The roles of receptors for lipid mediators in inflammation, immunity and barrier function

• Project/Area Number: 15H04708
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: Juntendo University
• Principal Investigator: Yokomizo Takehiko 順天堂大学, 医学(系)研究科(研究院), 教授 (60302840)
• Co-Investigator(Renkei-kenkyūsha): Okuno Toshiaki 順天堂大学, 大学院医学研究科, 准教授 (60361466) ; Saeki Kazuko 順天堂大学, 大学院医学研究科, 准教授 (00553273) ; Koga Tomoaki 順天堂大学, 大学院医学研究科, 助教 (30615092)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000); Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2015: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
• Keywords: 生理活性脂質 / 生体分子 / シグナル伝達 / バリア機能 / アラキドン酸 / 非ステロイド性消炎鎮痛剤 / 生理活性

Outline of Final Research Achievements

Following experiments were performed to clarify the roles of leukotriene B4 receptors BLT1 and BLT2 on inflammation, immunity and barrier function. I succeeded in establishing BLT1 flox/flox mice to generate cell-specific BLT1-deficient mice. We established a monoclonal antibody for mouse BLT1 and identified distinct subsets of macrophages and dendritic cells defined by BLT1 expression. These subsets are different in production of cytokines and lipid mediators. BLT2 was found to protect acute lung injury by a toxin pneumolysin by inhibiting the expression and signaling of cysteinyl leukotrienes. I also clarified the detailed molecular mechanism of BLT2-dependent barrier function in epithelial cells.

Research Products

• [Int'l Joint Research] ハーバード大学/コロラド大学デンバー校/Scripps研究所(米国)
• [Int'l Joint Research] Shanghai Jiao Tong University(中国)
• [Int'l Joint Research] ハーバード大学/Boston小児病院/the University of Texas(米国)
• [Int'l Joint Research] ハーバード大学医学部眼科学/Weil Cornell大学(米国)
• [Journal Article] Na+-mimicking ligands stabilize the inactive state of leukotriene B4 receptor BLT1 (2018)
  • Author(s): Hori Tetsuya、Okuno Toshiaki、Hirata Kunio、Yamashita Keitaro、Kawano Yoshiaki、Yamamoto Masaki、Hato Masakatsu、Nakamura Motonao、Shimizu Takao、Yokomizo Takehiko、Miyano Masashi、Yokoyama Shigeyuki
  • Journal Title: Nature Chemical Biology Volume: 14 Issue: 3 Pages: 262-269
  • DOI: 10.1038/nchembio.2547
  • Peer Reviewed / Open Access
• [Journal Article] The Relationship between TP53 Gene Status and Carboxylesterase 2 Expression in Human Colorectal Cancer (2018)
  • Author(s): Ishimine M, Lee HC, Nakaoka H, Orita H, Kobayashi T, Mizuguchi K, Endo M, Inoue I, Sato K, Yokomizo T
  • Journal Title: Disease Markers Volume: － Pages: 1-7
  • DOI: 10.1155/2018/5280736
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Leukotriene B4 receptor 2 regulates the proliferation migration and barrier integrity of bronchial epithelial cells (2018)
  • Author(s): M Liu J Shen H Yuan F Chen H Song H Qin Y Li J Xu Q Ye S Li K Saeki T Yokomizo
  • Journal Title: J Cell Physiol Volume: 印刷中 Issue: 8 Pages: 6117-6124
  • DOI: 10.1002/jcp.26455
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Altered eicosanoid production and phospholipid remodeling during cell culture (2018)
  • Author(s): Okuno Toshiaki、Gij?n Miguel A.、Zarini Simona、Martin Sarah A.、Barkley Robert M.、Johnson Christopher A.、Ohba Mai、Yokomizo Takehiko、Murphy Robert C.
  • Journal Title: Journal of Lipid Research Volume: 59 Issue: 3 Pages: 542-549
  • DOI: 10.1194/jlr.m083030
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Leukotriene receptors as potential therapeutic target (2018)
  • Author(s): Yokomizo, T., Nakamura, M.,Shimizu, T.
