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Creation of ALS treatment seed by latest comprehensive neuroscience research for Kii ALS/PDC

Research Project

Project/Area Number 15H04270
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionWakayama Medical University

Principal Investigator

Ito Hidefumi  和歌山県立医科大学, 医学部, 教授 (20250061)

Co-Investigator(Kenkyū-buntansha) 紀平 為子  関西医療大学, 保健医療学部, 教授 (30225015)
中山 宜昭  和歌山県立医科大学, 医学部, その他 (50590436)
綾木 孝  京都大学, 医学研究科, 特定病院助教 (60749555)
廣西 昌也  和歌山県立医科大学, 医学部, 講師 (80316116)
Co-Investigator(Renkei-kenkyūsha) ISHIGUCHI Hiroshi  和歌山県立医科大学, 医学部, 博士研究員 (70389443)
KAWAKAMI Hideshi  広島大学, 原爆放射線医科学研究所, 教授 (70253060)
TAKAHASHI Ryosuke  京都大学, 医学部, 教授 (90216771)
INOUE Haruhisa  京都大学, 医学部, 教授 (70332327)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2015: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Keywords筋萎縮性側索硬化症 / パーキンソン認知症複合 / 紀伊半島 / タウタンパク / TDP-43 / ポリユビキチン / 神経科学 / ポリユビキチン鎖 / タンパク分解系 / 神経炎症 / 神経病理 / 遺伝子解析
Outline of Final Research Achievements

We compared pathological features of Kii ALS among past cases and present cases. For tau pathology analysis, we examined distribution of NFT and glial cytoplasmic inclusions. In both the past and the present cases, NFT were found in motor cortex, frontal and temporal lobes, hippocampus, amygdala, and furthermore brainstem. NFT were found predominantly in superficial layer of cerebral cortex. In addition, we detected granular hazy inclusions and granular or fuzzy tau immunoreactivity in processes of astrocytes as glial cytoplasmic inclusions in both cases. In TDP-43 pathology analysis, unlike with conventional ALS, neurocytoplasmic inclusions were detected more abundant in hippocampus than basal ganglia in both cases.
These features of tau pathology and TDP-43 pathology were consistent in both past and present cases. Consequently, it is supposed that the basic pathological features of Kii ALS did not change through the change of living environment.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (61 results)

All 2018 2017 2016 2015 Other

All Journal Article (15 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 15 results,  Open Access: 10 results,  Acknowledgement Compliant: 3 results) Presentation (43 results) (of which Int'l Joint Research: 15 results) Book (2 results) Remarks (1 results)

  • [Journal Article] FKBP12-immunopositive inclusions in patients with α-synucleinopathies2018

    • Author(s)
      Honjo Yasuyuki、Ayaki Takashi、Horibe Tomohisa、Ito Hidefumi、Takahashi Ryosuke、Kawakami Koji
    • Journal Title

      Brain Research

      Volume: 1680 Pages: 39-45

    • DOI

      10.1016/j.brainres.2017.12.012

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Myotonic dystrophy type 1 with diabetes mellitus, mixed hypogonadism and adrenal insufficiency2018

    • Author(s)
      Takeshima Ken、Ariyasu Hiroyuki、Ishibashi Tatsuya、Kawai Shintaro、Uraki Shinsuke、Koh Jinsoo、Ito Hidefumi、Akamizu Takashi
    • Journal Title

      Endocrinology, Diabetes and Metabolism Case Reports

      Volume: 17 Pages: 1-6

    • DOI

      10.1530/edm-17-0143

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Decreased levels of PDI and P5 in oligodendrocytes in Alzheimer's disease2017

    • Author(s)
      Honjo Yasuyuki、Ayaki Takashi、Tomiyama Takami、Horibe Tomohisa、Ito Hidefumi、Mori Hiroshi、Takahashi Ryosuke、Kawakami Koji
    • Journal Title

