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Development of biomedical materials based on limited-degradation, separation, and reconjugation of biomass

Research Project

Project/Area Number 15H04531
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Wood science
Research InstitutionKyoto University

Principal Investigator

Kamitakahara Hiroshi  京都大学, 農学研究科, 教授 (10293911)

Co-Investigator(Kenkyū-buntansha) 増田 誠司  京都大学, 生命科学研究科, 准教授 (20260614)
飛松 裕基  京都大学, 生存圏研究所, 准教授 (20734221)
高野 俊幸  京都大学, 農学研究科, 教授 (50335303)
吉永 新  京都大学, 農学研究科, 准教授 (60273489)
田中 義正  長崎大学, 医歯薬学総合研究科(医学系), 准教授 (90280700)
蟹江 治  東海大学, 工学部, 教授 (90291062)
濱田 剛  長崎大学, 先端計算研究センター, 准教授 (00443010)
Research Collaborator Hayakawa Kazuhisa  
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2018: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Keywordsバイオマス / メチルセルロース / ヒドロゲル
Outline of Final Research Achievements

For the sake of the effective utilization of biomass resources, we developed derivatization-triggered fractionation of biomass, followed by the reconjugation of fractions to afford 3 biomass-based functional materials. Cellulose part was converted into thermoresponsive supramolecular hydrogels, biocompatible biomass-based plastics, and molecules for antibody drugs as medical materials. Hemicellulose part was converted to biomass-based surfactant. Lignin part was converted into amphiphilic nanoparticles.

Academic Significance and Societal Importance of the Research Achievements

日本は石油資源に乏しいが木材を始めとするバイオマス資源には恵まれており、その有効活用法の開発は重要である。本研究ではバイオマスの材料としての新しい利用法を開発するため、未利用バイオマスを原材料として化学反応を経てその成分を分離し、様々な高付加価値へ導く方法を見出した。本研究により見出された方法により、木質資源の有効利用が促進され、日本の林業に好影響を及ぼすことが期待できる。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (33 results)

All 2019 2018 2017 2016 2015 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (25 results) (of which Int'l Joint Research: 9 results,  Invited: 8 results) Book (1 results) Remarks (3 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Methylcelluloses end-functionalized with peptides as thermoresponsive supramolecular hydrogelators2019

    • Author(s)
      Suhara Ryo、Yamagami Mao、Kamitakahara Hiroshi、Yoshinaga Arata、Tanaka Yoshimasa、Takano Toshiyuki
    • Journal Title

      Cellulose

      Volume: 26 Issue: 1 Pages: 355-382

    • DOI

      10.1007/s10570-018-2027-5

    • NAID

      120006647338

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Thermo-reversible supramolecular hydrogels of trehalose-type diblock methylcellulose analogues2018

    • Author(s)
      Yamagami Mao、Kamitakahara Hiroshi、Yoshinaga Arata、Takano Toshiyuki
    • Journal Title

      Carbohydrate Polymers

      Volume: 183 Pages: 110-122

    • DOI

      10.1016/j.carbpol.2017.12.006

    • NAID

      120006477634

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A versatile pathway to end-functionalized cellulose ethers for click chemistry applications2016

    • Author(s)
      Kamitakahara, H., Suhara, R., Yamagami, M., Kawano, H., Okanishi, R., Asahi, T., Takano, T.
    • Journal Title

      Carbohydrate Polymers

      Volume: 151 Pages: 88-95

    • NAID

      120005867105

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] メチル化セロビオース-b-ジアルギニン/金属錯体の合成とその性質2019

    • Author(s)
      (京大農)○畑本 彩,上高原 浩,(長崎大院医歯薬)田中 義正,(京大農)高野 俊幸
    • Organizer
      第69回日本木材学会大会(函館大会)
    • Related Report
      2018 Annual Research Report
  • [Presentation] ジブロック型メチルセルロースの構造-物性相関2019

    • Author(s)
      (京大農)○杉本 瑛里香,上高原 浩,高野 俊幸
    • Organizer
      第69回日本木材学会大会(函館大会)
    • Related Report
      2018 Annual Research Report
  • [Presentation] 熱応答性ゲルである分子末端機能化メチルセルロースを足場とした炭酸カルシウムマイクロカプセルの形成とその応用2019

