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The mechanisms for maintenance of pregnancy or failure of pregnancy by the view point of feto-maternal immune-interaction

Research Project

Project/Area Number 15H04980
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionUniversity of Toyama

Principal Investigator

SAITO Shigeru  富山大学, 大学院医学薬学研究部(医学), 教授 (30175351)

Co-Investigator(Kenkyū-buntansha) 村口 篤  富山大学, 大学院医学薬学研究部(医学), 特別研究教授 (20174287)
二階堂 敏雄  富山大学, 事務局, 理事・副学長 (50180568)
瀧澤 俊広  日本医科大学, 大学院医学研究科, 大学院教授 (90271220)
Research Collaborator TSUDA Sayaka  
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2018: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2017: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Keywords産科学 / 胎児医学 / 免疫学
Outline of Final Research Achievements

Regulatory T (Treg) cells are necessary for the maintenance of allogenic pregnancy. Treg cells are decreased in miscarriage and preeclampsia. However, the repertoire of effector Treg cells at the feto-maternal interface in human pregnancy remains unknown. Our objective was to study T cell receptor (TCR) repertoires of Treg cells during pregnancy compared to normal and complicated pregnancies such as miscarriage and preeclampsia. The frequency of clonally expanded populations of effector Treg cells increased in decidua of 3rd trimester subjects compared to 1st trimester subjects. Clonally expanded populations of effector Treg cells decreased in preeclampsia compared with that in 3rd trimester normal pregnancy. Failure of clonal expansion of populations of decidual effector Treg cells might be related to the development of preeclampsia, and decreased decidual effector Treg cells might be related to miscarriage.

Academic Significance and Societal Importance of the Research Achievements

これまでマウスなどの動物実験では、母子間免疫寛容の破綻が流産を起こすことは証明されてきたが、ヒトでこのような事が生じるのかは不明であった。今回の研究成果により、ヒトでも胎児染色体正常流産では父親抗原特異的Treg細胞の減少ではなく、effector Treg細胞の減少が原因である可能性を示唆した。一方、妊娠高血圧腎症では父親抗原特異的Tregの減少が認められた。精漿は父親抗原特異的Tregを誘導する事を、私達はマウスで証明している。同棲期間が短い妊娠、コンドームで避妊しているカップル、初産婦で妊娠高血圧症候群が多い疫学的な事実は、父親抗原特異的Tregの誘導不全という結果をよく証明できる。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (194 results)

All 2019 2018 2017 2016 2015

All Journal Article (57 results) (of which Int'l Joint Research: 22 results,  Peer Reviewed: 54 results,  Open Access: 31 results,  Acknowledgement Compliant: 7 results) Presentation (128 results) (of which Int'l Joint Research: 19 results,  Invited: 39 results) Book (9 results)

  • [Journal Article] New Paradigm in the Role of Regulatory T Cells During Pregnancy2019

    • Author(s)
      Tsuda Sayaka、Nakashima Akitoshi、Shima Tomoko、Saito Shigeru
    • Journal Title

      Frontiers in Immunology

      Volume: 10 Pages: 573-573

    • DOI

      10.3389/fimmu.2019.00573

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differential response of immortalized human amnion mesenchymal and epithelial cells against oxidative stress2019

    • Author(s)
      Han L, Zhao QL, Yoshida T, Okabe M, Soko C, Rehman MU, Kondo T, Nikaido
    • Journal Title

      Free Radical Biology and Medicine

      Volume: 135 Pages: 79-86

    • DOI

      10.1016/j.freeradbiomed.2019.02.017

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Trophoblast-Specific Conditional Atg7 Knockout Mice Develop Gestational Hypertension2018

    • Author(s)
      Aoki A, Nakashima A, Kusabiraki T, Ono Y, Yoshino O, Muto M, Kumasawa K, Yoshimori T, Ikawa M, Saito S
    • Journal Title

      Am. J. Pathol.

      Volume: 188 Issue: 11 Pages: 2474-2486

    • DOI

      10.1016/j.ajpath.2018.07.021

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neutrophil Depletion Exacerbates Pregnancy Complications, Including Placental Damage, Induced by Silica Nanoparticles in Mice2018

    • Author(s)
      Higashisaka Kazuma、Nakashima Akitoshi、Iwahara Yuki、Aoki Aiko、Nakayama Masahiro、Yanagihara Itaru、Lin Ying、Nagano Kazuya、Tsunoda Shin-ichi、Saito Shigeru、Yoshioka Yasuo、Tsutsumi Yasuo
    • Journal Title

      Frontiers in Immunology

      Volume: 9 Pages: 1850-1850

    • DOI

      10.3389/fimmu.2018.01850

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] CD11c+ M1-like macrophages (MΦs) but not CD206+ M2-like MΦ are involved in folliculogenesis in mice ovary2018

