Spacial and temporal comics analysis dissolve the evolution and heterogeneity in ESCC.

• Project/Area Number: 15H04921
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Kyushu University
• Principal Investigator: Mimori Koshi 九州大学, 大学病院, 教授 (50322748)
• Co-Investigator(Kenkyū-buntansha): 土岐 祐一郎 大阪大学, 医学系研究科, 教授 (20291445) ; 鈴木 穣 東京大学, 大学院新領域創成科学研究科, 教授 (40323646) ; 宮野 悟 東京大学, 医科学研究所, 教授 (50128104) ; 山本 健 久留米大学, 医学部, 教授 (60274528) ; 伊藤 隆司 九州大学, 医学研究院, 教授 (90201326)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000); Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2016: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000); Fiscal Year 2015: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
• Keywords: CRT治療感受性（抵抗性） / evolution / 次世代シークエンサー / メチル化 / 食道癌 / 食道がん / LRP1B / LDL受容体 / APOBEC / SNP / オミックス解析 / multi regional analysis / Bioinformatics / エピゲノム解析 / 多様性 / methylation / clonality / CCFP

Outline of Final Research Achievements

Recent trends of the current research field of cancer evolution in the world compels us to shift from basic research to engender the results to forge the more clinical outcome. We treated CRT for 28 cases of esophageal cancer (EC) cases, fourteen cases were resistant to the treatment. In 4 out of 14 resistant tumors, we implemented the multi-sampling analysis of 4-6 specimens from pre-CRT tumors and post treatment recurrent tumors for applying to NGS analysis. Consequently, we discovered the recurrence specific evolutional phylogenic tree of evolution, the recurrence specific mutation signatures and the specific copy number aberration observed especially in recurrent tumors. Thanks to this grant, we could discover one of the approaches to connect the basic knowledge of the cancer evolution to the clinical works. In addition, we conducted the methylation analysis of 99 cases of primary EC, and identified a methylation associated mutated gene.

Research Products

• [Journal Article] GWAS Identifies Two Novel Colorectal Cancer Loci at 16q24.1 and 20q13.12. (2018)
  • Author(s): Tanikawa C, Kamatani Y, Takahashi A, Momozawa Y, Leveque K, Nagayama , Mimori K, Mori M, Ishii H, Inazawa J, Yasuda J, Tsuboi A, Shimizu A, Sasaki M, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Naito M, Wakai K, Koyama T, Takezaki T, Yuji K, Murakami Y, Nakamura Y, Kubo M, Matsuda K
  • Journal Title: Carcinogenesis Volume: Epub Issue: 5 Pages: 652-660
  • DOI: 10.1093/carcin/bgy026
  • Peer Reviewed / Open Access
• [Journal Article] Identification of ARL4C as a Peritoneal Dissemination-Associated Gene and Its Clinical Significance in Gastric Cancer. (2018)
  • Author(s): Hu Q, Masuda T, Sato K, Tobo T, Nambara S, Kidogami S, Hayashi N, Kuroda Y, Ito S, Eguchi H, Saeki H, Oki E, Maehara YMimori K
  • Journal Title: Ann Surg Oncol Volume: 25(3) Pages: 745-753
  • Peer Reviewed / Open Access
• [Journal Article] Combined mutation of Apc, Kras and Tgfbr2 effectively drives metastasis of intestinal cancer. (2018)
  • Author(s): Sakai E, Nakayama M, Oshima H, Kouyama Y, Niida A, Fujii S, Ochiai A, Nakayama KI, Minori K, Suzuki Y, Hong CP, Ock CY, Kim SJ, Oshima M.