    • Author(s)
      (京大農)○込山 活哉,上高原 浩,吉永 新,高野 俊幸
    • Organizer
      第69回日本木材学会大会(函館大会)
    • Related Report
      2018 Annual Research Report
  • [Presentation] Methylated hemicelluloses as surfactants prepared from sawdust2019

    • Author(s)
      Hiroshi Kamitakahara, Kentaro Miki, Toshiyuki Takano
    • Organizer
      257th ACS National Meeting & Exposition
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] End-functionalization of polysaccharide in cellulose chemistry2018

    • Author(s)
      Hiroshi Kamitakahara, Ryo Suhara, Mao Yamagami1, Haruko Kawano, Ryoko Okanishi, Kentaro Miki, Tomoyuki Asahi, Arata Yoshinaga, Yoshimasa Tanaka, Toshiyuki Takano
    • Organizer
      255th ACS National Meeting & Expo
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] トランス-1,4-ポリイソプレンへのセルロース誘導体の導入2018

    • Author(s)
      伊賀悠珠,上高原浩,高野俊幸,Agusta, Andria,Eiadthong, Wichan
    • Organizer
      第68回木材学会大会(京都)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 両末端に異なる置換基を有するメチル化セロビオースの合成2018

    • Author(s)
      三浦克也,上高原浩,田中義正,高野俊幸
    • Organizer
      第68回木材学会大会(京都)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 木質バイオマスのメチル化・分画・クリック反応による機能性材料の開発と評価2017

    • Author(s)
      三木 健太郎・上高原 浩・吉永新・飛松裕基・高野 俊幸
    • Organizer
      第67回日本木材学会大会
    • Place of Presentation
      九州大学
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] Synthesis, properties, and applications of cellulosic diblock copolymers (CELL 302)2017

    • Author(s)
      Hiroshi Kamitakahara
    • Organizer
      The 253rd ACS National Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Design and synthesis of regioselectively and blocky functionalized cellulose derivatives (KL06)2017

    • Author(s)
      Hiroshi Kamitakahara
    • Organizer
      5th EPNOE International Polysaccharide Conference 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 木質バイオマスを原料とした両親媒性マテリアルの合成2017

    • Author(s)
      上高原 浩, 三木 健太郎, 岡西 諒子, 高野 俊幸
    • Organizer
      平成29年度繊維学会年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Polysaccharide Chemistry in Solution2017

    • Author(s)
      Hiroshi Kamitakahara, Ryo Suhara, Mao Yamagami, Haruko Kawano, Kentaro Miki, Ryoko Okanishi, Tomoyuki Asahi, Arata Yoshinaga, Toshiyuki Takano
    • Organizer
      Workshop, Polysaccharide Solutions: Solvents, Characterization and Application
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 熱応答性超分子ヒドロゲル構造を惹起する新規メチルセルロースの合成と機能2017

    • Author(s)
      上高原 浩・須原 遼・山上 真緒・岡西 諒子・朝日 智之・吉永 新・高野 俊幸
    • Organizer
      第66回高分子討論会(愛媛)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Design and synthesis of end-functionalized methylcelluloses for thermoresponsive supramolecular hydrogels with multi-functions2017

    • Author(s)
      Hiroshi Kamitakahara, Atsushi Nakagawa, Ryo Suhara, Mao Yamagami, Haruko Kawano, Ryoko Okanishi, Kentaro Miki, Tomoyuki Asahi, Arata Yoshinaga, Toshiyuki Takano
    • Organizer
      The 4th International Cellulose Conference (ICC2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 未利用木質バイオマスを原料としたブロックコポリマーの合成とナノ粒子化2016

    • Author(s)
      三木 健太郎・上高原 浩・吉永新・高野 俊幸
    • Organizer
      第65回高分子討論会
    • Place of Presentation
      神奈川大学
    • Year and Date
      2016-10-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] 未利用木質バイオマスから両親媒性マテリアルへの新規化学変換法2016

    • Author(s)
      上高原 浩
    • Organizer
      バイオマス利用研究会第89回研究会
    • Place of Presentation
      (公財)京都高度技術研究所
    • Year and Date
      2016-09-16
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] End-functionalization of cellulose derivatives: design, synthesis, properties, and functions2016

