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Next generation type composite antibody therapy for TTR amyloidosis

Research Project

Project/Area Number 15H04841
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionKumamoto University

Principal Investigator

Ando Yukio  熊本大学, 大学院生命科学研究部(医), 教授 (20253742)

Co-Investigator(Kenkyū-buntansha) 池田 徳典  熊本大学, 医学部附属病院, 病院教員 (00613530)
植田 光晴  熊本大学, 医学部附属病院, 講師 (60452885)
三隅 洋平  熊本大学, 大学院生命科学研究部(医), 助教 (80625781)
大林 光念  熊本大学, 大学院生命科学研究部(保), 教授 (90361899)
山下 太郎  熊本大学, 医学部附属病院, 特任教授 (90381003)
田崎 雅義  熊本大学, 大学院生命科学研究部(保), 助教 (50613402)
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2018: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Keywords神経内科 / 家族性アミロイドニューロパチー / トランスサイレチン / 抗体治療 / iPS細胞 / 神経分子病態学 / 神経科学 / 家族性アミロイドニューロパチ― / 免疫療法 / ips細胞
Outline of Final Research Achievements

Although liver transplantation and low molecular weight compounds of tetrameric form stabilizer slow down the progression of familial amyloid polyneuropathy (FAP), significant numbers of the patients are non-responders. In addition, effect of gene silencing therapy, using antisense or siRNA TTR is still unclear. We newly considered the novel therapeutic strategy using next gereration type composite antibody therapy for TTR amyloidosis. On analyses, anti-TTR115-124, and TTR89-97 was effectively broke TTR amyloid fibrils.
To increase the effect, we examined combined administration of those antibodies and iPS derived macrophages. In vitro study revealed that amyloid braking ability was significantly enhanced. Now this project is in Phase I study in the collaboration of American venture company, Prothena.

Academic Significance and Societal Importance of the Research Achievements

様々な問題点のあるFAP治療に対して、これまでの研究実績を元に総合的な免疫療法を根治療法として実用化しようとしてPhase studyまでこぎ着けた画期的な研究である。複数の治療標的や様々な治療手法を組み合わせて検証することで、高い治療効果を持つ免疫療法が確立されつつある。
FAPのみならず種々のアミロイドーシスやタンパク蓄積症においては、実臨床で遭遇する患者はすでに蓄積が起こり症状も進行した状態である。本研究のごとくすでに蓄積したアミロイドも除去しようとする研究は、今後のアミロイドーシスをはじめとするプロテイノパチーに分類される神経疾患の治療研究に多大なインパクトを与えると考えられる。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (187 results)

All 2019 2018 2017 2016 2015 2014 Other

All Int'l Joint Research (1 results) Journal Article (86 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 83 results,  Open Access: 43 results,  Acknowledgement Compliant: 8 results) Presentation (95 results) (of which Int'l Joint Research: 33 results,  Invited: 12 results) Book (4 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Int'l Joint Research] Prothena Biosciences(米国)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Transthyretin Stabilizer Is Associated With Expanding Apical Sparing Area and Improving Global Cardiac Function in a Patient With Wild-Type Cardiac Amyloidosis2019

    • Author(s)
      Kato T, Ikeda N, Maurer MS, Ando Y, Tanno K.
    • Journal Title

      Circulation Journal

      Volume: 83 Issue: 3 Pages: 690

    • DOI

      10.1253/circj.CJ-18-0612

    • NAID

      130007604106

    • ISSN
      1346-9843, 1347-4820
    • Year and Date
      2019-02-25
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Therapeutic Potential of Polyamidoamine Dendrimer for Amyloidogenic Transthyretin Amyloidosis2019

    • Author(s)
      Inoue M, Ueda M, Higashi T, Anno T, Fujisawa K, Motoyama K, Mizuguchi M, Ando Y, Jono H, Arima H.
    • Journal Title

      ACS Chemical Neuroscience

      Volume: 印刷中 Issue: 5 Pages: 2584-2590

    • DOI

      10.1021/acschemneuro.9b00059

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Apolipoprotein E and clusterin inhibit the early phase of amyloid-β aggregation in an in vitro model of cerebral amyloid angiopathy2019

    • Author(s)
      Endo Y, Hasegawa K, Nomura R, Arishima H, Kikuta K, Yamashita T, Inoue Y, Ueda M, Ando Y, Wilson MR, Hamano T, Nakamoto Y, Naiki H.
    • Journal Title

      Acta Neuropathologica Communications

      Volume: 7 Issue: 1 Pages: 12-12

    • DOI

      10.1186/s40478-019-0662-1

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Accumulation of Heparan Sulfate S-Domains in Kidney Transthyretin Deposits Accelerates Fibril Formation and Promotes Cytotoxicity2019

    • Author(s)
      Kameyama H, Uchimura K, Yamashita T, Kuwabara K, Mizuguchi M, Hung SC, Okuhira K, Masuda T, Kosugi T, Ohgita T, Saito H, Ando Y, Nishitsuji K.
    • Journal Title

      The American Journal of Pathology

      Volume: 189 Issue: 2 Pages: 308-319

    • DOI

      10.1016/j.ajpath.2018.09.015

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A novel age-related venous amyloidosis derived from EGF-containing fibulin-like extracellular matrix protein 12019

    • Author(s)
      Tasaki M, Ueda M, Hoshii Y, Mizukami M, Matsumoto S, Nakamura M, Yamashita T, Ueda A, Misumi Y, Masuda T, Inoue Y, Torikai T, Nomura T, Tsuda Y, Kanenawa K, Isoguchi A, Okada M, Matsui H, Obayashi K, Ando Y.
    • Journal Title

      The Journal of Pathology

      Volume: 247 Issue: 4 Pages: 444-455

    • DOI

      10.1002/path.5203

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 【遺伝性心血管疾患のすべて】心筋疾患 心アミロイドーシス2019

    • Author(s)
      三隅洋平,安東由喜雄
    • Journal Title

      医学のあゆみ

      Volume: 268 Pages: 737-742

    • Related Report
      2018 Annual Research Report
  • [Journal Article] siRNAを用いた核酸医薬品の開発状況2019

    • Author(s)
      三隅洋平, 安東由喜雄
    • Journal Title

      Medical Science Digest

      Volume: 45 Pages: 17-20

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] First Nationwide Survey of 199 Patients with Amyloid A Amyloidosis in Japan2018

    • Author(s)
      Okuda Yasuaki、Yamada Toshiyuki、Ueda Mitsuharu、Ando Yukio
    • Journal Title

      Internal Medicine

      Volume: 57 Issue: 23 Pages: 3351-3355

    • DOI

      10.2169/internalmedicine.1099-18

    • NAID

      130007539655

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2018-12-01
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Utility of Single-Photon Emission Computed Tomography/Computed Tomography Fusion Imaging With <sup>99 m</sup>Tc-Pyrophosphate Scintigraphy in the Assessment of Cardiac Transthyretin Amyloidosis2018

    • Author(s)
      Tsuda N, Shiraishi S, Oda S, Ogasawara K, Sakamoto F, Tomiguchi S, Fujisue K, Takashio S, Izumiya Y, Tsujita K, Ando Y, Yamashita Y
    • Journal Title

      Circulation Journal

      Volume: 82 Issue: 7 Pages: 1970-1971

    • DOI

      10.1253/circj.CJ-17-1111

    • NAID

      130007410621

    • ISSN
      1346-9843, 1347-4820
    • Year and Date
      2018-06-25
    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Extreme Adhesion Activity of Amyloid Fibrils Induces Subcutaneous Insulin Resistance2018

    • Author(s)
      Nakamura M, Misumi Y, Nomura T, Oka W, Isoguchi A, Kanenawa K, Masuda T, Yamashita T, Inoue Y, Ando Y, Ueda M.
    • Journal Title

      Diabetes

      Volume: 68 Issue: 3 Pages: 609-616

    • DOI

      10.2337/db18-0846

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Non-Val30Met mutation, septal hypertrophy, and cardiac denervation in patients with mutant transthyretin amyloidosis2018

    • Author(s)
      Hirakawa Kyoko、Takashio Seiji、Marume Kyohei、Yamamoto Masahiro、Hanatani Shinsuke、Yamamoto Eiichiro、Sakamoto Kenji、Izumiya Yasuhiro、Kaikita Koichi、Oda Seitaro、Utsunomiya Daisuke、Shiraishi Shinya、Ueda Mitsuharu、Yamashita Taro、Yamashita Yasuyuki、Ando Yukio、Tsujita Kenichi
    • Journal Title

      ESC Heart Failure

      Volume: 6 Issue: 1 Pages: 122-130

    • DOI

      10.1002/ehf2.12361

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hereditary cardiac amyloidosis associated with Pro24Ser transthyretin mutation: a case report2018

    • Author(s)
      Yamamoto H, Hashimoto T, Kawamura S, Hiroe M, Yamashita T, Ando Y, Yokochi T.
    • Journal Title

      Journal of Medical Case Reports

      Volume: 12 Issue: 1 Pages: 370-370

    • DOI

      10.1186/s13256-018-1931-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of transgenic Caenorhabditis elegans expressing human transthyretin as a model for drug screening2018