    • Author(s)
      Ono Yosuke、Nagai Miwako、Yoshino Osamu、Koga Kaori、Nawaz Allah、Hatta Hideki、Nishizono Hirofumi、Izumi Gentaro、Nakashima Akitoshi、Imura Johji、Tobe Kazuyuki、Fujii Tomoyuki、Osuga Yutaka、Saito Shigeru
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 8171-8171

    • DOI

      10.1038/s41598-018-25837-3

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 17OHP-C in patients with spontaneous preterm labor and intact membranes: is there an effect according to the presence of intra-amniotic inflammation?2018

    • Author(s)
      Yoneda S, Yoneda N, Shiozaki A, Yoshino O, Ueno T, Niimi H, Kitajima I, Tamura K, Kawasaki Y, Makimoto M, Yoshida T, Saito S.
    • Journal Title

      Am J Reprod Immunol.

      Volume: 79 Issue: 3 Pages: 1-11

    • DOI

      10.1111/aji.12867

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sludge reflects intra-amniotic inflammation with or without microorganisms.2018

    • Author(s)
      Yoneda N, Yoneda S, Niimi H, Ito M, Fukuta K, Ueno T, Ito M, Shiozaki A, Kigawa M, Kitajima I, Saito S.
    • Journal Title

      Am J Reprod Immunol.

      Volume: 79(2) Issue: 2 Pages: 1-8

    • DOI

      10.1111/aji.12807

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] In which preterm labor-patients is intravenous maintenance tocolysis effective?2018

    • Author(s)
      Yoneda S, Yoneda N, Fukuta K, Shima T, Nakashima A, Shiozaki A, Yoshino O, Kigawa M, Yoshida T, Saito S.
    • Journal Title

      J Obstet Gynaecol Res.

      Volume: 44(3) Issue: 3 Pages: 397-407

    • DOI

      10.1111/jog.13547

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clonally Expanded Decidual Effector Regulatory T Cells Increase in Late Gestation of Normal Pregnancy, but Not in Preeclampsia, in Humans2018

    • Author(s)
      Tsuda Sayaka、Zhang Xiaoxin、Hamana Hiroshi、Shima Tomoko、Ushijima Akemi、Tsuda Kei、Muraguchi Atsushi、Kishi Hiroyuki、Saito Shigeru
    • Journal Title

      Frontiers in Immunology

      Volume: 9 Pages: 1934-1934

    • DOI

      10.3389/fimmu.2018.01934

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A cloning and expression system to probe T-cell receptor specificity and assess functional avidity to neoantigens2018

    • Author(s)
      Hu Z, Anandappa AJ, Sun J, Kim J, Leet DE, Bozym DJ, Chen C, Williams L, Shukla SA, Zhang W, Tabbaa D, Steelman S, Olive O, Livak KJ, Kishi H, Muraguchi A, Guleria I, Stevens J, Lane WJ, Burkhardt UE, Fritsch EF, Neuberg D, Ott PA, Keskin DB, Hacohen N, Wu CJ
    • Journal Title

      Blood

      Volume: 132 Issue: 18 Pages: 1911-1921

    • DOI

      10.1182/blood-2018-04-843763

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Analysis of the clinical significance of DCLK1(+) colorectal cancer using novel monoclonal antibodies against DCLK1.2018

    • Author(s)
      Dai T, Hu Y, Lv F, Ozawa T, Sun X, Huang J, Han X, Kishi H, Muraguchi A, Jin A.
    • Journal Title

      Onco Targets Ther.

      Volume: 11 Pages: 5047-5057

    • DOI

      10.2147/ott.s169928

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Human monoclonal antibodies against West Nile virus from Japanese encephalitis-vaccinated volunteers.2018

    • Author(s)
      Ozawa T, Masaki H, Takasaki T, Aoyama I, Yumisashi T, Yamanaka A, Konishi E, Ohnuki Y, Muraguchi A, Kishi H.
    • Journal Title

      Antiviral Res

      Volume: 154 Pages: 58-65

    • DOI

      10.1016/j.antiviral.2018.04.011

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of Tumoricidal TCRs from Tumor-Infiltrating Lymphocytes by Single-Cell Analysis2018

    • Author(s)
      Shitaoka Kiyomi、Hamana Hiroshi、Kishi Hiroyuki、Hayakawa Yoshihiro、Kobayashi Eiji、Sukegawa Kenta、Piao Xiuhong、Lyu Fulian、Nagata Takuya、Sugiyama Daisuke、Nishikawa Hiroyoshi、Tanemura Atsushi、Katayama Ichiro、Murahashi Mutsunori、Takamatsu Yasushi、Tani Kenzaburo、Ozawa Tatsuhiko、Muraguchi Atsushi
    • Journal Title

      Cancer Immunology Research

      Volume: 6 Issue: 4 Pages: 378-388

    • DOI

      10.1158/2326-6066.cir-17-0489

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of RUNX2 gene silencing on the gemcitabine sensitivity of p53 mutated pancreatic cancer MiaPaCa 2 spheres.2018

    • Author(s)
      Sang M, Nakamura M, Ogata T, Sun D, Shimozato O, Nikaido T, Ozaki T.
    • Journal Title

      Oncol Rep.

