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Molecular mechanisms involved in epicutaneous sensitization

Research Project

Project/Area Number 15H04866
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Collagenous pathology/Allergology
Research InstitutionNational Center for Child Health and Development

Principal Investigator

Saito Hirohisa  国立研究開発法人国立成育医療研究センター, 副所長室, 副所長 (40130166)

Co-Investigator(Kenkyū-buntansha) 中江 進  東京大学, 医科学研究所, 准教授 (60450409)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2017: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Keywords経皮膚感作 / 皮膚炎 / プロテアーゼ / アレルギー
Outline of Final Research Achievements

It has been shown that epicutaneous sensitization through eczema may be involved in the development of atopic dermatitis and subsequent other allergic diseases. Staphylococcus aureus is known to be colonized especially on the lesional skin of patients with atopic dermatitis and some of those are known to produce protease that may lead barrier dysfunction. Therefore, we sought to elucidate the effect of protease produced by staphylococcus aureus on skin. Consequently, we found that protease from staphylococcus aureus induced skin inflammation accompanied by acanthosis and inflammatory cell infiltration even in the absence of acquired immunity.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (24 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (6 results) Journal Article (18 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 17 results,  Open Access: 10 results,  Acknowledgement Compliant: 4 results)

  • [Int'l Joint Research] SIAF(Switzerland)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Stanford University School of Medicine/Department of Pathology(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Cambridge University/MRC Laboratory of Molecular Biology(英国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] SIAF(Switzerland)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Stanford University School of Medicine/Departments of Pathology(米国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Cambridge/MRC Laboratory of Molecular Biology(英国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] The optimal age for epicutaneous sensitization following tape-stripping in BALB/c mice2018

    • Author(s)
      Tamari M, Orimo K, Motomura K, Arae K, Matsuda A, Nakae S, Saito H, Morita H, Matsumoto K
    • Journal Title

      Allergology International

      Volume: 67 Issue: 3 Pages: 380-387

    • DOI

      10.1016/j.alit.2018.01.003

    • NAID

      130007420809

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recent advances in understanding the roles of blood platelets in the pathogenesis of allergic inflammation and bronchial asthma2018

    • Author(s)
      Takeda T, Morita H, Saito H, Matsumoto K, Matsuda A
    • Journal Title

      Allergology International

      Volume: 67 Issue: 3 Pages: 326-333

    • DOI

      10.1016/j.alit.2017.11.008

    • NAID

      130007420477

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] IL-25 enhances Th17 cell-mediated contact dermatitis by promoting IL-1b production by dermal dendritic cells2018

    • Author(s)
      Suto H, Nambu A, Morita H, Yamaguchi S, Numata T, Yoshizaki T, Shimura E, Arae K, Asada Y, Motomura K, Kaneko M, Abe T, Matsuda A, Iwakura Y, Okumura K, Saito H, Matsumoto K, Sudo K, Nakae S
    • Journal Title

      J Allergy Clin Immunol

      Volume: In press Issue: 5 Pages: 1500-1509

    • DOI

      10.1016/j.jaci.2017.12.1007

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Are both early egg introduction and eczema treatment necessary for primary prevention of egg allergy?2018

    • Author(s)
      Matsumoto K, Mori R, Miyazaki C, Ohya Y, Saito H
    • Journal Title

      J Allergy Clin Immunol

      Volume: In press Issue: 6 Pages: 1997-2001.e3

    • DOI

      10.1016/j.jaci.2018.02.033

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Two-step egg introduction for prevention of egg allergy in high-risk infants with eczema (PETIT): a randomised, double-blind, placebo-controlled trial.2017

    • Author(s)
      Natsume O, Kabashima S, Nakazato J, Yamamoto-Hanada K, Narita M, Kondo M, Saito M, Kishino A, Takimoto T, Inoue E, Tang J, Kido H, Wong GW, Matsumoto K, Saito H, Ohya Y; PETIT Study Team..
    • Journal Title

      Lancet

      Volume: 389 Issue: 10066 Pages: 276-286

    • DOI

      10.1016/s0140-6736(16)31418-0

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Regulatory roles of mast cells in imuune responses2016

    • Author(s)
      Morita H, Saito H, Matsumoto K, Nakae S.
    • Journal Title

      Semin Immunopathol

      Volume: 38 Issue: 5 Pages: 623-629

    • DOI

      10.1007/s00281-016-0566-0

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Epicutaneous allergic sensitization by cooperation between allergn protease activity and mechanical skin barrier damage in mice2016

    • Author(s)
      Shimura S, Takai T, Iida H, Maruyama N, Ochi H, Kamijo S, Nishioka I, Hara M, Matsuda A, Saito H, Nakae S, Ogawa H, Okumura K, Ikeda S.
    • Journal Title

      J Invest Dermatol

      Volume: 136 Issue: 7 Pages: 1408-1417

    • DOI

      10.1016/j.jid.2016.02.810

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Subcutaneous Allergic Sensitization to Protease Allergen Is Dependent on Mast Cells but Not IL-33: Distinct Mechanisms between Subcutaneous and Intranasal Routes2016

    • Author(s)
      Kamijo S, Suzuki M, Hara M, Shimura S, Ochi H, Maruyama N, Matsuda A, Saito H, Nakae S, Suto H, Ichikawa S, Ikeda S, Ogawa H, Okumura K, Takai T.
    • Journal Title

