Molecular epidemiology study of inflammation-associated disease development on the basis of long-term follow-up of atomic-bomb survivors

• Project/Area Number: 15H04791
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hygiene and public health
• Research Institution: Radiation Effects Research Foundation
• Principal Investigator: HAYASHI Tomonori 公益財団法人放射線影響研究所, 分子生物科学部, 副部長 (70333549)
• Co-Investigator(Kenkyū-buntansha): 徳永 勝士 東京大学, 大学院医学系研究科(医学部), 教授 (40163977) ; 安波 道郎 地方独立行政法人佐賀県医療センター好生館(ライフサイエンス研究所), 疾患ゲノムセンター, 部長 (80244127)
• Co-Investigator(Renkei-kenkyūsha): NAKACHI Kei 公益財団法人 放射線影響研究所, 分子生物科学部, 顧問 (00142117) ; Cologne John 公益財団法人 放射線影響研究所, 統計部, 主任研究員 (50344411) ; YOSHIDA Kengo 公益財団法人 放射線影響研究所, 分子生物科学部, 研究員 (70443596)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000); Fiscal Year 2017: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
• Keywords: ゲノム / 放射線 / 炎症 / 遺伝子多型 / microRNA

Outline of Final Research Achievements

We observed a significant interaction between certain genotype of CHEK2 gene, which is related to DNA damage response, and radiation exposure dose in the increase risk of proximal colon cancer in atomic-bomb survivors. Among 160,000 SNPs, the number of SNPs with P values less than 10-3 related to breast cancer, liver cancer, and colon cancer risks in atomic-bomb survivors were 10, 8, and 12 SNPs, respectively, but there were no SNPs with P values less than 10-6.
As a result of measurement of the membrane type IL-6R (mIL-6R) levels of healthy subjects by IL6R genotypes, the mIL-6R levels of the CD4+ helper T cells of the other genotype group was higher than that of the IL6R-A/A group, and the intracellular O2.- levels were significantly higher.

Research Products

• [Journal Article] Radiation- and Age-associated Changes in Peripheral Blood Dendritic Cell Populations among Aging Atomic Bomb Survivors in Japan (2018)
  • Author(s): Kajimura J, Lynch HE, Geyer S, French B, Yamaoka M, Shterev ID, Sempowski GD, Kyoizumi S, Yoshida K, Misumi M, Ohishi W, Hayashi T, Nakachi K, Kusunoki Y
  • Journal Title: Radiat Res Volume: 189 Pages: 84-94
  • DOI: 10.1667/rr4854
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Influenza Vaccine Response among Hiroshima Atomic-bomb Survivors (2018)
  • Author(s): Hayashi T, Lynch H, Geyer S, French B, Yoshida K, Furudoi K, Sasaki K, Morishita Y, Nagamura H, Maki M, Hu Y, Hayashi I, Kyoizumi S, Kusunoki Y, Ohishi W, Fujiwara S, Shterev I, Nikolich-Zugich J, Murasko D, Sempowski G, Nakachi K
  • Journal Title: Hiroshima Igaku (J Hiroshima Med Assoc) Volume: 71 Pages: 278-281
  • NAID: 40021565426
  • Int'l Joint Research
• [Journal Article] Aging-related changes in human T-cell repertoire over 20 years delineated by deep sequencing of peripheral T-cell receptors (2017)
  • Author(s): Yoshida K, Cologne JB, Cordova K, Misumi M, Yamaoka M, Kyoizumi S, Hayashi T, Robins H, Kusunoki Y.