      Volume: 印刷中 Pages: 2749-2758

    • DOI

      10.3892/or.2018.6344

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] In vivo attenuation of angiogenesis in hepatocellular carcinoma by Nigella sativa2018

    • Author(s)
      Fathy M, Nikaido T.
    • Journal Title

      Turk J Med Sci.

      Volume: 48 Pages: 178-186

    • DOI

      10.3906/sag-1701-86

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Endogenous and exogenous miR-520c-3p modulates CD44-mediated extravillous trophoblast invasion.2017

    • Author(s)
      Takahashi H, Ohkuchi A, Kuwata T, Usui R, Baba Y, Suzuki H, Chaw Kyi TT , Matsubara S, Saito S, Takizawa T.
    • Journal Title

      Placenta.

      Volume: 50 Pages: 25-31

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of autophagy in oocytogenesis, embryogenesis, implantation and pathophysiology of preeclampsia.2017

    • Author(s)
      Nakashima A, Aoki A, Kusabiraki T, Shima T, Yoshino O, Shi-Bin Cheng, Sharma S, Saito S.
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 43 Issue: 4 Pages: 633-643

    • DOI

      10.1111/jog.13292

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Association Between High-Avidity T-Cell Receptors, Induced by α-Fetoprotein-Derived Peptides, and Anti-Tumor Effects in Patients With Hepatocellular Carcinoma2017

    • Author(s)
      Nakagawa H, Mizukoshi E, Kobayashi E, Tamai T, Hamana H, Ozawa T, Kishi H, Kitahara M, Yamashita T, Arai K, Terashima T, Iida N, Fushimi K, Muraguchi A, Kaneko S
    • Journal Title

      Gastroenterology

      Volume: 152 Issue: 6 Pages: 1395-1406

    • DOI

      10.1053/j.gastro.2017.02.001

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification of an HLA class I allele closely involved in the auto-antigen presentation in acquired aplastic anemia2017

    • Author(s)
      Zaimoku Y, Takamatsu H, Hosomichi K, Ozawa T, Nakagawa N, Imi T, Maruyama H, Katagiri T, Kishi H, Tajima A, Muraguchi A, Kashiwase K, Nakao S
    • Journal Title

      Blood

      Volume: 印刷中 Issue: 21 Pages: 2908-2916

    • DOI

      10.1182/blood-2016-11-752378

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Highly functional T-cell receptor repertoires are abundant in stem memory T cells and highly shared among individuals2017

    • Author(s)
      Miyama Takahiko、Kawase Takakazu、Kitaura Kazutaka、Chishaki Ren、Shibata Masashi、Oshima Kumi、Hamana Hiroshi、Kishi Hiroyuki、Muraguchi Atsushi、Kuzushima Kiyotaka、Saji Hiroh、Shin-I Tadasu、Suzuki Ryuji、Ichinohe Tatsuo
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 668-668

    • DOI

      10.1038/s41598-017-03855-x

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of Novel Epitopes with Agonistic Activity for the Development of Tumor Immunotherapy Targeting TRAIL-R1.2017

    • Author(s)
      Guo L, Sun X, Hao Z, Huang J, Han X, You Y, Li Y, Shen M, Ozawa T, Kishi H, Muraguchi A, Jin A.
    • Journal Title

      J Cancer.

      Volume: 8 Issue: 13 Pages: 2542-2553

    • DOI

      10.7150/jca.19918

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hyperdry Human Amniotic Membrane (HD-AM) is Supporting Aciclovir Included Device of Poly-N-p-Vinyl-Benzyl-D-Lactonamide (PVLA) Sphere for Treatment of HSV-1 Infected Rabbit Keratitis Model2017

    • Author(s)
      Okabe M, Yoshida T, Suzuki M, Goto M, Omori M, Taguchi M, Toda A, Suzuki T, Nakagawa K, Hiramoto F, Ushijima T, Waki H, Fruichi E, Arai K, Zhou K, Moustafa Fathy Omar , Makamura M, Nomura Y, Kasama T, Katou K, Saito S, Nikaido T.
    • Journal Title

      J Biotechnol Biomater

      Volume: 07 Issue: 01 Pages: 251-251

    • DOI

      10.4172/2155-952x.1000251

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] CD24+SSEA4+ cells in Ovarian Carcinoma Cells Demonstrated the Characteristics as Cancer Stem Cells.2017

    • Author(s)
      Wang F, Yoshida T, Okabe M, Fathy M, Sun Y, Koike C, Saito S, Nikaido T.
    • Journal Title

      J Cancer Sci Ther

      Volume: 9 Pages: 3-3

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isolation of Stem-Like Cancer Cells in Primary Endometrial Cancer Using Cell Surface Markers CD133 and CXCR4.2017

    • Author(s)
      Sun Y, Yoshida T, Okabe M, Zhou K, Wang F, Soko C, Saito S, Nikaido T.
    • Journal Title

      Transl Oncol.