  • Journal Title: J Clin Invest Volume: In press
  • Peer Reviewed
• [Journal Article] Profiling of bioactive lipids in different dendritic cell subsets using an improved multiplex quantitative LC-MS/MS method (2018)
  • Author(s): Ohba, M., Saeki, K., Koga, T., Okuno, T., Konbayashi, Y.,Yokomizo, T.
  • Journal Title: Biochem Biophys Res Commun Volume: In press
• [Journal Article] Non-steroidal anti-inflammatory drug delays corneal wound healing by reducing production of 12-hydroxyheptadecatrienoic acid, a ligand for leukotriene B4 receptor 2 (2017)
  • Author(s): Iwamoto Satoshi、Koga Tomoaki、Ohba Mai、Okuno Toshiaki、Koike Masato、Murakami Akira、Matsuda Akira、Yokomizo Takehiko
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 13267-13267
  • DOI: 10.1038/s41598-017-13122-8
  • Peer Reviewed / Open Access
• [Journal Article] Identification, signaling, and functions of LTB4 receptors. (2017)
  • Author(s): Saeki K, Yokomizo T
  • Journal Title: Semin Immunol Volume: 33 Pages: 30-36
  • DOI: 10.1016/j.smim.2017.07.010
  • Peer Reviewed / Open Access
• [Journal Article] Biochemical and immunological characterization of a novel monoclonal antibody against mouse leukotriene B4 receptor 1. (2017)
  • Author(s): Sasaki F, Koga T, Saeki K, Okuno T, Kazuno S, Fujimura T, Ohkawa Y, Yokomizo T
  • Journal Title: PLoS One Volume: 12 Issue: 9 Pages: 0185133-0185133
  • DOI: 10.1371/journal.pone.0185133
  • Peer Reviewed / Open Access
• [Journal Article] Dioxin-induced increase in leukotriene B4 biosynthesis through the aryl hydrocarbon receptor and its relevance to hepatotoxicity owing to neutrophil infiltration (2017)
  • Author(s): Takeda Tomoki、Komiya Yukiko、Koga Takayuki、Ishida Takumi、Ishii Yuji、Kikuta Yasushi、Nakaya Michio、Kurose Hitoshi、Yokomizo Takehiko、Shimizu Takao、Uchi Hiroshi、Furue Masutaka、Yamada Hideyuki
  • Journal Title: Journal of Biological Chemistry Volume: 292 Issue: 25 Pages: 10586-10599
  • DOI: 10.1074/jbc.m116.764332
  • Peer Reviewed / Open Access
• [Journal Article] Urinary prostaglandin D2 metabolite excretion during the first six months of life was significantly lower in breast-fed than formula-fed infants (2017)
  • Author(s): Shoji Hiromichi、Ikeda Naho、Kitamura Tomohiro、Suganuma Hiroki、Ohba Mai、Okuno Toshiaki、Yokomizo Takehiko、Shimizu Toshiaki
  • Journal Title: Acta Paediatrica Volume: 107 Issue: 1 Pages: 95-100
  • DOI: 10.1111/apa.14068
  • Peer Reviewed / Open Access
• [Journal Article] Inhibition of Leukotriene B4 Action Mitigates Intracerebral Hemorrhage-Associated Pathological Events in Mice (2017)
  • Author(s): Hijioka, M., Anan, J., Ishibashi, H., Kurauchi, Y., Hisatsune, A., Seki, T., Koga, T., Yokomizo, T., Shimizu, T.,Katsuki, H.
  • Journal Title: J Pharmacol Exp Ther Volume: 360 Issue: 3 Pages: 399-408
  • DOI: 10.1124/jpet.116.238824
  • Peer Reviewed
• [Journal Article] Prolonged exposure to volatile anesthetic isoflurane worsens the outcome of polymicrobial abdominal sepsis (2017)
  • Author(s): Koutsogiannaki, S., Schaefers, M. M., Okuno, T., Ohba, M., Yokomizo, T., Priebe, G. P., DiNardo, J. A., Sulpicio, S. G.,Yuki, K.
