Organic synthesis using reactive salt intermediate
| Project/Area Number |
15H04632
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
有澤 光弘 大阪大学, 薬学研究科, 准教授 (40312962)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Keywords | 塩化学種 / 求核置換反応 / フッ素化合物 / ピリジニウム塩 / in situ protection法 / one-pot reaction / ホスホニウム塩 / ピリジニウム型塩化学種 / フッ素ライブラリー / 2－CF3ピリジン / ホスホニウム塩化学種 / エノン / α,β‐不飽和イミド / フッ素化合物ライブラリー / オキササイクリック化合物 / トリフロロメチレーション / α,β‐不飽和エステル / 合成化学 / 有機化学 / 分子プローブ |
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| Outline of Final Research Achievements |
As an organic synthesis using pyridinium salt intermediates efficient synthesis of ether compounds from acetals, N-CF3SCH2-indol derivatives, trifluoromethylthiomethyl ethers and fluoromethylethers from MOM-ethers has been developed.
As an organic synthesis using phosphonium salt intermediates new in situ protection methodology, selective transformations of ketones, beta,beta-disubstituted enones, and alpha,beta-unsaturated ketones in the presence of beta-monosubstituted enone, has been developed. One-pot six steps procedure for cyclic ether compounds from the compounds having eone and alpha,beta-unsaturated ketone in the same molecule has also been developed.
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Report
(4 results)
Research Products
(114 results)
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[Journal Article] Self-assembled Multi-layer Stabilized Nickel Nanoparticle Catalyst for Ligand-free Cross-coupling Reactions: in situ Metal Nanoparticle and Nanospace Simultaneous Organization2016
Author(s)
Naoyuki Hoshiya, Katsumasa Fujiki, Takahisa Taniguchi, Tetsuo Honma, Yusuke Tamenori, Mincen Xiao, Nozomi Saito, Mami Yokoyama, Akira Ishii, Hiromichi Fujioka, Satoshi Shuto, Yoshihiro Sato, Mitsuhiro Arisawa
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Journal Title
Adv. Synth. Catal.
Volume: 358
Issue: 15
Pages: 2449-2459
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] Synthetic Study of Laurenidificin2016
Author(s)
Yoshikawa,Y.; Yamakawa, M.; Kobayashi, T.;Arisawa, M.; Fujioka, H.
Organizer
Molecular Chirality Asia 2016
Place of Presentation
Osaka,Japan
Year and Date
2016-04-20
Related Report
Int'l Joint Research
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