  • Journal Title: Cancer Res. Volume: 78 Issue: 5 Pages: 1334-1346
  • DOI: 10.1158/0008-5472.can-17-3303
  • NAID: 120006452378
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Antitumor effects of the antiparasitic agent ivermectin via inhibition of Yes-associated protein 1 expression in gastric cancer. (2017)
  • Author(s): Nambara S, Masuda T, Nishio M, Kuramitsu S, Tobo T, Ogawa Y, Hu Q, Iguchi T, Kuroda Y, Ito S, Eguchi H, Sugimachi K, Saeki H, Oki E, Maehara Y, Suzuki A, Mimori K
  • Journal Title: Oncotarget. Volume: 8(64) Issue: 64 Pages: 107666-107677
  • DOI: 10.18632/oncotarget.22587
  • NAID: 120006454566
  • Peer Reviewed / Open Access
• [Journal Article] Circulating exosomal microRNA-203 is associated with metastasis possibly via inducing tumor-associated macrophages in colorectal cancer (2017)
  • Author(s): Takano Y, Masuda T, Iinuma H, Yamaguchi R, Sato K, Tobo T, Hirata H, Kuroda Y, Nambara S, Hayashi N, Iguchi T, Ito S, Eguchi H, Ochiya T, Yanaga K, Miyano S, Mimori K
  • Journal Title: Oncotarget Volume: 8(45) Issue: 45 Pages: 78598-78613
  • DOI: 10.18632/oncotarget.20009
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] MicroRNAs as Biomarkers in Colorectal Cancer. (2017)
  • Author(s): Masuda T, Hayashi N, Kuroda Y, Ito S, Eguchi H, Mimori K
  • Journal Title: Cancers (Basel). Volume: 9(9) Issue: 9 Pages: 124-124
  • DOI: 10.3390/cancers9090124
  • Peer Reviewed / Open Access
• [Journal Article] Japanese genome-wide association study identifies a significant colorectal cancer susceptibility locus at chromosome 10p14. (2017)
  • Author(s): Takahashi Y, Sugimachi K, Yamamoto K, Niida A, Shimamura T, Sato T, Watanabe M, Tanaka J, Kudo S, Sugihara K, Hase K, Kusunoki M, Yamada K, Shimada Y, Moriya Y, Suzuki Y, Miyano S, Mori M, Mimori K
  • Journal Title: Cancer Sci. Volume: 108(11) Issue: 11 Pages: 2239-2247
  • DOI: 10.1111/cas.13391
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical significance of ZNF750 gene expression, a novel tumor suppressor gene, in esophageal squamous cell carcinoma. (2017)
  • Author(s): Nambara S, Masuda T, Tobo T, Kidogami S, Komatsu H, Sugimachi K, Saeki H, Oki E, Maehara Y,Mimori K
  • Journal Title: Oncol Lett Volume: 14(2) Issue: 2 Pages: 1795-1801
  • DOI: 10.3892/ol.2017.6341
  • Peer Reviewed / Open Access
• [Journal Article] Significance of CD47 expression in gastric cancer (2017)
  • Author(s): Sudo Tomoya、Takahashi Yusuke、Sawada Genta、Uchi Ryutaro、Mimori Koshi、Akagi Yoshito
  • Journal Title: Oncology Letters Volume: 14 Issue: 1 Pages: 801-809
  • DOI: 10.3892/ol.2017.6257
  • Peer Reviewed / Open Access
• [Journal Article] DDR2 Expression Is Associated with a High Frequency of Peritoneal Dissemination and Poor Prognosis in Colorectal Cancer (2017)
  • Author(s): Sasaki S, Ueda M, Iguchi T, Kaneko M, Nakayama H, Watanabe T, Sakamoto A, Mimori K
  • Journal Title: Anticancer Res Volume: 37(5) Pages: 2587-2591
  • Peer Reviewed
• [Journal Article] Phosphoserine Phosphatase Is a Novel Prognostic Biomarker on Chromosome 7 in Colorectal Cancer (2017)
  • Author(s): Sato K, Masuda T, Hu Q, Tobo T, Kidogami S, Ogawa Y, Saito T, Nambara S, Komatsu H, Hirata H, Sakimura S, Uchi R, Hayashi N, Iguchi T, Eguchi H, Ito S, Nakagawa T, Mimori K:
  • Journal Title: Anticancer Res Volume: 37(5) Pages: 2365-2371
  • Peer Reviewed
• [Journal Article] Up-regulation of SLC9A9 Promotes Cancer Progression and Is Involved in Poor Prognosis in Colorectal Cancer (2017)