    • Author(s)
      Tsuda Yukimoto、Yamanaka Kunitoshi、Toyoshima Risa、Ueda Mitsuharu、Masuda Teruaki、Misumi Yohei、Ogura Teru、Ando Yukio
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 17884-17884

    • DOI

      10.1038/s41598-018-36357-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Origin of sporadic late-onset hereditary ATTR Val30Met amyloidosis in Japan2018

    • Author(s)
      Ueda Mitsuharu、Yamashita Taro、Misumi Yohei、Masuda Teruaki、Ando Yukio
    • Journal Title

      Amyloid

      Volume: 25 Issue: 3 Pages: 143-147

    • DOI

      10.1080/13506129.2018.1531842

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Teaching NeuroImages: Morphology of lumbosacral dorsal root ganglia and plexus in hereditary transthyretin amyloidosis2018

    • Author(s)
      Masuda T, Ueda M, Kitajima M, Morita K, Misumi Y, Yamashita T, Obayashi K, Yamashita Y, Ando Y
    • Journal Title

      Neurology

      Volume: 91 Issue: 19

    • DOI

      10.1212/wnl.0000000000006474

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Two cases of late onset familial amyloid polyneuropathy with a Glu61Lys transthyretin variant2018

    • Author(s)
      Nakano Y, Tadokoro K, Ohta Y, Sato K, Takemoto M, Hishikawa N, Yamashita T, Yamashita T, Ando Y, Abe K.
    • Journal Title

      Journal of the Neurological Sciences

      Volume: 390 Pages: 22-25

    • DOI

      10.1016/j.jns.2018.04.003

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Unwanted road to anemia in transthyretin familial amyloid polyneuropathy may continue irrespective of tafamidis treatment2018

    • Author(s)
      Ikeda T, Masuda T, Ueda M, Yamashita T, Misumi Y, Shinriki S, Ando Y.
    • Journal Title

      Annals of Clinical Biochemistry

      Volume: 印刷中 Issue: 5 Pages: 571-575

    • DOI

      10.1177/0004563218754587

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Late iodine enhancement and myocardial extracellular volume quantification in cardiac amyloidosis by using dual-energy cardiac computed tomography performed on a dual-layer spectral detector scanner.2018

    • Author(s)
      Oda S, Nakaura T, Utsunomiya D, Hirakawa K, Takashio S, Izumiya Y, Tsujita K, Hata H, Ando Y, Yamashita Y
    • Journal Title

      Amyloid

      Volume: 印刷中 Issue: 2 Pages: 137-138

    • DOI

      10.1080/13506129.2018.1424625

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diagnostic utility of cardiac troponin T level in patients with cardiac amyloidosis.2018

    • Author(s)
      Takashio S, Yamamuro M, Izumiya Y, Hirakawa K, Marume K, Yamamoto M, Ueda M, Yamashita T, Ishibashi-Ueda H, Yasuda S, Ogawa H, Ando Y, Anzai T, Tsujita K
    • Journal Title

      ESC Heart Fail

      Volume: 5 Issue: 1 Pages: 27-35

    • DOI

      10.1002/ehf2.12203

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Selection of DNA aptamer that blocks the fibrillogenesis of a proteolytic amyloidogenic fragment of β2 m.2018

    • Author(s)
      Fukasawa K, Higashimoto Y, Ando Y, Motomiya Y
    • Journal Title

      Ther Apher Dial

      Volume: 22 Issue: 1 Pages: 61-66

    • DOI

      10.1111/1744-9987.12591

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] In vitro and in vivo siRNA delivery to hepatocyte utilizing ternary complexation of lactosylated dendrimer/cyclodextrin conjugates, siRNA and low-molecular-weight sacran2018

    • Author(s)
      Hayashi Yuya、Higashi Taishi、Motoyama Keiichi、Jono Hirofumi、Ando Yukio、Arima Hidetoshi
    • Journal Title

      International Journal of Biological Macromolecules

      Volume: 107 Pages: 1113-1121

    • DOI

      10.1016/j.ijbiomac.2017.09.085

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genetic and clinical characteristics of hereditary transthyretin amyloidosis in endemic and non-endemic areas: experience from a single-referral center in Japan.2018

    • Author(s)
      Yamashita T, Ueda M, Misumi Y, Masuda T, Nomura T, Tasaki M, Takamatsu K, Sasada K, Obayashi K, Matsui H, Ando Y.
    • Journal Title

      Journal of Neurology

      Volume: 265 Issue: 1 Pages: 134-140

    • DOI

      10.1007/s00415-017-8640-7

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nationwide Survey of 741 Patients with Systemic Amyloid Light-chain Amyloidosis in Japan2018

    • Author(s)
      Shimazaki C, Hata H, Iida S, Ueda M, Katoh N, Sekijima Y, Ikeda S, Yazaki M, Fukushima W, Ando Y
    • Journal Title

      Internal Medicine

      Volume: 57 Issue: 2 Pages: 181-187

    • DOI

      10.2169/internalmedicine.9206-17

    • NAID

      130006309174

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 手根管症候群に潜む疾患の鑑別と治療 TTR-FAP:トランスサイレチン型家族性アミロイドポリニューロパチー2018

    • Author(s)
      山下太郎, 植田光晴, 安東由喜雄
    • Journal Title

      末梢神経

      Volume: 29 Pages: 224-231

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 神経アミロイドーシスのすべて 2017年診療ガイドライン2018

    • Author(s)
      増田曜章, 安東由喜雄
    • Journal Title

      神経治療学

      Volume: 35 Pages: 174-178

    • NAID

      130006201120

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 家族性アミロイドポリニューロパチーと自律神経障害2018

    • Author(s)
      増田曜章, 安東由喜雄
    • Journal Title

      自律神経

      Volume: 55 Pages: 81-84

    • NAID

      10031183951

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] アミロイドーシスの最近の知見2018

    • Author(s)
      山下太郎, 安東由喜雄
    • Journal Title

      皮膚病診療

      Volume: 40 Pages: 1086-1092

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 遺伝性ニューロパチー 家族性アミロイドポリニューロパチー2018

    • Author(s)
      植田光晴, 安東由喜雄
    • Journal Title

      Clinical Neuroscience

      Volume: 36 Pages: 1075-1079

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] トランスサイレチンフラグメントのアミロイド形成および細胞毒性の解析2018

    • Author(s)
      植田光晴, 三隅洋平, 増田曜章, 津田幸元, 井上泰輝, 野村隼也, 山下太郎, 安東由喜雄
    • Journal Title

      末梢神経

      Volume: 29 Pages: 42-49

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 主要疾患としびれ感、その対応 アミロイドニューロパチー2018

    • Author(s)
      三隅洋平, 安東由喜雄
    • Journal Title

      Clinical Neuroscience

      Volume: 36 Pages: 464-466

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diagnosis and management of transthyretin familial amyloid polyneuropathy in Japan: red-flag symptom clusters and treatment algorithm.2018

    • Author(s)
      Sekijima Y, Ueda M, Koike H, Misawa S, Ishii T, Ando Y
    • Journal Title

      Orphanet J Rare Dis

      Volume: 13 Issue: 1 Pages: 6-6

    • DOI

      10.1186/s13023-017-0726-x

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 家族性アミロイドポリニューロパチー.2018

    • Author(s)
      安東 由喜雄
    • Journal Title

      今日の治療指針

      Volume: 60 Pages: 960-961

    • Related Report
      2017 Annual Research Report
  • [Journal Article] A multicenter cross sectional study for bone-articular lesions associated with dialysis related amyloidosis in Japan.2017

    • Author(s)
      Nishi S, Hoshino J, Yamamoto S, Goto S, Fuji H, Ubara Y, Motomiya Y, Morita H, Takaichi K, Yamagata K, Shigematsu T, Ueda M, Ando Y
    • Journal Title

      Nephrology

      Volume: 印刷中 Issue: 7 Pages: 640-645

    • DOI

      10.1111/nep.13077

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] First nationwide survey on systemic wild-type ATTR amyloidosis in Japan2017

    • Author(s)
      Sekijima Y、Yazaki M、Ueda M、Koike H、Yamada M、Ando Y
    • Journal Title

      Amyloid

      Volume: 25 Issue: 1 Pages: 8-10

    • DOI

      10.1080/13506129.2017.1409706

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Light Chain Deposition Disease Diagnosed with Laser Micro-dissection, Liquid Chromatography, and Tandem Mass Spectrometry of Nodular Glomerular Lesions2017

    • Author(s)
      Kasagi T, Nobata H, Suzuki K, Miura N, Banno S, Takami A, Yamashita T, Ando Y, Imai H
    • Journal Title

      Internal Medicine

      Volume: 56 Issue: 1 Pages: 61-66

    • DOI

      10.2169/internalmedicine.56.7275

    • NAID

      130005239485

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinicopathological and biochemical findings of thyroid amyloid in hereditary transthyretin amyloidosis with and without liver transplantation.2017

    • Author(s)
      Huang G, Ueda M, Tasaki M, Yamashita T, Misumi Y, Masuda T, Suenaga G, Inoue Y, Kinoshita Y, Matsumoto S, Mizukami M, Tsuda Y, Nomura T, Obayashi K, Ando Y
    • Journal Title