      Volume: 10 Issue: 6 Pages: 976-987

    • DOI

      10.1016/j.tranon.2017.07.007

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Phosphorylated Akt Protein at Ser473 Enables HeLa Cells to Tolerate Nutrient-Deprived Conditions.2017

    • Author(s)
      Fathy M, Awale S, Nikaido T.
    • Journal Title

      Asian Pac J Cancer Prev.

      Volume: 18 Pages: 3255-3260

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Complex Structure of the Mouse Placental Labyrinth Revealed by Double Immunofluorescence Labeling of Slc2a1 and Gjb22017

    • Author(s)
      Chaw Kyi-Tha-Thu, Toshihiro Takizawa
    • Journal Title

      Journal of Nippon Medical School

      Volume: 84 Issue: 3 Pages: 108-109

    • DOI

      10.1272/jnms.84.108

    • NAID

      130005809229

    • ISSN
      1345-4676, 1347-3409
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fabrication of 3D-culture platform with sandwich architecture for preserving liver-specific functions of hepatocytes using 3D bioprinter.2017

    • Author(s)
      Arai K, Yoshida T, Okabe M, Goto M, Mir TA, Soko C, Tsukamoto Y, Akaike T, Nikaido T, Zhou K, Nakamura M
    • Journal Title

      J Biomed Master Res A.

      Volume: 105 Issue: 6 Pages: 1583-1592

    • DOI

      10.1002/jbm.a.35905

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Endogenous and exogenous miR-520c-3p modulates CD44-mediated extravillous trophoblast invasion2017

    • Author(s)
      Takahashi H, Ohkuchi A, Kuwata T, Usui R, Baba Y, Suzuki H, Chaw Kyi TT, Matsubara S, Saito S, Takizawa T
    • Journal Title

      Placenta

      Volume: 50 Pages: 25-31

    • DOI

      10.1016/j.placenta.2016.12.016

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A new era in reproductive medicine: consequences of third-party oocyte donation for maternal and fetal health.2016

    • Author(s)
      Saito S, Nakabayashi Y, Nakashima A, Shima T, Yoshino O
    • Journal Title

      Semin Immunol.

      Volume: 38 Issue: 6 Pages: 687-697

    • DOI

      10.1007/s00281-016-0577-x

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dual Positive Regulation of Embryo Implantation by Endocrine and Immune Systems - Step-by-Step Maternal Recognition of the Developing Embryo.2016

    • Author(s)
      Fujiwara H, Araki Y, Imakawa K, Saito S, Daikoku T, Shigeta M, Kanzaki H, Mori T.
    • Journal Title

      Am J Reprod Immunol.

      Volume: 75 Issue: 3 Pages: 281-9

    • DOI

      10.1111/aji.12478

    • NAID

      120005743891

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Decidual soluble factors, through modulation of dendritic cells functions, determine the immune response patterns at the feto-maternal interface.2016

    • Author(s)
      Ahmadabad HN, Salehnia M, Saito S, Moazzeni SM.
    • Journal Title

      J Reprod Immunol.

      Volume: 114 Pages: 10-17

    • DOI

      10.1016/j.jri.2016.01.001

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antibiotic Therapy Increases the Risk of Preterm Birth in Preterm Labor without Intra-Amniotic Microbes, but may Prolong the Gestation Period in Preterm Labor with Microbes, Evaluated by Rapid and High-Sensitive PCR System2016

    • Author(s)
      Yoneda S, Shiozaki A, Yoneda N, Ito M, Shima T, Fukuda K, Ueno T, Niimi H, Kitajima I, Kigawa M, Saito S
    • Journal Title

      American Journal of Reproductive Immunology

      Volume: 75(4) Issue: 4 Pages: 440-50

    • DOI

      10.1111/aji.12484

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Role of Paternal Antigen-Specific Treg Cells in Successful Implantation.2016

    • Author(s)
      Saito S, Shima T, Nakashima A, Inada K, Yoshino O.
    • Journal Title

      Am J Reprod Immunol.