  • Journal Title: Toxicol Sci Volume: in press Pages: 402-411
  • DOI: 10.1093/toxsci/kfw261
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A synthetic leukotriene B4 receptor type 2 agonist accelerates the cutaneous wound healing process in diabetic rats by indirect stimulation of fibroblasts and direct stimulation of keratinocytes (2017)
  • Author(s): Luo, L., Tanaka, R., Kanazawa, S., Lu, F., Hayashi, A., Yokomizo, T.,Mizuno, H.
  • Journal Title: J Diabetes Complications Volume: 31 Issue: 1 Pages: 13-20
  • DOI: 10.1016/j.jdiacomp.2016.09.002
  • Peer Reviewed / Open Access
• [Journal Article] Intravenous anesthetic propofol binds to 5-lipoxygenase and attenuates leukotriene B4 production (2017)
  • Author(s): Okuno, T., Koutsogiannaki, S., Ohba, M., Chamberlain, M., Bu, W., Lin, F. Y., Eckenhoff, R. G., Yokomizo, T.,Yuki, K.
  • Journal Title: FASEB J Volume: 31 Issue: 4 Pages: 1584-1594
  • DOI: 10.1096/fj.201601095r
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] 皮膚保護作用を有する脂質メディエーター12-HHT (2017)
  • Author(s): 石井由美子, 劉珉, 佐伯和子、横溝岳彦
  • Journal Title: 臨床免疫・アレルギー科 Volume: 67 Pages: 106-14
  • NAID: 40021064298
• [Journal Article] The leukotriene B4 receptor BLT2 protects barrier function via actin polymerization with phosphorylation of myosin phosphatase target subunit 1 in human keratinocytes (2016)
  • Author(s): Chiba, T., Nakahara, T., Hashimoto-Hachiya, A., Yokomizo, T., Uchi, H.,Furue, M.
  • Journal Title: Exp Dermatol Volume: 25 Issue: 7 Pages: 532-536
  • DOI: 10.1111/exd.12976
  • Peer Reviewed
• [Journal Article] Modulation of leukotriene B4 receptor 1 signaling by receptor for advanced glycation end products, RAGE. (2016)
  • Author(s): Ichiki T, Koga T, Okuno T, Saeki K, Yamamoto Y, Yamamoto H, Sakaguchi M, Yokomizo T
  • Journal Title: FASEB J Volume: 30 Issue: 5 Pages: 1811-1822
  • DOI: 10.1096/fj.201500117
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Receptor for Advanced Glycation End Products Regulates Leukotriene B4 Receptor 1 Signaling (2016)
  • Author(s): Ichiki, T., Koga, T.,Yokomizo, T.
  • Journal Title: DNA Cell Biol Volume: 35 Issue: 12 Pages: 747-750
  • DOI: 10.1089/dna.2016.3552
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] BLT1 signalling protects the liver against acetaminophen hepatotoxicity by preventing excessive accumulation of hepatic neutrophils (2016)
  • Author(s): Kojo, K., Ito, Y., Eshima, K., Nishizawa, N., Ohkubo, H., Yokomizo, T., Shimizu, T., Watanabe, M.,Majima, M.
  • Journal Title: Sci Rep Volume: 6 Issue: 1 Pages: 29650-29650
  • DOI: 10.1038/srep29650
  • Peer Reviewed / Open Access
• [Journal Article] CD10-Equipped Melanoma Cells Acquire Highly Potent Tumorigenic Activity: A Plausible Explanation of Their Significance for a Poor Prognosis (2016)
  • Author(s): Oba, J., Nakahara, T., Hashimoto-Hachiya, A., Liu, M., Abe, T., Hagihara, A., Yokomizo, T.,Furue, M.
  • Journal Title: PLoS One Volume: 11 Issue: 2 Pages: e0149285-e0149285
  • DOI: 10.1371/journal.pone.0149285
  • Peer Reviewed / Open Access
• [Journal Article] Leukotriene B4 receptor type 2 protects against pneumolysin-dependent acute lung injury (2016)
  • Author(s): Shigematsu, M., Koga, T., Ishimori, A., Saeki, K., Ishii, Y., Taketomi, Y., Ohba, M., Jo-Watanabe, A., Okuno, T., Harada, N., Harayama, T., Shindou, H., Li, J. D., Murakami, M., Hoka, S.,Yokomizo, T.