      Neuropathology

      Volume: 37 Issue: 6 Pages: 495-501

    • DOI

      10.1111/neup.12395

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Three-year follow-up of high-dose ubiquinol supplementation in a case of familial multiple system atrophy with compound heterozygous COQ2 mutations.2017

    • Author(s)
      Mitsui J, Koguchi K, Momose T, Takahashi M, Matsukawa T, Yasuda T, Tokushige S, Ishiura H, Goto J, Nakazaki S, Kondo T, Ito H, Yamamoto Y and Tsuji S.
    • Journal Title

      Cerebellum

      Volume: - Issue: 3 Pages: 1-9

    • DOI

      10.1007/s12311-017-0846-9

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] iPSC-based drug repositioning identifies Src/c-Abl as a therapeutic target for ALS motor neurons2017

    • Author(s)
      Imamura K, Izumi Y, 他24名, Hosokawa M, Akiyama H, Ayaki T, Ito H, Takahashi R, Yamanaka S, Inoue H
    • Journal Title

      Science Translational Medicine

      Volume: 9 Issue: 391 Pages: 391-391

    • DOI

      10.1126/scitranslmed.aaf3962

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Inhibition of Inwardly Rectifying Potassium (Kir) 4.1 Channels Facilitates Brain-Derived Neurotrophic Factor (BDNF) Expression in Astrocytes2017

    • Author(s)
      Kinboshi Masato、Mukai Takahiro、Nagao Yuki、Matsuba Yusuke、Tsuji Yoshimi、Tanaka Shiho、Tokudome Kentaro、Shimizu Saki、Ito Hidefumi、Ikeda Akio、Inanobe Atsushi、Kurachi Yoshihisa、Inoue Seiji、Ohno Yukihiro
    • Journal Title

      Frontiers in Molecular Neuroscience

      Volume: 10 Pages: 408-408

    • DOI

      10.3389/fnmol.2017.00408

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Multiple proteinopathies in familial ALS cases with optineurin mutation.2017

    • Author(s)
      Ayaki T, Ito H, Komure O, Kamada M, Nakamura M, Wate R, Kusaka H, Yamaguchi Y, Li F, Kawakami H, Urushitani M, Takahashi R
    • Journal Title

      J Neuropathol Exp Neurol

      Volume: 77 Issue: 2 Pages: 128-138

    • DOI

      10.1093/jnen/nlx109

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nicotine elicits convulsive seizures by activating amygdalar neurons.2017

    • Author(s)
      Iha HA, Kunisawa N, Shimizu S, Tokudome K, Mukai T, Kinboshi M, Ikeda A, Ito H, Serikawa T, Ohno Y
    • Journal Title

      Frontiers in Pharmacology

      Volume: 8 Pages: 57-57

    • DOI

      10.3389/fphar.2017.00057

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis.2016

    • Author(s)
      Nakazawa S, Oikawa D, Ishii R, Ayaki T, Takahashi H, Takeda H, Ishitani R, Kamei K, Takeyoshi I, Kawakami H, Iwai K, Hatada I, Sawasaki T, Ito H, Nureki O, and Tokunaga F.
    • Journal Title

      Nat. Commun.

      Volume: 7 Issue: 1 Pages: 12547-12547

    • DOI

      10.1038/ncomms12547

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Activated caspase-9 immunoreactivity in glial and neuronal cytoplasmic inclusions in multiple system atrophy.2016

    • Author(s)
      Kawamoto Y, Ayaki T, Urushitani M, Ito H, Takahashi R.
    • Journal Title

      Neurosci Lett.