  • Journal Title: Exp Gerontol Volume: 96 Pages: 29-37
  • DOI: 10.1016/j.exger.2017.05.015
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Fate Decision Between Group 3 Innate Lymphoid and Conventional NK Cell Lineages by Notch Signaling in Human Circulating Hematopoietic Progenitors (2017)
  • Author(s): Kyoizumi S, Kubo Y, Kajimura J, Yoshida K, Hayashi T, Nakachi K, Moore MA, van den Brink MRM, Kusunoki Y
  • Journal Title: J Immunol Volume: 199 Pages: 2777-2793
  • DOI: 10.4049/jimmunol.1601711
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Relationship between spontaneous gammaH2AX foci formation and progenitor functions in circulating hematopoietic stem and progenitor cells among atomic-bomb survivors (2016)
  • Author(s): Kajimura J, Kyoizumi S, Kubo Y, Misumi M, Yoshida K, Hayashi T, Imai K, Ohishi W, Nakachi K, Weng NP, Young LF, Shieh JH, Moore MA, van den Brink MRM, Kusunoki Y
  • Journal Title: Mutat Res-Gen Tox En Volume: 802 Pages: 59-65
  • DOI: 10.1016/j.mrgentox.2016.04.006
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Circulating hematopoietic stem and progenitor cells in aging atomic bomb survivors (2016)
  • Author(s): Kyoizumi S, Kubo Y, Misumi M, Kajimura J, Yoshida K, Hayashi T, Imai K, Ohishi W, Nakachi K, Young LF, Shieh JH, Moore MA, van den Brink MRM, Kusunoki Y
  • Journal Title: Radiat Res Volume: 185 Pages: 69-76
  • DOI: 10.1667/rr14209.1
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Long term effects of radiation exposure on telomere lengths of leukocytes and its associated biomarkers among atomic-bomb survivors (2016)
  • Author(s): Lustig A, Shterev I, Geyer SM, Shi A, Hu Y, Morishita Y, Nagamura H, Sasaki K, Maki M, Hayashi I, Furukawa K, Yoshida K, Kajimura J, Kyoizumi S, Kusunoki Y, Ohishi W, Nakachi K, Weng NP, Hayashi T
  • Journal Title: Oncotarget Journal Volume: 7 Pages: 38988-98
  • DOI: 10.18632/oncotarget.8801
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Acute systemic DNA damage in youth does not impair immune defense with aging (2016)
  • Author(s): Pugh JL, Foster SA, Sukhina AS, Petravic J, Uhrlaub JL, Padilla-Torres J, Hayashi T, Nakachi K, Smithey MJ, Nikolich-Zugich J
  • Journal Title: Aging Cell Volume: 15 Pages: 686-93
  • DOI: 10.1111/acel.12478
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Metabolic profile as a potential modifier of long-term radiation effects on peripheral lymphocyte subsets in atomic bomb survivors (2016)
  • Author(s): Yoshida K, Nakashima E, Kyoizumi S, Hakoda M, Hayashi T, Hida A, Ohishi W, Kusunoki Y
  • Journal Title: Radiat Res Volume: 186 Pages: 275-82
  • DOI: 10.1667/rr14336.1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Long-term effects of radiation exposure and metabolic status on telomere length of peripheral blood T cells in atomic bomb survivors (2016)
  • Author(s): Yoshida K, Misumi M, Kubo Y, Yamaoka M, Kyoizumi S, Ohishi W, Hayashi T, Kusunoki Y
  • Journal Title: Radiat Res Volume: 186 Pages: 367-76
  • DOI: 10.1667/rr14389.1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Long-term effects of radiation exposure on leukocyte telomere lengths and related biomarkers among atomic-bomb survivors (2016)
  • Author(s): Hayashi T, Lustig A, Shterev I, Geyer S, Shi A, Yoshida K, Kajimura J, Hayashi I, Kyoizumi S, Kusunoki Y, Ohishi W, Nakachi K, Weng NP
  • Journal Title: Nagasaki Med J Volume: 91 Pages: 241-5
  • Acknowledgement Compliant
• [Journal Article] Effects of atomic-bomb radiation on human immune responses. Report 28: Hematopoietic stem and progenitor cells circulating in A-bomb survivors (2016)
  • Author(s): Kusunoki Y, Kyoizumi S, Kajimura J, Misumi M, Kubo Y, Yamaoka M, Yoshida K, Hayashi T, Ohishi W, Nakachi K
  • Journal Title: Nagasaki Med J Volume: 91 Pages: 246-51
  • NAID: 40021055548
  • Acknowledgement Compliant
• [Journal Article] Nucleotide excision repair gene ERCC2 and ERCC5 variants increase risk of uterine cervical cancer (2016)
  • Author(s): Joo J, Yoon KA, Hayashi T, Kong SY, Shin HJ, Park B, Kim YM, Hwang SH, Kim J, Shin A, Kim JY
  • Journal Title: Cancer Res Treat Volume: 48 Pages: 708-14
  • DOI: 10.4143/crt.2015.098
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] CD14 and IL18 gene polymorphisms associated with colorectal cancer subsite risks among atomic bomb survivors (2015)
  • Author(s): Hu Y, Yoshida K, Cologne JB, Maki M, Morishita Y, Sasaki K, Hayashi I, Ohishi W, Hida A, Kyoizumi S, Kusunoki Y, Tokunaga K, Nakachi K, Hayashi T
  • Journal Title: Human Genome Variation Volume: 2 Pages: 15035-15035
  • DOI: 10.1038/hgv.2015.35
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Telomere G-tail length is a promising biomarker related to white matter lesions and endothelial dysfunction in patients with cardiovascular risk: A cross-sectional study (2015)
  • Author(s): Nezu T, Hosomi N, Takahashi T, Anno K, Aoki S, Shimamoto A, Maruyama H, Hayashi T, Matsumoto M, Tahara H.
