Prion protein binds to aldolase A of bovine intestinal M cells

• Project/Area Number: 15H04586
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Animal production science
• Research Institution: Tohoku University
• Principal Investigator: Aso Hisashi 東北大学, 農学研究科, 教授 (50241625)
• Co-Investigator(Kenkyū-buntansha): 北澤 春樹 東北大学, 農学研究科, 准教授 (10204885) ; 奥 夏美 (岡田夏美 / 岡田 夏美) 東北大学, 農学研究科, 技術一般職員 (10621584) ; 野地 智法 東北大学, 農学研究科, 准教授 (10708001) ; 渡邊 康一 東北大学, 農学研究科, 助教 (80261494)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000); Fiscal Year 2017: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2015: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
• Keywords: プリオン / M細胞 / アルドラーゼA / ウシ腸管上皮細胞 / マウス腸管上皮細胞 / 侵入 / トランスサイトーシス / 抗体阻害 / 牛腸管上皮細胞株 / マウス腸管上皮細胞株 / 受容体 / 複合体

Outline of Final Research Achievements

BSE is a fatal neurodegenerative disorder in cattle and is linked to variant Creutzfeldt-Jakob disease in humans. We show that M cells can incorporate large numbers of PrP coated magnetic particles into intracellular vesicles, which we collected. The results of 2-DE show a specific protein associated with the PrP-coated particles. This protein was identified as aldolase A using LC-MS/MS analysis. The binding of rbPrP to aldolase A was inhibited by pre-treatment of anti-aldolase A antibody. We established the aldolase-knockout cell line (MIE ALDOA -/- cells) by TALEN method. After the differentiation for M cell, MIE ALDOA -/- cells lacked the ability of transporting PrP coated magnetic particles into the basal media through the intracellular vesicles.
These results suggest that bovine M cells synthesize aldolase A, and that aldolase A-positive M cells may play a key role in the invasion of BSE into the body.

Research Products

• [Journal Article] Immunobiotics for the bovine host: their interaction with intestinal epithelial cells and their effect on antiviral immunity. (2018)
  • Author(s): Julio Villena, Hisashi Aso, Victor P. Rutten, Hideki Takahashi, Willem Van Eden and Haruki Kitazawa
  • Journal Title: Frontiers in Immunology Volume: 9 Pages: 326-326
  • DOI: 10.3389/fimmu.2018.00326
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Identification of a novel mechanism of action of bovine IgG antibodies specific for Staphylococcus aureus (2018)
  • Author(s): Furukawa Mutsumi、Yoneyama Hiroshi、Hata Eiji、Iwano Hidetomo、Higuchi Hidetoshi、Ando Tasuke、Sato Mika、Hayashi Tomohito、Kiku Yoshio、Nagasawa Yuya、Niimi Kanae、Usami Katsuki、Ito Kumiko、Watanabe Kouichi、Nochi Tomonori、Aso Hisashi
  • Journal Title: Veterinary Research Volume: 49 Issue: 1 Pages: 22-22
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  • NAID: 120006798140
  • Peer Reviewed / Open Access
• [Journal Article] Exopolysaccharides from Lactobacillus delbrueckii OLL1073R-1 modulate innate antiviral immune response in porcine intestinal epithelial cells (2017)
  • Author(s): Paulraj Kanmani, Leonardo Albarra2018.00326in, Hisakazu Kobayashi, Hikaru Iida, Ryoya Komatsu, A.K.M. Humayun Kober, Wakako Ikeda-Ohtsubo, Yoshihito Suda, Hisashi Aso, Seiya Makino, Hiroshi Kano, Tadao Saito, JulioVillen, Haruki Kitazawa
  • Journal Title: Molecular Immunology Volume: 93 Pages: 253-265
  • DOI: 10.1016/j.molimm.2017.07.009
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Transcriptomic analysis of the innate antiviral immune response in porcine intestinal epithelial cells: influence of immunobiotic lactobacilli. (2017)
  • Author(s): Albarracin, L., H. Kobayashi, H. Iida, N. Sato, T. Nochi, H. Aso, S. Salva, S. Alvarez, H. Kitazawa, J. Villena
  • Journal Title: Front. Immunol. Volume: 8(57) Pages: 1-15
  • DOI: 10.3389/fimmu.2017.00057
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Effects of a moderate-fat diet enriched with fish oil on intestinal lipid absorption in a senescence-accelerated prone mouse model (2017)
  • Author(s): Kazushi Yamamoto; Yui Iwagaki; Koichi Watanabe; Tomonori Nochi; Hisashi Aso; Tsoyoshi Tsuduki