  • Author(s): Ueda M, Iguchi T, Masuda T, Komatsu H, Nambara S, Sakimura S, Hirata H, Uchi R, Eguchi H, Ito S, Sugimachi K, Mizushima T, Doki Y, Mori M, Mimori K
  • Journal Title: Anticancer Res Volume: 37(5) Pages: 2255-2263
  • Peer Reviewed
• [Journal Article] phyC: Clustering cancer evolutionary trees. (2017)
  • Author(s): Matsui Y, Niida A, Uchi R, Mimori K, Miyano S, Shimamura T:
  • Journal Title: PLoS Comput Biol. Volume: 13(5) Issue: 5 Pages: 1005509-1005509
  • DOI: 10.1371/journal.pcbi.1005509
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Overexpression of heat-shock factor 1 is associated with a poor prognosis in esophageal squamous cell carcinoma. (2017)
  • Author(s): Tsukao Y, Yamasaki M, Miyazaki Y, Makino T, Takahashi T, Kurokawa Y, Miyata H, Nakajima K, Takiguchi S, Mimori K, Mori M, Doki Y:
  • Journal Title: Oncol Lett. Volume: 13(3) Issue: 3 Pages: 1819-1825
  • DOI: 10.3892/ol.2017.5637
  • Peer Reviewed / Open Access
• [Journal Article] The loss of CASP4 expression is associated with poor prognosis in esophageal squamous cell carcinoma (2017)
  • Author(s): Shibamoto M, Hirata H, Eguchi H, Sawada G, Sakai N, Kajiyama Y, Mimori K
  • Journal Title: Oncology Letters Volume: 13 Issue: 3 Pages: 1761-6
  • DOI: 10.3892/ol.2017.5646
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Altered expression of Hippo signaling pathway molecules in intrahepatic cholangiocarcinoma. (2017)
  • Author(s): Sugimachi K, Nishio M, Aishima S, Kuroda Y, Iguchi T, Komatsu H, Hirata H, Sakimura S, Eguchi H, Bekki Y, Takenaka K, Maehara Y, Suzuki A, Mimori K.
  • Journal Title: ONCOLOGY Volume: - Issue: 1 Pages: 67-74
  • DOI: 10.1159/000463390
  • Peer Reviewed / Open Access
• [Journal Article] Extraction of cell-free DNA from urine, using polylysine-coated silica particles. (2017)
  • Author(s): Takano S, Hu Q, Amamoto T, Refinetti P, Mimori K, Funatsu T, Kato M
  • Journal Title: Anal Bioanal Chem. Volume: 409(16) Issue: 16 Pages: 4021-4025
  • DOI: 10.1007/s00216-017-0345-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] MOB1-YAP1/TAZ-NKX2.1 axis controls bronchioalveolar cell differentiation, adhesion and tumour formation. Oncogene (2017)
  • Author(s): Otsubo K, Goto H, Nishio M, Kawamura K, Yanagi S, Nishie W, Sasaki T, Maehama T, Nishina H, Mimori K, Nakano T, Shimizu H, Mak TW, Nakao K, Nakanishi Y, Suzuki A
  • Journal Title: Oncogene Volume: 印刷中 Issue: 29 Pages: 4201-4211
  • DOI: 10.1038/onc.2017.58
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Clinical Significance of FANCD Gene Expression and its Association with Tumor Progression in Hepatocellular Carcinoma. (2017)
  • Author(s): Komatsu H, Masuda T, Iguchi T, Nambara S, Sato K, Hu Q, Hirata H, Ito S, Eguchi H, Sugimachi K, Eguchi H, Doki Y, Mori M, Mimori K
  • Journal Title: Anticancer Res Volume: 37(3) Pages: 1083-1090
  • Peer Reviewed
• [Journal Article] Clinical Impact of Tumor-Infiltrating Lymphocytes in Esophageal Squamous Cell Carcinoma. (2017)
  • Author(s): Sudo T, Nishida R, Kawahara A, Saisho K, Mimori K, Yamada A, Mizoguchi A, Kadoya K, Matono S, Mori N, Tanaka T, Akagi Y.
  • Journal Title: Ann Surg Oncol. Volume: in press Issue: 12 Pages: 3763-3770
  • DOI: 10.1245/s10434-017-5796-4
  • Peer Reviewed / Open Access
• [Journal Article] Downregulation of ST6GALNAC1 is associated with esophageal squamous cell carcinoma development. (2017)
  • Author(s): Iwaya T, Sawada G, Amano S, Kume K, Ito C, Endo F, Konosu M, Shioi Y, Akiyama Y, Takahara T, Otsuka K, Nitta H, Koeda K, Mizuno M, Nishizuka S, Sasaki A, Mimori K.