      Amyloid

      Volume: 印刷中 Issue: 1 Pages: 1-6

    • DOI

      10.1080/13506129.2016.1276440

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification and Assessment of Cardiac Amyloidosis by Myocardial Strain Analysis of Cardiac Magnetic Resonance Imaging2017

    • Author(s)
      Oda S, Utsunomiya D, Nakaura T, Yuki H, Kidoh M, Morita K, Takashio S, Yamamuro M, Izumiya Y, Hirakawa K, Ishida T, Tsujita K, Ueda M, Yamashita T, Ando Y, Hata H, Yamashita Y
    • Journal Title

      Circulation Journal

      Volume: 81 Issue: 7 Pages: 1014-1021

    • DOI

      10.1253/circj.CJ-16-1259

    • NAID

      130006887042

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Novel screening for transthyretin amyloidosis by using fat ultrasonography.2017

    • Author(s)
      Misumi Y, Ueda M, Yamashita T, Masuda T, Kinoshita Y, Tasaki M, Nagase T, Ando Y
    • Journal Title

      Ann Neurol

      Volume: 印刷中 Issue: 4 Pages: 604-608

    • DOI

      10.1002/ana.24914

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A novel transthyretin variant V28S (p.V48S) with a double-nucleotide substitution in the same codon.2017

    • Author(s)
      Okada M, Misumi Y, Ueda M, Yamashita T, Masuda T, Tasaki M, Ando Y.
    • Journal Title

      Amyloid

      Volume: 24 Issue: 4 Pages: 231-232

    • DOI

      10.1080/13506129.2017.1381082

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early skin denervation in hereditary and iatrogenic transthyretin amyloid neuropathy.2017

    • Author(s)
      Masuda T, Ueda M, Suenaga G, Misumi Y, Tasaki M, Izaki A, Yanagisawa Y, Inoue Y, Motokawa H, Matsumoto S, Mizukami M, Arimura A, Deguchi T, Nishio Y, Yamashita T, Inomata Y, Obayashi K, Ando Y
    • Journal Title

      Neurology

      Volume: 88 Issue: 23 Pages: 2192-2197

    • DOI

      10.1212/wnl.0000000000004016

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inflammatory state exists in familial amyloid polyneuropathy that may be triggered by mutated transthyretin.2017

    • Author(s)
      Suenaga G, Ikeda T, Masuda T, Motokawa H, Yamashita T, Takamatsu K, Misumi Y, Ueda M, Matsui H, Senju S, Ando Y.
    • Journal Title

      Sci. Rep

      Volume: 7(1) Issue: 1 Pages: 1579-2017

    • DOI

      10.1038/s41598-017-01775-4

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sushi repeat-containing protein 1: a novel disease-associated molecule in cerebral amyloid angiopathy.2017

    • Author(s)
      Inoue Y, Ueda M, Tasaki M, Takeshima A, Nagatoshi A, Masuda T, Misumi Y, Kosaka T, Nomura T, Mizukami M, Matsumoto S, Yamashita T, Takahashi H, Kakita A, Ando Y.
    • Journal Title

      Acta Neuropathologica

      Volume: 134 Issue: 4 Pages: 605-617

    • DOI

      10.1007/s00401-017-1720-z

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cardiovascular magnetic resonance myocardial T1 mapping to detect and quantify cardiac involvement in familial amyloid polyneuropathy.2017

    • Author(s)
      Oda S, Utsunomiya D, Morita K, Nakaura T, Yuki H, Kidoh M, Hirata K, Taguchi N, Tsuda N, Shiraishi S, Namimoto T, Hirakawa K, Takashio S, Izumiya Y, Yamamuro M, Hokimoto S, Tsujita K, Ueda M, Yamashita T, Ando Y, Yamashita Y
    • Journal Title

      Eur Radiol

      Volume: 27(11) Issue: 11 Pages: 4631-4638

    • DOI

      10.1007/s00330-017-4845-5

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A late-onset case of hereditary transthyretin amyloidosis with a novel compound heterozygous mutation.2017

    • Author(s)
      Matsumoto S, Ueda M, Yamashita T, Amano T, Misumi Y, Tasaki M, Masuda T, Mizukami M, Furuya H, Ando Y
    • Journal Title

      Amyloid

      Volume: 24 Issue: sup1 Pages: 97-98

    • DOI

      10.1080/13506129.2017.1286585

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of amyloid precursor protein from autopsy and biopsy specimens using LMD-LC-MS/MS: the experience at Kumamoto University.2017

    • Author(s)
      Tasaki M, Ueda M, Obayashi K, Kinoshita Y, Matsumoto S, Mizukami M, Masuda T, Misumi Y, Yamashita T, Ando Y
    • Journal Title

      Amyloid

      Volume: 24 Issue: sup1 Pages: 167-168

    • DOI

      10.1080/13506129.2017.1286583

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] In vitro and in vivo assessment of novel derivatives for detecting various amyloid deposits.2017

    • Author(s)
      Izaki A, Obayashi K, Suenaga G, Ueda M, Yamashita T, Tasaki M, Yanagisawa Y, Masuda T, Misumi Y, Ando Y
    • Journal Title

      Amyloid

      Volume: 24 Issue: sup1 Pages: 17-17

    • DOI

      10.1080/13506129.2017.1287070

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A case with a novel variant transthyretin A36D presenting cardiac phenotype.2017

    • Author(s)
      Nomura T, Yamashita T, Misumi Y, Ueda M, Masuda T, Tasaki M, Ando Y
    • Journal Title

      Amyloid

      Volume: 24 Issue: sup1 Pages: 100-100

    • DOI

      10.1080/13506129.2017.1287072

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Iatrogenic systemic transthyretin amyloid deposits in a case with domino liver transplantation: an autopsy case study.2017

    • Author(s)
      Tsuda Y, Misumi Y, Ueda M, Tasaki M, Huang G, Masuda T, Suenaga G, Kinoshita Y, Obayashi K, Yamashita T, Ando Y
    • Journal Title

      Amyloid

      Volume: 24 Issue: sup1 Pages: 125-125

    • DOI

      10.1080/13506129.2017.1287071

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antibody therapy for transthyretin-related hereditary amyloid polyneuropathy: another therapeutic option.2017

    • Author(s)
      Ando Y, Ueda M
    • Journal Title

      Amyloid

      Volume: 24 Issue: sup1 Pages: 113-114

    • DOI

      10.1080/13506129.2017.1293514

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term effects of liver transplantation on small-fiber dysfunction in Japanese transthyretin (ATTR) V30M hereditary amyloidosis with polyneuropathy (FAP).2017

    • Author(s)
      Obayashi K, Ueda M, Yamashita T, Tasaki M, Izaki A, Yanagisawa Y, Masuda T, Misumi Y, Ando Y
    • Journal Title

      Amyloid

      Volume: 24 Issue: sup1 Pages: 99-99

    • DOI

      10.1080/13506129.2017.1286586

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hereditary transthyretin amyloidosis associated with a transthyretin variant Thr59Arg2017

    • Author(s)
      Watanabe T, Obayashi K, Misumi Y, Tasaki M, Shinriki S, Ando T, Akagami T, Ueda M, Yamashita T, Hirotani S, Ando Y.
    • Journal Title

      Amyloid

      Volume: 24 Issue: sup1 Pages: 119-119

    • DOI

      10.1080/13506129.2017.1294057

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Disruption of blood-nerve barriers in hereditary transthyretin (ATTR) amyloidosis.2017

    • Author(s)
      Koike H, Ikeda S, Takahashi M, Kawagashira Y, Iijima M, Misumi Y, Ando Y, Ikeda SI, Katsuno M, Sobue G
    • Journal Title

      Amyloid

      Volume: 24(suppl) Issue: sup1 Pages: 89-90

    • DOI

      10.1080/13506129.2017.1278691

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinicopathological and biochemical findings of late-onset hereditary transthyretin amyloidosis 16 years after liver transplantation: an autopsy case study.2017

    • Author(s)
      Mizukami M, Ueda M, Tasaki M, Misumi Y, Masuda T, Matsumoto S, Yamashita T, Ando Y
    • Journal Title

      Amyloid

      Volume: 24 Issue: sup1 Pages: 122-122

    • DOI

      10.1080/13506129.2017.1295941

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinicopathological characteristics of a patient with ureteral amyloidosis.2017

    • Author(s)
      Yanagisawa Y, Obayashi K, Tasaki M, Izaki A, Masuda T, Misumi Y, Ueda M, Yamashita T, Ando Y
    • Journal Title

      Amyloid

      Volume: 24 Issue: sup1 Pages: 101-101

    • DOI

      10.1080/13506129.2017.1287696

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of a diagnostic center for amyloidosis in Japan by Kumamoto University.2017

    • Author(s)
      Yamashita T, Ueda M, Tasaki M, Masuda T, Misumi Y, Takamatsu K, Obayashi K, Ando Y
    • Journal Title

      Amyloid

      Volume: 24 Issue: sup1 Pages: 169-170

    • DOI

      10.1080/13506129.2017.1295951

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of deposited peptides in amyloid lesions of AL amyloidosis by mass spectrometry2017

    • Author(s)
      杉本 俊哉, 田﨑 雅義,山下 太郎,植田 光晴,安東 由喜雄,大林 光念,奥野 豊,畑 裕之
    • Journal Title

      Rinsho Ketsueki

      Volume: 58 Issue: 6 Pages: 589-594

    • DOI

      10.11406/rinketsu.58.589

    • NAID

      130005709603

    • ISSN
      0485-1439, 1882-0824
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The interface between the immune system and autonomic nervous system2017

    • Author(s)
      Nakane S, Mukaino A, Ando Y.
    • Journal Title

      Japanese Journal of Clinical Immunology

      Volume: 40 Issue: 5 Pages: 352-360

    • DOI

      10.2177/jsci.40.352

    • NAID

      130006251922

    • ISSN
      0911-4300, 1349-7413
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 家族性アミロイドポリニューロパチーの臨床と治療.2017

    • Author(s)
      安東 由喜雄
    • Journal Title

      最新医学

      Volume: 72(8) Pages: 1193-1199

    • NAID

      40021294268

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] タファミジス:遺伝性トランスサイレチンアミロイドーシスに対する蛋白質安定化剤.2017

    • Author(s)
      山下 太郎, 安東 由喜雄
    • Journal Title

      心臓(日本医学出版・日本循環器学会)Heart’s Selection特集 循環器領域における代謝性疾患に対する新薬

      Volume: 49(5) Pages: 428-443

    • NAID

      130006736197

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] トランスサイレチン(ATTR)型脳アミロイド血管症/軟膜アミロイドーシス.2017

    • Author(s)
      山下 太郎, 安東 由喜雄
    • Journal Title

      日本神経治療学会 標準的神経治療 アミロイドーシス

      Volume: 印刷中

    • Related Report
      2017 Annual Research Report
  • [Journal Article] アミロイドーシスを疑う臨床症状と症候.2017

    • Author(s)
      山下 太郎, 安東 由喜雄
    • Journal Title

      医学のあゆみ 医歯薬出版株式会社. 別冊

      Volume: 印刷中 Pages: 33-40

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] アミロイド蛋白質の免疫組織化学的・蛋白質化学的同定法.2017

    • Author(s)
      植田光晴・安東由喜雄
    • Journal Title

      医学のあゆみ 医歯薬出版株式会社. 別冊

      Volume: 印刷中 Pages: 41-45

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 遺伝性ATTR型脳アミロイド血管症/家族性ATTR型眼軟膜アミロイドーシスの臨床像.2017

    • Author(s)
      山下 太郎, 安東 由喜雄
    • Journal Title

      神経内科

      Volume: 88(3) Pages: 305-310

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A clinical evaluation of renal amyloidosis in the Japan renal biopsy registry: a cross-sectional study.2017

    • Author(s)
      Nishi S, Muso E, Shimizu A, Sugiyama H, Yokoyama H, Ando Y, Goto S, Fujii H
    • Journal Title

      Clin Exp Nephrol

      Volume: 印刷中 Issue: 4 Pages: 624-632

    • DOI

      10.1007/s10157-016-1326-0

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Knee osteoarthritis associated with different kinds of amyloid deposits and the impact of aging on type of amyloid.2016

    • Author(s)
      Yanagisawa A, Ueda M, Sueyoshi T, Nakamura E, Tasaki M, Suenaga G, Motokawa H, Toyoshima R, Kinoshita Y, Misumi Y, Yamashita T, Sakaguchi M, Westermark P, Mizuta H, Ando Y.
    • Journal Title

      Amyloid

      Volume: 23 Issue: 1 Pages: 26-32

    • DOI

      10.3109/13506129.2015.1115758

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Labial salivary gland biopsy for diagnosing immunoglobulin light chain amyloidosis: a retrospective analysis.2016

    • Author(s)
      Suzuki T, Kusumoto S, Yamashita T, Masuda A, Kinoshita S, Yoshida T, Takami-Mori F, Takino H, Ito A, Ri M, Ishida T, Komatsu H, Ueda M, Ando Y, Inagaki H, Iida S.
    • Journal Title

      Annals of Hematology

      Volume: 95 (2) Issue: 2 Pages: 279-285

    • DOI

      10.1007/s00277-015-2549-y

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long-term outcome of patients with hereditary transthyretin V30M amyloidosis with polyneuropathy after liver transplantation.2016

    • Author(s)
      Okumura K, Yamashita T, Masuda T, Misumi Y, Ueda A, Ueda M, Obayashi K, Jono H, Yamashita S, Inomata Y, Ando Y.
    • Journal Title

      Amyloid

      Volume: 23 Issue: 1 Pages: 39-45

    • DOI

      10.3109/13506129.2015.1123149

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phase 1 study of bortezomib in combination with melphalan and dexamethasone in Japanese patients with relapsed AL amyloidosis.2016

    • Author(s)
      Shimazaki C, Fuchida S, Suzuki K, Ishida T, Imai H, Sawamura M, Takamatsu H, Abe M, Miyamoto T, Hata H, Yamada M, Ando Y
    • Journal Title

      Int J Hematol

      Volume: 103 Issue: 1 Pages: 79-85

    • DOI

      10.1007/s12185-015-1901-2

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effects of tafamidis treatment on transthyretin (TTR) stabilization, efficacy, and safety in Japanese patients with familial amyloid polyneuropathy (TTR-FAP) with Val30Met and non-Varl30Met: A phase III, open-label study.2016

    • Author(s)
      Ando Y, Sekijima Y, Obayashi K, Yamashita T, Ueda M, Misumi Y, Morita H, Machii K, Ohta M, Takata A, Ikeda S.
    • Journal Title

      J Neurol Sci

      Volume: 362 Pages: 266-271

    • DOI

      10.1016/j.jns.2016.01.046

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transthyretin-related familial amyloidotic polyneuropathy found with abnormal urinalysis at a general health checkup.2016

    • Author(s)
      Yoshimura Y, Kuwabara T, Shiraishi N, Kakizoe Y, Tasaki M, Obayashi K, Ando Y, Mukoyama M.
    • Journal Title

      Nephrology

      Volume: 21 Issue: 4 Pages: 341-2

    • DOI

      10.1111/nep.12610

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Endoscopic Findings of Small-Bowel Lesions in Familial Amyloid Polyneuropathy: A Case Report.2016

    • Author(s)
      Asakura K, Yanai S, Nakamura S, Kawaski K, Eizuka M, Ishida K, Sugai T, Ueda M, Yamashita T, Ando Y, Matsumoto T.
    • Journal Title

      Medicine (Baltimore)

      Volume: 95(11) Issue: 11 Pages: e2896-e2896

    • DOI

      10.1097/md.0000000000002896

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sources of variation of transthyretin in healthy subjects in East and Southeast Asia: Clinical and experimental evidence for the effect of alcohol on transthyretin metabolism.2016

    • Author(s)
      Jono H, Su Y, Obayashi K, Tanaka Y, Ishiguro A, Nishimura H, Shinriki S, Ueda M, Ikeda K, Yamagata K, Ichihara K, Ando Y; Scientific Committee for the Asia-Pacific Federation of Clinical Biochemistry.
    • Journal Title

      Clin Chim Acta

      Volume: 458 Pages: 240-5

    • DOI

      10.1016/j.cca.2016.04.011

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hereditary amyloidosis with cardiomyopathy caused by the novel variant transthyretin A36D.2016

    • Author(s)
      Yamashita T, Ueda M, Saga N, Nanto K, Tasaki M, Masuda T, Misumi Y, Oda S, Fujimoto A, Amano T, Takamatsu K, Yamashita S, Obayashi K, Matsui H, Ando Y.
    • Journal Title

      Amyloid

      Volume: in press Issue: 3 Pages: 207-208

    • DOI

      10.1080/13506129.2016.1202228

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of macrophages in the pathogenesis of familial amyloid polyneuropathy and efficacy of human iPS cell-derived macrophages in its treatment.2016

    • Author(s)
      Suenaga G, Ikeda T, Komohara Y, Takamatsu K, Kakuma T, Tasaki M, Misumi Y, Ueda M, Ito T, Senju S, Ando Y
    • Journal Title

      PLoS One

      Volume: 11 Issue: 10 Pages: e0163944-e0163944

    • DOI

      10.1371/journal.pone.0163944

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Novel antibody for the treatment of transthyretin amyloidosis.2016

    • Author(s)
      Hosoi A, Su Y, Torikai M, Jono H, Ishikawa D, Soejima K, Higuchi H, Guo J, Ueda M, Suenaga G, Motokawa H, Ikeda T, Senju S, Nakashima T, Ando Y
    • Journal Title

      J Biol Chem

      Volume: 25 Issue: 48 Pages: 25096-25105

    • DOI

      10.1074/jbc.m116.738138

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Schwann cell and endothelial cell damage in transthyretin familial amyloid polyneuropathy.2016

    • Author(s)
      Koike H, Ikeda S, Takahashi M, Kawagashira Y, Iijima M, Misumi Y, Ando Y, Ikeda SI, Katsuno M, Sobue G
    • Journal Title

      Neurology

      Volume: 87 Issue: 21 Pages: 2220-2229

    • DOI

      10.1212/wnl.0000000000003362

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influence of heparin molecular size on the induction of C- terminal unfolding in β2-microglobulin.2016

    • Author(s)
      Fukasawa K, Higashimoto Y, Motomiya Y, Uji Y, Ando Y
    • Journal Title

      Mol Biol Res Commun

      Volume: 5 Pages: 225-232

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Rapid detection of wild-type and mutated transthyretins.2015

    • Author(s)
      Tasaki M, Ueda M, Obayashi K, Motokawa H, Kinoshita Y, Suenaga G, Yanagisawa A, Toyoshima R, Misumi Y, Masuda T, Yamashita T, Ando Y
    • Journal Title

      Annals of Clinical Biochemistry

      Volume: epub Issue: 4 Pages: 508-510

    • DOI

      10.1177/0004563215605541

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recipient Aging Accelerates Acquired Transthyretin Amyloidosis After Domino Liver Transplantation.2015

    • Author(s)
      Misumi Y., Narita Y., Oshima T., Ueda M., Yamashita T., Tasaki M., Obayashi K., Isono K., Inomata Y., Ando Y.
    • Journal Title

      Liver Transpl

      Volume: 22(5) Issue: 5 Pages: 656-664

    • DOI

      10.1002/lt.24371

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evolving landscape in the management of transthyretin amyloidosis.2015

    • Author(s)
      Hawkins PN., Ando Y., Dispenzeri A., Gonzalez-Duarte A., Adams D., Suhr OB.
    • Journal Title

      Ann Med

      Volume: 47(8) Issue: 8 Pages: 625-638

    • DOI

      10.3109/07853890.2015.1068949

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Two brothers homozygous for the TTR V30M both presenting with a phenotype dominated by central nervous complications.2015

    • Author(s)
      Uchida Y, Takada K, Tsugu Y, Ueda M, Yamashita T, Ando Y, Kobayashi S, Koike H, Watanabe T, Matsumoto T, Toyoda T, Yamada G, Matsukawa N.
    • Journal Title

      Amyloid

      Volume: 22 Issue: 4 Pages: 261-262

    • DOI

      10.3109/13506129.2015.1104661

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of insulin amyloid fibril formation by cyclodextrins.2015

    • Author(s)
      Kitagawa K, Misumi Y, Ueda M, Hayashi Y, Tasaki M, Obayashi K, Yamashita T, Jono H, Arima H, Ando Y.
    • Journal Title

      Amyloid

      Volume: 22 Issue: 3 Pages: 181-186

    • DOI

      10.3109/13506129.2015.1064818

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of liver transplantation and tafamidis in hereditary transthyretin amyloidosis caused by transthyretin Leu55Pro mutation; a case report.2015

    • Author(s)
      Kon T., Misumi Y., Nishijima H., Honda M., Suzuki C., Baba M., Inomata Y., Obayashi K., Ando Y., Tomiyama M.
    • Journal Title

      Amyloid

      Volume: 22(3) Issue: 3 Pages: 203-204

    • DOI

      10.3109/13506129.2015.1031373

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Discovery of γ-Mangostin as an Amyloidogenesis Inhibitor.2015

    • Author(s)
      Yokoyama T, Ueda M, Ando Y, Mizuguchi M.
    • Journal Title

      Sci Rep

      Volume: 5 Issue: 1 Pages: 13570-13570

    • DOI

      10.1038/srep13570

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Wild-type ATTR amyloidosis of the ureter in a 56-year-old woman with rheumatoid arthritis and Sj&ouml;gren’s syndrome.2015

    • Author(s)
      Shinoda K., Taki H., Obayashi K., Ando Y., Watanabe A., Komiya A., Fuse H., Tsuneyama K., Tobe K.
    • Journal Title

      Int J Clin Exp Pathol

      Volume: 8(7) Pages: 8624-8427

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Liver transplantation for hereditary transthyretin amyloidosis: After 20 years still the best therapeutic alternative?2014

    • Author(s)
      Ericzon BG
    • Journal Title

      Transplantation

      Volume: - Issue: 9 Pages: 1847-1854

    • DOI

      10.1097/tp.0000000000000574

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 循環器症状を伴う末梢神経障害疾患 TTR-FAPを見逃さない2019

    • Author(s)
      安東由喜雄
    • Organizer
      第83回日本循環器学会学術集会ファイアサイドセミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] アミロイドーシスのすべて-2017年診療ガイドライン2018

    • Author(s)
      安東由喜雄
    • Organizer
      日本神経学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 治す神経難病の実践2018

    • Author(s)
      安東由喜雄
    • Organizer
      第45回メトロポリタンニューロサイエンスクラブ(MNC)
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 治す神経難病の実践-アミロイドニューロパチー2018

    • Author(s)
      安東由喜雄
    • Organizer
      第4回Nagoya Neurology Forum
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 見逃してはいけない日常診療に潜むアミロイーシス ~Red-flagによるTTR-FAP鑑別診断~2018

    • Author(s)
      安東由喜雄
    • Organizer
      第36回日本神経治療学会学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] アミロイドーシスが引き起こす様々なニューロパチーの最新の知見2018

    • Author(s)
      安東由喜雄
    • Organizer
      第224回日本神経学会九州地方会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Correlation of heart rate variability analysis and MIBG myocardial scintigraphy in patients with PD2018

    • Author(s)
      Nakahara K, Nakane S, Ando Y
    • Organizer
      The XVIth International Symposium on Amyloidosis
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Quantification of skin denervation in patients with transthyretin amyloid neuropathy2018

    • Author(s)
      Masuda T, Ueda M, Misumi Y, Matsumoto S, Nomura T, Tasaki M, Yamashita T, Sonoda Y, Obayashi K, Ando Y
    • Organizer
      The XVIth International Symposium on Amyloidosis
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Pupillary autonomic dysfunction as an early bioker in patients with hereditary transthyretin amyloidosis2018

    • Author(s)
      Masuda T, Ueda M, Nagatoshi C, Misumi Y, Nomura T, Tasaki M, Yamashita T, Obayashi K, Ando Y
    • Organizer
      The XVIth International Symposium on Amyloidosis
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Two siblings with hereditary transthyretin amyloidosis: a rare TTR variant T49S (pT69S)2018

    • Author(s)
      Masataka Y, Masuda T, Yamashita T, Ueda M, Misumi Y, Ando T, Masuyama T, Ando Y
    • Organizer
      The XVIth International Symposium on Amyloidosis, , ,
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A transgenic Caenorhabditis elegans expressing transthyretin as a model in transthyretin amyloidosis2018

    • Author(s)
      Tsuda Y, Ueda M, Yamanaka K, Masuda T, Misumi Y, Ogura T, Ando Y
    • Organizer
      The XVIth International Symposium on Amyloidosis
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] DNA aptamer raised against the C-terminal domain of β2-microglobulin inhibits the fibrillogenesis of ⊿N6β2m2018

    • Author(s)
      Tsuda Y, Higashimoto Y, Fukasawa K, Motomiya Y, Ando Y
    • Organizer
      The XVIth International Symposium on Amyloidosis
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Rapid detection of mutated transthyretin using direct MALDI-TOF MS.2018

    • Author(s)
      Nomura T, Ueda M, Matsumoto S, Mizukami M, Nakamura M, Kanenawa K, Tsuda Y, Inoue Y, Masuda T, Misumi Y, Yamashita T, Ando Y
    • Organizer
      The XVIth International Symposium on Amyloidosis
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analyses of prostatic corpora amylacea2018

    • Author(s)
      Kanenawa K, Ueda M, Matsumoto S, Mizukami M, Isoguchi A, Yamamoto S, Tsuda Y, Misumi Y, Masuda T, Obayashi K, Yamashita T, Ando Y
    • Organizer
      The XVIth International Symposium on Amyloidosis
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Transthyretin Fragments in Peripheral Blood Cells2018

    • Author(s)
      Matsumoto S, Ueda M, Tasaki M, Misumi Y, Masuda T, Mizukami M, Kanenawa K, Nakamura M, Obayashi K, Yamashita T, Ando Y
    • Organizer
      The XVIth International Symposium on Amyloidosis
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mechanism of the insulin resistance at the site of insulin amyloidoma2018

    • Author(s)
      Nakamura M, Misumi Y, Oka W, Nomura T, Mizukami M, Matsumoto S, Ueda M, Yamashita T, Ando Y
    • Organizer
      The XVIth International Symposium on Amyloidosis
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Genetical and geographical features of hereditary transthyretin amyloidosis in2018

    • Author(s)
      Yamashita T, Ueda M, Misumi Y, Masuda T, Nomura T, Tasaki M, Takamatsu K, Sasada K, Obayashi K, Matsui H, Ando Y
    • Organizer
      The XVIth International Symposium on Amyloidosis
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Is liver transplantation effective for non-V30M hereditary transthyretin amyloidosis ? The XVIth International Symposium on Amyloidosis2018

    • Author(s)
      Yamashita T, Ueda M, Nomura T, Tsuda Y, Inoue Y, Masuda T, Misumi Y, Takamatsu K, Obayashi K, Ando Y
    • Organizer
      The XVIth International Symposium on Amyloidosis
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Tafamidis or transplantation of the liver: Which should be chosen for hereditary transthyretin amyloidosis?2018

    • Author(s)
      Yamashita T, Kato Y, Ueda M, Inoue Y, Masuda T, Misumi Y, Nomura T, Watari M, Obayashi K, Ando Y
    • Organizer
      The XVIth International Symposium on Amyloidosis
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Transthyretin amyloid-related cerebral angitis after liver transplantation2018

    • Author(s)
      Yamashita T, Ohnishi K, Ueda M, Masuda T, Inoue Y, Misumi Y, Ueda A, Obayashi K, Takeya M, Ando Y
    • Organizer
      The XVIth International Symposium on Amyloidosis
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Changes in nerve excitability indices in hereditary transthyretin amyloidosis2018

    • Author(s)
      Yamashita T, Ueda M, Misawa S, Inoue Y, Masuda T, Misumi Y, Takamatsu K, Obayashi K, Kuwabara S, Ando Y
    • Organizer
      The XVIth International Symposium on Amyloidosis
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Patisiran, an investigational RNAi therapeutic for patients with hereditary transthyretin-mediated (hATTR) amyloidosis: Phase 3 APOLLO study subanalysis of ese patients2018

    • Author(s)
      Yamashita T, Sekijima Y, Koike H, Ueda M, Yoshinaga T, Kodaira M, Sobue G, Katsuno M, Singh T, Hashimoto Y, Kadam K, A Hou, Ando Y
    • Organizer
      The XVIth International Symposium on Amyloidosis
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Amyloidosis Medical Practice Center in Japan by Kumamoto University.2017

    • Author(s)
      Yamashita T, Ueda M, Tasaki M, Masuda1 T, Misumi M, Takamatsu K, Obayashi K, Ando Y
    • Organizer
      VI Advance and Research in TTR Amyloidosis
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2017-02-24
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Evaluation of MIBG scintigraphy in the Movement Disorder Society Parkinson’s disease criteria2017

    • Author(s)
      Ikenoshita S, Ikeda T, Yamashita S, Sakamoto F, Shiraishi S, Nakahara K, Masuda T, Ando Y
    • Organizer
      XXIII World Congress of Neurology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Memantine attenuates vascular amyloid β deposits and spontaneous hemorrhages in mouse models of cerebral amyloid angiopathy2017

    • Author(s)
      Inoue Y, Ueda M, Masuda T, Misumi Y, Yamashita T, Ando Y
    • Organizer
      Alzheimer's Association International Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Early skin denervation in transthyretin amyloid neuropathy. Driving change: Novel research into early screening and diagnosis of hereditary transthyretin amyloidosis polyneuropathy2017

    • Author(s)
      Ueda M, Masuda T, Ando Y
    • Organizer
      PNS 2017 annual meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Amyloid formation and toxicity of fragmented transthyretin2017

    • Author(s)
      Ueda M, Misumi Y, Masuda T, Tsuda Y, Inoue Y, Tasaki M, Yamashita T, Ando Y
    • Organizer
      XXIII World Congress of Neurology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Novel findings of amyloidosis: Analyses by mass spectrometry. Clinical Mass Spectrometry Meeting Anatomical and Chemical Pathology2017

    • Author(s)
      Ueda M, Tasaki M, Inoue Y, Ando Y
    • Organizer
      The 29th World Congress of World Association of Societies of Pathology and Laboratory Medicine
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Novel diagnostic and treatment strategies in amyloidosis2017

    • Author(s)
      Ueda M, Masuda T, Misumi Y, Tasaki M, Inoue Y, Yamashita T, Ando Y
    • Organizer
      Medical and Nursing Symposium between Shandong University and Kumamoto University
    • Related Report
      2017 Annual Research Report
  • [Presentation] Skin denervation in patients with hereditary and wild-type transthyretin amyloidosis2017

    • Author(s)
      Masuda T, Ueda M, Misumi Y, Nomura T, Tasaki M, Yamashita T, Obayashi K, Ando Y
    • Organizer
      International Society for Autonomic Neuroscience
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Impact of skin denervation in patients with wild-type transthyretin amyloidosis2017

    • Author(s)
      Masuda T, Ueda M, Misumi Y, Suenaga G, Matsumoto S, Nomura T, Tasaki M, Yamashita T, Obayashi K, Ando Y
    • Organizer
      XXIII World Congress of Neurology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Pupillary autonomic nervous dysfunction in hereditary transthyretin amyloidosis2017

    • Author(s)
      Nagatoshi C, Masuda T, Ueda M, Misumi Y, Nomura T, Tasaki M, Yamashita T, Obayashi K, Ando Y
    • Organizer
      XXIII World Congress of Neurology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Amyloid angiopathy in hereditary transthyretin amyloidosis2017

    • Author(s)
      Nomura T, Misumi Y, Ueda M, Masuda T, Yamashita T, Ando Y
    • Organizer
      XXIII World Congress of Neurology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Transthyretin related amyloidosis  -Diagnosis, pathogenesis, and therapies-2017

    • Author(s)
      Ando Y
    • Organizer
      Pre-Conference Seminar of The 5th Hong Kong Neurological Congress and 30th annual Scientific Meeting ofThe Hong Kong Neurological Society
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 脳アミロイドアンギオパチーの新規病態関連因子SRPX1の解析.2017

    • Author(s)
      井上泰輝,植田光晴,田﨑雅義,竹島明,永利聡仁,増田曜章,三隅洋平,小阪崇幸,野村隼也,水上真由美,松本紗也加,山下太郎,高橋均,柿田明美,安東由喜雄
    • Organizer
      第5回日本アミロイドーシス研究会学術集会,京都
    • Related Report
      2017 Annual Research Report
  • [Presentation] 脳アミロイドアンギオパチーの新規病態関連因子SRPX1の解析.2017

    • Author(s)
      井上泰輝,植田光晴,田﨑雅義,竹島明,永利聡仁,増田曜章,三隅洋平,小阪崇幸,野村隼也,水上真由美,松本紗也加,山下太郎,高橋均,柿田明美,安東由喜雄
    • Organizer
      第36回日本認知症学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 遺伝性トランスサイレチンアミロイドーシス患者からドミノ肝移植を受けた二次レシピエントに生じる医原性アミロイドーシスの臨床像の解析.2017

    • Author(s)
      三隅洋平、植田光晴、増田曜章、野村隼也、山下太郎、安東由喜雄
    • Organizer
      第28回日本末梢神経学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 遺伝性トランスサイレチンアミロイドーシス早期診断のポイント.2017

    • Author(s)
      三隅洋平、安東由喜雄
    • Organizer
      第28回日本末梢神経学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] TTRアミロイドーシス実験モデルを用いた病態解析及び治療法の開発.シンポジウム「アミロイドーシス研究入門: 線維形成実験からマウスモデルまで」2017

    • Author(s)
      植田光晴、安東由喜雄
    • Organizer
      第5回日本アミロイドーシス研究会学術集会,京都
    • Related Report
      2017 Annual Research Report
  • [Presentation] トランスサイレチンフラグメントのアミロイド形成および細胞毒性の解析.2017

    • Author(s)
      植田光晴、三隅洋平、増田曜章、水口峰之、井上泰輝、津田幸元、野村隼也、松本沙也加、水上真由美、金縄京佑、中村真琴、山下太郎、安東由喜雄
    • Organizer
      第28回日本末梢神経学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 遺伝性脳アミロイドアンギオパチー.2017

    • Author(s)
      植田明彦、山下太郎、安東由喜雄
    • Organizer
      第49回日本動脈硬化学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 生検皮膚組織を用いたATTRアミロイドーシスの病態評価.2017

    • Author(s)
      増田曜章、植田光晴、安東由喜雄
    • Organizer
      第5回日本アミロイドーシス研究会学術集会,京都
    • Related Report
      2017 Annual Research Report
  • [Presentation] 野生型トランスサイレチンアミロイドーシスにおける小径線維障害の検討.2017

    • Author(s)
      増田曜章、植田光晴、三隅洋平、野村隼也、松本紗也加、田崎雅義、小阪崇幸、山下太郎、大林光念、安東由喜雄
    • Organizer
      第28回日本末梢神経学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] TTRアミロイト?沈着を来たす線虫モテ?ルの開発に向けた検討.2017

    • Author(s)
      津田幸元、植田光晴、山中邦俊、小椋光、安東由喜雄
    • Organizer
      第5回日本アミロイドーシス研究会学術集会,京都
    • Related Report
      2017 Annual Research Report
  • [Presentation] 遺伝性ATTRアミロイドーシスにおける微小血管障害の解析.2017

    • Author(s)
      野村隼也、三隅洋平、増田曜章、植田光晴、山下太郎、安東由喜雄
    • Organizer
      第5回日本アミロイドーシス研究会学術集会,京都
    • Related Report
      2017 Annual Research Report
  • [Presentation] 肝移植後に長期経過した遺伝性トランスサイレチンアミロイドーシスの解析2017

    • Author(s)
      野村隼也、植田光晴、大嶋俊範、三隅洋平、増田曜章、山下太郎、安東由喜雄
    • Organizer
      第35回日本神経治療学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] トランスサイレチンアミロイドーシス線虫モデルを用いた治療薬の検討.2017

    • Author(s)
      金縄 京佑、津田 幸元、植田 光晴、山中 邦俊、小椋 光、安東 由喜雄
    • Organizer
      第5回日本アミロイドーシス研究会学術集会,京都
    • Related Report
      2017 Annual Research Report
  • [Presentation] 血球成分におけるトランスサイレチン断片化機構の解析.2017

    • Author(s)
      松本紗也加、植田光晴、田崎雅義、三隅洋平、増田曜章、水上真由美、金縄京佑、中村真琴、大林光念、山下太郎、安東由喜雄
    • Organizer
      第5回日本アミロイドーシス研究会学術集会,京都
    • Related Report
      2017 Annual Research Report
  • [Presentation] 変異型TTR Tyr114Cys型遺伝性トランスサイレチンアミロイドーシス新規モデルマウスの作成および病理・生化学的解析.2017

    • Author(s)
      水上真由美、植田光晴、三隅洋平、増田曜章、松本紗也加、大林光念、山下太郎、安東由喜雄
    • Organizer
      第5回日本アミロイドーシス研究会学術集会,京都
    • Related Report
      2017 Annual Research Report
  • [Presentation] 線維芽細胞がTTRアミロイド沈着形態に与える影響に関する三次元培養系解析.2017

    • Author(s)
      中村真琴、三隅洋平、木下祐美子、野村隼也、植田光晴、増田曜章、山下太郎、安東由喜雄
    • Organizer
      第5回日本アミロイドーシス研究会学術集会,京都
    • Related Report
      2017 Annual Research Report
  • [Presentation] 臨床化学を通して我々は何をやってきたのか2016

    • Author(s)
      安東由喜雄
    • Organizer
      第56回日本臨床化学会
    • Place of Presentation
      熊本
    • Year and Date
      2016-12-02
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] C末端側トランスサイレチンのアミロイド形成における生化学的解析2016

    • Author(s)
      植田光晴、水口峰之、三隅洋平、増田曜章、津田幸元、田崎雅義、松本紗也加、水上真由美、末永元輝、井上泰輝、木下祐美子、野村隼也、山下太郎、大林光念、安東由喜雄
    • Organizer
      第56回日本臨床化学会 年次学術集会
    • Place of Presentation
      熊本
    • Year and Date
      2016-12-02
    • Related Report
      2016 Annual Research Report
  • [Presentation] 家族性アミロイドポリニューロパチーと自律神経障害2016

    • Author(s)
      安東由喜雄
    • Organizer
      第59回日本自律神経学会
    • Place of Presentation
      熊本
    • Year and Date
      2016-11-10
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 家族性アミロイドポリニューロパチーにおけるアミロイド形成過程の解析2016

    • Author(s)
      植田光晴、水口峰之、三隅洋平、増田曜章、津田幸元、田崎雅義、松本紗也加、水上真由美、末永元輝、井上泰輝、木下祐美子、野村隼也、山下太郎、大林光念、安東由喜雄
    • Organizer
      第69回日本自律神経学会総会
    • Place of Presentation
      熊本
    • Year and Date
      2016-11-10
    • Related Report
      2016 Annual Research Report
  • [Presentation] 同一コドン内の二塩基置換による遺伝性トランスサイレチンアミロイドーシスATTR Val28Serの臨床像解析2016

    • Author(s)
      三隅洋平、岡田匡充、植田光晴、山下太郎、増田曜章、田崎雅義、安東由喜雄
    • Organizer
      第69回日本自律神経学会総会
    • Place of Presentation
      熊本
    • Year and Date
      2016-11-10
    • Related Report
      2016 Annual Research Report
  • [Presentation] トランスサイレチンアミロイドーシス診断のポイントと治療最前線2016

    • Author(s)
      植田光晴、安東由喜雄
    • Organizer
      第20回日本心不全学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2016-10-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] アミロイドアンギオパチーの最新の知見2016

    • Author(s)
      安東由喜雄
    • Organizer
      第13回早期認知症学会
    • Place of Presentation
      熊本
    • Year and Date
      2016-09-17
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Hereditary transthyretin Y114C-related cerebral amyloid angiopathy.2016

    • Author(s)
      Yamashita T, Ando Y
    • Organizer
      4th Annual Meeting of the Japan Amyloidosis Research Society, Special Symposium: Central Nervous System Involvement in the Patients with ATTR Amyloidosis
    • Place of Presentation
      Tokyo
    • Year and Date
      2016-08-19
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 同一コドン内の二塩基置換による新規遺伝性トランスサイレチンアミドーシスATTR Val28Ser (p.Val48Ser)の一症例2016

    • Author(s)
      三隅洋平、岡田匡充、植田光晴、山下太郎、増田曜章、田崎雅義、安東由喜雄
    • Organizer
      第4回日本アミロイドーシス研究会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2016-08-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] アミロイドアンギオパチーの病態と治療の展望.シンポジウム「アミロイドーシスと腎:診断と治療の進歩」2016

    • Author(s)
      植田光晴、井上泰輝、山下太郎、安東由喜雄
    • Organizer
      第59回日本腎臓学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] Antibody therapy for familial amyloid polyneuropathy.2016

    • Author(s)
      Ando Y
    • Organizer
      XVth International Symposium on amyloidosis, Uppsala
    • Place of Presentation
      Uppsala, Sweden
    • Year and Date
      2016-07-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Establishment of a Diagnostic Center for Amyloidosis in Japan by Kumamoto Universityx.2016

    • Author(s)
      Yamashita T, Ando Y
    • Organizer
      XVth International Symposium on amyloidosis, Uppsala
    • Place of Presentation
      Uppsala, Sweden
    • Year and Date
      2016-07-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Role of C-terminal portion of transthyretin on amyloid formation.2016

    • Author(s)
      Ueda M, Mizuguchi M, Misumi Y, Tasaki M, Suenaga G, Matsumoto S, Mizukami M, Masuda T, Yamashita T, Kluve-Beckerman B, Liepnieks JJ, Benson MD, Ando Y
    • Organizer
      XVth International Symposium on amyloidosis, Uppsala
    • Place of Presentation
      Uppsala, Sweden
    • Year and Date
      2016-07-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Multiple nodular pulmonary and subcutaneous amyloidosis associated with Sj&ouml;gren syndrome.2016

    • Author(s)
      Kinoshita Y, Misumi Y, Ueda M, Tasaki M, Masuda T, Suenaga G, Inoue Y, Obayashi K, Yamashita T, Ando Y
    • Organizer
      XVth International Symposium on amyloidosis, Uppsala
    • Place of Presentation
      Uppsala, Sweden
    • Year and Date
      2016-07-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ここまで治るようになった家族性アミロイドポリニューロパチー 教育コース 「ここまで治る!神経疾患の新たな治療」2016

    • Author(s)
      山下太郎, 安東由喜雄
    • Organizer
      第57回日本神経学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2016-05-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] 家族性アミロイドポリニューロパチーにおける末梢神経障害の軸索興奮性測定による解析2016

    • Author(s)
      山下太郎, 三澤園子, 増田曜章, 三隅洋平, 植田光晴, 高松孝太郎, 桑原聡, 安東由喜雄
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸
    • Year and Date
      2016-05-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] 熊本震災における神経内科力2016

    • Author(s)
      安東由喜雄
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸
    • Year and Date
      2016-05-18
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 抹消神経障害の鑑別と治療の最前線・FAPの治療戦略2016

    • Author(s)
      安東由喜雄
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸
    • Year and Date
      2016-05-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] Amyloid formation of C-terminal portion of transthyretin.2016

    • Author(s)
      Ueda M, Mizuguchi M, Misumi Y, Masuda T, Tasaki M, Suenaga G, Inoue Y, Tsuda Y, Nomura T, Kinoshita Y, Matsumoto S, Mizukami M, Yamashita T, Ando Y
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸
    • Year and Date
      2016-05-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] コンパウンドヘテロ変異を有した遺伝性トランスサイレチンアミロイドーシスの1例。2016

    • Author(s)
      天野朋子、植田光晴、山下太郎、三隅洋平、増田曜章、古谷博和、安東由喜雄
    • Organizer
      第213回日本神経学会九州地方会
    • Place of Presentation
      福岡
    • Year and Date
      2016-03-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] Occurrence factors and clinical picture of iatrogenic transthyretin amyloidosis after domino liver transplantation.2016

    • Author(s)
      Misumi Y, Oshima T, Ueda M, Yamashita T, Tasaki M, Masuda T, Obayashi K, Ando Y
    • Organizer
      XVth International Symposium on amyloidosis, Uppsala
    • Place of Presentation
      Uppsala, Sweden
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 自律神経障害からみたアミロイドーシスの多様性と診断法。2015

    • Author(s)
      山下太郎、安東由喜雄
    • Organizer
      第68回日本自律神経学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-11-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] FAP肝を移植された二次レシピエントに生じる医原性アミロイドーシスの病態解析。2015

    • Author(s)
      三隅洋平, 安東由喜雄
    • Organizer
      第68回日本自律神経学会総会
    • Place of Presentation
      愛知
    • Year and Date
      2015-10-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] トランスサイレチン型家族性アミロイドポリニューロパチーの治療最前線。2015

    • Author(s)
      山下太郎、安東由喜雄
    • Organizer
      日本遺伝看護学会第14回学術大会
    • Place of Presentation
      熊本
    • Year and Date
      2015-10-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] 全身性アミロイドーシスに伴う手根管症候群の病態。2015

    • Author(s)
      山下太郎、安東由喜雄
    • Organizer
      第26回 日本末梢神経学会学術集会パネルディスカッション 2「全身疾患に伴う手根管症候群の病態」
    • Place of Presentation
      松本
    • Year and Date
      2015-09-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] シェーグレン症候群との関連が疑われたALアミロイドーシスの1例。2015

    • Author(s)
      波止聡司、長尾洋一郎、三隅洋平、山下太郎、前田寧、安東由喜雄
    • Organizer
      第310回日本内科学会九州地方会
    • Place of Presentation
      佐賀
    • Year and Date
      2015-08-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] アミロイドーシスの早期診断と早期治療の重要性。2015

    • Author(s)
      山下太郎、安東由喜雄
    • Organizer
      第3回日本アミロイドーシス研究会学術集会 モーニングセミナー
    • Place of Presentation
      東京
    • Year and Date
      2015-08-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 家族性アミロイドポリニューロパチーの表皮内神経線維密度と臨床像の関連。2015

    • Author(s)
      増田曜章、植田光晴、田崎雅義、三隅洋平、山下太郎、大林光念、安東由喜雄
    • Organizer
      第3回日本アミロイドーシス研究会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2015-08-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] FAP肝を移植された二次レシピエントに生じる医原性アミロイドーシスの臨床像の解析。2015

    • Author(s)
      三隅洋平、植田光晴、山下太郎、田崎雅義、増田曜章、大林光念、安東由喜雄
    • Organizer
      第3回日本アミロイドーシス研究会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2015-08-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] FAP の病態における単球、マクロファージの関与と iPS-MP を利用した新規治療法開発の検討。2015

    • Author(s)
      末永元輝、池田徳典、千住覚、菰原義弘、本川拓誠、田崎雅義、三隅洋平、植田光晴、西村泰治、竹屋元裕、安東由喜雄
    • Organizer
      第3回日本アミロイドーシス研究会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2015-08-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 肝移植後も緩徐に症候が進行した集積地出身で高齢発症の家族性アミロイドポリニューロパチー症例の病理解析と生化学的検討。2015

    • Author(s)
      本川拓誠、植田光晴、田崎雅義、三隅洋平、末永元基、木下祐美子、豊島梨沙、黄冠男、馬翊竑、増田曜章、大林光念、山下太郎、安東由喜雄
    • Organizer
      第3回日本アミロイドーシス研究会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2015-08-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] トランスサイレチンを発現する線虫モデルの作成と解析。2015

    • Author(s)
      豊島梨沙、植田光晴、山中邦俊、小椋光、安東由喜雄
    • Organizer
      第3回日本アミロイドーシス研究会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2015-08-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] Acquired systemic transthyretin amyloid deposits in a case with domino liver transplantation: an autopsy study.2015

    • Author(s)
      Guannan Huang, Mitsuharu Ueda, Masayoshi Tasaki, Yohei Misumi, Teruaki Masuda, Yasuteru Inoue, Genki Suenaga, Hiroaki Motokawa, Risa Toyoshima, Yumiko Kinoshita, Konen Obayashi, Taro Yamashita, Yukio Ando
    • Organizer
      第3回日本アミロイドーシス研究会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2015-08-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] シェーグレン症候群との関連が疑われた多発性の限局性ALアミロイドーシスの1例。2015

    • Author(s)
      木下祐美子、三隅洋平、長尾洋一郎、波止聡司、田崎雅義、増田曜章、山下太郎、前田寧、安東由喜雄
    • Organizer
      第3回日本アミロイドーシス研究会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2015-08-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 新規 portal アミロイドーシス原因蛋白質の発見2015

    • Author(s)
      岡本菜紗、田崎雅義、星井嘉信、植田光晴、木下祐美子、三隅洋平、増田曜章、山下太郎、大林光念、安東由喜雄
    • Organizer
      第3回日本アミロイドーシス研究会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2015-08-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] Cerebral amyloid angiopathyを伴ったホモ接合型ATTR V30Mアミロイドーシス。2015

    • Author(s)
      打田佑人、植田光晴、小林晋、小池春樹、高田幸児、継泰城、山下太郎、安東由喜雄
    • Organizer
      第3回日本アミロイドーシス研究会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2015-08-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 肝移植後に著明なステロイド関連心筋肥大を呈した家族性アミロイドポリニューロパチーの症例解析2015

    • Author(s)
      坂下直実、山下太郎、中川雄伸、安東由喜雄、竹屋元裕
    • Organizer
      第3回日本アミロイドーシス研究会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2015-08-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] AApoAIアミロイドーシスにおけるヘパラン硫酸多硫酸化ドメインの役割。2015

    • Author(s)
      桑原香織、西辻和親、山下太郎、小林典裕、内村健治、安東由喜雄、斎藤博幸、坂下直実
    • Organizer
      第3回日本アミロイドーシス研究会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2015-08-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 透析アミロイド沈着部位に共存するグリコサミノグリカン及びプロテオグリカンの検討-病理切片を用いた免疫組織化学的観察とプロテオーム解析-。2015

    • Author(s)
      山口格、大越忠和、内田研造、田崎雅義、山下太郎、安東由喜雄、内木宏延
    • Organizer
      第3回日本アミロイドーシス研究会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2015-08-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] アミロイドβ2microglobulinのLC/MS解析。2015

    • Author(s)
      本宮善恢、宇治義則、末永元輝、安東由喜雄
    • Organizer
      第3回日本アミロイドーシス研究会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2015-08-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 免疫染色で確定診断が困難なALアミロイドーシス。2015

    • Author(s)
      杉本俊哉、田崎雅義、遠藤慎也、藤井絵理、山下太郎、大林光念、西村直、奥野豊、満屋裕明、安東由喜雄、畑裕之
    • Organizer
      第3回日本アミロイドーシス研究会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2015-08-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 家族性アミロイドポリニューロパチーの早期診断における皮膚生検の有用性の検討。2015

    • Author(s)
      増田曜章、植田光晴、野村隼也、田崎雅義、三隅洋平、山下太郎、大林光念、安東由喜雄
    • Organizer
      第56回日本神経学会学術大会
    • Place of Presentation
      新潟
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 家族性アミロイドポリニューロパチーの病態解析と治療における展望。2015

    • Author(s)
      植田光晴、安東由喜雄
    • Organizer
      第56回日本神経学会学術大会
    • Place of Presentation
      新潟
    • Year and Date
      2015-05-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] 家族性アミロイドポリニューロパチーの心筋におけるアミロイド沈着の進展様式の解析。2015

    • Author(s)
      三隅洋平、大嶋俊範、植田光晴、大林光念、山下太郎、安東由喜雄
    • Organizer
      第56回日本神経学会学術大会
    • Place of Presentation
      新潟
    • Year and Date
      2015-05-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] アミロイドーシス診療体制構築事業の平成26年度病型診断の報告。2015

    • Author(s)
      山下太郎、田崎雅義、増田曜章、大嶋俊範、軸丸美香、高松孝太郎、三隅洋平、植田光晴、大林光念、安東由喜雄
    • Organizer
      第56回日本神経学会学術大会
    • Place of Presentation
      新潟
    • Year and Date
      2015-05-20
    • Related Report
      2015 Annual Research Report
  • [Book] Clinical Questions & Pearls 「末梢神経疾患」2018

    • Author(s)
      増田 曜章, 安東 由喜雄
    • Total Pages
      404
    • Publisher
      中外医学社
    • ISBN
      9784498228986
    • Related Report
      2017 Annual Research Report
  • [Book] 映画に描かれた疾患と募る想い2018

    • Author(s)
      安東 由喜雄
    • Total Pages
      288
    • Publisher
      医歯薬出版
    • ISBN
      9784263731802
    • Related Report
      2017 Annual Research Report
  • [Book] 最新 アミロイドーシスのすべて 診療ガイドライン2017とQ&A2017

    • Author(s)
      安東 由喜雄
    • Total Pages
      264
    • Publisher
      医歯薬出版
    • ISBN
      9784263731758
    • Related Report
      2017 Annual Research Report
  • [Book] 最新 アミロイドーシスのすべて -診療ガイドライン2017とQ&A2017

    • Author(s)
      安東由喜雄、植田光晴、山下太郎、三隅洋平 他
    • Total Pages
      250
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] 新規なアミロイド線維生成抑制剤2016

    • Inventor(s)
      城野博史、有馬英俊、安東由喜雄、本山敬一、東大志
    • Industrial Property Rights Holder
      国立大学法人熊本大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-06-10
    • Related Report
      2016 Annual Research Report
    • Overseas

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Published: 2015-04-16   Modified: 2020-03-30  

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