  • Journal Title: Sci Rep Volume: 6 Issue: 1 Pages: 34560-34560
  • DOI: 10.1038/srep34560
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Integrative genomic and proteomic analyses identifies glycerol-3-phosphate acyltransferase as a target of low-dose ionizing radiation in EBV infected-B cells (2016)
  • Author(s): Tabe, Y., Hatanaka, Y., Nakashiro, M., Sekihara, K., Yamamoto, S., Matsushita, H., Kazuno, S., Fujimura, T., Ikegami, T., Nakanaga, K., Matsumoto, H., Ueno, T., Aoki, J., Yokomizo, T., Konopleva, M., Andreeff, M., Miida, T., Iwabuchi, K.,Sasai, K.
  • Journal Title: Int J Radiat Biol Volume: 92 Issue: 1 Pages: 24-34
  • DOI: 10.3109/09553002.2015.1106021
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] 古くて新しい脂質メディエーター・12-ヒドロキシヘプタデカトリエン酸の生理作用 (2016)
  • Author(s): 横溝岳彦
  • Journal Title: 生体の科学 Volume: 67 Pages: 232-236
• [Journal Article] 微量サンプル中の微量脂質を定量化する驚異の質量分析技術 (2016)
  • Author(s): 横溝岳彦
  • Journal Title: LiSA Volume: 23 Pages: 1179-88
• [Journal Article] 「脂質マシナリー」研究 脂質メディエーターの最新の研究成果 (2016)
  • Author(s): 横溝岳彦
  • Journal Title: 腎臓内科・泌尿器科 Volume: 4 Pages: 610-617
  • NAID: 40021041094
• [Journal Article] Leukotriene B4 receptor type 2 (BLT2) enhances skin barrier function by regulating tight junction proteins. (2016)
  • Author(s): Ishii Y, Saeki K, Liu M, Sasaki F, Koga T, Kitajima K, Meno C, Okuno T, Yokomizo T
  • Journal Title: FASEB J Volume: 30 Issue: 2 Pages: 933-947
  • DOI: 10.1096/fj.15-279653
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The absence of the leukotriene B4 receptor BLT1 attenuates peripheral inflammation and spinal nociceptive processing following intraplantar formalin injury (2015)
  • Author(s): Asahara M, Ito N, Yokomizo T, Nakamura M, Shimizu T, Yamada Y.
  • Journal Title: Mol Pain Volume: 11 Pages: 1-12
  • DOI: 10.1186/s12990-015-0010-9
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The leukotriene B4 receptor BLT1 is stabilized by transmembrane helix capping mutations. (2015)
  • Author(s): Hori, T., Nakamura, M., Yokomizo, T., Shimizu, T., Miyano, M.
  • Journal Title: Biochem Biophys Rep Volume: 4 Pages: 243-249
  • DOI: 10.1016/j.bbrep.2015.09.007
  • Peer Reviewed / Open Access
• [Journal Article] An inhaled phosphodiesterase 4 inhibitor E6005 suppresses pulmonary inflammation in mice (2015)
  • Author(s): Kubota S, Watanabe M, Shirato M, Okuno T, Higashimoto I, Machida K, Yokomizo T, Inoue H
  • Journal Title: Eur J Pharmacol Volume: 768 Pages: 41-48
  • DOI: 10.1016/j.ejphar.2015.10.013
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Biochemical characterization of three BLT receptors in zebrafish. (2015)
  • Author(s): Okuno T, Ishitani T, Yokomizo T.
  • Journal Title: PLoS ONE Volume: 10 Issue: 3 Pages: 0117888-0117888
  • DOI: 10.1371/journal.pone.0117888
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Resolvin E1 inhibits dendritic cell migration in the skin and attenuates contact hypersensitivity responses. (2015)
  • Author(s): Sawada Y, Honda T, Hanakawa S, Nakamizo S, Murata T, Ueharaguchi-Tanada Y, Ono S, Amano W, Nakajima S, Egawa G, Tanizaki H, Otsuka A, Kitoh A, Dainichi T, Ogawa N, Kobayashi Y, Yokomizo T, Arita M, Nakamura M, Miyachi Y, Kabashima K.