  • Journal Title: Int J Oncol. Volume: 50(2) Issue: 2 Pages: 441-447
  • DOI: 10.3892/ijo.2016.3817
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The Expression of CCAT2, a Novel Long Noncoding RNA Transcript, and rs6983267 Single-Nucleotide Polymorphism Genotypes in Colorectal Cancers. (2017)
  • Author(s): Kasagi Y, Oki E, Ando K, Ito S, Iguchi T, Sugiyama M, Nakashima Y, Ohgaki K, Saeki H, Mimori K, Maehara Y:
  • Journal Title: Oncology. Volume: 92(1) Issue: 1 Pages: 48-54
  • DOI: 10.1159/000452143
  • Peer Reviewed / Open Access
• [Journal Article] Overexpression of CXCR7 Is a Novel Prognostic Indicator in Gastric Cancer. (2016)
  • Author(s): Nambara S, Iguchi T, Oki E, Tan P, Maehara Y, Mimori K.
  • Journal Title: Dig Surg Volume: Epub Issue: 4 Pages: 312-318
  • DOI: 10.1159/000452977
  • Peer Reviewed / Open Access
• [Journal Article] Attenuated RND1 Expression Confers Malignant Phenotype and Predicts Poor Prognosis in Hepatocellular Carcinoma (2016)
  • Author(s): Komatsu H, Iguchi T, Masuda T, Hirata H, Ueda M, Kidogami S, Ogawa Y, Sato K, Hu Q, Nambara S, Saito T, Sakimura S, Uchi R, Ito S, Eguchi H, Sugimachi K, Eguchi H, Doki Y, Mori M, Mimori K.
  • Journal Title: Ann Surg Oncol. Volume: 24(3) Issue: 3 Pages: 850-859
  • DOI: 10.1245/s10434-016-5573-9
  • Peer Reviewed / Open Access
• [Journal Article] miR-146a Polymorphism (rs2910164) Predicts Colorectal Cancer Patients' Susceptibility to Liver Metastasis. (2016)
  • Author(s): Iguchi T, Nambara S, Masuda T, Komatsu H, Ueda M, Kidogami S, Ogawa Y, Hu Q, Sato K, Saito T, Hirata H, Sakimura S, Uchi R, Hayashi N, Ito S, Eguchi H, Sugimachi K, Maehara Y, Mimori K.
  • Journal Title: PLoS One. Volume: 11(11) Issue: 11 Pages: e0165912-e0165912
  • DOI: 10.1371/journal.pone.0165912
  • Peer Reviewed / Open Access
• [Journal Article] Somatic mutations in plasma cell-free DNA are diagnostic markers for esophageal squamous cell carcinoma recurrence (2016)
  • Author(s): Ueda M, Iguchi T, Masuda T, Nakahara Y, Hirata H, Uchi R, Niida A, Momose K, Sakimura S, Chiba K, Eguchi H, Ito S, Sugimachi K, Yamasaki M, Suzuki Y, Miyano S, Doki Y, Mori M, Mimori K
  • Journal Title: Oncotarget Volume: 7(38) Issue: 38 Pages: 62280-62291
  • DOI: 10.18632/oncotarget.11409
  • Peer Reviewed / Open Access
• [Journal Article] 8q24 Polymorphisms and Diabetes Mellitus Regulate Apolipoprotein A-IV in Colorectal Carcinogenesis (2016)
  • Author(s): Sugimachi K, Yamaguchi R, Eguchi H, Ueda M, Niida A, Sakimura S, Hirata H, Uchi R, Shinden Y, Iguchi T, Morita K, Yamamoto K, Miyano S, Mori M, Maehara Y, Mimori K
  • Journal Title: Ann Surg Oncol Volume: 23(Suppl 4) Issue: S4 Pages: 546-551
  • DOI: 10.1245/s10434-016-5374-1
  • Peer Reviewed / Open Access
• [Journal Article] Expression of PD-L1 and HLA Class I in Esophageal Squamous Cell Carcinoma: Prognostic Factors for Patient Outcome. (2016)
  • Author(s): Ito S, Okano S, Morita M, Saeki H, Tsutsumi S, Tsukihara H, Nakashima Y, Ando K, Imamura Y, Ohgaki K, Oki E, Kitao H, Mimori K, Maehara Y.