      Volume: 628 Pages: 207-212

    • DOI

      10.1016/j.neulet.2016.06.036

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Quantitative reference value of dopamine transporter single-photon emission computed tomography in healthy Japanese older adults.2016

    • Author(s)
      Koh J, Yamamoto K, Sakata M, MurataKY, Ito H
    • Journal Title

      Neurology and Clinical Neuroscience

      Volume: 4 Issue: 6 Pages: 215-219

    • DOI

      10.1111/ncn3.12082

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] CUL2-mediated clearance of misfolded TDP-43 is paradoxically affected by VHL in oligodendrocytes in ALS.2016

    • Author(s)
      Uchida T, Tamaki Y, Ayaki T, Shodai A, Kaji S, Morimura T, Banno Y, Nishitsuji K, Sakashita N, Maki T, Yamashita H, Ito H, Takahashi R, Urushitani M.
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 19118-19136

    • DOI

      10.1038/srep19118

    • NAID

      120005689210

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of soybean ingestion on pharmacokinetics of levodopa and motor symptoms of Parkinson's disease - In relation to the effects of Mucuna pruriens.2016

    • Author(s)
      Nagashima Y, Kondo T, Sakata M, Koh J, Ito H.
    • Journal Title

      J Neurol Sci.

      Volume: 361 Pages: 229-234

    • DOI

      10.1016/j.jns.2016.01.005

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased GADD34 in oligodendrocytes in Alzheimer's disease.2015

    • Author(s)
      Honjo Y, Ayaki T, Tomiyama T, Horibe T, Ito H, Mori H, Takahashi R, Kawakami K.
    • Journal Title

      Neurosci Lett.

      Volume: 602 Pages: 50-55

    • DOI

      10.1016/j.neulet.2015.06.052

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Methotrexate myelopathy after intrathecal chemotherapy: a case report2015

    • Author(s)
      Murata K, Maeba A, Yamanegi M, Nakanishi I, Ito H
    • Journal Title

      Journal of Medical Case Reports

      Volume: 9 Issue: 1 Pages: 135-138

    • DOI

      10.1186/s13256-015-0597-5

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Comparative immunohistochemical study on the past and the recent Kii amyotrophic lateral sclerosis patients2017

    • Author(s)
      Tsuji K, Ito H, et al
    • Organizer
      XXIII World Congress of Neurology 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Updated epidemiological assessment of amyotrophic lateral sclerosis in Wakayama Prefecture, Japan, using data from the Japanese specified disease treatment research program2017

    • Author(s)
      Hironishi M, Ito H, et al
    • Organizer
      XXIII World Congress of Neurology 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Assessment of the motor cortex using susceptibility-weighted imaging in patients with amyotrophic lateral sclerosis2017

    • Author(s)
      Yasui M, Ito H, et al
    • Organizer
      XXIII World Congress of Neurology 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A subset of ubiquitin-positive pathologic structures in the brain of Alzheimer’s disease patients also shows linear ubiquitin chain immunoreactivity2017

    • Author(s)
      Nakayama Y, Ito H, et al
    • Organizer
      XXIII World Congress of Neurology 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A comparison of striatal dopamine transporter function In dementia with Lewy bodies and Parkinson disease with dementia.2017

    • Author(s)
      Kajimoto Y, Ito H, et al
    • Organizer
      XXIII World Congress of Neurology 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Altered functional connectivity of right temporal cortex in Parkinson’s disease with high impulsivity2017

    • Author(s)
      Koh J, Ito H, et al
    • Organizer
      XXIII World Congress of Neurology 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Validation of the Questionnaire for impulsive-compulsive disorders in Parkinson’s disease-rating scale (QUIP-RS) in Japanese.2017

    • Author(s)
      Takahashi M, Ito H, et al
    • Organizer
      XXIII World Congress of Neurology 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Efficacy of levodopa-carbidopa intestinal gel infusion in advanced Parkinson’s disease patients in our hospital2017

    • Author(s)
      Sakata M, Ito H, et al
    • Organizer
      XXIII World Congress of Neurology 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Subjective evaluation of the coaching in patients with Parkinson’s disease2017

    • Author(s)
      Nakanishi I, Ito H, et al
    • Organizer
      XXIII World Congress of Neurology 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Recall of vegetable names in Alzheimer’s disease2017

