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Metabolome-wide metabolic profiling and non-communicable disease prevention in a population-based cohort study

Research Project

Project/Area Number 15H04778
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Epidemiology and preventive medicine
Research InstitutionKeio University

Principal Investigator

Takebayashi Toru  慶應義塾大学, 医学部(信濃町), 教授 (30265780)

Co-Investigator(Kenkyū-buntansha) 岡村 智教  慶應義塾大学, 医学部(信濃町), 教授 (00324567)
原田 成  慶應義塾大学, 医学部(信濃町), 助教 (10738090)
西脇 祐司  東邦大学, 医学部, 教授 (40237764)
曽我 朋義  慶應義塾大学, 環境情報学部(藤沢), 教授 (60338217)
竹内 文乃  慶應義塾大学, 医学部(信濃町), 講師 (80511196)
Research Collaborator IIDA Miho  
HIRAYAMA Akiyoshi  
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
Fiscal Year 2017: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Keywordsメタボローム / コホート研究 / 分岐鎖アミノ酸 / メタボロミクス疫学 / インスリン抵抗性 / 動脈硬化 / 測定精度 / 疫学 / メタボローム解析 / 代謝プロファイル
Outline of Final Research Achievements

We explored plasma biomarker candidates for non-communicable disease prevention by metabolomic profiling in the Tsuruoka Metabolomics Cohort Study. First, the mean and SD values for each metabolite by 5-yr age group were reported to the open-access, academic journal. Then the significant association between metabolic syndrome and 13 polar metabolites including branched chain amino acids (BCAA) was found. Further, BCAA was found to be a subclinical biomarker candidate for dyslipidemia.

Academic Significance and Societal Importance of the Research Achievements

本研究では、定量性の高い解析手法であるキャピラリー電気泳動質量分析法を用いて94種類の極性代謝物の血漿中濃度に関する日本人一般住民集団での年齢群別の平均値/分布を明らかにし、その精度が十分に高いことを示した。また統計学的解析により、閉経後女性のメタボリックシンドロームに血漿中分岐鎖アミノ酸が関連してこと、さらに、分岐鎖アミノ酸がインスリン抵抗性とは独立して脂質異常症と関連していることを明らかにしたことから、今後、これらの疾患の予測やリスク評価に用いることが可能かを検証する予定である。

Report

(4 results)
  • 2018 Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (29 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (2 results) Journal Article (7 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 5 results,  Acknowledgement Compliant: 2 results) Presentation (19 results) (of which Int'l Joint Research: 6 results,  Invited: 2 results) Remarks (1 results)

  • [Int'l Joint Research] National Institute of Aging(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Imperial College London(United Kingdom)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Reliability of plasma polar metabolite concentrations in a large-scale cohort study using capillary electrophoresis-mass spectrometry2018

    • Author(s)
      Harada Sei、Hirayama Akiyoshi、Chan Queenie、Kurihara Ayako、Fukai Kota、Iida Miho、Kato Suzuka、Sugiyama Daisuke、Kuwabara Kazuyo、Takeuchi Ayano、Akiyama Miki、Okamura Tomonori、Ebbels Timothy M. D.、Elliott Paul、Tomita Masaru、Sato Asako、Suzuki Chizuru、Sugimoto Masahiro、Soga Tomoyoshi、Takebayashi Toru
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 1 Pages: e0191230-e0191230

    • DOI

      10.1371/journal.pone.0191230

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 鶴岡メタボロームコホート研究2017

    • Author(s)
      原田成、武林亨
    • Journal Title

      実験医学

      Volume: 35 Pages: 2888-2892

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Set up and Prospect of New Cohort Studies:KOBE Study and Tsuruoka Metabolomics Cohort Study2016

    • Author(s)
      西田陽子, 原田成, 武林亨, 岡村智教
    • Journal Title

      呼吸と循環

      Volume: 64 Issue: 1 Pages: 71-77

    • DOI

      10.11477/mf.1404205885

    • ISSN
      0452-3458, 1882-1200
    • Year and Date
      2016-01-15
    • Related Report
      2016 Annual Research Report
  • [Journal Article] Profiling of plasma metabolites in postmenopausal women with metabolic syndrome2016

    • Author(s)
      Iida M, Harada S, Kurihara A, Fukai K, Kuwabara K, Sugiyama D, Takeuchi A, Okamura T, Akiyama M, Nishiwaki Y, Suzuki A, Hirayama A, Sugimoto M, Soga T, Tomita M, Banno K, Aoki D, Takebayashi T.
    • Journal Title

      Menopause

      Volume: 23 Pages: 749-758

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Metabolic Profiling of Total Physical Activity and Sedentary Behavior in Community-Dwelling Men.2016