  • Journal Title: Ann Surg Oncol. Volume: 23(Suppl 4) Issue: S4 Pages: 508-515
  • DOI: 10.1245/s10434-016-5376-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Rapid diagnosis of lymph node metastasis in breast cancer using a new fluorescent method with γ-glutamyl hydroxymethyl rhodamine green. (2016)
  • Author(s): Shinden Y, et al
  • Journal Title: Sci Rep. Volume: 6 Issue: 1 Pages: 27525-27525
  • DOI: 10.1038/srep27525
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] HOXB7 Expression is a Novel Biomarker for Long-term Prognosis After Resection of Hepatocellular Carcinoma. (2016)
  • Author(s): Komatsu H, Iguchi T, Masuda T, Ueda M, Kidogami S, Ogawa Y, Nambara S, Sato K, Hu Q, Saito T, Hirata H, Sakimura S, Uchi R, Hayashi N, Ito S, Eguchi H, Sugimachi K, Eguchi H, Doki Y, Mori M, Mimori K.
  • Journal Title: Anticancer Res. Volume: 36(6) Pages: 2767-73
  • Peer Reviewed
• [Journal Article] Aberrant Methylation of FOXE1 Contributes to a Poor Prognosis for Patients with Colorectal Cancer. (2016)
  • Author(s): Sugimachi K, Matsumura T, Shimamura T, Hirata H, Uchi R, Ueda M, Sakimura S, Iguchi T, Eguchi H, Masuda T, Morita K, Takenaka K, Maehara Y, Mori M, Mimori K.
  • Journal Title: Ann Surg Oncol. Volume: 23(12) Issue: 12 Pages: 3948-3955
  • DOI: 10.1245/s10434-016-5289-x
  • Peer Reviewed / Open Access
• [Journal Article] Decreased Expression of Fructose-1,6-bisphosphatase Associates with Glucose Metabolism and Tumor Progression in Hepatocellular Carcinoma. (2016)
  • Author(s): Hirata H, Sugimachi K, Komatsu H, Ueda M, Masuda T, Uchi R, Sakimura S, Nambara S, Saito T, Shinden Y, Iguchi T, Eguchi H, Ito S, Terashima K, Sakamoto K, Hirakawa M, Honda H, Mimori K.
  • Journal Title: Cancer Res. Volume: 76(11) Issue: 11 Pages: 3265-76
  • DOI: 10.1158/0008-5472.can-15-2601
  • Peer Reviewed / Open Access
• [Journal Article] Increased Copy Number of the Gene Encoding SF3B4 Indicates Poor Prognosis in Hepatocellular Carcinoma. (2016)
  • Author(s): Iguchi T, Komatsu H, Masuda T, Nambara S, Kidogami S, Ogawa Y, Hu Q, Saito T, Hirata H, Sakimura S, Uchi R, Hayashi N, Ito S, Eguchi H, Sugimachi K, Maehara Y, Mimori K.
  • Journal Title: Anticancer Res. Volume: 36(5) Pages: 2139-44
  • Peer Reviewed
• [Journal Article] Downregulation of SIRT4 Expression Is Associated with Poor Prognosis in Esophageal Squamous Cell Carcinoma. (2016)
  • Author(s): Nakahara Y, Yamasaki M, Sawada G, Miyazaki Y, Makino T, Takahashi T, Kurokawa Y, Nakajima K, Takiguchi S, Mimori K, Mori M, Doki Y.
  • Journal Title: Oncology. Volume: Epub Issue: 6 Pages: 347-355
  • DOI: 10.1159/000445323
  • Peer Reviewed / Open Access
• [Journal Article] Integrated Molecular Profiling of Human Gastric Cancer Identifies DDR2 as a Potential Regulator of Peritoneal Dissemination. (2016)
  • Author(s): Kurashige J, Hasegawa T, Niida A, Sugimachi K, Deng N, Mima K, Uchi R, Sawada G, Takahashi Y, Eguchi H, Inomata M, Kitano S, Fukagawa T, Sasako M, Sasaki H, Sasaki S, Mori M, Yanagihara K, Baba H, Miyano S, Tan P, Mimori K.