  • Journal Title: J Exp Med Volume: 212 Issue: 11 Pages: 1921-1930
  • DOI: 10.1084/jem.20150381
  • NAID: 120005733188
  • Peer Reviewed / Open Access
• [Journal Article] ROCK-Isoform-Specific Polarization of Macrophages Associated with Age-Related Macular Degeneration (2015)
  • Author(s): Zandi S, Nakao S, Chun K H, Fiorina P, Sun D, Arita R, Zhao M, Kim E, Schueller O, Campbell S, Taher M, Melhorn M I, Schering A, Gatti F, Tezza S, Xie F, Vergani A, Yoshida S, Ishikawa K, Yamaguchi M, Sasaki F, Schmidt-Ullrich R, Hata Y, Enaida H, Yuzawa M, Yokomizo T, 4名
  • Journal Title: Cell Rep Volume: 10 Issue: 7 Pages: 1173-86
  • DOI: 10.1016/j.celrep.2015.01.050
  • Peer Reviewed / Open Access
• [Presentation] Protective roles of 12-hydroxyheptadecatrienoic acid/BLT2 in acute lung injury (2017)
  • Author(s): Shigematsu, M, Koga, T, Saeki, K, Ohba, M, Okuno, T and Yokomizo, T
  • Organizer: Keystone Symposium, Lipidomics and Bioactive Lipids in Metabolism and Disease
  • Place of Presentation: Tahoe
  • Year and Date: 2017-02-26
  • Int'l Joint Research
• [Presentation] マウスアレルギー性結膜炎モデルにおけるレゾルビンの効果 (2017)
  • Author(s): 岩本怜、 岡野美樹子、 横溝岳彦、 村上晶、松田彰
  • Organizer: 第121回日本眼科学会
• [Presentation] マウス眼球部位別の脂質の網羅的脂肪酸分子種解析 (2017)
  • Author(s): 平形寿彬、 李賢哲、 村上晶、 松田彰、横溝岳彦
  • Organizer: 第121回日本眼科学会
• [Presentation] The effect of dietary omega-3 fatty acids on allergic conjunctivitis in mice. (2017)
  • Author(s): Hirakata、 T.、 Lee、 C. H.、 Ohba、 M.、 Matsuda、 A.、 Murakami、 A.、Yokomizo、 T.
  • Organizer: ARVO 2017
  • Int'l Joint Research
• [Presentation] 12-HHT/BLT2 axis protects against pneumolysin-dependent acute lung injury (2017)
  • Author(s): Saeki、 K.、 Shigematsu、 M.、 Koga、 T.、 Ohba、 M.、 Okuno、 T.、Yokomizo、 T.
  • Organizer: Keystone Symposium、 Integrating Metabolism and Immunity
  • Int'l Joint Research
• [Presentation] LC-MS/MSを用いた簡便な遊離脂肪酸測定法の開発 (2017)
  • Author(s): 李賢哲、 濱弘太郎、 横山和明、横溝岳彦
  • Organizer: 第59回日本脂質生化学会
• [Presentation] 静脈麻酔薬プロポフォールは5リポキシゲナーゼに直接結合しロイコトリエンB4産生を抑制する (2017)
  • Author(s): 奥野利明、 大塲麻生、 Chamberlain、 M.、 Bu、 W.、 Liu、 F.-Y.、 Eckenhoff、 R. G.、 横溝岳彦、結城公一
  • Organizer: 第59回日本脂質生化学会
• [Presentation] BLT2受容体の上皮保護作用 (2017)
  • Author(s): 横溝岳彦
  • Organizer: 第38回日本炎症・再生学会 (シンポジウム)
  • Invited
• [Presentation] 12-HHT/BLT2 axis protects acute lung injury (2017)
  • Author(s): Yokomizo、 T.