  • Journal Title: Nutrition Volume: 50 Pages: 26-35
  • Peer Reviewed / Open Access
• [Journal Article] Development of an in vitro immunobiotic evaluation system against rotavirus infection in bovine intestinal epitheliocytes (2017)
  • Author(s): Kobayashi, H., P. Kanmani, T. Ishizuka, A. Miyazaki, J. Soma, L. Albarracin, Y. Suda, T. Nochi, H. Aso, N. Iwabuchi, J-z. Xiao, T. Saito, J. Villena, H. Kitazawa
  • Journal Title: Beneficial Microbes Volume: 8 (2) Issue: 2 Pages: 309-321
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  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Modulation of porcine intestinal epitheliocytes immunetranscriptome response by Lactobacillus jensenii TL2937: finding new biomarkers for the selection of antiinflammatory immunobiotics. (2016)
  • Author(s): Kobayashi, H., L. Albarracin, N. Sato, P. Kanmani, AKM H. Kober, W. Ikeda-Ohtsubo, Y. Suda, T. Nochi, H. Aso, S. Makino, H. Kano, S. Ohkawara, T. Saito, J. Villena, H. Kitazawa
  • Journal Title: Beneficial Microbes, Benef Microbes Volume: 7 Issue: 5 Pages: 769-782
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• [Journal Article] Lactogenic hormones alter cellular and extracellular microRNA expression in bovine mammary epithelial cell culture (2016)
  • Author(s): Susumu Muroya, Tatsuro Hagi, Ataru Kimura, Hisashi Aso, Masatoshi Matsuzaki and Masaru Nomura
  • Journal Title: Journal of Animal Science and Biotechnology Volume: 7 Issue: 1 Pages: 8-8
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• [Journal Article] Dynamic Metabolic Regulation by a Chromosome Segment from a Wild Relative During Fruit Development in a Tomato Introgression Line, IL8-3 (2016)
  • Author(s): Hiroki Ikeda, Tomoki Shibuya, Shunsuke Imanishi, Hisashi Aso, Manabu Nishiyama and Yoshinori Kanayama
  • Journal Title: Plant and Cell Physiology Volume: 57 Issue: 6 Pages: 1257-1270
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• [Journal Article] Mycoplasma pneumonia of swine (MPS) resistance and immune characteristics of pig lines generated by crossing an MPS pulmonary lesion selected Landrace line and a highly immune capacity selected Large White line. (2016)
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  • Journal Title: Animal Science Journal Volume: 印刷中 Issue: 8 Pages: 972-981
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• [Journal Article] Immunogenic properties of Landrace pigs selected for resistance to mycoplasma pneumonia of swine. (2016)
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  • Journal Title: Animal Science Journal Volume: 印刷中 Issue: 5 Pages: 638-645
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• [Journal Article] Immunoregulatory effects triggered by immunobiotic Lactobacillus jensenii TL2937 strain involve efficient phagocytosis in porcine antigen presenting cells. (2016)
  • Author(s): Kohichiro Tsukida, Takuya Takahashi, Hikaru Iida, Paulraj Kanmani, Yoshihito Suda, Tomonori Nochi, Shuichi Ohwada, Hisashi Aso, Sou Ohkawara, Seiya Makino, Hiroshi Kano, Tadao Saito, Julio Villena, and Haruki Kitazawa
  • Journal Title: BMC Immunology Volume: 17 Issue: 1 Pages: 1-18
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  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Immunogenic properties of Landrace pigs selected for resistance to mycoplasma pneumonia of swine. (2016)
  • Author(s): Borjigin L, Shimazu T, Katayama Y, Li M, Satoh T, Watanabe K, Kitazawa H, Roh S, Aso H, Katoh K, Uchida T, Suda Y, Sakuma A, Nakajo M and Suzuki K
  • Journal Title: Animal Science Journal Volume: 印刷中 Issue: 3 Pages: 321-329
  • DOI: 10.1111/asj.12440
  • Peer Reviewed / Open Access
• [Journal Article] 2.Immunobiotic Bifidobacteria Strains Modulate Rotavirus Immune Response in Porcine Intestinal Epitheliocytes via Pattern Recognition Receptor Signaling. (2016)
  • Author(s): Ishizuka T, Kanmani P, Kobayashi H, Miyazaki A, Soma J, Suda Y, Aso H, Nochi T, Iwabuchi N, Xiao JZ, Saito T, Villena J, Kitazawa H.