    • Author(s)
      Fukai K, Harada S, Iida M, Kurihara A, Takeuchi A, Kuwabara K, Sugiyama D, Okamura T, Akiyama M, Nishiwaki Y, Oguma Y, Suzuki A, Suzuki C, Hirayama A, Sugimoto M, Soga T, Tomita M, Takebayashi T
    • Journal Title

      PLoS One

      Volume: 11 Issue: 10 Pages: e0164877-e0164877

    • DOI

      10.1371/journal.pone.0164877

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Relationship between Non-High-Density Lipoprotein Cholesterol and Low-Density Lipoprotein Cholesterol in the General Population:2016

    • Author(s)
      Kuwabara K, Harada S, Sugiyama D, Kurihara A, Kubota Y, Higashiyama A, Hirata T, Nishida Y, Kawasaki M, Takebayashi T, Okamura T
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 23 Issue: 4 Pages: 477-490

    • DOI

      10.5551/jat.33100

    • NAID

      130005141417

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Metabolomic profiling reveals novel biomarkers of alcohol intake and alcohol-induced liver injury in community-dwelling men.2016

    • Author(s)
      Harada S, Takebayashi T, Kurihara A, Akiyama M, Suzuki A, Hatakeyama Y, Sugiyama D, Kuwabara K, Takeuchi A, Okamura T, Nishiwaki Y, Tanaka T, Hirayama A, Sugimoto M, Soga T, Tomita M.
    • Journal Title

      Environ Health Prev Med.

      Volume: 21(1) Issue: 1 Pages: 18-26

    • DOI

      10.1007/s12199-015-0494-y

    • NAID

      210000000441

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 大規模疫学研究におけるCE-MS血液メタボロミクス測定値の信頼性: 鶴岡メタボロームコホート研究2018

    • Author(s)
      原田成
    • Organizer
      第28日日本疫学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 総身体活動量・座位時間と血漿メタボロームの関連:鶴岡メタボロームコホート2017

    • Author(s)
      深井航太、原田成、栗原綾子、加藤寿寿華、岡村智教、杉山大典、平山明由、曽我朋義、冨田勝、武林亨
    • Organizer
      第27回日本疫学会学術総会
    • Place of Presentation
      ベルクラシック甲府(山梨県甲府市)
    • Year and Date
      2017-01-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] 大規模地域コホートにおける腎機能低下と血漿メタボロームの関連:鶴岡メタボロームコホート2017

    • Author(s)
      原田成、栗原綾子、深井航太、加藤寿寿華、岡村智教、杉山大典、平山明由、曽我朋義、冨田勝、武林亨
    • Organizer
      第27回日本疫学会学術総会
    • Place of Presentation
      ベルクラシック甲府(山梨県甲府市)
    • Year and Date
      2017-01-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] 鶴岡メタボロームコホート研究:進捗と今後2017

    • Author(s)
      武林亨
    • Organizer
      日本人類遺伝学会第62回大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 高血圧とメタボロミクス疫学研究2017

    • Author(s)
      武林亨
    • Organizer
      第40回日本高血圧学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Plasma metabolome associated with obesity in community dwellers: Tsuruoka metabolomic cohort study2017

    • Author(s)
      Kurihara, A
    • Organizer
      IUNS 21st International Congress of Nutrition
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 閉経後女性における出産経験の有無と血漿メタボロームの関連:鶴岡メタボロームコホート研究2016

    • Author(s)
      飯田美穂、武林亨、阪埜浩司、青木大輔
    • Organizer
      第31回日本女性医学学会学術集会
    • Place of Presentation
      ウェスティン都ホテル京都(京都府京都市)
    • Year and Date
      2016-11-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] 地域在住者における健康意識に影響を与える社会経済的要因と生活習慣要因の探索2016

    • Author(s)
      加藤寿寿華、深井航太、原田成、栗原綾子、岡村智教、杉山大典、武林亨
    • Organizer
      第75回日本公衆衛生学会学術総会
    • Place of Presentation
      大阪グランフロント(大阪府大阪市)
    • Year and Date
      2016-10-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] Profiling of plasma metabolites in postmenopausal women with metabolic syndrome2016

    • Author(s)
      Iida M, Harada S, Kurihara A, Fukai K, Kuwabara K, Sugiyama D, Takeuchi A, Okamura T, Akiyama M, Nishiwaki Y, Suzuki A, Hirayama A, Sugimoto M, Soga T, Tomita M, Banno K, Aoki D, Takebayashi T.
    • Organizer
      第12回メタボロミクス学会学術集会
    • Place of Presentation
      ダブリン(アイルランド)
    • Year and Date
      2016-06-27
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Metabolic profiling of total physical activity and sedentary behavior in community-dwelling men2016