  • Organizer: 58th International Conference on the Bioscience of Lipids
  • Int'l Joint Research / Invited
• [Presentation] 長期間の高強度持久的運動トレーニングによる骨格筋内のアシルカルニチン分子種濃度の変動 (2017)
  • Author(s): 川西範明、 高木香奈、 李賢哲、 奥野利明、 横溝岳彦、町田修一
  • Organizer: 第72回日本体力医学会大会
• [Presentation] 生理活性脂質研究の醍醐味 (2017)
  • Author(s): 横溝岳彦
  • Organizer: 57回日本臨床化学会総会 特別講演
  • Invited
• [Presentation] C-terminal region of BLT2 receptor restricts its localization to the lateral membrane (2017)
  • Author(s): Hara、 T.、 Saeki、 K.、Yokomizo、 T.
  • Organizer: 15th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases
  • Int'l Joint Research
• [Presentation] Intravenous anesthetic propofol binds to 5-lipoxygenase and attenuates LTB4 production in vivo and in vitro (2017)
  • Author(s): Okuno、 T.、 Koutsogiannaki、 S.、 Ohba、 M.、 Chamberlain、 M.、 Bu、 W.、 Lin、 F.-Y.、 Eckenhoff、 R. G.、 Yokomizo
  • Organizer: 15th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases
  • Int'l Joint Research
• [Presentation] Role of LTB4-BLT1 signaling in mice pain model following hind paw incision (2017)
  • Author(s): Hashimoto、 Y.、 Asahara、 M.、 Ito、 N.、 Yamada、 Y.、 Yokomizo、 T.、Shimizu、 T.
  • Organizer: 15th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases
  • Int'l Joint Research
• [Presentation] Dietary omega-3 fatty acids alleviate the allergic conjunctivitis in mice (2017)
  • Author(s): Hirakata、 T.、 Lee、 C. H.、 Ohba、 M.、 Okuno、 T.、 Matsuda、 A.、 Murakami、 A.、Yokomizo、 T.
  • Organizer: 15th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases
  • Int'l Joint Research
• [Presentation] Biological roles of BLT receptors (2017)
  • Author(s): Yokomizo、 T.
  • Organizer: 15th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases
  • Int'l Joint Research / Invited
• [Presentation] 麻酔薬プロポフォールの抗炎症作用機序の解明 (2017)
  • Author(s): 奥野利明、 横溝岳彦、結城公一
  • Organizer: 第14回東京呼吸器リサーチフォーラム
• [Presentation] ロイコトリエンB4第一受容体BLT1による免疫活性化機構の解析 (2017)
  • Author(s): 古賀友紹、 佐々木文之、 佐伯和子、 奥野利明、 中尾光善、横溝岳彦
  • Organizer: 2017年度生命科学系学会合同年次大会(ConBio2017)
• [Presentation] 薬物代謝酵素カルボキシルエステラーゼのヒト大腸癌における発現調節機構の解明 (2017)
  • Author(s): 伊志嶺百々子、 李賢哲、 折田創、 遠藤未来美、 水口このみ、 佐藤浩一、 中岡博史、 井ノ上逸朗、横溝岳彦
  • Organizer: 2017年度生命科学系学会合同年次大会(ConBio2017)
• [Presentation] トリグリセリド減少効果を有するサプリメントの複数同時添加による効果の検討 (2017)
  • Author(s): 泉宜秀、 李賢哲、横溝岳彦
  • Organizer: 2017年度生命科学系学会合同年次大会(ConBio2017)
• [Presentation] ロイコトリエンA4水解酵素の代謝における解析 (2017)
  • Author(s): 鵜澤博嗣、 古賀友紹、 佐伯和子、 宮塚健、 綿田裕孝、横溝岳彦
  • Organizer: 2017年度生命科学系学会合同年次大会(ConBio2017)
• [Presentation] BLT2のC末端領域はBLT2の細胞間接着部位への局在に重要である (2017)
  • Author(s): 原琢弥、 佐伯和子、横溝岳彦
  • Organizer: 2017年度生命科学系学会合同年次大会(ConBio2017)
• [Presentation] 静脈麻酔薬プロポフォールは5-リポキシゲナーゼに結合してロイコトリエンの産生を抑制する (2017)
  • Author(s): 奥野利明、 Koutsogiannaki、 S.、 大塲麻生、 Chamberlain、 M.、 Bu、 W.、 Lin、 F.-Y.、 Eckenhoff、 R.、 横溝岳彦、結城公一
  • Organizer: 2017年度生命科学系学会合同年次大会(ConBio2017)
• [Presentation] A fatty acid 12-hydroxyheptadecatrienoic acid accelerates corneal wound healing through leukotriene B4 receptor 2, BLT2 (2017)
  • Author(s): Yokomizo、 T.、 Iwamoto、 S.、 Koga、 T.、 Ohba、 M.、 Okuno、 T.、 Koike、 M.、 Murakami、 A.、Matsuda、 A.
