Elucidation of mitochondrial stress response mechanism leading to anti aging and searching for diagnostic molecule, efficacy
Project/Area Number |
15H04764
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Laboratory medicine
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Research Institution | Kyushu University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
松島 雄一 九州大学, 医学研究院, 助教 (20571342)
瀬戸山 大樹 九州大学, 大学病院, 助教 (30550850)
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Co-Investigator(Renkei-kenkyūsha) |
YAGI Mikako 九州大学, 大学病院, 学術研究員 (70536135)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2015: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
|
Keywords | ミトコンドリア / 老化 / stress応答 / 代謝物 / TFAM / ストレス応答 / 抗老化 |
Outline of Final Research Achievements |
Calorie restriction, exercise therapy is said to lead to longevity and anti-metabolic, but detailed molecular mechanisms and indicators have not been identified. We verified the hypothesis that adaptive responses of cells and mild mitochondrial stress due to mild mitochondrial stress lead to improvement not only of function restoration of mitochondria but also systemic pathology through secretory protein induction. We analyzed mitochondrial protein p32 knockout mice and found that mild mitochondrial stress caused ER stress. We also found that the transcription factor ATF4 is involved in this pathway. Mild mitochondrial stress conversely provoked an adaptive response and was expected to improve the general condition through secretory proteins.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] The Association of Polymorphisms in the Gene Encoding Gonadotropin-Releasing Hormone with Serum Testosterone Level during Androgen Deprivation Therapy and Prognosis of Metastatic Prostate Cancer.2018
Author(s)
Shiota M, Fujimoto N, Takeuchi A, Kashiwagi E, Dejima T, Inokuchi J, Tatsugami K, Yokomizo A, Kajioka S, Uchiumi T, Eto M.
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Journal Title
The Journal of Urology
Volume: 199
Issue: 3
Pages: 734-740
DOI
Related Report
Peer Reviewed
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[Journal Article] Biallelic C1QBP Mutations Cause Severe Neonatal-, Childhood-, or Later-Onset Cardiomyopathy Associated with Combined Respiratory-Chain Deficiencies2017
Author(s)
Feichtinger RG, Olahova M, Kishita Y, Garone C, Kremer LS, Yagi M, Uchiumi T, Murayama K, Ohtake A, Rebelo-Guiomar P, Kohda M, Kang D, Mayr JA, Taylor RW, Okazaki Y, Minczuk M, Prokisch H et al
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Journal Title
The American Journal of Human Genetics
Volume: 101
Issue: 4
Pages: 525-538
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] The clinical presentation and genotype of protein C deficiency with double mutations of the protein C gene.2017
Author(s)
Inoue H, Terachi SI, Uchiumi T, Sato T, Urata M, Ishimura M, Koga Y, Hotta T, Hara T, Kang D, Ohga S.
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Journal Title
Pediatr Blood Cancer
Volume: 2017
Issue: 7
Pages: e26404-e26404
DOI
Related Report
Peer Reviewed
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[Journal Article] Serum depletion induced cancer stem cell-like phenotype due to nitric oxide synthesis in oncogenic HRas transformed cells.2016
Author(s)
Monji, K., Uchiumi, T., Hoshizawa, S., Yagi, M., Matsumoto, T, Y., Setoyama, D., Matsushima, Y., Gotoh, K., Amamoto, R., and Kang, D.
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Journal Title
Oncotarget
Volume: 7
Issue: 46
Pages: 75221-75234
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] The expression of ubiquitous mitochondrial creatine kinase is downregulated as prostate cancer progression2016
Author(s)
Amamoto, R. Uchiumi, T. Yagi, M. Monji,K. Song, Y. Oda, Y. Shiota,M. Yokomizo, A. Naito, S. Kang, D.
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Journal Title
Journal of Cancer
Volume: 7
Issue: 1
Pages: 50-59
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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