  • Journal Title: PLoS One. Volume: 11 Issue: 3 Pages: 1-19
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• [Journal Article] Cyclophilin A is a new M cell marker of bovine intestinal epithelium. (2016)
  • Author(s): Tetsuya Hondo , Shunsuke Someya , Yuya Nagasawa , Shunsuke Terada, Hitoshi Watanabe, Xiangning Chen, Kouichi Watanabe, Shyuichi Ohwada, Haruki Kitazawa, Michael T. Rose, Tomonori Nochi, Hisashi Aso
  • Journal Title: Cell and Tissue Research Volume: 364 Issue: 3 Pages: 585-597
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• [Journal Article] Simultaneous analysis of serotonin, tryptophan and tryptamine levels in common fresh fruits and vegetables in Japan using fluorescence HPLC (2016)
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• [Journal Article] Serotonin improves high fat diet induced obesity in mice. (2016)
  • Author(s): Watanabe H.†, Nakano T.†, Saito R.†, Akasaka D., Saito K., Ogasawara H., Minashima T., Miyazawa K., Kanaya T., Takakura I., Inoue N., Ikeda I., Chen X., Miyake M., Kitazawa H., Shirakawa H., Sato K., Tahara K., Nagasawa Y., Rose M.T., Ohwada S., Watanabe K., Aso H.
  • Journal Title: PLoS One Volume: 11 Issue: 1 Pages: 1-14
  • DOI: 10.1371/journal.pone.0147143
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• [Journal Article] The stimulatory effect of plasma samples from fattening cattle on adipogenesis related gene expression in preadipocyte cells (2015)
  • Author(s): Hitoshi WATANABE, Xiangning CHEN, Noriaki SHOJI, Ryo SAITO, Tatsuya NAKANO, Kazuki SAITO, Keisuke SUMIYOSHI, Michael T. ROSE, Natumi OKADA, Kouichi WATANABE and Hisashi ASO
  • Journal Title: Animal Science Journal Volume: 86 Issue: 7 Pages: 698-706
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• [Journal Article] Extracellular cyclophilin A possesses chemotaxic activity in cattle (2015)
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  • Journal Title: Vet Res Volume: 46 Issue: 1 Pages: 80-89
  • DOI: 10.1186/s13567-015-0212-1
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Prion protein binds to aldolase A of bovine intestinal M cells. (2015)
  • Author(s): Nagasawa Y, Takahashi Y, Itani W, Watanabe H, Hidaka Y, Mr. Morita S, Watanabe K, Ohwada S, Kitazawa H, Imamura M, Yokoyama T, Horiuchi M, Sakaguchi S, Mohri S, Michael Rose , Nochi T, Aso H.
  • Journal Title: Open journal of Veterinary medicine Volume: 5 Issue: 03 Pages: 43-60
  • DOI: 10.4236/ojvm.2015.53007
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The toll-like receptor family protein RP105/MD-1 complex is involved in the immunoregulatory effect of exopolysaccharides from Lactobacillus plantarum N14. (2015)
  • Author(s): Murofushi, Y., J. Villena, P. Kanmani, H. Kitazawa et al.
  • Journal Title: Mol. Immunol. Volume: 64 Issue: 1 Pages: 63-75
  • DOI: 10.1016/j.molimm.2014.10.027
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• [Journal Article] Advanced Application of Porcine Intramuscular Adipocytes for Evaluating Anti-Adipogenic and Anti-Inflammatory Activities of Immunobiotics. (2015)
  • Author(s): Masahiko Suzuki, Asuka Tada, Paulraj Kanmani, Hitoshi Watanabe, Hisashi Aso, Yoshihito Suda, Tomonori Nochi, Kenji Miyazawa, Kazutoyo Yoda, Fang He, Masataka Hosoda, Tadao Saito, Julio Villena, Haruki Kitazawa
  • Journal Title: PLoS ONE Volume: 10 (3) Issue: 3 Pages: 1-20
  • DOI: 10.1371/journal.pone.0119644
  • Peer Reviewed / Open Access
• [Journal Article] Transportation of sublingual antigens across sublingual ductal epithelial cells to the ductal antigen-presenting cells in mice. (2015)
  • Author(s): Nagai Y, Shiraishi D, Tanaka Y, Nagasawa Y, Ohwada S, Shimauchi H, Aso H, Endo Y, Sugawara S.
