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Long-term trends in atrial fibrillation and bio-psycho-social risk factors among Japanese

Research Project

Project/Area Number 15H04775
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Epidemiology and preventive medicine
Research InstitutionFukushima Medical University

Principal Investigator

Ohira Tetsuya  福島県立医科大学, 医学部, 教授 (50448031)

Co-Investigator(Kenkyū-buntansha) 鈴木 均  福島県立医科大学, 医学部, 博士研究員 (10347213)
木山 昌彦  公益財団法人大阪府保健医療財団大阪がん循環器病予防センター(予防推進部・循環器病予防健診部・健康開発, その他部局等, その他 (10450925)
山岸 良匡  筑波大学, 医学医療系, 准教授 (20375504)
崔 仁哲  大阪大学, 医学系研究科, 助教 (40375514)
岡田 武夫  公益財団法人大阪府保健医療財団大阪がん循環器病予防センター(予防推進部・循環器病予防健診部・健康開発, その他部局等, その他 (70450921)
北村 明彦  大阪大学, 医学系研究科, 招へい准教授 (80450922)
Research Collaborator Tanaka Mari  
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2018: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Keywords心房細動 / 危険因子 / 推移 / コホート研究 / 生活習慣 / 炎症 / 白血球 / 高感度CRP / 疫学研究 / 心理社会的因子 / リスクファクター / 心理的因子 / 前向き研究 / 地域住民 / 動脈硬化 / 社会医学 / 循環器・高血圧 / ストレス / 前向きコホート研究 / 肥満 / 飲酒 / 避難
Outline of Final Research Achievements

The aim of this study is to investigate trends in atrial fibrillation and its bio-psycho-social risk factors among Japanese men and women who participated in the Circulatory Risk in Communities Study (CIRCS), a long-term cohort study conducted in Akita, Osaka, and Kochi. Furthermore, we investigated a novel risk factors for atrial fibrillation, and we aimed to gain a new insight for preventive programs for atrial fibrillation from results of this study.
The subjects were residents in Akita, Osaka, Kochi, and evacuation areas of Fukushima. Thirty years trends in atrial fibrillation in Akita, Osaka, and Kochi were evaluated. As a result, the prevalence rates of atrial fibrillation increased from 1980s to 2000s, especially late 2000s. Furthermore, psychological stress after the Great East Japan Earthquake, anger, augmentation index (AI),high sensitive CRP, and serum levels of NT-proBNP were associated with risk of atrial fibrillation as a novel risk factors.

Academic Significance and Societal Importance of the Research Achievements

心房細動は心不全の原因になることに加え、脳卒中の重要な危険因子であるが、高齢化に伴い我が国の心房細動有病率は上昇傾向にあると推測されている。その発症には年齢、生活習慣、及び心理社会的因子の影響が考えられるが、これらの影響の推移をみた研究はほとんどない。本研究では我が国の地域住民において、心房細動が年齢調整後も増加傾向にあることを明らかにした。また、その要因として、高血圧等の従来の危険因子の影響は弱くなりつつあり、社会心理的ストレスの影響が強くなっている可能性を示した。この結果は今後の我が国の心房細動予防対策に貢献できるものと考える。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (10 results)

All 2019 2017 2016 2015

All Journal Article (7 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 5 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (3 results) (of which Invited: 2 results)

  • [Journal Article] Association between markers of arterial stiffness and atrial fibrillation in the Circulatory Risk in Communities Study (CIRCS).2017

    • Author(s)
      Cui R, Yamagishi K, Muraki I, Hayama-Terada M, Umesawa M, Imano H, Li Y, Eshak ES, Ohira T, Kiyama M, Okada T, Kitamura A, Tanigawa T, Iso H; CIRCS investigators.
    • Journal Title

      Atherosclerosis

      Volume: 263 Pages: 244-248

    • DOI

      10.1016/j.atherosclerosis.2017.06.918

    • NAID

      120007128953

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in cardiovascular risk factors after the Great East Japan Earthquake: A review of the Comprehensive Health Check in the Fukushima Health Management Survey.2017

    • Author(s)
      Ohria T, Nakano H, Nagai M, Yumiya Y, Zhang W, Uemura M, Sakai A, Hashimoto S.
    • Journal Title

      Asia Pac J Public Health

      Volume: 29(2_suppl)

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dehydroepiandrosterone-sulfate is associated with cardiovascular reactivity to stress in women2016

    • Author(s)
      Hirokawa K, Ohira T, Nagayoshi M, Kajiura M, Imano H, Kitamura A, Kiyama M, Okada T, Iso H.
    • Journal Title

      Psychonueroendcrinology

      Volume: 69 Pages: 116-122

    • DOI

      10.1016/j.psyneuen.2016.04.005

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Occupational status and job stress in relation to cardiovascular stress reactivity in Japanese workers.2016

    • Author(s)
      Hirokawa K, Ohira T, Nagayoshi M, Kajiura M, Imano H, Kitamura A, Kiyama M, Okada T, Iso H.
    • Journal Title

      Prev Med Rep

      Volume: 4 Pages: 61-67

    • DOI

      10.1016/j.pmedr.2016.05.010

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 笑いを不整脈診療にいかす.2016

    • Author(s)
      大平哲也
    • Journal Title

      不整脈  News & Views

      Volume: 42 Pages: 11-12

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 笑いと心臓病2016

    • Author(s)
      大平哲也
    • Journal Title

      Therapeutic Research

      Volume: 37 Pages: 441-445

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Increased prevalence of atrial fibrillation after the Great East Japan Earthquake: Results from the Fukushima Health Management Survey2015

    • Author(s)
      Suzuki H, Ohira T, Takeishi Y, Hosoya M, Yasumura S, Satoh H, Kawasaki Y, Takahashi A, Sakai A, Ohtsuru A, Kobashi G, Ozasa K, Yamashita S, Kamiya K, Abe M, for the Fukushima Health Management Survey Group
    • Journal Title

      International Journal of Cardiology

      Volume: 198 Pages: 102-105

    • DOI

      10.1016/j.ijcard.2015.06.151

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 高感度CRPレベル別にみた心房細動発症のリスク (CIRCS)2019

    • Author(s)
      田中麻理、今野弘規、村木功、久保田康彦、手塚一秀、羽山実奈、清水悠路、岡田武夫、木山昌彦、山岸良匡、梅澤光政、大平哲也、崔仁哲、山海知子、谷川武、北村明彦、佐藤眞一、磯博康
    • Organizer
      第29回日本疫学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 笑いと心臓病2016

    • Author(s)
      大平哲也
    • Organizer
      第80回循環器学会学術総会
    • Place of Presentation
      仙台
    • Year and Date
      2016-03-20
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 笑いと心臓病との関連についてのエビデンス2015

    • Author(s)
      大平哲也
    • Organizer
      第63回日本心臓病学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2015-09-19
    • Related Report
      2015 Annual Research Report
    • Invited

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Published: 2015-04-16   Modified: 2020-03-30  

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