| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2017: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
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| Outline of Final Research Achievements |
Among the idiosyncratic toxicity, liver injury and skin hypersensitivity are considered to be complicated by multiple factors, and the elucidation of the mechanism has been delayed. In this study, we focused on drug hypersensitivity related to HLA polymorphism, which is considered to be difficult to reproduce in animals, and created the mouse model that can reproduce it for the first time. It has been confirmed that administration of certain drugs to this mouse causes organ damage via immune activation as seen in humans.
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