Pathophysiological mechanism for the high incidence of overeating-induced obesity, NASH and hepatic carcinogenesis in post-menoposal women
| Project/Area Number |
15H04935
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
橋本 悦子 東京女子医科大学, 医学部, 教授 (40130273)
有泉 俊一 東京女子医科大学, 医学部, 准教授 (40277158)
徳重 克年 東京女子医科大学, 医学部, 教授 (60188729)
正田 純一 筑波大学, 医学医療系, 教授 (90241827)
柳川 徹 筑波大学, 医学医療系, 准教授 (10312852)
後藤 直宏 東京海洋大学, 食品生産科学科, 教授 (60323854)
磯辺 智範 筑波大学, 医学医療系, 准教授 (70383643)
蕨 栄治 筑波大学, 医学医療系, 講師 (70396612)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2017: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
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| Keywords | 脂肪性肝炎 / 肝癌 / 女性ホルモン / 転写因子 / 臓器連環 / 非アルコール性脂肪性肝炎 / 性差 / 遺伝子改変マウス / LPS / 臓器連関 / クッパー細胞 / 非アルコール性脂肪性肝疾患 / エストラジオール / p62遺伝子欠損マウス |
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| Outline of Final Research Achievements |
DKO mice represent a phenotype similar to human NASH. This study investigated sex differences in the phenotypes in the mice. Both male and female mice at 8 weeks showed normal liver histology. At 30 weeks, while the livers of male mice became fatty and fibrotic, those of female mice showed only minimal changes of steatosis and no fibrosis. Even for the female mice at 50 weeks, while the large lipid droplets were found, only minimal changes of fatty and fibrotic changes were observed in the livers. The magnitude of NASH histological changes was found to be weaker in female than in male mice. The results importantly suggest that female hormones may attenuate NASH pathophysiology by inhibiting overeating obesity and LPS-induced inflammatory responses.
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Report
(4 results)
Research Products
(43 results)
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[Journal Article] Risk estimation model for nonalcoholic fatty liver disease in the Japanese using multiple genetic markers.2018
Author(s)
Kawaguchi T, Shima T, Mizuno M, Mitsumoto Y, Umemura A, Kanbara Y, Tanaka S, Sumida Y, Yasui K, Takahashi M, Matsuo K, Itoh Y, Tokushige K, Hashimoto E, Kiyosawa K, Kawaguchi M, Itoh H, Uto H, Komorizono Y, Shirabe K, Takami S, Takamura T, Kawanaka M, Yamada R, Matsuda F, Okanoue T
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Journal Title
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Wisteria floribunda Agglutinin-Sialylated Mucin Core Polypeptide 1 is a Sensitive Biomarker for Biliary Tract Carcinoma and Intrahepatic Cholangiocarcinoma: A Multicenter Study.2016
Author(s)
Shoda J, Matsuda A, Shida T, Yamamoto M, Nagino M, Tsuyuguchi T, Yasaka T, Tazuma S, Uchiyama K, Unno M, Ohkohchi N, Nakanuma Y, Kuno A, Narimatsu H.
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Journal Title
J Gastroenterol
Volume: 52
Issue: 2
Pages: 218-228
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Genomic sequencing identifies ELF3 as a driver of ampullary carcinoma.2016
Author(s)
Yachida Shinichi, Wood Laura D, Suzuki Masami, Takai Erina, Totoki Yasushi, Kato Mamoru, Luchini Claudio, Arai Yasuhito, Nakamura Hiromi, Hama Natsuko, Elzawahry
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Journal Title
Cancer Cell
Volume: 29
Pages: 229-240
Related Report
Peer Reviewed
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[Journal Article] Wisteria floribunda Agglutinin-Sialylated Mucin Core Polypeptide 1 is a Sensitive Biomarker for Biliary Tract Carcinoma and Intrahepatic Cholangiocarcinoma: A Multicenter Study.2016
Author(s)
Shoda J, Matsuda A, Shida T, Yamamoto M, Nagino M, Tsuyuguchi T, Yasaka T, Tazuma S, Uchiyama K, Unno M, Ohkohchi N, Nakanuma Y, Kuno A, Narimatsu H.
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Journal Title
J Gastroenterology
Volume: 52
Pages: 218-228
Related Report
Peer Reviewed
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[Journal Article] Highly sensitive measurement of qualitative changes in glycosylation of mucin 1 for serodiagnosis of cholangiocarcinoma.2015
Author(s)
Matsuda A, Kuno A, Nakagawa T, Ikegara Y, Irimura T, Yamamoto M, Nakanuma Y, Miyoshi E, Nakamori S, Nakanishi H, Viwatthanasittiphong C, Strivatanakul P, Miwa M, Shoda J, Narimatsu H.
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Journal Title
Anal Chem
Volume: 87
Pages: 7274-81
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Whole exome sequencing reveals recurrent mutations in BRCA2 and FAT genes in acinar cell carcinomas of the pancreas.2015
Author(s)
Furukawa T, Sakamoto H, Takeuchi S, Mitra A, Kuboki Y, Yamamoto T, Hatori T, Yamamoto M, Sugiyama M, Ohike N, Yamaguchi H, Shimizu M, Shibata N, Shimizu K, Shiratori K.
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Journal Title
Scientific Reports
Volume: 5
Issue: 1
Pages: 8829-8829
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Book] 肝胆膵2016
Author(s)
川本徹, 山本雅一, 正田純一
Publisher
メディカルビュー社
Related Report
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