| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2015: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Outline of Final Research Achievements |
Calorie restriction, exercise therapy is said to lead to longevity and anti-metabolic, but detailed molecular mechanisms and indicators have not been identified. We verified the hypothesis that adaptive responses of cells and mild mitochondrial stress due to mild mitochondrial stress lead to improvement not only of function restoration of mitochondria but also systemic pathology through secretory protein induction. We analyzed mitochondrial protein p32 knockout mice and found that mild mitochondrial stress caused ER stress. We also found that the transcription factor ATF4 is involved in this pathway. Mild mitochondrial stress conversely provoked an adaptive response and was expected to improve the general condition through secretory proteins.
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