  • Journal Title: Sci Rep. Volume: 6 Issue: 1 Pages: 22371-22371
  • DOI: 10.1038/srep22371
  • NAID: 120006352400
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical and biological significance of circulating tumor cells in cancer. (2016)
  • Author(s): Masuda T, Hayashi N, Iguchi T, Ito S, Eguchi H, Mimori K.
  • Journal Title: Mol Oncol. Volume: 10 Issue: 3 Pages: 408-17
  • DOI: 10.1016/j.molonc.2016.01.010
  • Peer Reviewed / Open Access
• [Journal Article] Integrated Multiregional Analysis Proposing a New Model of Colorectal Cancer Evolution. (2016)
  • Author(s): R. Uchi (他40名, 山本36番目)
  • Journal Title: PLoS Genetics Volume: 12 Issue: 2 Pages: 1-24
  • DOI: 10.1371/journal.pgen.1005778
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Genomic Landscape of Esophageal Squamous Cell Carcinoma in a Japanese Population. (2016)
  • Author(s): G. Sawada (他43名, 山本21番目)
  • Journal Title: Gastroenterology Volume: 150 Issue: 5 Pages: 1171-1182
  • DOI: 10.1053/j.gastro.2016.01.035
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical and biological significance of transcription termination factor, RNA polymerase I in human liver hepatocellular carcinoma. (2016)
  • Author(s): Komatsu H, Iguchi T, Ueda M, Nambara S, Saito T, Hirata H, Sakimura S1, Takano Y1, Uchi R1, Shinden Y, Eguchi H, Masuda T, Sugimachi K, Eguchi H, Doki Y, Mori M, Mimori K.
  • Journal Title: Oncol Rep Volume: 35 Issue: 4 Pages: 2073-80
  • DOI: 10.3892/or.2016.4593
  • Peer Reviewed / Open Access
• [Journal Article] As a Novel Prognostic Marker, Cysteine/histidine-rich 1 (CYHR1) is a Therapeutic Target in Patients with Esophageal Squamous Cell Carcinoma. (2015)
  • Author(s): Desaki R, Sawada G, Okumura H, Ikeda R, Tanabe K, Komatsu H, Mimori K, Mori M, Kita Y, Uchikado Y, Arigami T, Uenosono Y, Owaki T, Ishigami S, Natsugoe S.
  • Journal Title: Ann Surg Oncol. Volume: Epub Issue: 2 Pages: 586-593
  • DOI: 10.1245/s10434-015-5031-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Dysregulated YAP1/TAZ and TGF signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice (2015)
  • Author(s): Nishio, M., Sugimachi, K., Goto, H., Wang, J., Morikawa, T., Miyachi, Y., Takano, Y., Hikasa, H., Itoh, T., Suzuki, S.O., Kurihara, H., Aishima, S., Leask, A., Sasaki, T., Nakano, T., Nishina, H., Nishikawa, Y., Sekido, Y., Nakao, K., Shin-ya, K., Mimori, K. and Suzuki, A.
  • Journal Title: PNAS Volume: 113 Issue: 1 Pages: 71-80
  • DOI: 10.1073/pnas.1517188113
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] An Integrative Analysis to Identify Driver Genes in Esophageal Squamous Cell Carcinoma (2015)
  • Author(s): Sawada G, Niida A, Hirata H, Komatsu H, Uchi R, Shimamura T, Takahashi Y, Kurashige J, Matsumura T, Ueo H, Takano Y, Ueda M, Sakimura S, Shinden Y, Eguchi H, Sudo T, Sugimachi K, Yamasaki M, Tanaka F, Tachimori Y, Kajiyama Y, Natsugoe S, Fujita H, Tanaka Y, Calin G, Miyano S, Doki Y, Mori M, Mimori K
  • Journal Title: PLoS One Volume: 10(10) Issue: 10 Pages: e0139808-e0139808
  • DOI: 10.1371/journal.pone.0139808
  • Peer Reviewed / Open Access
• [Journal Article] Identification of Recurrence-Related microRNAs from Bone Marrow in Hepatocellular Carcinoma Patients. (2015)
  • Author(s): Sugimachi K, Sakimura S, Tomokuni A, Uchi R, Hirata H, Komatsu H, Shinden Y, Iguchi T, Eguchi H, Masuda T, Morita K, Shirabe K, Eguchi H, Maehara Y, Mori M, Mimori K
  • Journal Title: J Clin Med. Volume: 4 Issue: 8 Pages: 1600-11
  • DOI: 10.3390/jcm4081600
  • Peer Reviewed / Open Access
• [Journal Article] Exosomal microRNA in serum is a novel biomarker of recurrence in human colorectal cancer. (2015)
  • Author(s): Matsumura T, Sugimachi K, Iinuma H, Mori M, Ochiya T, Mimori K.