    • Author(s)
      Ishiguchi H, Ito H, et al
    • Organizer
      XXIII World Congress of Neurology 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clinical and pathological features in patients with Nakajo-Nishimura syndrome and inclusion body myositis2017

    • Author(s)
      Mori M, Ito H, et al
    • Organizer
      XXIII World Congress of Neurology 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Myositis and muscular inclusions in Nakajo-Nishimura syndrome2017

    • Author(s)
      Ayaki T, Ito H, et al
    • Organizer
      XXIII World Congress of Neurology 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of transient receptor potential channel in a cardiotoxin injury muscle model2017

    • Author(s)
      Murata K, Ito H, et al
    • Organizer
      XXIII World Congress of Neurology 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Superficial siderosis associated with duplicated dura mater2017

    • Author(s)
      Hosokawa M, Ito H, et al
    • Organizer
      XXIII World Congress of Neurology 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] MRI and MR Spectroscopy are useful to evaluate patients with hypoglycemic encephalopathy2017

    • Author(s)
      Nakatani K, Ito H, et al
    • Organizer
      XXIII World Congress of Neurology 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 和歌山県にて近年発症した紀伊ALSの一剖検例2016

    • Author(s)
      中山宜昭、辻郁在、綾木孝、廣西昌也、村田顕也、森野豊之、川上秀史、伊東秀文、
    • Organizer
      第57回日本神経病理学会総会学術研究会
    • Place of Presentation
      ホテルニューキャッスル(弘前)
    • Year and Date
      2016-06-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] 神経難病患者の退院支援における家庭訪問の重要性2016

    • Author(s)
      福島優、中島珠生、寺本ゆみ、坂本麻美、檜皮谷泰寛、伊東秀文
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸コンベンションセンター・神戸ポートピアホテル
    • Year and Date
      2016-05-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] 和歌山県における筋萎縮性側索硬化症の発症状況と発症関連遺伝子に関する研究2016

    • Author(s)
      廣西昌也、中山宜昭、紀平為子、吉田宗平、森野豊之、川上秀史、伊東秀文
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸コンベンションセンター・神戸ポートピアホテル
    • Year and Date
      2016-05-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] 抗ARS抗体陽性筋炎の臨床病理学的検討2016

    • Author(s)
      中山宜昭、樽谷潤子、細川万生、安井昌彰、綾木孝、村田顕也、鈴木重明、伊東秀文
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸コンベンションセンター・神戸ポートピアホテル
    • Year and Date
      2016-05-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] 抗HMGCR抗体陽性筋症の臨床病理学的検討2016

    • Author(s)
      萬翔子、細川万生、髙真守、檜皮谷泰寛、村田顕也、鈴木重明、伊東秀文
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸コンベンションセンター・神戸ポートピアホテル
    • Year and Date
      2016-05-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] アルテプラーゼ静注療法(IVtPA)適応拡大に伴う当院実施状況の検討2016

    • Author(s)
      阪田麻友美、石口宏、伊東秀文
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸コンベンションセンター・神戸ポートピアホテル
    • Year and Date
      2016-05-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] 簡便な髄鞘密度強調法を用いたパーキンソン病の病理変化検出:T1w/T2w ratio image2016

    • Author(s)
      髙真守、石田卓也、堂西倫弘、金桶吉起、寺田正樹、伊東秀文
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸コンベンションセンター・神戸ポートピアホテル
    • Year and Date
      2016-05-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] パーキンソン病における臨床症状とDAT SPECTの関連について2016

    • Author(s)
      梶本賀義、中谷公美子、伊東秀文
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸コンベンションセンター・神戸ポートピアホテル
    • Year and Date
      2016-05-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] Parkinson病におけるMotion sensorを用いた長時間記録による活動量・不随意運動の検討2016

    • Author(s)
      石口宏、阪田麻友美、伊東秀文
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸コンベンションセンター・神戸ポートピアホテル
    • Year and Date
      2016-05-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] パーキンソン病における3軸加速度センサーを用いた運動症状評価の有用性2016

