坂本佳那，永井智隆，永本翠，江邉裕祐，西村貴洋
  • Organizer: 日本化学会第99春季年会
• [Presentation] イリジウム触媒を用いたアミノメチル基のアルケンによる sp3 C-H ジアルキル化反応 (2018)
  • Author(s): 服部大志，西村貴洋
  • Organizer: 日本化学会第98春季年会
• [Presentation] Hydroxoiridium-Catalyzed Regioselective Hydroarylation of Conjugated Dienes via π-Allyliridium Intermediates (2018)
  • Author(s): Midori Nagamoto, Hideki Yorimitsu, Takahiro Nishimura
  • Organizer: 日本化学会第98春季年会
• [Presentation] イリジウム触媒を用いたインドリン誘導体の末端アルケンによるsp3 C-Hアルキル化反応 (2018)
  • Author(s): 中村威久海，山内大輔，西村貴洋
  • Organizer: 日本化学会第98春季年会
• [Presentation] イリジウム触媒を用いるクロメン誘導体のエナンチオ選択的ヒドロアリール化反応 (2018)
  • Author(s): 坂本佳那，西村貴洋
  • Organizer: 日本化学会第98春季年会
• [Presentation] イリジウム触媒によるインドリン誘導体のsp3 C-Hアルキル化反応 (2018)
  • Author(s): 中村威久海，山内大輔，西村貴洋
  • Organizer: 第38回有機合成若手セミナー「明日の有機合成を担う人のために」
• [Presentation] イリジウム触媒を使った高原子効率型付加反応 (2018)
  • Author(s): 西村貴洋
  • Organizer: 第38回有機合成若手セミナー「明日の有機合成を担う人のために」
  • Invited
• [Presentation] イリジウム／キラルジエン触媒による芳香族ケチミンと1,3-エンインのエナンチオ選択的(3 + 2)環化反応 (2018)
  • Author(s): 坂本佳那，西村貴洋
  • Organizer: 第38回有機合成若手セミナー「明日の有機合成を担う人のために」
• [Presentation] Catalytic C-H Alkylation by Way of Amidoiridium Species (2018)
  • Author(s): Takahiro Nishimura
  • Organizer: International Congress on Pure & Applied Chemistry (ICPAC) Langkawi 2018
  • Int'l Joint Research / Invited
• [Presentation] Iridium-Catalyzed Direct sp3 C-H Alkylation of Aminoalkyl Groups with Alkenes (2018)
  • Author(s): Hiroshi Hattori, Ikumi Nakamura, Daisuke Yamauchi, Takahiro Nishimura
  • Organizer: The 14th International Kyoto Conference on New Aspects of Organic Chemistry
  • Int'l Joint Research
• [Presentation] Ir-Catalyzed Enantioselective Hydroarylation of 2H-Chromene with Aromatic Ketones (2018)
  • Author(s): Kana Sakamoto, Takahiro Nishimura
  • Organizer: The 14th International Kyoto Conference on New Aspects of Organic Chemistry
  • Int'l Joint Research
• [Presentation] 遷移金属触媒を用いた高原子効率型反応の開発 (2017)
  • Author(s): 西村貴洋
  • Organizer: 第79回講演会 有機化学研究会（白鷺セミナー）
  • Invited
• [Presentation] イリジウム触媒を用いた芳香族アミドのオルト位C-H活性化を経るアルケニル化およびアルキル化反応 (2017)
  • Author(s): 福田淳一，永本翠，幡野幸，西村貴洋，依光英樹
  • Organizer: 第37回有機合成若手セミナー「明日の有機合成を担う人のために」
• [Presentation] ヒドロキソイリジウム触媒による1,3-ジエンの位置選択的ヒドロアリール化反応 (2017)
  • Author(s): 永本翠，依光英樹，西村貴洋
  • Organizer: 第64回有機金属化学討論会
• [Presentation] ヒドロキソイリジウム触媒を用いた芳香族アミドの直接オルト位アルケニル化およびアルキル化反応 (2017)
  • Author(s): 福田淳一，永本翠，幡野幸，西村貴洋，依光英樹
  • Organizer: 第34回有機合成化学セミナー
• [Presentation] イリジウム触媒を用いたグリカールのジアステレオ選択的ヒドロアリール化反応 (2017)
  • Author(s): 永井将貴，江邉裕祐，西村貴洋，依光英樹
  • Organizer: 日本化学会第97春季年会
• [Presentation] ヒドロキソイリジウム触媒を用いた 芳香族アミドのアルキンによる オルト位アルケニル化反応 (2017)
  • Author(s): 福田淳一，永本翠，幡野幸，西村貴洋，依光英樹
  • Organizer: 日本化学会第97春季年会