    • Author(s)
      Fukai K, Harada S, Iida M, Kurihara A, Takeuchi A, Kuwabara K, Sugiyama D, Okamura T, Akiyama M, Nishiwaki Y, Oguma Y, Suzuki A, Suzuki C, Hirayama A, Sugimoto M, Soga T, Tomita M, Takebayashi T
    • Organizer
      第12回メタボロミクス学会学術集会
    • Place of Presentation
      ダブリン(アイルランド)アイルランド
    • Year and Date
      2016-06-27
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Plasma metabolome associated with chronic kidney disease in general population2016

    • Author(s)
      Harada S, Kurihara A, Fukai K, Iida M, Takeuchi A, Kuwabara K, Sugiyama D, Okamura T, Akiyama M, Nishiwaki Y, Oguma Y, Suzuki A, Suzuki C, Hirayama A, Sugimoto M, Soga T, Tomita M, Takebayashi T
    • Organizer
      第12回メタボロミクス学会学術集会
    • Place of Presentation
      ダブリン(アイルランド)
    • Year and Date
      2016-06-27
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 糖尿病前症の血漿メタボローム解析:鶴岡メタボロームコホート研究2016

    • Author(s)
      飯田美穂、武林亨、阪埜浩司、青木大輔
    • Organizer
      第16回日本抗加齢医学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-06-10
    • Related Report
      2016 Annual Research Report
  • [Presentation] 勤労者における座位時間と分岐鎖アミノ酸の関連2016

    • Author(s)
      深井航太、原田成、栗原綾子、加藤寿寿華、岡村智教、杉山大典、平山明由、曽我朋義、冨田勝、武林亨
    • Organizer
      第89回日本産業衛生学会総会
    • Place of Presentation
      福島県文化センター(福島県福島市)
    • Year and Date
      2016-05-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] Metabolomic profiling of postmenopausal women with accumulated risk factors of metabolic syndrome2016

    • Author(s)
      IIda M, Takebayashi T, Banno K, Aoki D
    • Organizer
      第64回米国産婦人科学会学術講演会
    • Place of Presentation
      ワシントンDC(アメリカ)
    • Year and Date
      2016-05-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 地域在住者における尿酸値増加に伴う極性代謝物質のプロファイル変化2016

    • Author(s)
      石川碧、原田成、栗原綾子、深井航太、杉山大典、桑原和代、平山明由、富田勝 、岡村智教、武林亨
    • Organizer
      第26回日本疫学会総会
    • Place of Presentation
      米子コンベンションセンター(鳥取県米子市)
    • Year and Date
      2016-01-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 閉経後女性におけるメタボリック症候群の血漿Metabolome解析― 鶴岡 Metabolome Cohort Study ―2015

    • Author(s)
      飯田美穂、武林亨、阪埜浩司、青木大輔
    • Organizer
      第30回日本女性医学会学術集会
    • Place of Presentation
      メルパルク名古屋(愛知県名古屋市)
    • Year and Date
      2015-11-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] Simultaneous quantification of wide range of lipid mediators in human plasma using liquid chromatography electrospray ionization tandem mass spectrometry2015

    • Author(s)
      Ishikawa T, Ikeda K, Takebayashi T, Soga T, Tomita M
    • Organizer
      11th Annual Meeting of Metabolomics Society
    • Place of Presentation
      San Franscsco(USA)
    • Year and Date
      2015-06-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 生産年齢人口の男性における血漿中メタボロームと身体活動量の関連:鶴岡メタボロームコホート研究2015

    • Author(s)
      深井航太、原田成、栗原綾子、岡村智教、杉山大典、平山明由、曽我朋義、冨田勝、武林亨
    • Organizer
      第88回日本産業衛生学会総会
    • Place of Presentation
      グランフロント大阪(大阪府大阪市)
    • Year and Date
      2015-05-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] Biomarkers of accumulated metabolic syndrome risk factors among postmenopausal women: Tsuruoka Metabolomic Cohort Study2015

    • Author(s)
      Iida M, Takebayashi T, Banno K, Tanaka M, Aoki D
    • Organizer
      第67回日本産婦人科学会学術講演会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2015-04-09
    • Related Report
      2015 Annual Research Report
  • [Remarks] 鶴岡みらい健康調査(鶴岡メタボロームコホート研究) 現在までの成果

    • URL

      http://tsuruoka-mirai.net/modules/contents/publish.html

    • Related Report
      2016 Annual Research Report

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Published: 2015-04-16   Modified: 2022-10-07  

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