| Project/Area Number |
15H04976
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Nagoya City University |
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Principal Investigator |
Okada Atsushi 名古屋市立大学, 大学院医学研究科, 准教授 (70444966)
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| Co-Investigator(Kenkyū-buntansha) |
安井 孝周 名古屋市立大学, 大学院医学研究科, 教授 (40326153)
安藤 亮介 名古屋市立大学, 医学(系)研究科(研究院), その他 (30381867)
田口 和己 名古屋市立大学, 医学(系)研究科(研究院), 研究員 (00595184)
戸澤 啓一 名古屋市立大学, 大学院医学研究科, 教授 (40264733)
郡 健二郎 名古屋市立大学, その他部局等, 学長 (30122047)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2017: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
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| Keywords | 尿路結石 / メタボリックシンドローム / オステオポンチン / マクロファージ / 白色脂肪細胞 / ベージュ細胞 / 抗オステオポンチン抗体 / β3作動薬 / 褐色脂肪組織 / アディポサイトカイン / 脂肪細胞 / 動脈硬化 / 共培養 / 遺伝子欠損マウス |
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| Outline of Final Research Achievements |
We have reported that urolithiasis is a condition of Metabolic Syndrome (MetS). In this study, the following study was conducted to elucidate the relation between calculus formation stone formation stone matrix osteopontin (OPN) in MetS environment.
[1] Establishment of a co-culture system of adipocytes, macrophages and tubule cells, the attachment ability of calcium oxalate monohydrate crystals was most enhanced in the co-existence environment of three cells rather than tubule cells alone. [2] β3 agonist inducing beige cells with anti-MetS action was administered, and stone formation was significantly suppressed. [3] Urinary stones and arteriosclerosis were significantly suppressed by administering anti-OPN antibody to MetS model mice.
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