  • Journal Title: Clinical and Experimental Allergy Volume: 45 Issue: 3 Pages: 677-686
  • DOI: 10.1111/cea.12329
  • Peer Reviewed / Open Access
• [Presentation] 末梢セロトニンの褐色脂肪細胞活性化による抗肥満作用 (2018)
  • Author(s): 田口輝明・甲藤士郎・田中孝太朗・庄 涛・吉村 梢・渡邊康一・野地智法・麻生 久
  • Organizer: 日本畜産学会第124回大会
• [Presentation] 初産牛における乳汁中の体細胞数と炎症誘起因子シクロフィリンA濃度との相関解析 (2018)
  • Author(s): 海野 剛・浦川めぐみ・庄 涛・田中孝太朗・吉村 梢・佐藤佑子・伊藤 愛・小林宏子・渡邊康一・野地智法・麻生 久
  • Organizer: 日本畜産学会第124回大会
• [Presentation] ブタにおける二次リンパ組織の形態形成機序の解明 (2018)
  • Author(s): 古川睦実・伊藤 駿・鈴木俊一・淵本大一郎・渡邊康一・麻生 久・野地智法
  • Organizer: 日本畜産学会第124回大会
• [Presentation] Development of immune and microbial environments is independently regulated in the mammary gland (2017)
  • Author(s): Niimi K., Usami K., Aso H., Nochi T.
  • Organizer: 日本免疫学会第46回学術集会
• [Presentation] Important role of the immunological network between large intestine and mammary gland in breastfeeding (2017)
  • Author(s): Usami K., Niimi K., Kamioka M., Kiyono H., Aso H., Nochi T.
  • Organizer: 日本免疫学会第46回学術集会
• [Presentation] プロバイオティクス枯草菌によるウシ乳房炎の発症軽減効果 (2017)
  • Author(s): 浦川めぐみ・佐藤秀俊・庄 涛・田口輝明・海野 剛・田中孝太朗・甲藤士郎・吉村 梢・小林宏子・伊藤 愛・高田直和・芦田延久・大友直樹・渡邊康一・野地智法・麻生 久
  • Organizer: 日本乳房炎研究会第22回学術集会
• [Presentation] 二次リンパ組織の形態形成に関するブタ胎仔を用いた組織学的研究 (2017)
  • Author(s): 古川睦実、伊藤 駿、盛田彰太郎、鈴木俊一、淵本大一郎、中井美智子、大西 彰、新實香奈枝、宇佐美克紀、佐々木志保、渡邊康一、麻生 久、野地智法
  • Organizer: 日本獣医学会第160回学術集会
• [Presentation] X-SCIDモデルブタ（IL2Rg欠損ブタ）の各種臓器内に認められるＴ細胞およびＢ細胞分布に関する組織学的研究 (2017)
  • Author(s): 伊藤 駿、古川睦実、盛田彰太郎、鈴木俊一、淵本大一郎、中井美智子、大西 彰、新實香奈枝、宇佐美克紀、佐々木志保、渡邊康一、麻生 久、野地智法
  • Organizer: 日本獣医学会第160回学術集会
• [Presentation] Effects of common microbial ligands for TLRs on adipogenesis and inflammation in porcine adipocytes (2017)
  • Author(s): 井形愛美・K.AKM Humayun・Tada A.・A. Leonardo・Ikeda-Ohtsubo W.・Aso H.・Yoda K.・Miyazawa K.・He Fang・Saito T.・Villena J.・Kitazawa H.
  • Organizer: 日本畜産学会第123回大会
• [Presentation] Dispensable role of indigenous bacteria in developing the mammary gland functions (2017)
  • Author(s): Niimi K.・Usami K.・Furukawa M.・Sasaki S.・Ito S.・Banba Y.・Watanabe K.・Aso H.・Nochi T.
  • Organizer: 日本畜産学会第123回大会
• [Presentation] 末梢セロトニンの骨格筋線維型移行および代謝亢進作用の解明 (2017)
  • Author(s): 甲藤士郎・田口輝明・田中孝太朗・庄 涛・吉村 梢・渡邊康一・野地智法・麻生 久
  • Organizer: 日本畜産学会第123回大会
• [Presentation] Development of advanced evaluation system of anti-disease immunobiotics (2017)
  • Author(s): Komatsu R.・Iida H.・K.AKM Humayun・Albarracin Leonardo 3・Suda Y.・Ikeda-Ohtsubo W.・Aso H.・Iwabuchi N.・Xiao Jin-zhong・Saito T.・Villena J.・Kitazawa H.