      Volume: 75 Issue: 3 Pages: 310-316

    • DOI

      10.1111/aji.12469

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impairment of the accumulation of decidual T cells, NK cells, and monocytes, and the poor vascular remodeling of spiral arteries, were observed in oocyte donation cases, regardless of the presence or absence of preeclampsia.2016

    • Author(s)
      Nakabayashi Y, Nakashima A, Yoshino O, Shima T, Shiozaki A, Adachi T, Nakabayashi M, Okai T, Kushima M, Saito S
    • Journal Title

      J Reprod Immunol.

      Volume: 114 Pages: 65-74

    • DOI

      10.1016/j.jri.2015.07.005

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel, rapid and efficient method of cloning functional antigen-specific T-cell receptors from single human and mouse T-cells.2016

    • Author(s)
      Hamana H, Shitaoka K, Kishi H, Ozawa T, Muraguchi A.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 474 Pages: 709-714

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Construction and characterization of human oral mucosa equivalent using hyper-dry amniotic membrane as a matrix.2016

    • Author(s)
      Qi Fangfang, Toshiko Yoshida, Takeshi Koike, Hitoshi Aizawa, Tetsu Shimane, Yinghui Li, Shinichi Yamada, Motonori Okabe, Toshiko Nikaido, Hiroshi Kurita.
    • Journal Title

      Archives of Oral Biology

      Volume: 65 Pages: 26-34

    • DOI

      10.1016/j.archoralbio.2016.01.011

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A human amnion-derived extracellular matrix-coated cell-free scaffold for cartilage repair: in vitro and in vivo studies.2016

    • Author(s)
      Nogami M, Kimura T, et al.
    • Journal Title

      Tissue Engineering

      Volume: 22 Issue: 7-8 Pages: 680-688

    • DOI

      10.1089/ten.tea.2015.0285

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Polymicrobial Amniotic Fluid Infection with Mycoplasma/Ureaplasma and Other Bacteria Induces Severe Intra-Amniotic Inflammation Associated with Poor Perinatal Prognosis in Preterm Labor2015

    • Author(s)
      Yoneda N, Yoneda S, Niimi H, Ueno T, Hayashi S, Ito M, Shiozaki A, Urushiyama D, Hata K, Suda W, Hattori M, Kigawa M, Kitajima I, Saito S.
    • Journal Title

      American Journal of Reproductive Immunology

      Volume: 75(2) Issue: 2 Pages: 112-25

    • DOI

      10.1111/aji.12456

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Melting temperature mapping method: A novel method for identification of unknown pathogenic microorganisms within three hours of sample of collection.2015

    • Author(s)
      Niimi H, Ueno T, Hayashi S, Abe A, Tsurue T, Mori M, Tabata H, Minami H, Goto M, Akiyama M, Yamamoto Y, Saito S, Kitajima I
    • Journal Title

      Scientific Reports.

      Volume: 5 Issue: 1 Pages: 12543-12543

    • DOI

      10.1038/srep12543

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Eukaryote-Made Thermostable DNA Polymerase Enables Rapid PCR-Based Detection of Mycoplasma, Ureaplasma and Other Bacteria in the Amniotic Fluid of Preterm Labor Cases.2015

    • Author(s)
      Ueno T, Niimi H, Yoneda N, Yoneda S, Mori M, Tabata T, Minami H, Saito S, Kitajima I
    • Journal Title

      PLoS One.

      Volume: 10(6) Issue: 6 Pages: 1-17

    • DOI

      10.1371/journal.pone.0129032

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prevalence of Regulatory T-Cell Subtypes in Preeclampsia.2015

    • Author(s)
      Toldi G, Vasarhelyi ZE, Rigo J Jr, Orban C, Tamassy Z, Bajnok A, Shima T, Saito S, Molvarec A
    • Journal Title

      Am J Reprod Immunol.

      Volume: 74 Issue: 2 Pages: 110-115

    • DOI

      10.1111/aji.12380

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Accurate prediction for the stage of histological chorioamnionitis before delivery by amniotic fluid IL-8 level2015

    • Author(s)
      Yoneda S, Shiozaki A, Ito M, Yoneda N, Inada K, Yonezawa R, Kigawa M, Saito S
    • Journal Title

      Am J Reprod Immunol.

      Volume: 未定 Issue: 6 Pages: 12360-12360

    • DOI

      10.1111/aji.12360

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Paternal antigen-specific proliferating regulatory T cells are increased in uterine-draining lymph nodes just before implantation and in pregnant uterus just after implantation by seminal plasma-priming in allogeneic mouse pregnancy.2015

    • Author(s)
      Shima T, Inada K, Nakashima A, Ushijima A, Ito M, Yoshino O, Saito S.
    • Journal Title

      J Reprod Immunol.

      Volume: 108 Pages: 78-82

    • DOI

      10.1016/j.jri.2015.02.005

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Helios-positive functional regulatory T cells are decreased in decidua of miscarriage cases with normal fetal chromosomal content.2015

    • Author(s)
      Inada K, Shima T, Ito M, Ushijima A, Saito S.
    • Journal Title

      J Reprod Immunol.