  • Organizer: Keystone Symposium, GPCR Structure and Function
  • Int'l Joint Research
• [Presentation] 12-hydroxyheptadecatrienoic acid accelerates epithelial wound healing through leukotriene B4 receptor 2, BLT2 (2017)
  • Author(s): Yokomizo、 T.
  • Organizer: Keystone Symposium, the resolution of inflammation in health and disease
  • Int'l Joint Research
• [Presentation] 皮膚バリア機能を維持する生理活性脂質12-HHT (2016)
  • Author(s): 横溝岳彦
  • Organizer: 第9回セラミド研究会
  • Place of Presentation: 東京
  • Year and Date: 2016-10-27
  • Invited
• [Presentation] 上皮創傷治癒を促進する生理活性脂質の同定とその応用 (2016)
  • Author(s): 横溝岳彦
  • Organizer: 第1回Ocular Surface & Glaucoma Seminar
  • Place of Presentation: 東京
  • Year and Date: 2016-10-21
  • Invited
• [Presentation] HMGB1/RAGE相互作用を阻害する新規低分子化合物の創製 (2016)
  • Author(s): 玉田賢弥, 中島槙吾, 佐藤聡, 吉森篤史, 市木貴子, 佐々木文之, 横溝岳彦, 鈴木雄祐, 渡邊伸央, 井上茂亮、田沼靖一
  • Organizer: 第89回日本生化学会
  • Place of Presentation: 仙台
  • Year and Date: 2016-09-25
• [Presentation] RAGEはロイコトリエンB4第一受容体BLT1と機能的に相互作用する (2016)
  • Author(s): 市木貴子, 古賀友紹, 奥野利明, 佐伯和子, 阪口政清, 山本靖彦、横溝岳彦
  • Organizer: 第89回日本生化学会
  • Place of Presentation: 仙台
  • Year and Date: 2016-09-25
• [Presentation] N-アシルリン脂質代謝酵素ABHD4の生化学的解析および脂質解析 (2016)
  • Author(s): 李賢哲, ベンジャミン, クラヴァット、横溝岳彦
  • Organizer: 第89回日本生化学会
  • Place of Presentation: 仙台
  • Year and Date: 2016-09-25
• [Presentation] The roles of 12-hydroxyheptadecatrienoic acid/BLT2 axis in skin (2016)
  • Author(s): Shigematsu, M, Koga, T, Saeki, K, Okuno, T and Yokomizo, T
  • Organizer: 57th ICBL, International Conference on the Bioscience of Lipids
  • Place of Presentation: Chamonix-Mont-Blanc, France
  • Year and Date: 2016-09-04
  • Int'l Joint Research
• [Presentation] ロイコトリエン受容体と皮膚機能 (2016)
  • Author(s): 横溝岳彦
  • Organizer: 第31回日本乾癬学会 教育講演
  • Place of Presentation: 宇都宮
  • Year and Date: 2016-09-02
  • Invited
• [Presentation] 12-hydroxyheptadecatrienoic acid (12-HHT) as a novel lipid mediator (2016)
  • Author(s): Yokomizo, T, Y, Ishii, Shimegatsu, M, Saeki, K and Okuno, T
  • Organizer: 第58回日本脂質生化学会
  • Place of Presentation: 秋田
  • Year and Date: 2016-06-09
  • Invited
• [Presentation] 持久的運動トレーニングおよび高脂肪食餌負荷が骨格筋のリン脂質分子種濃度に及ぼす影響 (2016)
  • Author(s): 川西範明, 高木香奈, 李賢哲, 奥野, 利明, 横溝岳彦、町田修一
  • Organizer: 第58回日本脂質生化学会
  • Place of Presentation: 秋田
  • Year and Date: 2016-06-09
• [Presentation] Roles of leukotriene B4 receptor type 2 on skin barrier function and wound healing (2016)
  • Author(s): Yokomizo, T
  • Organizer: 2016 Korea-Japan Bioactive Lipid Joint Symposium
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2016-05-11
  • Int'l Joint Research / Invited