  • Organizer: 日本畜産学会第123回大会
• [Presentation] 授乳期特有の乳腺免疫の発達に関わるＴ細胞の役割とは (2017)
  • Author(s): 宇佐美克紀・新實香奈枝・古川睦実・佐々木志保・伊藤 駿・馬場柚里・渡邊康一・麻生 久・野地智法
  • Organizer: 東北畜産学会第67回大会
• [Presentation] 授乳期の乳腺の機能形成おける役割 (2017)
  • Author(s): 佐々木志保・新實香奈枝・宇佐美克紀・古川睦実・伊藤 駿・馬場柚里・渡邊康一・麻生 久・野地智法
  • Organizer: 東北畜産学会第67回大会
• [Presentation] マウス腸管上皮M 細胞におけるアルドラーゼA受容体の探索 (2017)
  • Author(s): 鈴木 京・長澤裕哉・田中孝太朗・庄 涛・田口輝明・北澤春樹・渡邊康一・野地智法・麻生 久
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  • Organizer: 日本畜産学会第122回大会
  • Place of Presentation: 神戸市、神戸大学
• [Presentation] ウシ血中樹状細胞の精製法確立と枯草菌給与による活性化機構の解明 (2017)
  • Author(s): 庄 涛・浦川めぐみ・鈴木 京・田口輝明・佐藤秀俊・高田直和・及川俊徳・小林宏子・伊藤 愛・芦田延久・今林寛和・渡邊康一・野地智法・麻生 久
  • Organizer: 日本畜産学会第122回大会
  • Place of Presentation: 神戸市、神戸大学
• [Presentation] 枯草菌の給与が乳牛の血中栄養因子および免疫因子に与える影響 (2017)
  • Author(s): 浦川めぐみ・佐藤秀俊・庄 涛・鈴木 京・田口輝明・小林宏子・伊藤 愛・高田 直和・及川俊徳・芦田延久・今林寛和・渡邊康一・野地智法・麻生 久
  • Organizer: 日本畜産学会第122回大会
  • Place of Presentation: 神戸市、神戸大学
• [Presentation] 黄色ブドウ球菌特異的IgG 抗体はSortase A非依存的に細胞増殖を阻害する (2017)
  • Author(s): 古川睦実・米山 裕・秦 英司・安藤太助・林 智人・菊 佳男・長澤裕哉・渡邊康一・麻生 久・野地智法
  • Organizer: 第90回日本細菌学会総会
  • Place of Presentation: 仙台市、仙台国際センター
• [Presentation] 免疫不全ブタを用いたパイエル板の機能及び形態形成に関する免疫学的研究 (2016)
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  • Organizer: 第121回日本畜産学会大会
  • Place of Presentation: 東京、日本獣医生命大学
  • Year and Date: 2016-03-28
• [Presentation] Long term differentiation model of PIP cells for evaluating anti-adipogenic activities of immunobiotics (2016)
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  • Organizer: 第121回日本畜産学会大会
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• [Presentation] Immunoregulatory activity of immunogenics on PIE cells against PolyI:C stimulation (2016)
  • Author(s): Paulraj Kanmani、小林永和、Humayun Kober、麻生久、大坪和香子、江草信太郎、齋藤忠夫、北澤春樹
  • Organizer: 第121回日本畜産学会大会
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  • Author(s): 飯田ひかる・遠野雅徳・須田義人・麻生 久・大坪和香子・齋藤忠夫・北澤春樹
  • Organizer: 第120回日本畜産学会大会
  • Place of Presentation: 東京、日本獣医生命大学
  • Year and Date: 2016-03-28
• [Presentation] 黄色ブドウ球菌（SA）の死菌接種によって産生されるポリクローナル抗体はSAに対する増殖阻害効果を有する (2016)
  • Author(s): 古川睦実・米山 裕・秦 英司・岩野英知・樋口豪紀・安藤太助・佐藤美佳・林 智人・菊 佳男・長澤裕哉・新實香奈枝・宇佐美克紀・佐々木志保・伊藤 駿・渡邊康一・麻生 久・野地智法
  • Organizer: 第6回家畜感染症学会
  • Place of Presentation: 福岡市、九州大学西新プラザ