    • Author(s)
      檜皮谷泰寛、阪田麻友美、伊東秀文
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸コンベンションセンター・神戸ポートピアホテル
    • Year and Date
      2016-05-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] ANCA関連血管炎性ニューロパチーの臨床病理学的検討2016

    • Author(s)
      村田顕也、安井昌彰、髙真守、中山宜昭、萬翔子、細川万生、梶本賀義、檜皮谷泰寛、廣西昌也、伊東秀文
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸コンベンションセンター・神戸ポートピアホテル
    • Year and Date
      2016-05-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] 脳表ヘモジデリン沈着症の臨床・画像的検討と病態の解明2016

    • Author(s)
      細川万生、中谷公美子、檜皮谷泰寛、北山真理、西岡和哉、村田顕也、中尾直之、伊東秀文
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸コンベンションセンター・神戸ポートピアホテル
    • Year and Date
      2016-05-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] DLB診断のための簡易スクリーニング検査の検討2016

    • Author(s)
      森めぐみ、廣西昌也、小倉光博、篠崎和弘、伊東秀文
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸コンベンションセンター・神戸ポートピアホテル
    • Year and Date
      2016-05-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] MRI SWI法を用いたALSの一次運動野の画像評価2016

    • Author(s)
      安井昌彰、中山宜昭、廣西昌也、伊東秀文
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸コンベンションセンター・神戸ポートピアホテル
    • Year and Date
      2016-05-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] MAPT遺伝子に新規変異を認めたFTDP-17の剖検例2015

    • Author(s)
      倉重毅志、森野豊之、城間紀之、山崎雄、髙橋哲也、有廣光司、丸山博文、伊東秀文、川上秀史、松本昌泰
    • Organizer
      第56回日本神経病理学会総会学術研究会
    • Place of Presentation
      九州大学医学部百年講堂
    • Year and Date
      2015-06-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] Optineurin遺伝子にヘテロ接合E478G変異を認めた家族性ALSの一剖検例2015

    • Author(s)
      綾木孝、伊東秀文、小牟禮修、辰己新水、漆谷真、川上秀史、髙橋良輔
    • Organizer
      第56回日本神経病理学会総会学術研究会
    • Place of Presentation
      九州大学医学部百年講堂
    • Year and Date
      2015-06-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] 脳表ヘモジデリン沈着症の臨床・画像的検討2015

    • Author(s)
      細川万生、中谷公美子、檜皮谷泰寛、北山真理、西岡和哉、村田顕也、中尾直之、伊東秀文
    • Organizer
      第56回日本神経学会学術大会
    • Place of Presentation
      朱鷺メッセ(新潟コンベンションセンター)・ホテル日航新潟
    • Year and Date
      2015-05-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] 当院認知症疾患医療センター受診患者における超高齢者の臨床的特徴2015

    • Author(s)
      廣西昌也、檜皮谷泰寛、小倉光博、篠崎和弘、伊東秀文
    • Organizer
      第56回日本神経学会学術大会
    • Place of Presentation
      朱鷺メッセ(新潟コンベンションセンター)・ホテル日航新潟
    • Year and Date
      2015-05-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] Parkinson病におけるMotion Sensorを用いた不随意運動の検討2015

    • Author(s)
      石口宏、中谷公美子、伊東秀文
    • Organizer
      第56回日本神経学会学術大会
    • Place of Presentation
      朱鷺メッセ(新潟コンベンションセンター)・ホテル日航新潟
    • Year and Date
      2015-05-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] パーキンソン病における3軸加速度センサーを用いた運動症状評価の有用性2015

    • Author(s)
      檜皮谷泰寛、阪田麻友美、伊東秀文
    • Organizer
      第56回日本神経学会学術大会
    • Place of Presentation
      朱鷺メッセ(新潟コンベンションセンター)・ホテル日航新潟
    • Year and Date
      2015-05-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] VHLとCUL2;TDP-43の凝集を促進するVHLと分解を促進するCUL22015

