• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of the combined immune-modulatory therapies for canine cancer

Research Project

Project/Area Number 15H04598
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Veterinary medical science
Research InstitutionYamaguchi University

Principal Investigator

MIZUNO TAKUYA  山口大学, 共同獣医学部, 教授 (90398826)

Co-Investigator(Kenkyū-buntansha) 富張 瑞樹  帯広畜産大学, 畜産学部, 准教授 (00552754)
中川 貴之  東京大学, 大学院農学生命科学研究科(農学部), 准教授 (40447363)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2017: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Keywordsdog / cancer / immune checkpoint / oncolytic virotherapy / DNA vaccine / 犬 / 腫瘍 / 免疫 / ガン / 治療 / レオウイルス
Outline of Final Research Achievements

In this study, several clinical trials, such as oncolytic virotherapy using reovirus, DNA vaccine therapy, and PD-1 chimeric antibody therapy for canine cancer had been accomplished. Nineteen dogs with various tumors were enrolled for oncolytic virotherapy, which were evaluated. Several dogs showed clinical improvement. As as DNA vaccination therapy, novel adjuvant therapy had not established using mice model, but clinical trials had been done, and showed two dogs with malignant melanoma survived for more than 2 years. Regarding immunecheckpoint antibody therapy, PD-1 chimeric antibody therapy had been established based on monoclonal antibody against canine PD-1, which was developed in our laboratory and now has been evaluated for cancer-bearing dogs.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (10 results)

All 2018 2017 2016

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 2 results) Presentation (5 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results)

  • [Journal Article] Development and characterization of monoclonal antibodies against canine PD-1 and PD-L1.2018

    • Author(s)
      Nemoto Y, Shosu K, Okuda M, Noguchi S, Mizuno T.
    • Journal Title

      Vet Immunol Immunopathol

      Volume: 198 Pages: 19-25

    • DOI

      10.1016/j.vetimm.2018.02.007

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oncolytic reovirus therapy: Pilot study in dogs with spontaneously occurring tumours.2018

    • Author(s)
      Hwang CC, Igase M, Sakurai M, Haraguchi T, Tani K, Itamoto K, Shimokawa T, Nakaichi M, Nemoto Y, Noguchi S, Coffey M, Okuda M, Mizuno T.
    • Journal Title

      Vet Comp Oncol.

      Volume: - Issue: 2 Pages: 229-238

    • DOI

      10.1111/vco.12361

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bosutinib, an SRC inhibitor, induces caspase-independent cell death associated with permeabilization of lysosomal membranes in melanoma cells.2017

    • Author(s)
      Noguchi S, Shibutani S, Fukushima K, Mori T, Igase M, Mizuno T.
    • Journal Title

      Vet Comp Oncol

      Volume: 印刷中 Issue: 1 Pages: 69-76

    • DOI

      10.1111/vco.12312

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Programmed Cell Death Ligand 1 Expression in Canine Cancer.2016

    • Author(s)
      Shosu K, Sakurai M, Inoue K, Nakagawa T, Sakai H, Morimoto M, Okuda M, Noguchi S, Mizuno T.
    • Journal Title

      In Vivo

      Volume: 30 Pages: 195-204

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oncolytic reovirus synergizes with chemotherapeutic agents to promote cell death in canine mammary gland tumor2016

    • Author(s)
      Igase M, Hwang CC, Kambayashi S, Kubo M, Coffey M, Miyama TS, Baba K, Okuda M, Noguchi S, Mizuno T
    • Journal Title

      Can J Vet Res.

      Volume: 80 Pages: 21-31

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Presentation] Development of therapeutic antibody for canine cancers.2018

    • Author(s)
      Mizuno T.
    • Organizer
      The 9th Joint Symposium of Veterinary Research in East Asia
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Pilot study of oncolytic reovirus therapy in dogs with spontaneouasly occurring tumors.2017

    • Author(s)
      Igase M, Hwang CC, Sakurai M, Shimokawa T, Haraguchi T, Tani K, Itamoto K, Nakaichi M, Nemoto Y, Shimokawa T, Okuda M, Noguchi S, Mizuno T.
    • Organizer
      Asian Meeting of Animal Medicine Specialties 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ATM kinaseの阻害は、犬の悪性黒色腫細胞株においてレオウイルスの細胞死を促進する2017

    • Author(s)
      伊賀瀬雅也、野口俊助、水野拓也
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Inhibition of the ATM enhaned the reovirus-induced cell death in canine melanoma cells.2017

    • Author(s)
      Igase M, Mizuno T.
    • Organizer
      The 5th Sapporo Summer Seminar for One Health
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ATM kinase阻害による犬メラノーマ細胞株に対する腫瘍溶解性ウイルスの細胞傷害増強効果の検討2017

    • Author(s)
      伊賀瀬雅也、野口俊助、根本有希、水野拓也
    • Organizer
      第160回日本獣医学会学術集会
    • Related Report
      2017 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi