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Peripheral Circadian Dysregulation and Metabolic Disorders

Research Project

Project/Area Number 15H04849
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Metabolomics
Research InstitutionYamaguchi University

Principal Investigator

TANIZAWA Yukio  山口大学, 大学院医学系研究科, 教授 (00217142)

Co-Investigator(Kenkyū-buntansha) 太田 康晴  山口大学, 医学部, 准教授(寄附講座等) (60448280)
田部 勝也  山口大学, 医学部附属病院, 講師 (00397994)
幡中 雅行  山口大学, 医学(系)研究科(研究院), 助教 (60572534)
秋山 優  山口大学, 医学部附属病院, 助教 (90717547)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Keywords体内時計 / 糖尿病 / 糖代謝 / インスリン分泌 / E4BP4 / DBP / サーカディアンリズム / 時計遺伝子 / インスリン抵抗性 / ランゲルハンス氏島 / インスリン / 肝臓 / 肝糖代謝 / 糖新生 / マクロファージ / 概日リズム / 代謝調節 / 概日周期
Outline of Final Research Achievements

We all have biological clock inside the body. Biological clock is composed of clock genes, which have feedback loop of expression regulation, and make 24-hours circadian expression rhythm. Clocks regulate many biological processes including metabolism. Dysregulation of the biological clock causes many disease processes including metabolic disorders, such as diabetes mellitus. We found that DBP and E4BP4, which are reciprocally expressed and regulate the same set of target genes, play crucial role among clock genes. Abnormalities in this system cause severe insulin secretory defects and diabetes in a mouse model. In addition, those genes appear to be important in the regulation of liver metabolism.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (56 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (1 results) Journal Article (13 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 9 results,  Open Access: 8 results,  Acknowledgement Compliant: 3 results) Presentation (40 results) (of which Int'l Joint Research: 11 results,  Invited: 5 results) Book (2 results)

  • [Int'l Joint Research] Indiana University(米国)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Effects of Pemafibrate, a Novel Selective PPARα Modulator, on Lipid and Glucose Metabolism in Patients With Type 2 Diabetes and Hypertriglyceridemia: A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial2018

    • Author(s)
      Araki Eiichi、Yamashita Shizuya、Arai Hidenori、Yokote Koutaro、Satoh Jo、Inoguchi Toyoshi、Nakamura Jiro、Maegawa Hiroshi、Yoshioka Narihito、Tanizawa Yukio、Watada Hirotaka、Suganami Hideki、Ishibashi Shun
    • Journal Title

      Diabetes Care

      Volume: 41 Issue: 3 Pages: 538-546

    • DOI

      10.2337/dc17-1589

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Remission of hyperglycemia after withdrawal of oral antidiabetic drugs in Japanese patients with early-stage type 2 diabetes2018

    • Author(s)
      Hirukawa Hidenori、Hashiramoto Mitsuru、Tanizawa Yukio、Kaku Kohei、Pioglitazone and Sulfonylurea Remission from Type 2 Diabetes Mellitus and Anti-Atherosclerosis in Japan (PREVENT-J) study group
    • Journal Title

      Journal of Diabetes Investigation

      Volume: in press Issue: 5 Pages: 1119-1127

    • DOI

      10.1111/jdi.12813

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular clock as a regulator of β-cell function2018

    • Author(s)
      Taguchi Akihiko、Ohta Yasuharu、Tanizawa Yukio
    • Journal Title

      Journal of Diabetes Investigation

      Volume: 9 Issue: 3 Pages: 453-456

    • DOI

      10.1111/jdi.12835

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] インスリン抵抗性研究の最前線ー肝におけるインスリン抵抗性ー2018

    • Author(s)
      太田康晴、谷澤幸生
    • Journal Title

      最新医学

      Volume: 73 Pages: 24-29

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Interorgan Crosstalk Contributing to β-Cell Dysfunction.2017

    • Author(s)
      Tanabe K., Amo-Shiinoki K., Hatanaka M., Tanizawa Y.
    • Journal Title

      J Diabetes Res.

      Volume: 2017 Pages: 1-8

    • DOI

      10.1155/2017/3605178

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Causes of death in Japanese patients with diabetes based on the results of a survey of 45,708 cases during 2001-2010: Report of the Committee on Causes of Death in Diabetes Mellitus2017

    • Author(s)
      Nakamura Jiro、Kamiya Hideki、Haneda Masakazu、Inagaki Nobuya、Tanizawa Yukio、Araki Eiichi、Ueki Kohjiro、Nakayama Takeo
    • Journal Title

      Journal of Diabetes Investigation

      Volume: 8 Issue: 3 Pages: 397-410

    • DOI

      10.1111/jdi.12645

    • NAID

      40021217934

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clock Gene Dysregulation Induced by Chronic ER Stress Disrupts β-cell Function.2017

    • Author(s)
      Ohta Y., Taguchi A., Matsumura T., Nakabayashi H., Akiyama M., Yamamoto K., Fujimoto R., Suetomi R., Yanai A., Shinoda K., Tanizawa Y.
    • Journal Title

      EBioMedicine

      Volume: 18 Pages: 146-156

    • DOI

      10.1016/j.ebiom.2017.03.040

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Chronic high fat feeding restricts islet mRNA translation initiation independently of ER stress via DNA damage and p53 activation2017

    • Author(s)
      Hatanaka Masayuki、Anderson-Baucum Emily、Lakhter Alexander、Kono Tatsuyoshi、Maier Bernhard、Tersey Sarah A.、Tanizawa Yukio、Evans-Molina Carmella、Mirmira Raghavendra G.、Sims Emily K.
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 3758-3758

    • DOI

      10.1038/s41598-017-03869-5

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of an intensified multifactorial intervention on cardiovascular outcomes and mortality in type 2 diabetes (J-DOIT3): an open-label, randomised controlled trial2017

    • Author(s)
      Ueki K, Sasako T, Okazaki Y, Kato M, Okahata S, Katsuyama H, Haraguchi M, Morita A, Ohashi K, Hara K, Morise A, Izumi K, Ishizuka N, Ohashi Y, Noda M, Kadowaki T
    • Journal Title

      Lancet Diabetes Endocrinol

      Volume: 5 Issue: 12 Pages: 951

    • DOI

      10.1016/s2213-8587(17)30327-3

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Wolfram症候群2017

    • Author(s)
      椎木幾久子、田部勝也、谷澤幸生
    • Journal Title

      月刊糖尿病

      Volume: 9 Pages: 36-44

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Wolfram症候群の臨床像と遺伝的特徴2017

    • Author(s)
      田部勝也、松永仁恵、椎木幾久子、谷澤幸生
    • Journal Title

      月刊糖尿病

      Volume: 9 Pages: 45-53

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 少遺伝子型 (oligogenic) 糖尿病の解析 (2) Wolfram症候群と糖尿病2016

    • Author(s)
      田部勝也、 谷澤幸生
    • Journal Title

      Diabetes Frontier

      Volume: 27 Pages: 466-471

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Altered expression of circadian clock genes during peripheral blood stem cell mobilization induced by granulocyte colony-stimulating factor.2015

    • Author(s)
      Sugiyama A, Yujiri T, Tanaka M, Tanaka Y, Nakamura Y, Tanizawa Y.
    • Journal Title

      Chronobiology International

      Volume: 32 Issue: 7 Pages: 934-941

    • DOI

      10.3109/07420528.2015.1053910

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Metabolic Insufficiency Caused By Cellular Stresses Is Implicated in Beta-Cell Dedifferentiation in the Mouse Model of Wolfram Syndrome2018

    • Author(s)
      Kikuko Amo-Shiinoki, Katsuya Tanabe, Masayuki Hatanaka, Hiroshi Masutani, Yukio Tanizawa
    • Organizer
      78th Annual Meeting and Scientific Sessions of the American Diabetes Association
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 小胞体ストレスに対する膵β細胞保護におけるアドレノメデュリンの役割2018

    • Author(s)
      秋山優、末富吏佐、太田康晴、松村卓郎、中林容子、近藤学、幡中雅行、田部勝也、谷澤幸生
    • Organizer
      第91回日本内分泌学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Circadian Dysregulation によるインスリン分泌不全と肝インスリン抵抗性2018

    • Author(s)
      太田康晴,田口昭彦,松村卓郎,福田尚文,山本薫,柳井章江,秋山優,藤本留理子,神吉けい太,汐田剛史,水上洋一,篠田晃,谷澤幸生
    • Organizer
      第61回日本糖尿病学会年次学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Wolfram症候群をモデルとした細胞内ストレスによる膵β細胞可塑性制御の解明2018

    • Author(s)
      椎木幾久子,田部勝也,幡中雅行,西村渉,佐藤吉彦,駒津光久,増谷弘,谷澤幸生
    • Organizer
      第61回日本糖尿病学会年次学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 小胞体ストレス応答蛋白Wolfram Syndrome 1(WFS1)の肝インスリン抵抗性への役割2018

    • Author(s)
      橋本麻美子,高俊弘,澤田正二郎,石垣泰,鈴木亨,近藤敬一,宇野健司,今井淳太,山田哲也,石原寿光,谷澤幸生,片桐秀樹
    • Organizer
      第61回日本糖尿病学会年次学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 肝における出力系時計遺伝子DBP/E4BP4によるエネルギー代謝調節2018

    • Author(s)
      松村卓郎,太田康晴,田口昭彦,福田尚文,柳井章江,水上洋一,秋山優,末冨吏佐,山本薫,藤本留理子,神吉けい太,汐田剛史,篠田晃,谷澤幸生
    • Organizer
      第61回日本糖尿病学会年次学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Wolfram症候群のモデルマウスでは膵β細胞脱分化を来す2017

    • Author(s)
      田部勝也、椎木幾久子、幡中雅行、谷澤幸生
    • Organizer
      第90回日本内分泌学会学術集会
    • Place of Presentation
      京都市(京都市勧業館みやこめっせ)
    • Year and Date
      2017-04-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] DBPシグナルを介した時計遺伝子によるインスリン分泌調節機構2017

    • Author(s)
      太田康晴、田口昭彦、松村卓郎、中林容子、秋山優、藤本留理子、末冨吏沙、山本薫、谷澤幸生
    • Organizer
      第90回日本内分泌学会学術集会
    • Place of Presentation
      京都市(京都市勧業館みやこめっせ)
    • Year and Date
      2017-04-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Genetic Deficiency of TXNIP Prevents Diabetes Progression in the Mouse Model of Wolfram Syndrome.2017

    • Author(s)
      Shinoki K., Tanabe K., Hatanaka M., Harano R., Masutani H., Tanizawa Y.
    • Organizer
      77th Annual Meeting and Scientific Sessions of the American Diabetes Association
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] DBP signal has pivotal role in the circadian regulation of liver metabolism2017

    • Author(s)
      Matsumura T, Ohta Y, Taguchi A, Fukuda N, Akiyama M, Fujimoto R, Tanizawa Y
    • Organizer
      International Diabetes Federation Congress 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ER and oxidative stresses induce and Txnip knock-out prevents β-cell dedifferentiation and failure in Wolfram syndrome2017

    • Author(s)
      Yukio Tanizawa, Kikuko Amo-Shiinoki, Katsuya Tanabe, Masayuki Hatanaka, Risa Harano, Hiroshi Masutani
    • Organizer
      International Diabetes Federation Congress 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Wolfram症候群のモデルマウスでは膵β細胞脱分化を来す2017

    • Author(s)
      田部勝也、椎木幾久子、幡中雅行、谷澤幸生
    • Organizer
      第90回日本内分泌学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] DBPシグナルを介した時計遺伝子によるインスリン分泌調節機構2017

    • Author(s)
      太田康晴、田口昭彦、松村卓郎、中林容子、秋山 優、藤本留理子、末冨吏佐、山本 薫、谷澤幸生
    • Organizer
      第90回日本内分泌学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Circadian Dysregulation と肝インスリン抵抗性2017

    • Author(s)
      太田康晴、松村卓郎、田口昭彦、福田尚文、秋山 優、藤本留理子、神吉けい太、汐田剛史、谷澤幸生
    • Organizer
      第60回日本糖尿病学会年次学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒトの糖尿病においてβ細胞脱分化はβ細胞不全に関連する2017

    • Author(s)
      椎木幾久子、田部勝也、幡中雅行、近藤 学、西村 渉、木村徳宏、星井嘉信、池田栄二、水上浩哉、八木橋操六、佐藤吉彦、駒津光久、谷澤幸生
    • Organizer
      第60回日本糖尿病学会年次学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 大規模臨床研究 J-BRABD Registry:第4回中間報告2017

    • Author(s)
      山田祐一郎、中村二郎、植木浩二郎、谷澤幸生、綿田裕孝、下村伊一郎、西村理明、山崎 力、門脇 孝
    • Organizer
      第60回日本糖尿病学会年次学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 過食肥満動物Agoutiマウスは高脂肪食負荷により非アルコール性脂肪肝炎(NASH)を発症する2017

    • Author(s)
      香川正太、田部勝也、長島史裕、谷澤幸生
    • Organizer
      第60回日本糖尿病学会年次学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Wolfram症候群においてβ細胞脱分化は糖尿病の成因として重要である2017

    • Author(s)
      田部勝也、椎木幾久子、幡中雅行、谷澤幸生
    • Organizer
      第32回日本糖尿病合併症学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 時計遺伝子DBP, E4BP4の機能異常と肝インスリン抵抗性2017

    • Author(s)
      松村卓郎、太田康晴、田口昭彦、谷澤幸生、福田尚文、藤本留理子、山本 薫、神吉けい太、汐田剛史
    • Organizer
      第32回日本糖尿病合併症学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 時計遺伝子DBP、E4BP4の異常は肝インスリン抵抗性を惹起する2017

    • Author(s)
      松村卓郎、太田康晴、田口昭彦、山本 薫、福田尚文、藤本留理子、秋山優、神吉けい太、汐田剛史、谷澤幸生
    • Organizer
      第29回分子糖尿病学シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] Wfs1-Defiency Causes Beta-Cell Dedifferentiation Associated with Enhanced ER Stress and Oxidative Stress, Independently of Hyperglycemia.2016

    • Author(s)
      Shinoki K., Tanabe K., Hatanaka M., Tanizawa Y.
    • Organizer
      7th AASD Scientific Meeting and Annual Scientific Meeting of the Hong Kong Society of Endocrinology, Metabolism and Reproduction
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2016-11-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clock gene dysreguration induced by chronic endoplasmic reticulum stress disrupts β-cell function.2016

    • Author(s)
      Ohta Y., Tanizawa Y.
    • Organizer
      The 11TH IDF-WPR Congress & 8TH AASD Scientific Meeting.
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2016-10-27
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 肝細胞特異的E4BP4過剰発現マウスを用いた時計遺伝子を介する糖代謝調節機構の解明2016

    • Author(s)
      松村卓郎、太田康晴、田口昭彦、福田尚文、秋山 優、末冨吏佐、山本 薫、谷澤幸生、神吉けい太、汐田剛史
    • Organizer
      第37回日本肥満学会
    • Place of Presentation
      東京都(東京ファッションタウン)
    • Year and Date
      2016-10-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] Beta-cell Dedifferentiation Plays a Central Role in Beta-Cell Failure in a Model of Wolfram Syndrome.2016

    • Author(s)
      Shinoki K., Tanabe K., Hatanaka M., Kondo M., Tanizawa Y.
    • Organizer
      76th Annual Meeting and Scientific Sessions of the American Diabetes Association
    • Place of Presentation
      Hong Kong, China
    • Year and Date
      2016-06-10
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] β cell dedifferentiation plays a central role in β cell failure in a model of Wolfram syndrom2016

    • Author(s)
      田部勝也、椎木幾久子、幡中雅行、谷澤幸生
    • Organizer
      第59回日本糖尿病学会年次学術集会
    • Place of Presentation
      京都市(国立京都国際会館)
    • Year and Date
      2016-05-19
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 膵β細胞におけるDBPシグナルはfirst meal摂取時の鋭敏なインスリン分泌にとって重要である2016

    • Author(s)
      松村卓郎、太田康晴、田口昭彦、中林容子、秋山 優、末冨吏佐、山本 薫。谷澤幸生
    • Organizer
      第89回日本内分泌学会学術総会
    • Place of Presentation
      京都市(国立京都国際会館)
    • Year and Date
      2016-04-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] 膵島炎症に対するn-3PUFAの抑制効果とその発現機構の解明2016

    • Author(s)
      椎木幾久子、田部勝也、谷澤幸生
    • Organizer
      第19回日本病態栄養学会
    • Place of Presentation
      パシフィコ横浜、横浜市
    • Year and Date
      2016-01-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] Wfs1欠損マウスにおける膵β細胞脱分化とその意義の解明2015

    • Author(s)
      椎木幾久子、田部勝也、幡中雅行、香川正太、秋山 優、谷澤幸生
    • Organizer
      第27回分子糖尿病シンポジウム
    • Place of Presentation
      丸ビルホール&コンファレンススクエア(東京都)
    • Year and Date
      2015-12-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] Wfs1-deficiency causes beta-cell dedifferentiation associated with enhanced ER stress and oxidative stress, independently of hyperglycemia.2015

    • Author(s)
      Kikuko Amo-Shinoki, Katsuya Tanabe, Masayuki Hatanaka, Yukio Tanizawa
    • Organizer
      7th AASD Scientific Meeting and Annual Scientific Meeting of the Hong Kong Society of Endocrinology, Metabolism and Reproduction
    • Place of Presentation
      Hong Kong Convention and Exhibition Centre, Hong Kong, Special Administrative Region of the People’s Republic of China
    • Year and Date
      2015-11-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Wfs1 Deficiency Causes Beta-Cell Dedifferentiation Associated with Enhanced ER Stress and Oxidative Stress, Independently of Hyperglycemia.2015