      J Immunol

      Volume: 196 Issue: 9 Pages: 3559-3569

    • DOI

      10.4049/jimmunol.1500717

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Platelets constitutively express IL-33 protein and modulate eosinophilic airway inflammation.2016

    • Author(s)
      Takeda T, Unno H, Morita H, Futamura K, Emi-Sugie M, Arae K, Shoda T, Okada N, Igarashi A, Inoue E, Kitazawa H, Nakae S, Saito H, Matsumoto K, Matsuda A.
    • Journal Title

      J Allergy Clin Immunol

      Volume: In Press Issue: 5 Pages: 1395-1403

    • DOI

      10.1016/j.jaci.2016.01.032

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Sera of patients with infantile eosinophilic gastroenteritis showed a specific increase in both thymic stromal lymphopoietin and IL-33 levels2016

    • Author(s)
      Shoda T, Matsuda A, Arai K, Shimizu H, Morita H, Orihara K, Okada N, Narita M, Ohya Y, Saito H, Matsumoto K, Nomura I.
    • Journal Title

      J Allergy Clin Immunol.

      Volume: in press Issue: 1 Pages: 299-303

    • DOI

      10.1016/j.jaci.2015.11.042

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Recent advances in understanding the roles of vascular endothelial cells in allergic inflammation2016

    • Author(s)
      Shoda T, Futamura K, Orihara K, Emi-Sugie M, Saito H, Matsumoto K, Matsuda A.
    • Journal Title

      Allergology International

      Volume: 65 Issue: 1 Pages: 21-29

    • DOI

      10.1016/j.alit.2015.08.001

    • NAID

      130005290335

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transepidermal water loss measurement during infancy can predict the subsequent development of atopic dermatitis regardless of filaggrin mutations2016

    • Author(s)
      Horimukai K, Morita K, Narita M, Kondo M, Kabashima S, Inoue E, Sasaki T, Niizeki H, Saito H, Matsumoto K, Ohya Y.
    • Journal Title

      Allergology International

      Volume: 65 Issue: 1 Pages: 103-108

    • DOI

      10.1016/j.alit.2015.09.004

    • NAID

      130005290309

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] IL-25 and IL-33 Contribute to Development of Eosinophilic Airway Inflammation in Epicutaneously Antigen-Sensitized Mice.2015

    • Author(s)
      Morita H, Arae K, Unno H, Toyama S, Motomura K, Matsuda A, Suto H, Okumura K, Sudo K, Takahashi T, Saito H, Matsumoto K, Nakae S.
    • Journal Title

      PLoS One.

      Volume: 10 Issue: 7 Pages: e0134226-e0134226

    • DOI

      10.1371/journal.pone.0134226

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] An Interleukin-33-Mast Cell-Interleukin-2 Axis Suppresses Papain-Induced Allergic Inflammation by Promoting Regulatory T Cell Numbers.2015

    • Author(s)
      Morita H, Arae K, Unno H, Miyauchi K, Toyama S, Nambu A, Oboki K, Ohno T, Motomura K, Matsuda A, Yamaguchi S, Narushima S, Kajiwara N, Iikura M, Suto H, McKenzie AN, Takahashi T, Karasuyama H, Okumura K, Azuma M, Moro K, Akdis CA, Galli SJ, Koyasu S, Kubo M, Sudo K, Saito H, Matsumoto K, Nakae S.
    • Journal Title

      Immunity

      Volume: 43 Issue: 1 Pages: 175-86

    • DOI

      10.1016/j.immuni.2015.06.021

    • NAID

      40020962854

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Measurement of allergen-specific secretory IgA in stool of neonates, infants and toddlers by protection against degradation of immunoglobulins and allergens2015

    • Author(s)
      Norio Kamemura, Miwa Takashima, Hideaki Morita, Kenji Matsumoto, Hiroshi Saito, and Hiroshi Kido.
    • Journal Title

      The Journal of Medical Investigation

      Volume: 62 Issue: 3.4 Pages: 137-144

    • DOI

      10.2152/jmi.62.137

    • NAID

      130005099155

    • ISSN
      1343-1420, 1349-6867
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Total serum IgE level influences oral food challenge tests for IgE-mediated food allergies.2015

    • Author(s)
      Horimukai K, Hayashi K, Tsumura Y, Nomura I, Narita M, Ohya Y, Saito H, Matsumoto K.
    • Journal Title

      Allergy

      Volume: 70 Issue: 3 Pages: 334-7

    • DOI

      10.1111/all.12562

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Global DNA hypomethylation coupled to cellular transformation and metastatic ability.2015

    • Author(s)
      Funaki S, Nakamura T, Nakatani T, Umehara H, Nakashima H, Okumura M, Oboki K, Matsumoto K, Saito H, Nakano T.
    • Journal Title

      FEBS lett.

      Volume: 589 Issue: 24PartB Pages: 4053-60

    • DOI

      10.1016/j.febslet.2015.11.020

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification of a polyI:C-inducible membrane protein that participates in dendritic cell-mediated natural killer cell activation.2015

    • Author(s)
      Ebihara T, Azuma M, Oshiumi H, Kasamatsu J, Iwabuchi K, Matsumoto K, Saito H, Taniguchi T, Matsumoto M, Seya T.
    • Journal Title

      J Exp Med

      Volume: 212 Issue: 8 Pages: 1337-1337

    • DOI

      10.1084/jem.2009157307012015c

    • NAID

      120002722561

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed

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Published: 2015-04-16   Modified: 2022-10-07  

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