      Volume: 107 Pages: 10-19

    • DOI

      10.1016/j.jri.2014.09.053

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] NK活性高値の不育症症例における漢方療法の効果と気血水スコアの関連.2015

    • Author(s)
      鮫島 梓, 米澤理可, 齋藤真実, 齋藤 滋
    • Journal Title

      産婦人科漢方研究のあゆみ.

      Volume: 32 Pages: 33-38

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 着床と免疫2015

    • Author(s)
      齋藤 滋
    • Journal Title

      Hormone Frontier in Gynecology.

      Volume: 22 Pages: 67-71

    • Related Report
      2015 Annual Research Report
  • [Journal Article] A Human Anti-M2 Antibody Mediates Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) and Cytokine Secretion by Resting and Cytokine-Preactivated Natural Killer (NK) Cells2015

    • Author(s)
      Venkateswara R. Simhadri, Milena Dimitrova, John L. Mariano, Olatz Zenarruzabeitia, Weimin Zhong, Tatsuhiko Ozawa, Atsushi Muraguchi, Hiroyuki Kishi, Maryna C. Eichelberger, Francisco Borrego
    • Journal Title

      PLoS One

      Volume: 10 Issue: 4 Pages: e0124677-e0124677

    • DOI

      10.1371/journal.pone.0124677

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Monoclonal Antibody Against Citrullinated Peptides Obtained From Rheumatoid Arthritis Patients Reacts With Numerous Citrullinated Microbial and Food Proteins2015

    • Author(s)
      Reina Tsuda, Tatsuhiko Ozawa, Eiji Kobayashi, Hiroshi Hamana, Hirofumi Taki, Kazuyuki Tobe, Eiji Sugiyama, Masahiro Iwamoto, Johji Imura, Hiroyuki Kishi, Atsushi Muraguchi
    • Journal Title

      Arthritis & Rheumatology

      Volume: 67 Issue: 8 Pages: 2020-2031

    • DOI

      10.1002/art.39161

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Production of monoclonal antibodies against GPCR using cell-free synthesized GPCR antigen and biotinylated liposome-based interaction assay2015

    • Author(s)
      Takeda H, Ogasawara T, Ozawa T, Muraguchi A, Jih PJ, Morishita R, Uchigashima M, Watanabe M, Fujimoto T, Iwasaki T, Endo Y, Sawasaki T
    • Journal Title

      Sci Rep

      Volume: 5 Issue: 1 Pages: 11333-11333

    • DOI

      10.1038/srep11333

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Immunological features of T cells induced by human telomerase reverse transcriptase-derived peptides in patients with hepatocellular carcinoma.2015

    • Author(s)
      E Mizukoshi, H Nakagawa, M Kitahara, T Yamashita, K Arai, H Sunagozaka, K Fushimi, E Kobayashi, H Kishi, A Muraguchi, S Kaneko.
    • Journal Title

      Cancer Lett

      Volume: 364 Issue: 2 Pages: 98-105

    • DOI

      10.1016/j.canlet.2015.04.031

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of broadly conserved cross-species protective Leishmania antigen and its responding CD4 + T cells2015

    • Author(s)
      Z. Mou, J. Li, T. Boussoffara, H. Kishi, H. Hamana, P. Ezzati, C. Hu, W. Yi, D. Liu, F. Khadem, I. Okwor, P. Jia, K. Shitaoka, S. Wang, M. Ndao, C. Petersen, J. Chen, S. Rafati, H. Louzir, A. Muraguchi, J. a Wilkins, and J. E. Uzonna,
    • Journal Title

      Science Translational Medicine

      Volume: 7 Issue: 310 Pages: 1-13

    • DOI

      10.1126/scitranslmed.aac5477

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Human Amnion-derived stem cells have immunosuppressive properties.2015

    • Author(s)
      Li J, Koike C, Sugimoto J, Yoshida T, Okabe M, and Nikaido T
    • Journal Title

      Cell Transplantation

      Volume: 24 Issue: 10 Pages: 2065-2076

    • DOI

      10.3727/096368914x685230

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Use of hyperdry amniotic membrane in operations for cleft palate: a study in rats.2015

    • Author(s)
      Tsuno H, Noguchi M, Okabe M, Tomihara K, Yoshida T, Nikaido T.
    • Journal Title

      Br J Oral Maxillofac Surg.