• [Presentation] Iridium-Catalyzed Oxidative Cyclization of N-Sulfonyl Alkenamides and Alkenoic Acids (2017)
  • Author(s): Midori Nagamoto, Takahiro Nishimura, Hideki Yorimitsu
  • Organizer: 日本化学会第97春季年会
• [Presentation] Iridium-Catalyzed Asymmetric Reactions with High Atom Efficiency by way of C-H Bond Activation (2017)
  • Author(s): Takahiro Nishimura
  • Organizer: Kyoto Symposium on Organic and Organometallic Chemistry
  • Invited
• [Presentation] ヒドロキソイリジウム触媒を用いたビニルエーテルのアゾールを配向基とする不斉ヒドロアリール化反応 (2016)
  • Author(s): 山内大輔，西村貴洋，依光英樹
  • Organizer: 日本化学会第９６春季年会
  • Place of Presentation: 同志社大学 京田辺キャンパス，京都
  • Year and Date: 2016-03-25
• [Presentation] イリジウム/キラルジエン触媒を用いた2-アルキルアミノピリジンのC(sp3)-H活性化を経るエナンチオ選択的なアルキル化反応 (2016)
  • Author(s): 永井将貴，永本 翠，西村貴洋，依光英樹
  • Organizer: 日本化学会第９６春季年会
  • Place of Presentation: 同志社大学 京田辺キャンパス，京都
  • Year and Date: 2016-03-25
• [Presentation] イリジウム触媒による2-プロパノールを還元剤とするアリールエーテルの還元的炭素-酸素結合開裂反応 (2016)
  • Author(s): 日部雄太，江邉裕祐，西村貴洋，依光英樹
  • Organizer: 日本化学会第９６春季年会
  • Place of Presentation: 同志社大学 京田辺キャンパス，京都
  • Year and Date: 2016-03-24
• [Presentation] Iridium-catalyzed asymmetric cyclization of N-sulfonyl alkenyl amides (2016)
  • Author(s): NAGAMOTO, Midori; YANAGI, Tomoyuki; NISHIMURA, Takahiro; YORIMITSU, Hideki
  • Organizer: 日本化学会第９６春季年会
  • Place of Presentation: 同志社大学 京田辺キャンパス，京都
  • Year and Date: 2016-03-24
• [Presentation] Iridium-Catalyzed Asymmetric Hydroarylation of Allylic Ethers: Isomerization of Allylic Ethers into Vinylic Ethers and Their Regioselective Hydroarylation (2016)
  • Author(s): EBE, Yusuke; ONODA, Mitsuki; NISHIMURA, Takahiro; YORIMITSU, Hideki
  • Organizer: 日本化学会第９６春季年会
  • Place of Presentation: 同志社大学 京田辺キャンパス，京都
  • Year and Date: 2016-03-24
• [Presentation] Iridium-Catalyzed Asymmetric [3 + 2] Annulation of N-Acyl Ketimines with Alkynes via C-H activation: Unexpected Switch of the Enantioselectivity Induced by Protic Acids (2016)
  • Author(s): Nagamoto Midori, Yamauchi Daisuke, Nishimura, Takahiro, Yorimitsu Hideki
  • Organizer: Molecular Chirality Asia 2016
  • Int'l Joint Research
• [Presentation] イリジウム触媒を用いたC-H結合活性化を経る炭素-炭素結合形成反応の開発 (2016)
  • Author(s): 江邉裕祐，西村貴洋，依光英樹
  • Organizer: 第5回 JACI/GSCシンポジウム
• [Presentation] イリジウム触媒を用いたN-スルホニルアルケニルアミドの分子内環化反応 (2016)
  • Author(s): 永本翠，柳智征，西村貴洋，依光英樹
  • Organizer: 第36回有機合成若手セミナー
• [Presentation] Iridium-Catalyzed Regio- and Enantioselective Hydroarylation of Alkenyl Ethers (2016)
  • Author(s): Yusuke Ebe, Mitsuki Onoda, Takahiro Nishimura, Hideki Yorimitsu
  • Organizer: 第63回有機金属化学討論会
• [Presentation] Development of Iridium-Catalyzed Carbon-Carbon Bond Forming Reactions via C-H Bond Activation (2016)
  • Author(s): Yusuke Ebe, Takahiro Nishimura, Hideki Yorimitsu