  • Journal Title: Br J Cancer Volume: 113(2) Issue: 2 Pages: 275-281
  • DOI: 10.1038/bjc.2015.201
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Overexpression of Transcription Termination Factor 1 is Associated with a Poor Prognosis in Patients with Colorectal Cancer. (2015)
  • Author(s): Ueda M, Iguchi T, Nambara S, Saito T, Komatsu H, Sakimura S, Hirata H, Uchi R, Takano Y, Shinden Y, Eguchi H, Masuda T, Sugimachi K, Yamamoto H, Doki Y, Mori M, Mimori K.
  • Journal Title: Ann Surg Oncol. Volume: Epub Issue: S3 Pages: 1490-1498
  • DOI: 10.1245/s10434-015-4652-7
  • Peer Reviewed / Open Access
• [Journal Article] A Long Non-coding RNA Activated by Transforming Growth Factor-β is an Independent Prognostic Marker of Gastric Cancer. (2015)
  • Author(s): Saito T, Kurashige J, Nambara S, Komatsu H, Hirata H, Ueda M, Sakimura S, Uchi R, Takano Y, Shinden Y, Iguchi T, Eguchi H, Ehata S, Murakami K, Sugimachi K, Mimori K.
  • Journal Title: Ann Surg Oncol. Volume: Epub Issue: S3 Pages: 915-922
  • DOI: 10.1245/s10434-015-4554-8
  • Peer Reviewed / Open Access
• [Presentation] 大腸がんにおける進化機構のシフトによる腫瘍内多様性の創出 (2018)
  • Author(s): 三森功士
  • Organizer: 第14回日本消化管学会総会学術集会
• [Presentation] 大腸がんにおける新たな進化と選択圧について (2018)
  • Author(s): 三森功士
  • Organizer: 第2回消化器外科臨床応用をめざす研究交流会
  • Invited
• [Presentation] 日本人食道癌致死率逓減のための分子遺伝学的特徴と超早期診断の実現 (2017)
  • Author(s): 三森功士
  • Organizer: 第35回日本口腔腫瘍学会
  • Place of Presentation: 福岡
  • Year and Date: 2017-01-26
  • Invited
• [Presentation] 大腸がんにおける新たな進化と多様性創出機構について (2017)
  • Author(s): 三森功士
  • Organizer: Translation Research Seminar
• [Presentation] がん転移再発の早期診断におけるctDNAの臨床的有用性について (2017)
  • Author(s): 三森功士
  • Organizer: JBICバイオ関連基盤技術研究会
• [Presentation] 薬物動態から見直す大腸がん化学療法 (2017)
  • Author(s): 三森功士
  • Organizer: 第28回日本消化器癌発生学会
  • Invited
• [Presentation] 消化器がん転移再発診断と治療評価法に関するctDNA解析の臨床的有用性と今後の課題 (2017)
  • Author(s): 三森功士
  • Organizer: 第55回日本癌治療学会学術集会
• [Presentation] 大腸発がんから進行がんにいたる過程のゲノムレベル進化について (2017)
  • Author(s): 三森功士
  • Organizer: 第3回がんゲノム・エピゲノムセミナー
• [Presentation] ctDNAにおいて突然変異の検出が可能な原発巣の特徴 (2017)
  • Author(s): 三森功士
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] 消化器がん症例の様々な臨床的局面における血中ctDNA突然変異検出の意義 (2017)
  • Author(s): 三森功士
  • Organizer: 第26回日本がん転移学会
• [Presentation] 消化器癌におけるctDNA検出の臨床的意義と臨床応用にむけての提言 (2017)