      Volume: 53 Issue: 4 Pages: 358-363

    • DOI

      10.1016/j.bjoms.2015.01.018

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Bioprinting with pre-cultured cellular constructs towards tissue engineering of hierarchical tissues.2015

    • Author(s)
      Nakamura M, Mir T A, Arai K, Ito S, Yoshida T, Iwanaga S, Kitano H, Obara C, Nikaido T..
    • Journal Title

      International Journal of Bioprinting

      Volume: 1(1) Issue: 1 Pages: 39-48

    • DOI

      10.18063/ijb.2015.01.007

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Maternal peripheral blood natural killer cells incorporate placenta-associated microRNAs during pregnancy.2015

    • Author(s)
      Ishida Y, Zhao D, Ohkuchi A, Kuwata T, Yoshitake H, Yuge K, Takizawa T, Matsubara S, Suzuki M, Saito S, Takizawa T
    • Journal Title

      Int J Mol Med.

      Volume: 35 Issue: 6 Pages: 1511-1524

    • DOI

      10.3892/ijmm.2015.2157

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Fc gamma receptor IIb participates in maternal IgG trafficking of human placental endothelial cells.2015

    • Author(s)
      Ishikawa T, Takizawa T, Iwaki J, Mishima T, Ui-Tei K, Takeshita T, Matsubara S, Takizawa T.
    • Journal Title

      nt. J. Mol. Med.

      Volume: 35 Issue: 5 Pages: 1273-1789

    • DOI

      10.3892/ijmm.2015.2141

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 胎盤由来microRNA : 妊娠高血圧症候群との関連(特集 胎盤のバイオマーカー)2015

    • Author(s)
      瀧澤俊広、大口昭英、Banyar Than Naing
    • Journal Title

      産科と婦人科

      Volume: 82 Pages: 1011-1016

    • NAID

      40020568053

    • Related Report
      2015 Annual Research Report
  • [Presentation] 若年女性膠原病患者のライフイベントを考える~免疫から見た妊娠維持機構とその破綻~.2019

    • Author(s)
      齋藤 滋
    • Organizer
      Tokyo Autoimmune Disease Seminar.
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] WoCBA(Women of Childbearing Age)患者の現状と治療課題~免疫から見た妊娠維持機構とその破綻~.2019

    • Author(s)
      齋藤 滋
    • Organizer
      第7回東山免疫膠原病フォーラム.
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 妊娠高血圧症候群の最近の話題.2019

    • Author(s)
      齋藤 滋
    • Organizer
      第31回富山県母性衛生学会総会・学術集会.
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 周産期の三大疾患である流産、早産、妊娠高血圧症候群の病態とその治療戦略.2019

    • Author(s)
      齋藤 滋
    • Organizer
      平成30年度橿孳会講演会.
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Clonal populations of Treg cells decrease in preeclampsia but not in miscarriage.2018

    • Author(s)
      Saito S.
    • Organizer
      1th International Workshop Reproductive Immunology, Immunological Tolerance and Immunology of Preeclampsia
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Pathophysiology of preterm labor from the viewpoints of infection and inflammation.2018

    • Author(s)
      Saito S
    • Organizer
      The 38th Annual Meeting of the American Society for Reproductive Immunology / The 6th Annual Meeting of the Chinese Society for Reproductive Immunology.
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] WoCBA (Women of Child-Bearing Age) 患者の現状と治療課題 ~免疫からみた妊娠維持機構とその破綻~.2018

    • Author(s)
      齋藤 滋
    • Organizer
      第28回日本リウマチ学会北海道・東北支部学術集会.
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] WoCBA (Women of Child-Bearing Age) 患者の現状と治療課題 ~免疫からみた妊娠維持機構とその破綻~.2018

    • Author(s)
      齋藤 滋
    • Organizer
      第46回日本臨床免疫学会総会.
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 医療安全からみたWoCBA (Women of Child-Bearing Age) 患者の現状と治療課題 ~免疫からみた妊娠維持機構とその破綻~.2018

    • Author(s)
      齋藤 滋
    • Organizer
      第28回 日本リウマチ学会近畿支部学術集会.
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] WoCBA (Women of Child-Bearing Age) 患者の現状と治療課題 ~免疫からみた妊娠維持機構とその破綻~.2018

    • Author(s)
      齋藤 滋
    • Organizer
      第30回 中部リウマチ学会.
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 妊婦の腸内細菌が出産、出生時に与える影響.2018

    • Author(s)
      齋藤 滋
    • Organizer
      第7回日本DOHaD学会学術集会.
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] WoCBA (Women of Child-Bearing Age) 患者の現状と治療課題 ~免疫からみた妊娠維持機構とその破綻~.2018

    • Author(s)
      齋藤 滋
    • Organizer
      第39回日本炎症・再生医学会 ランチョンセミナー.
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 増える!腸の現代病~炎症性腸疾患(IBD)合併妊娠の管理の実際~.2018

    • Author(s)
      齋藤 滋
    • Organizer
      第70回日本産科婦人科学会学術講演会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Clonally expanded decidual effector Treg cells increase in late gestation of normal pregnancy, but not in preeclampsia in human.2018