  • Journal Title: EBioMedicine Volume: 2(8) Pages: 958-65
  • DOI: 10.1016/j.ebiom.2015.05.025
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Radiation-associated breast cancer risk and ATM genotypes among atomic-bomb survivors (2015)
  • Author(s): Hayashi T, Hu Y, Yoshida K, Ohishi W, Hida A, Hayashi I, Kyoizumi S, Kusunoki Y, Nakachi K.
  • Journal Title: Hiroshima Medical Journal Volume: 印刷中
  • NAID: 40020843467
  • Acknowledgement Compliant
• [Presentation] Longitudinal study of effects of radiation exposure on leukocyte telomere lengths among atomic-bomb survivors (2017)
  • Author(s): Hayashi T, Lustig A, Shterev I, Geyer SM, Shi A, Hu Y, Morishita Y, Nagamura H, Hayashi I, Yoshida K, Kyoizumi S, Kusunoki Y, Ohishi W, Nakachi K, Weng NP
  • Organizer: 63rd Annual Meeting of the Radiation Research Society
  • Int'l Joint Research
• [Presentation] 原爆被爆者における結腸がんのリスクはCHEK2遺伝子多型に関連している (2017)
  • Author(s): 森下ゆかり、牧 真由美、佐々木圭子、長村浩子、吉田健吾、林 幾江、大石和佳、飛田あゆみ、京泉誠之、安波道郎、徳永勝士、林 奉権
  • Organizer: がん予防学術大会2017大阪
• [Presentation] 広島原爆被爆者のインフルエンザワクチン応答 (2017)
  • Author(s): 林 奉権、Lynch HE、Geyer SM、French B、吉田健吾、古土井圭子、佐々木圭子、森下ゆかり、長村浩子、牧 真由美、胡 軼群、林 幾江、京泉誠之、楠 洋一郎、大石和佳、藤原佐枝子、Shterev I、Nikolich-Zugich J、Murasko D、Sempowski GD、中地 敬
  • Organizer: 第58回 原子爆弾後障害研究会
• [Presentation] CHEK2遺伝子多型および放射線被曝線量に基づく原爆被爆者の放射線関連結腸がんリスク (2017)
  • Author(s): 林 奉権、大石和佳、京泉誠之
  • Organizer: 第76回 日本癌学会学術総会
• [Presentation] ワクチン接種前のＴ細胞頻度、サイトカインレベルとインフルエンザワクチン応答との関係 (2017)
  • Author(s): 林 奉権、吉田健吾、京泉誠之、楠 洋一郎
  • Organizer: 第46回 日本免疫学会学術集会
• [Presentation] 長期保存ホルマリン固定パラフィン包埋甲状腺がん組織から抽出したDNAのゲノムシークエンスへの検討 (2017)
  • Author(s): 林 奉権、藤原 恵、中川英刀、森下ゆかり、佐々木圭子、牧 真由美、長村浩子、藤田征志、Wagner S、Jones K、Hicks B、Chanock SJ、馬淵清彦、小笹晃太郎
  • Organizer: 2017年度生命科学系学会合同年次大会
• [Presentation] 健常成人におけるディープシーケンシングを用いた末梢血T細胞受容体レパトアの縦断的解析 (2016)
  • Author(s): 吉田健吾、林 奉権、京泉誠之、Robins H、楠 洋一郎
  • Organizer: 第45回 日本免疫学会学術集会
  • Place of Presentation: 沖縄コンベンションセンター （沖縄県宜野湾市）
  • Year and Date: 2016-12-05
• [Presentation] 原爆被爆者における末梢血造血前駆細胞の解析 (2016)
  • Author(s): 京泉誠之、久保美子、三角宗近、梶村順子、吉田健吾、林 奉権、今井一枝、大石和佳、中地 敬、Young LF、Shieh JH、Moore MA、van den Brink MRM、楠 洋一郎
  • Organizer: 第59回 日本放射線影響学会
  • Place of Presentation: ＪＭＳアステールプラザ (広島県広島市）
  • Year and Date: 2016-10-26
• [Presentation] 原爆被爆者におけるリンパ球サブセットと代謝指標プロファイルの関連性 (2016)
  • Author(s): 吉田健吾、中島栄二、京泉誠之、箱田雅之、林 奉権、飛田あゆみ、大石和佳、楠 洋一郎
  • Organizer: 第59回 日本放射線影響学会
  • Place of Presentation: ＪＭＳアステールプラザ (広島県広島市）
  • Year and Date: 2016-10-26
• [Presentation] 原爆被爆者の白血球テロメア長に及ぼす放射線被ばくと疾患発祥の長期的影響 (2016)
  • Author(s): 林 奉権、Lustig A、Shterev I、Geyer SM、Shi A、吉田健吾、梶村順子、林 幾江、京泉誠之、楠 洋一郎、大石和佳、中地 敬、Weng NP
