Molecular epidemiology study of inflammation-associated disease development on the basis of long-term follow-up of atomic-bomb survivors
Project/Area Number |
15H04791
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Hygiene and public health
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Research Institution | Radiation Effects Research Foundation |
Principal Investigator |
HAYASHI Tomonori 公益財団法人放射線影響研究所, 分子生物科学部, 副部長 (70333549)
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Co-Investigator(Kenkyū-buntansha) |
徳永 勝士 東京大学, 大学院医学系研究科(医学部), 教授 (40163977)
安波 道郎 地方独立行政法人佐賀県医療センター好生館(ライフサイエンス研究所), 疾患ゲノムセンター, 部長 (80244127)
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Co-Investigator(Renkei-kenkyūsha) |
NAKACHI Kei 公益財団法人 放射線影響研究所, 分子生物科学部, 顧問 (00142117)
Cologne John 公益財団法人 放射線影響研究所, 統計部, 主任研究員 (50344411)
YOSHIDA Kengo 公益財団法人 放射線影響研究所, 分子生物科学部, 研究員 (70443596)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2017: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
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Keywords | ゲノム / 放射線 / 炎症 / 遺伝子多型 / microRNA |
Outline of Final Research Achievements |
We observed a significant interaction between certain genotype of CHEK2 gene, which is related to DNA damage response, and radiation exposure dose in the increase risk of proximal colon cancer in atomic-bomb survivors. Among 160,000 SNPs, the number of SNPs with P values less than 10-3 related to breast cancer, liver cancer, and colon cancer risks in atomic-bomb survivors were 10, 8, and 12 SNPs, respectively, but there were no SNPs with P values less than 10-6. As a result of measurement of the membrane type IL-6R (mIL-6R) levels of healthy subjects by IL6R genotypes, the mIL-6R levels of the CD4+ helper T cells of the other genotype group was higher than that of the IL6R-A/A group, and the intracellular O2.- levels were significantly higher.
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Report
(4 results)
Research Products
(50 results)
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[Journal Article] Radiation- and Age-associated Changes in Peripheral Blood Dendritic Cell Populations among Aging Atomic Bomb Survivors in Japan2018
Author(s)
Kajimura J, Lynch HE, Geyer S, French B, Yamaoka M, Shterev ID, Sempowski GD, Kyoizumi S, Yoshida K, Misumi M, Ohishi W, Hayashi T, Nakachi K, Kusunoki Y
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Journal Title
Radiat Res
Volume: 189
Pages: 84-94
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Influenza Vaccine Response among Hiroshima Atomic-bomb Survivors2018
Author(s)
Hayashi T, Lynch H, Geyer S, French B, Yoshida K, Furudoi K, Sasaki K, Morishita Y, Nagamura H, Maki M, Hu Y, Hayashi I, Kyoizumi S, Kusunoki Y, Ohishi W, Fujiwara S, Shterev I, Nikolich-Zugich J, Murasko D, Sempowski G, Nakachi K
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Journal Title
Hiroshima Igaku (J Hiroshima Med Assoc)
Volume: 71
Pages: 278-281
NAID
Related Report
Int'l Joint Research
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[Journal Article] Relationship between spontaneous gammaH2AX foci formation and progenitor functions in circulating hematopoietic stem and progenitor cells among atomic-bomb survivors2016
Author(s)
Kajimura J, Kyoizumi S, Kubo Y, Misumi M, Yoshida K, Hayashi T, Imai K, Ohishi W, Nakachi K, Weng NP, Young LF, Shieh JH, Moore MA, van den Brink MRM, Kusunoki Y
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Journal Title
Mutat Res-Gen Tox En
Volume: 802
Pages: 59-65
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Circulating hematopoietic stem and progenitor cells in aging atomic bomb survivors2016
Author(s)
Kyoizumi S, Kubo Y, Misumi M, Kajimura J, Yoshida K, Hayashi T, Imai K, Ohishi W, Nakachi K, Young LF, Shieh JH, Moore MA, van den Brink MRM, Kusunoki Y
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Journal Title
Radiat Res
Volume: 185
Pages: 69-76
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Long term effects of radiation exposure on telomere lengths of leukocytes and its associated biomarkers among atomic-bomb survivors2016
Author(s)
Lustig A, Shterev I, Geyer SM, Shi A, Hu Y, Morishita Y, Nagamura H, Sasaki K, Maki M, Hayashi I, Furukawa K, Yoshida K, Kajimura J, Kyoizumi S, Kusunoki Y, Ohishi W, Nakachi K, Weng NP, Hayashi T