  • Author(s): 三森功士
  • Organizer: 第72回日本消化器外科学会
• [Presentation] プロパゲルマニウム（SK-818）の骨髄由来細胞制御機構による癌転移巣増殖制御について (2017)
  • Author(s): 三森功士
  • Organizer: 第38回日本炎症・再生医学会
  • Invited
• [Presentation] 大腸がんの進化と転移再発を決める選択圧について (2017)
  • Author(s): 三森功士
  • Organizer: 昭和大学横浜北部病院2017年消化器センター軽井沢セミナー
  • Invited
• [Presentation] がん治療における革新的変化を踏まえた最先端技術，新たな開発戦略の現状と今後の方向性 (2017)
  • Author(s): 三森功士
  • Organizer: 第23回抗悪性腫瘍薬開発フォーラム
• [Presentation] 食道扁平上皮癌におけるSF3B4の臨床学的意義についての検討 (2016)
  • Author(s): 木戸上真也、黒田陽介、小松久晃、吉川幸宏、胡慶江、南原翔、林直樹、伊藤修平、江口英利、増田隆明、土岐祐一郎、森正樹、三森功士
  • Organizer: 第75回日本癌学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2016-10-06
• [Presentation] 食道癌における新規EMT制御遺伝子CDC37L1の同定とその臨床病理学的意義. (2016)
  • Author(s): 林直樹、井口友宏、上田正射、南原翔、小松久晃、伊藤修平、江口英利、増田隆明、夏越祥次、三森功士
  • Organizer: 第71回日本消化器外科学会
  • Place of Presentation: 徳島
  • Year and Date: 2016-07-20
• [Presentation] 食道癌におけるＥＭＴのnegative regulatorであるUHRF2の臨床病理学的意義の検討 (2016)
  • Author(s): 木戸上真也、井口友宏、小松久晃、林直樹、伊藤修平、増田隆明、江口英利、土岐祐一郎、森正樹、三森功士
  • Organizer: 第70回日本食道学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2016-07-04
• [Presentation] 食道癌における血中cell free DNA測定の臨床学的意義 (2016)
  • Author(s): 伊藤修平、上田正射、澤田元太、井口友宏、江口英利、増田隆明、山崎誠、森正樹、土岐祐一郎、三森功士
  • Organizer: 第70回日本食道学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2016-07-04
• [Presentation] 食道扁平上皮癌におけるZNF750発現の臨床学的意義 (2016)
  • Author(s): 南原翔、澤田元太、胡慶江、木戸上真也、小松久晃、上田正射、林直樹、井口友宏、江口英利、伊藤修平、増田隆明、杉町圭史、前原喜彦、三森功士
  • Organizer: 第116回日本外科学会
  • Place of Presentation: 大阪
  • Year and Date: 2016-04-14
• [Presentation] 食道扁平上皮癌におけるZNF750発現の意義について (2015)
  • Author(s): 南原翔、澤田元太、新井田厚司、内龍太郎、新田吉陽、井口友宏、江口英利、伊藤修平、増田隆明、杉町圭史、前原喜彦、三森功士
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-08
• [Presentation] ゲノム変異（コピー数増幅、突然変異）を伴う食道癌関連EMT誘導遺伝子の同定 (2015)
  • Author(s): 井口友宏、南原翔、小松久晃、上田正射、高野裕樹、新田吉陽、江口英利、杉町圭史、前原喜彦、三森功士
  • Organizer: 第70回日本消化器外科学会総会
  • Place of Presentation: 浜松
  • Year and Date: 2015-07-15
• [Presentation] Comprehensive Mutation Analysis of Response to Chemoradiothrapy in Esophageal Squamous Cell Carcinoma. (2015)
  • Author(s): H Hirata, R Uchi, M Ueda, S Sakimura, Y Shinden, T Iguchi, K Atsumi, D Tsurumaru, K Sakamoto, K Sugimachi, M Hirakawa, T Sasaki, K Nakamura, H Honda, K Mimori.
  • Organizer: ICRR
  • Place of Presentation: 京都
  • Year and Date: 2015-05-25
  • Int'l Joint Research