  • Organizer: 第59回 日本放射線影響学会
  • Place of Presentation: ＪＭＳアステールプラザ (広島県広島市）
  • Year and Date: 2016-10-26
• [Presentation] Influenza vaccine response in 2011-2013 among Hiroshima atomic-bomb survivors (2016)
  • Author(s): Hayashi T, Lynch HE, Geyer SM, Yoshida K, Furudoi K, Sasaki K, Morishita Y, Nagamura H, Maki M, Hu Y, Hayashi I, Kyoizumi S, Kusunoki Y, Ohishi W, Fujiwara S, Shterev I, Nikolich-Zugich J, Murasko D, Sempowski GD, Nakachi K
  • Organizer: The 62nd Annual Meeting of Radiation Research Society
  • Place of Presentation: Waikoloa Village (Big Island, Hawaii, USA)
  • Year and Date: 2016-10-16
  • Int'l Joint Research
• [Presentation] Interaction effects between previous radiation exposure and the frequency of gamma H2AX foci in progenitor functions of circulating hematopoietic stem and progenitor cells among A-bomb survivors (2016)
  • Author(s): Kajimura J, Kyoizumi S, Kubo Y, Misumi M, Yoshida K, Hayashi T, Imai K, Ohishi W, Nakachi K, Weng NP, Young LF, Shieh JH, Moore MA, van den Brink MRM, Kusunoki Y
  • Organizer: The 62nd Annual Meeting of Radiation Research Society
  • Place of Presentation: Waikoloa Village (Big Island, Hawaii, USA)
  • Year and Date: 2016-10-16
  • Int'l Joint Research
• [Presentation] ATM遺伝子多型および放射線被曝線量に基づく原爆被爆者の乳がんリスク (2016)
  • Author(s): 林 奉権、大石和佳、京泉誠之、楠 洋一郎、中地 敬
  • Organizer: 第75回 日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜 (神奈川県横浜市）
  • Year and Date: 2016-10-06
• [Presentation] Impact of early life exposure in ionizing radiation on influenza vaccine response in an elderly Japanese cohort (2016)
  • Author(s): Lynch HE, Hayashi T, Geyer SM, Yoshida K, Furudoi K, Sasaki K, Morishita Y, Nagamura H, Maki M, Hu Y, Hayashi I, Kyoizumi S, Kusunoki Y, Ohishi W, Fujiwara S, Shterev I, Nikolich-Zugich J, Murasko D, Sempowski GD, Nakachi K
  • Organizer: International Congress of Immunology 2016
  • Place of Presentation: Melbourne Convention and Exhibition Centre （Victoria, Australia)
  • Year and Date: 2016-08-21
  • Int'l Joint Research
• [Presentation] 原爆被爆者における近位結腸がんのリスクはIL18遺伝子多型に関連している (2016)
  • Author(s): 森下ゆかり、Cologne JB、牧 真由美、佐々木圭子、吉田健吾、林 幾江、大石和佳、飛田あゆみ、京泉誠之、楠 洋一郎、徳永勝士、中地 敬、林 奉権
  • Organizer: がん予防学術大会2016
  • Place of Presentation: 名古屋大学鶴舞キャンパス （愛知県名古屋市）
  • Year and Date: 2016-07-01
• [Presentation] Effects of aging, radiation, and genetic background on intracellular ROS levels in human and mice (2016)
  • Author(s): Hayashi T, Yoshida K, Kyoizumi S, Nakachi K, Kusunoki Y
  • Organizer: 13th Japan-Korea Cancer and Aging Symposium