    • Author(s)
      内田司、小代明美、玉木良高、辰己新水、守村敏史、綾木孝、伊東秀文、坂下直実、髙橋良輔、漆谷真
    • Organizer
      第56回日本神経学会学術大会
    • Place of Presentation
      朱鷺メッセ(新潟コンベンションセンター)・ホテル日航新潟
    • Year and Date
      2015-05-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] パーキンソン治療における八升豆の可能性について(L-DOPA薬物動態の検討)2015

    • Author(s)
      阪田麻友美、近藤智善、伊東秀文
    • Organizer
      第56回日本神経学会学術大会
    • Place of Presentation
      朱鷺メッセ(新潟コンベンションセンター)・ホテル日航新潟
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 健常者20例におけるDAT-SPECTの検討2015

    • Author(s)
      高真守、山元和巳、阪田麻友美、檜皮谷泰寛、廣西昌也、村田顕也、伊東秀文
    • Organizer
      第56回日本神経学会学術大会
    • Place of Presentation
      朱鷺メッセ(新潟コンベンションセンター)・ホテル日航新潟
    • Year and Date
      2015-05-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] パーキンソン病患者におけるDATスキャンの検討2015

    • Author(s)
      梶本賀義、髙橋麻衣子、伊東秀文
    • Organizer
      第56回日本神経学会学術大会
    • Place of Presentation
      朱鷺メッセ(新潟コンベンションセンター)・ホテル日航新潟
    • Year and Date
      2015-05-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] インフリキシマブが奏功した神経サルコイドーシスの2例2015

    • Author(s)
      安井昌彰、中山宜昭、檜皮谷泰寛、細川万生、廣西昌也、伊東秀文
    • Organizer
      第56回日本神経学会学術大会
    • Place of Presentation
      朱鷺メッセ(新潟コンベンションセンター)・ホテル日航新潟
    • Year and Date
      2015-05-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] 抗Lrp4抗体陽性重症筋無力症の2例の検討2015

    • Author(s)
      森めぐみ、萬翔子、細川万生、安井昌彰、檜皮谷泰寛、廣西昌也、村田顕也、樋口理、中根俊成、松尾秀徳、伊東秀文
    • Organizer
      第56回日本神経学会学術大会
    • Place of Presentation
      朱鷺メッセ(新潟コンベンションセンター)・ホテル日航新潟
    • Year and Date
      2015-05-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] 抗ganglionic acetylcholine receptor抗体陽性AAGの臨床的多様性について2015

    • Author(s)
      中山宜昭、髙橋麻衣子、綾木孝、村田顕也、中根俊成、樋口理、松尾秀徳、伊東秀文
    • Organizer
      第56回日本神経学会学術大会
    • Place of Presentation
      朱鷺メッセ(新潟コンベンションセンター)・ホテル日航新潟
    • Year and Date
      2015-05-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] 糖代謝障害性脳症の3T MRIによる検討2015

    • Author(s)
      中谷公美子、石口宏、伊東秀文
    • Organizer
      第56回日本神経学会学術大会
    • Place of Presentation
      朱鷺メッセ(新潟コンベンションセンター)・ホテル日航新潟
    • Year and Date
      2015-05-20
    • Related Report
      2015 Annual Research Report
  • [Book] 今日の治療指針2016

    • Author(s)
      伊東秀文
    • Total Pages
      2096
    • Publisher
      医学書院
    • Related Report
      2015 Annual Research Report
  • [Book] 治療薬UP-TO-DATE20162016

    • Author(s)
      中西一郎、伊東秀文
    • Total Pages
      1204
    • Publisher
      メディカルレヴュー社
    • Related Report
      2015 Annual Research Report
  • [Remarks] 和歌山県立医科大学神経内科 研究・論文業績

    • URL

      http://www.wakayama-med.ac.jp/med/neurology/contents/kenkyu-ronbun.html

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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