    • Author(s)
      Hiroshi Kamitakahara, Ryo Suhara, Mao Yamagami, Haruko Kawano, Kentaro Miki, Ryoko Okanishi, Tomoyuki Asahi, Arata Yoshinaga, Toshiyuki Takano
    • Organizer
      252nd ACS national meeting
    • Place of Presentation
      Philadelphia
    • Year and Date
      2016-08-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 単糖あるいはオリゴ糖を分子末端に有するメチル化多糖の合成とその構造―物性相関2016

    • Author(s)
      岡西諒子、上高原浩、高野俊幸
    • Organizer
      セルロース学会第23回年次大会
    • Place of Presentation
      つくばカピオ
    • Year and Date
      2016-07-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] 温度応答性ジブロック型メチルセルロース類縁体のガラス基板への固定化2016

    • Author(s)
      朝日智之, 上高原浩, 高野俊幸
    • Organizer
      セルロース学会第23回年次大会
    • Place of Presentation
      つくばカピオ
    • Year and Date
      2016-07-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] 木質バイオマスの新規分子構造変換法 ―誘導体化・分離・クリック反応・ナノ粒子化―2016

    • Author(s)
      三木健太郎、上高原浩、飛松裕基、吉永新、高野俊幸
    • Organizer
      セルロース学会第23回年次大会
    • Place of Presentation
      つくばカピオ
    • Year and Date
      2016-07-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] 未利用バイオマスの新規分子構造変換法 -木質ナノ材料への展開-2016

    • Author(s)
      三木健太郎、飛松裕基、上高原浩、高野俊幸
    • Organizer
      第66回日本木材学会大会(名古屋)
    • Place of Presentation
      名古屋大学、名古屋
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] Thermoresponsive supramolecular hydrogels of end-functionalized methylcelluloses as three-dimensional scaffolds for bio-inspired mineralization2016

    • Author(s)
      Hiroshi Kamitakahara, Mao Yamagami, Ryo Suhara, Arata Yoshinaga, Toshiyuki Takano
    • Organizer
      251st ACS national meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2016-03-13
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Thermo-responsive supramolecular hydrogels of end-functionalized methyl celluloses2015

    • Author(s)
      H. Kamitakahara, M.Yamagami, R. Suhara, A. Nakagawa, A. Yoshinaga, T. Takano
    • Organizer
      ISWFPC 2015 (18th International Symposium on Wood, Fibre, and Pulping Chemistry)
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2015-09-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 木質バイオマスの限定的分解-分離-再結合反応の開発とその応用2015

    • Author(s)
      上高原 浩
    • Organizer
      日本木材学会バイオマス変換研究会 夏季講演会「バイオマス変換の研究最前線」
    • Place of Presentation
      北海道大学, 札幌
    • Year and Date
      2015-07-11
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 分子末端機能化メチルセルロースからなる熱応答性超分子ヒドロゲル:生体模倣ミネラリゼーションの3次元足場として2015

    • Author(s)
      上高原 浩, 山上 真緒, 須原 遼, 吉永 新, 高野 俊幸
    • Organizer
      セルロース学会第22回年次大会
    • Place of Presentation
      北海道大学, 札幌
    • Year and Date
      2015-07-09
    • Related Report
      2015 Annual Research Report
  • [Book] Chapter 12. Thermoresponsive Supramolecular Hydrogels Comprising Diblock Methylcellulose Derivatives; Biomass as Renewable Raw Material to Obtain Bioproducts of High-Tech Value2018

    • Author(s)
      Hiroshi Kamitakahara; Editors: Valentin I. Popa and Irina Volf
    • Total Pages
      474
    • Publisher
      Elsevier
    • ISBN
      9780444637741
    • Related Report
      2017 Annual Research Report
  • [Remarks] 京都大学大学院農学研究科森林科学専攻 生物材料化学分野

    • URL

      http://www.chembio.kais.kyoto-u.ac.jp/

    • Related Report
      2017 Annual Research Report
  • [Remarks]

    • URL

      http://www.chembio.kais.kyoto-u.ac.jp/Chembio/Index.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 京都大学大学院農学研究科森林科学専攻生物材料化学分野

    • URL

      http://www.chembio.kais.kyoto-u.ac.jp/Chembio/Index.html

    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] ジブロック型オリゴ糖及びそれを含む界面活性剤2019

    • Inventor(s)
      上高原浩、杉本瑛里香
    • Industrial Property Rights Holder
      上高原浩、杉本瑛里香
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2018 Annual Research Report

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Published: 2015-04-16   Modified: 2020-03-30  

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