  • Place of Presentation: Ramada Plaza Jeju (Jeju-do, South Korea)
  • Year and Date: 2016-02-25
  • Int'l Joint Research
• [Presentation] Obesity-associated factors and immune homeostasis among atomic-bomb survivors (2016)
  • Author(s): Yoshida K, Nakashima E, Misumi M, Kyoizumi S, Ohishi W, Hayashi T, Kusunoki Y
  • Organizer: 10th AACR-JCA Joint Conference
  • Place of Presentation: Hyatt Regency Maui (Hawaii, USA)
  • Year and Date: 2016-02-16
  • Int'l Joint Research
• [Presentation] 原爆被爆者の免疫及び炎症指標への放射線被ばくの影響 (2016)
  • Author(s): 林 奉権、吉田健吾、林 幾江、梶村順子、京泉誠之、中地 敬、楠 洋一郎
  • Organizer: 第15回 分子予防環境医学研究会
  • Place of Presentation: 自治医科大学 (栃木県下野市）
  • Year and Date: 2016-01-29
  • Invited
• [Presentation] Assessment of breast cancer risk among atomic-bomb surviovrs based on ATM polymorphisms, radiation dose, and age at exposure (2016)
  • Author(s): Hayashi T, Yoshida K, Ohishi W, Kyoizumi S, Kusunoki Y, Nakachi K
  • Organizer: 2016 San Antonio Breast Cancer Symposium
  • Place of Presentation: Henry B. Gonzalez Convention Center (San Antonio, Texas, USA)
  • Int'l Joint Research
• [Presentation] 原爆放射線のヒト免疫応答に及ぼす影響．第28報：原爆被爆者における循環性造血幹細胞と前駆細胞 (2016)
  • Author(s): 楠 洋一郎、京泉誠之、梶村順子、三角宗近、久保美子、山岡美佳、吉田健吾、林 奉権、大石和佳、中地 敬
  • Organizer: 第57回 原子爆弾後障害研究会
  • Place of Presentation: 長崎原爆資料館 (長崎県長崎市)
• [Presentation] 原爆被爆者の白血球テロメア長とそれに関連するバイオマーカーに及ぼす放射線被ばくの長期的影響 (2016)
  • Author(s): 林 奉権、Lustig A、Shterev I、Geyer SM、Shi A、吉田健吾、梶村順子、林 幾江、京泉誠之、楠 洋一郎、大石和佳、中地 敬、Weng NP
  • Organizer: 第57回 原子爆弾後障害研究会
  • Place of Presentation: 長崎原爆資料館 (長崎県長崎市)
• [Presentation] ゲノム解析の経験：遺伝的な近さ、検証およびSNPセット（経路） (2016)
  • Author(s): Cologne JB、三角宗近、林 奉権
  • Organizer: 久留米大学バイオ統計学セミナー
  • Place of Presentation: 久留米大学バイオ統計センター (福岡県久留米市）
• [Presentation] Age, smoking, and radiation effects on the production of reactive oxygen species in blood cells of atomic-bomb survivors and their association with immune-related biomarkers (2015)
  • Author(s): Hayashi T, Furukawa K, Ohishi W, Hayashi I, Yoshida K, Kyoizumi S, Kusunoki Y, Nakachi K
  • Organizer: International Chemical Congress of Pacific Basin Societies 2015
  • Place of Presentation: Hawaii Convention Center (Hawaii, USA)
  • Year and Date: 2015-12-15
  • Int'l Joint Research
• [Presentation] 原爆被爆者と放射線照射マウスにおける血液中炎症関連指標と細胞内活性酸素レベルへの年齢、放射線と遺伝的背景の長期的影響 (2015)
  • Author(s): 林 奉権、吉田健吾、京泉誠之、楠 洋一郎
  • Organizer: 第44回 日本免疫学会学術集会
  • Place of Presentation: 札幌コンベンションセンター （北海道札幌市）
  • Year and Date: 2015-11-18
• [Presentation] IL6R遺伝子多型および放射線被曝線量に基づく原爆被爆者の放射線関連がんリスク (2015)
  • Author(s): 林 奉権、京泉誠之、楠 洋一郎、大石和佳、中地 敬