• [Presentation] Receptor for advanced glycation endproducts modulates leukotriene B4 receptor 1 signaling (2016)
  • Author(s): Ichiki, T, Koga, T, Okuno, T, Saeki, K, Yamamoto, Y, Sakaguchi, M and Yokomizo, T
  • Organizer: ASBMB meeting
  • Place of Presentation: San Diego
  • Year and Date: 2016-04-02
  • Int'l Joint Research
• [Presentation] Generation of chimeric high-affinity monoclonal antibody for FLAG tag (2016)
  • Author(s): Ikeda, K, Sasaki, F, Ueno, A, Okuno, T, Koga, T and Yokomizo, T
  • Organizer: ASBMB meeting
  • Place of Presentation: San Diego
  • Year and Date: 2016-04-02
  • Int'l Joint Research
• [Presentation] BLT2 receptor protects against lethal acute lung injury induced by a pneumococcal toxin pneumolysin (2016)
  • Author(s): Shigematsu, M, Koga, T, Saeki, K, Okuno, T and Yokomizo, T
  • Organizer: ASBMB meeting
  • Place of Presentation: San Diego
  • Year and Date: 2016-04-02
  • Int'l Joint Research
• [Presentation] Roles of leukotriene B4 receptor type 2 in skin barrier function and wound healing. (2016)
  • Author(s): Ishii Y, Liu M, Saeki K, Kabashima K, *Yokomizo T.
  • Organizer: Keystone Symposium, Immunity in Skin Development, Homeostasis and Disease
  • Place of Presentation: Granlibakken Tahoe, USA
  • Year and Date: 2016-02-28
  • Int'l Joint Research
• [Presentation] 生理活性脂質受容体BLT1とBLT2：眼疾患治療応用の可能性. (2015)
  • Author(s): 横溝岳彦
  • Organizer: 第35回日本眼薬理学会 特別講演
  • Place of Presentation: 東京
  • Year and Date: 2015-09-05
  • Invited
• [Presentation] Distinct roles of two leukotriene B4 receptors. (2015)
  • Author(s): Yokomizo, T
  • Organizer: 14th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases.
  • Place of Presentation: Budapest, Hungary
  • Year and Date: 2015-07-12
  • Int'l Joint Research / Invited
• [Presentation] 国策としての脂質研究のサポートを (2015)
  • Author(s): 横溝岳彦
  • Organizer: 第57回日本脂質生化学会
  • Place of Presentation: 東京
  • Year and Date: 2015-05-28
  • Invited
• [Book] Bioactive lipid mediators (2015)
  • Author(s): Yokomizo, T and Murakami M
  • Total Pages: 426
  • Publisher: S@ringer
• [Book] 脂質疾患学 (2015)
  • Author(s): 村上 誠、横溝岳彦
  • Total Pages: 222
  • Publisher: 羊土社
• [Remarks] 順天堂大学生化学第一講座のホームページ
  • URL: http://plaza.umin.ac.jp/j_bio/
• [Remarks] プレスリリース：角膜上皮障害の修復メカニズムを解明
  • URL: http://www.juntendo.ac.jp/news/20171016-01.html
• [Remarks] プレスリリース：ロイコトリエンB4受容体の構造 －GPCRに対する逆作動薬探索の効率化に向けて－
  • URL: http://www.juntendo.ac.jp/news/20180109-01.html
• [Remarks] 順天堂大学医学部生化学第一講座
  • URL: http://plaza.umin.ac.jp/j_bio/
• [Remarks] 順天堂大学医学部生化学教室
  • URL: http://plaza.umin.ac.jp/j_bio/