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Journal Title
Oncotarget Journal
Volume: 7
Pages: 38988-98
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Long-term effects of radiation exposure on leukocyte telomere lengths and related biomarkers among atomic-bomb survivors2016
Author(s)
Hayashi T, Lustig A, Shterev I, Geyer S, Shi A, Yoshida K, Kajimura J, Hayashi I, Kyoizumi S, Kusunoki Y, Ohishi W, Nakachi K, Weng NP
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Journal Title
Nagasaki Med J
Volume: 91
Pages: 241-5
Related Report
Acknowledgement Compliant
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[Journal Article] Nucleotide excision repair gene ERCC2 and ERCC5 variants increase risk of uterine cervical cancer2016
Author(s)
Joo J, Yoon KA, Hayashi T, Kong SY, Shin HJ, Park B, Kim YM, Hwang SH, Kim J, Shin A, Kim JY
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Journal Title
Cancer Res Treat
Volume: 48
Pages: 708-14
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] CD14 and IL18 gene polymorphisms associated with colorectal cancer subsite risks among atomic bomb survivors2015
Author(s)
Hu Y, Yoshida K, Cologne JB, Maki M, Morishita Y, Sasaki K, Hayashi I, Ohishi W, Hida A, Kyoizumi S, Kusunoki Y, Tokunaga K, Nakachi K, Hayashi T
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Journal Title
Human Genome Variation
Volume: 2
Pages: 15035-15035
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Longitudinal study of effects of radiation exposure on leukocyte telomere lengths among atomic-bomb survivors2017
Author(s)
Hayashi T, Lustig A, Shterev I, Geyer SM, Shi A, Hu Y, Morishita Y, Nagamura H, Hayashi I, Yoshida K, Kyoizumi S, Kusunoki Y, Ohishi W, Nakachi K, Weng NP
Organizer
63rd Annual Meeting of the Radiation Research Society
Related Report
Int'l Joint Research
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[Presentation] Influenza vaccine response in 2011-2013 among Hiroshima atomic-bomb survivors2016
Author(s)
Hayashi T, Lynch HE, Geyer SM, Yoshida K, Furudoi K, Sasaki K, Morishita Y, Nagamura H, Maki M, Hu Y, Hayashi I, Kyoizumi S, Kusunoki Y, Ohishi W, Fujiwara S, Shterev I, Nikolich-Zugich J, Murasko D, Sempowski GD, Nakachi K
Organizer
The 62nd Annual Meeting of Radiation Research Society
Place of Presentation
Waikoloa Village (Big Island, Hawaii, USA)
Year and Date
2016-10-16
Related Report
Int'l Joint Research
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[Presentation] Interaction effects between previous radiation exposure and the frequency of gamma H2AX foci in progenitor functions of circulating hematopoietic stem and progenitor cells among A-bomb survivors2016
Author(s)
Kajimura J, Kyoizumi S, Kubo Y, Misumi M, Yoshida K, Hayashi T, Imai K, Ohishi W, Nakachi K, Weng NP, Young LF, Shieh JH, Moore MA, van den Brink MRM, Kusunoki Y
Organizer
The 62nd Annual Meeting of Radiation Research Society
Place of Presentation
Waikoloa Village (Big Island, Hawaii, USA)
Year and Date
2016-10-16
Related Report
Int'l Joint Research
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[Presentation] Impact of early life exposure in ionizing radiation on influenza vaccine response in an elderly Japanese cohort2016
Author(s)
Lynch HE, Hayashi T, Geyer SM, Yoshida K, Furudoi K, Sasaki K, Morishita Y, Nagamura H, Maki M, Hu Y, Hayashi I, Kyoizumi S, Kusunoki Y, Ohishi W, Fujiwara S, Shterev I, Nikolich-Zugich J, Murasko D, Sempowski GD, Nakachi K
Organizer
International Congress of Immunology 2016
Place of Presentation
Melbourne Convention and Exhibition Centre (Victoria, Australia)
Year and Date
2016-08-21
Related Report
Int'l Joint Research
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[Presentation] Age, smoking, and radiation effects on the production of reactive oxygen species in blood cells of atomic-bomb survivors and their association with immune-related biomarkers2015
Author(s)
Hayashi T, Furukawa K, Ohishi W, Hayashi I, Yoshida K, Kyoizumi S, Kusunoki Y, Nakachi K
Organizer
International Chemical Congress of Pacific Basin Societies 2015
Place of Presentation
Hawaii Convention Center (Hawaii, USA)
Year and Date
2015-12-15
Related Report
Int'l Joint Research
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