  • Organizer: 第74回 日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場 （愛知県名古屋市）
  • Year and Date: 2015-10-08
• [Presentation] 原爆被爆者とマウスにおける細胞内活性酸素レベルへの年齢、放射線と遺伝的背景の影響 (2015)
  • Author(s): 林 奉権、吉田健吾、森下ゆかり、佐々木圭子、牧 真由美、長村浩子、古土井圭子、林 幾江、京泉誠之、楠 洋一郎
  • Organizer: 第22回 日本免疫毒性学会学術年会
  • Place of Presentation: 京都大学 (京都府京都市）
  • Year and Date: 2015-09-10
• [Presentation] 原爆被爆者に発生する放射線関連乳がんリスクとATM遺伝子型 (2015)
  • Author(s): 林 奉権、胡 軼群、吉田健吾、大石和佳、飛田あゆみ、林 幾江、京泉誠之、楠 洋一郎、中地 敬
  • Organizer: 第56回 原子爆弾後障害研究会
  • Place of Presentation: 広島国際会議場 （広島県広島市）
  • Year and Date: 2015-06-07
• [Presentation] ATM遺伝子型の機能的意義および原爆被爆者に発生する放射線関連乳がんリスクの遺伝子型別検討 (2015)
  • Author(s): 林 奉権、胡 軼群、吉田健吾、大石和佳、飛田あゆみ、林 幾江、京泉誠之、楠 洋一郎、中地 敬
  • Organizer: がん予防学術大会2015さいたま
  • Place of Presentation: ラフレさいたま (埼玉県さいたま市）
  • Year and Date: 2015-06-05
• [Presentation] Functional significance of IL6R genotypes with special reference to radiation-associated cancer risks among atomic-bomb survivors (2015)
  • Author(s): Hayashi T, Hu Y, Yoshida K, Ohishi W, Hida A, Hayashi I, Kyoizumi S, Kusunoki Y, Nakachi K
  • Organizer: 15th International Congress of Radiation Research
  • Place of Presentation: 国立京都国際会館 (京都府京都市）
  • Year and Date: 2015-05-25
  • Int'l Joint Research
• [Presentation] Relationship between radiation exposure doses and IL7 receptor protein expression levels, based on IL7R genotype (2015)
  • Author(s): Yoshida K, Kusunoki Y, Yamaoka M, Maki M, Hayashi T
  • Organizer: 15th International Congress of Radiation Research
  • Place of Presentation: 国立京都国際会館 (京都府京都市）
  • Year and Date: 2015-05-25
  • Int'l Joint Research
• [Presentation] Radiation effects studies on intracellular ROS levels in atomic-bomb survivors and mice (2015)
  • Author(s): Hayashi T
  • Organizer: 15th International Congress of Radiation Research
  • Place of Presentation: 国立京都国際会館 (京都府京都市）
  • Year and Date: 2015-05-25
  • Int'l Joint Research
• [Presentation] 55年間以上ホルマリン保存した臓器のDNAの断片化の検討 (2015)
  • Author(s): 藤原 恵、坂谷暁夫、林 奉権
  • Organizer: 第104回 日本病理学会総会
  • Place of Presentation: 名古屋国際会議場 (愛知県名古屋市)
  • Year and Date: 2015-04-30
• [Presentation] ATM genotyping modulates the risk of radiation-associated breast cancer among atomic-bomb survivors (2015)
  • Author(s): Hayashi T, Hu Y, Yoshida K, Ohishi W, Hida A, Hayashi I, Kyoizumi S, Kusunoki Y, Nakachi K
  • Organizer: 106th Annual Meeting of the American Association for Cancer Research (AACR)
  • Place of Presentation: Philadelphia （USA)
  • Year and Date: 2015-04-18
  • Int'l Joint Research
• [Remarks] 分子生物科学部ホームページ
  • URL: http://www.rerf.or.jp/dept/radi/index.html