    • Author(s)
      Shinoki K., Tanabe K., Hatanaka M., Ohta Y., Tanizawa Y.
    • Organizer
      75th Annual Meeting and Scientific Sessions of the American Diabetes Association
    • Place of Presentation
      Boston Convention and Exhibition Center, Boston, MA, USA.
    • Year and Date
      2015-06-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Adrenomedullin Has a Cytoprotective Role in Pancreatic β-Cells Against ER Stress.2015

    • Author(s)
      Akiyama M., Suetomi R., Ohta Y., Nakabayashi H., Kondo M., Tanabe K., Tanizawa Y.
    • Organizer
      75th Annual Meeting and Scientific Sessions of the American Diabetes Association
    • Place of Presentation
      Boston Convention and Exhibition Center, Boston, MA, USA.
    • Year and Date
      2015-06-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 患者から学ぶ膵β細胞研究-physician scientistのゆめ-2015

    • Author(s)
      谷澤幸生
    • Organizer
      第58回日本糖尿病学会年次学術集会
    • Place of Presentation
      海峡メッセ下関、下関市
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Wolfram症候群の実態と糖尿病発症機構の解明2015

    • Author(s)
      田部勝也
    • Organizer
      第58回日本糖尿病学会年次学術集会
    • Place of Presentation
      海峡メッセ下関、下関市
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 糖尿病病態における膵β細胞翻訳機能解析2015

    • Author(s)
      幡中雅行
    • Organizer
      第58回日本糖尿病学会年次学術集会
    • Place of Presentation
      海峡メッセ下関、下関市
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 膵ラ氏島におけるアドレノメデュリンは小胞体ストレスに対して自己防御的な作用をもつ2015

    • Author(s)
      末冨吏佐、秋山 優、太田康晴、中林容子、近藤 学、田部勝也、谷澤幸生
    • Organizer
      第58回日本糖尿病学会年次学術集会
    • Place of Presentation
      グランプラス セント・バレンタイン、下関市
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] SNARE調節因子DOC2bによる個体糖代謝調節2015

    • Author(s)
      野見山隆太、江本政広、福田尚文、松井久未子、坂根亜由子、三好 淳、佐々木卓也、谷澤幸生
    • Organizer
      第58回日本糖尿病学会年次学術集会
    • Place of Presentation
      グランプラス セント・バレンタイン、下関市
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] WFS1欠損膵島における膵β細胞脱分化機構の解析2015

    • Author(s)
      椎木幾久子、田部勝也、幡中雅行、永尾優子、太田康晴、谷澤幸生
    • Organizer
      第58回日本糖尿病学会年次学術集会
    • Place of Presentation
      グランプラス セント・バレンタイン、下関市
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] DBPシグナルはグルコース応答性のインスリン分泌とりわけfirst meal摂取時のインスリン分泌にとって重要である2015

    • Author(s)
      松村卓郎、太田康晴、田口昭彦、中林容子、秋山 優、末冨吏佐、谷澤幸生
    • Organizer
      第58回日本糖尿病学会年次学術集会
    • Place of Presentation
      シーモールホール、下関市
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] Gsk-3による小胞体ストレス応答制御と膵β細胞アポトーシス誘導における意義とその解明2015

    • Author(s)
      永尾優子、田部勝也、椎木幾久子、幡中雅行、太田康晴、谷澤幸生
    • Organizer
      第58回日本糖尿病学会年次学術集会
    • Place of Presentation
      シーモールホール、下関市
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] DBP/E4BP4 plays a pivotal role in circadian regulation of β-cell function.2015

    • Author(s)
      Ohta Y., Taguchi A., Akiyama M., Nakabayashi H., Suetomi R., Yanai A., Shinoda K., Tanizawa Y.
    • Organizer
      16th Servier-IGIS(International Group on Insulin Secretion) symposium
    • Place of Presentation
      The Royal Riviera Hotel, St. Jean Cap Ferrat, France
    • Year and Date
      2015-04-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Book] 糖尿病UP DATE賢島セミナー2016 2型糖尿病への効果的なインスリン治療とは 病状・病態に応じたシームレスな管理・治療2017

    • Author(s)
      谷澤幸生(堀田 饒 、清野 裕、門脇 孝、羽田 勝計、中村 二郎 編)
    • Total Pages
      248
    • Publisher
      メディカル・ジャーナル社
    • ISBN
      9784908437090
    • Related Report
      2017 Annual Research Report
  • [Book] 難治性内分泌代謝疾患Update ウォルフラム(Wolfram)症候群2015

    • Author(s)
      谷澤幸生、松永仁恵
    • Total Pages
      175
    • Publisher
      診断と治療社
    • Related Report
      2015 Annual Research Report

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Published: 2015-04-16   Modified: 2022-10-07  

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