  • Organizer: 6th Asia-Oceania Conference on Sustainable and Green Chemistry
  • Int'l Joint Research
• [Presentation] Iridium-Catalyzed Alkylation of 2-(Alkylamino)pyridines via Secondary sp3 C-H Bond Activation (2016)
  • Author(s): Masaki Nagai, Midori Nagamoto, Takahiro Nishimura, Hideki Yorimitsu
  • Organizer: The International Symposium on Homogeneous Catalysis (ISHCXX KYOTO 2016)
  • Int'l Joint Research
• [Presentation] Iridium-Catalyzed Alkylation of 2-(Alkylamino)pyridines via Secondary sp3 C-H Bond Activation (2016)
  • Author(s): 永井将貴，永本翠，西村貴洋，依光英樹
  • Organizer: 第33回有機合成化学セミナー
• [Presentation] Iridium-Catalyzed Alkylation of 2-(Alkylamino)pyridines via Secondary sp3 C-H Bond Activation (2016)
  • Author(s): 永井将貴，永本翠，西村貴洋，依光英樹
  • Organizer: 第6回CSJ化学フェスタ2016
• [Presentation] イリジウム触媒によるアゾールを配向基とするビニルエーテルの不斉ヒドロアリール化反応 (2016)
  • Author(s): 山内大輔，西村貴洋，依光英樹
  • Organizer: 第6回CSJ化学フェスタ2016
• [Presentation] Iridium-Catalyzed Asymmetric Reactions with High Atom Efficiency via C-H Bond Activation (2016)
  • Author(s): Takahiro Nishimura
  • Organizer: The 7th International Collaborative and Cooperative Chemistry Symposium
  • Int'l Joint Research / Invited
• [Presentation] Atom-Efficient Asymmetric Reactions via C-H Bond Activation (2016)
  • Author(s): Takahiro Nishimura
  • Organizer: 9th Asian-European Symposium on Metal-Mediated Efficient Organic Synthesis
  • Int'l Joint Research / Invited
• [Presentation] 高い原子効率を実現する反応の開発 (2016)
  • Author(s): 西村貴洋
  • Organizer: 第十一回有機元素化学セミナー
  • Invited
• [Presentation] Branch-Selective Hydroarylation of Vinyl Ethers Catalyzed by Iridium Complexes (2015)
  • Author(s): Takahiro Nishimura, Yusuke Ebe
  • Organizer: 13th International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-13)
  • Place of Presentation: Kyoto
  • Year and Date: 2015-11-11
  • Int'l Joint Research
• [Presentation] ヒドロキソイリジウム触媒によるサリチルアルデヒドのビシクロアルケンへの付加反応 (2015)
  • Author(s): 永本 翠，西村貴洋
  • Organizer: 第６２回有機金属化学討論会
  • Place of Presentation: 関西大学，大阪
  • Year and Date: 2015-09-09
• [Presentation] イリジウム触媒による分岐型選択的なアリールおよびアルキルビニルエーテル類のヒドロアリール化反応 (2015)
  • Author(s): 西村貴洋，江邉裕祐
  • Organizer: 第６２回有機金属化学討論会
  • Place of Presentation: 関西大学，大阪
  • Year and Date: 2015-09-09
• [Presentation] イリジウム触媒によるα-オキソカルボキシアミドと1,3-ジエンの不斉[3 + 2]環化反応 (2015)
  • Author(s): 幡野 幸，西村貴洋
  • Organizer: 第６２回有機金属化学討論会
  • Place of Presentation: 関西大学，大阪
  • Year and Date: 2015-09-08
• [Remarks] 大阪市立大学 精密有機化学研究室 研究成果
  • URL: http://www.sci.osaka-cu.ac.jp/chem/foc/publication.html
• [Remarks] 大阪市立大学大学院理学研究科物質分子系専攻精密有機化学研究室
  • URL: http://www.sci.osaka-cu.ac.jp/chem/foc/
• [Remarks] 京都大学 有機化学研究室
  • URL: http://kuchem.kyoto-u.ac.jp/orgchem/yorimitsu_lab/index.html