• [Presentation] フローサイトメトリーを用いた授乳期の乳腺に認められるIgA産生形質細胞の性状解析 (2016)
  • Author(s): 宇佐美克紀・新實香奈枝・古川睦実・藤田勇気・阿部未来・渡邊康一・麻生 久・野地智法
  • Organizer: 第159回日本獣医学会
  • Place of Presentation: 藤沢市、日本大学生物資源科学部
• [Presentation] 褐色脂肪細胞の活性化による経口セロトニンの抗肥満作用 (2016)
  • Author(s): 田口輝明・日高湧介・海野 剛・對木陽淳・陳 香凝・北澤春樹・渡邊康一・野地智法・麻生 久
  • Organizer: 第66回東北畜産学会大会
  • Place of Presentation: 盛岡市、いわて県民情報交流センター
• [Presentation] 枯草菌給与によるウシ分娩前後における血中樹状細胞の機能解析 (2016)
  • Author(s): 庄 涛・浦川めぐみ・佐藤秀俊・高田直和・及川俊徳・小林宏子・伊藤 愛・芦田延久・今林寛和・渡邊康一・野地智法・麻生 久
  • Organizer: 第66回東北畜産学会大会
  • Place of Presentation: 盛岡市、いわて県民情報交流センター
• [Presentation] 黄色ブドウ球菌のin vitroでの増殖阻害を可能にするウシポリクローナル抗体の作製 (2016)
  • Author(s): 枯草菌給与によるウシ分娩前後における血中樹状細胞の機能解析
  • Organizer: 第66回東北畜産学会大会
  • Place of Presentation: 盛岡市、いわて県民情報交流センター
• [Presentation] 腸管Ｍ細胞が産生するアルドラーゼＡのプリオン蛋白取込み機構への関与 (2015)
  • Author(s): 鈴木 京・長澤裕哉・陳 香凝・庄 涛・田口輝明・渡邊康一・大和田修一・北澤春樹・麻生 久
  • Organizer: 第158回日本獣医学会学術集会
  • Place of Presentation: 北海道、酪農学園大学
  • Year and Date: 2015-09-11
• [Presentation] Ｘ連鎖重症複合免疫不全症（X-SCID）疾患モデルブタを用いた骨髄移植治療による腸管でのリンパ組織新生に関する研究 (2015)
  • Author(s): 盛田彰太郎・鈴木俊一・大西 彰・渡邊康一・麻生 久・野地智法
  • Organizer: 第158回日本獣医学会学術集会
  • Place of Presentation: 北海道、酪農学園大学
  • Year and Date: 2015-09-11
• [Presentation] Ｘ連鎖重症複合免疫不全症（X-SCID）疾患モデルブタを用いた骨髄移植治療後の腸管関連リンパ組織新生に関する形態学的研究 (2015)
  • Author(s): 盛田彰太郎・鈴木俊一・渡邊康一・麻生 久・大西 彰・野地智法
  • Organizer: 第65回東北畜産学会大会
  • Place of Presentation: 仙台、東北大学
  • Year and Date: 2015-08-27
• [Presentation] 腸管Ｍ細胞が産生するアルドラーゼＡのプリオン蛋白取込みへの関与 (2015)
  • Author(s): 鈴木 京・長澤裕哉・陳 香凝・庄 涛・田口輝明・渡邊康一・大和田修一・北澤春樹・麻生 久
  • Organizer: 第65回東北畜産学会大会
  • Place of Presentation: 仙台、東北大学
  • Year and Date: 2015-08-27
• [Book] Energy homeostasis by peripheral serotonin (2017)
  • Author(s): Hitoshi Watanabe, Michael Rose, Yoshinori Kanayama, Hitoshi Shirakawa and Hisashi Aso
  • Total Pages: 305
  • Publisher: InTech Team
  • ISBN: 9789535152903
• [Book] 新編家畜生理学 (2015)
  • Author(s): 麻生 久、野地 智法
  • Total Pages: 319
  • Publisher: 養賢堂
• [Remarks] 東北大学大学院農学研究科機能形態学分野
  • URL: http://www.agri.tohoku.ac.jp/keitai/index-j.html
• [Remarks] 東北大学大学院農学研究科食と農免疫国際教育研究センター
  • URL: http://www.agri.tohoku.ac.jp/cfai/index.html
• [Remarks] 東北大学大学院農学研究科機能形態学分野ホームページ
  • URL: http://www.agri.tohoku.ac.jp/keitai/index-j.html
• [Remarks] 食と農免疫国際教育研究センター
  • URL: http://www.agri.tohoku.ac.jp/cfai/index.html