Development of a screening technique of protein-protein interaction inhibitors in the cytosolic environment
| Project/Area Number |
15H04190
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biofunction/Bioprocess
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KAWAHARA MASAHIRO 東京大学, 大学院工学系研究科(工学部), 准教授 (50345097)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | 蛋白質 / 創薬 / 遺伝子 / スクリーニング / シグナル伝達 |
|---|
| Outline of Final Research Achievements |
This study is directed to develop a technique to easily detect protein-protein interactions in the cytosolic environment as well as to enable inhibitor screening. To attain these, two kinds of signaling proteins are utilized to design a system that converts protein-protein interactions into growth signals as readout. Consequently, we successfully detect protein-protein interactions with cell growth and evaluate the inhibitors.
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Report
(4 results)
Research Products
(69 results)