    • Author(s)
      Sayaka Tsuda, Hiroyuki Kishi, Xiaoxin Zhang, Tomoko Shima, Hiroshi Hamana, Akemi Ushijima, Atsushi Muraguchi, Shigeru Saito.
    • Organizer
      American-Sino Joint Meeting of Reproductive Immunology 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ヒト妊娠における制御性T細胞のT細胞受容体レパートリー.2018

    • Author(s)
      津田 さやか, Xiaoxin Zhang, 浜名 洋,島 友子,牛島 明美,村口 篤, 岸 裕幸,齋藤 滋
    • Organizer
      Toyama Academic GALA 2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] ヒトの妊娠高血圧腎症と胎児染色体正常流産症例では脱落膜effector 制御性T細胞のクローナリティーと数が異なる.2018

    • Author(s)
      津田 さやか, Xiaoxin Zhang, 浜名 洋, 島 友子, 牛島 明美, 津田 桂, 村口 篤, 岸 裕幸, 齋藤 滋.
    • Organizer
      第39回日本妊娠高血圧学会総会・学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 制御性T細胞のsingle-cell TCRレパートリー解析により示唆された流産と妊娠高血圧腎症の免疫学的病態の相違.2018

    • Author(s)
      津田 さやか, Xiaoxin Zhang, 浜名 洋, 島 友子, 牛島 明美, 津田 桂, 村口 篤, 岸 裕幸, 齋藤 滋.
    • Organizer
      第33回日本生殖免疫学会総会・学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] T-ISAAC法を用いたペプチド特異的T細胞のTCRレパトア解析.2018

    • Author(s)
      小林栄治,村口 篤,岸 裕幸.
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] TILでクローナルなT細胞受容体は,腫瘍に対して細胞障害性を示し,腫瘍関連抗原を認識する.2018

    • Author(s)
      下岡清美,浜名 洋,小林栄治,早川芳弘,村口 篤,岸 裕幸.
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 効率的な大腸癌免疫療法の確立に向けた腫瘍浸潤リンパ球レパートリー解析.2018

    • Author(s)
      祐川健太,浜名 洋,下岡清美,小林栄治,北條荘三,奧村知之,長田拓哉,村口 篤,岸 裕幸,藤井 努.
    • Organizer
      第29回日本消化器癌発生学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 酵母表面ディスプレイ法を用いたTCRの抗原ペプチド/MHCライブラリーの作製とそのスクリーニング.2018

    • Author(s)
      小澤龍彦,大貫 燿,浜名 洋,小林栄治,呂 福蓮,村口 篤,岸 裕幸.
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] TCR repertoire analysis of peptide-specific T cells using immunospot array assay on a chip (T-ISAAC) technology.2018

    • Author(s)
      Kobayashi E, Ozawa T, Hamana H, Shitaoka K, Muraguchi A, Kishi H.
    • Organizer
      第47回日本免疫学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] A rapid and simple protocol for cDNA cloning of tumor antigen-specific TCR.2018

    • Author(s)
      Hamana H, Ozawa T, Kobayashi E, Shitaoka K, Muraguchi A, Kishi H.
    • Organizer
      第47回日本免疫学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] The development of antigen detection system using yeast surface display library.2018

    • Author(s)
      Ohnuki Y, Ozawa T, Hamana H, Kobayashi E, Lyu F, Muraguchi A, Kishi H.
    • Organizer
      第47回日本免疫学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Tumor infiltrating lymphocyte repertoire analysis of colon cancer.2018

    • Author(s)
      Sukegawa K, Hamana H, Shitaoka K, Kobayashi E, Saeki S, Nagata T, Fujii T, Muraguchi A, Kishi H.
    • Organizer
      第47回日本免疫学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Clonally expanded populations of cytotoxic T cell in tumor infiltrated lymphocyte and peripheral blood in uterine endometrial cancer.2018

    • Author(s)
      Tsuda K, Kishi H, Nakashima A, Hamana H, Tsuda S, Shima T, Shitaoka K, Kobayashi E, Ozawa T, Muraguchi A, Saito S.
    • Organizer
      第47回日本免疫学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Development of TCR-antigen identification system using “cis-interaction” of TCR and peptide/MHC complex on a T cell.2018

    • Author(s)
      Yamaguchi S, Kishi H, Shitaoka K, Hamana H, Kobayashi E, Ozawa T, Muraguchi A.
    • Organizer
      第47回日本免疫学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 妊娠初期流産における末梢血および脱落膜NK細胞の遺伝子発現解析:mRNA-miRNA解析2018

    • Author(s)
      小古山学、大口昭英、島友子、松原茂樹、齋藤滋、瀧澤俊広
    • Organizer
      第70回日本産科婦人科学会学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] マウス子宮NK細胞のI型グルコース輸送体(Slc2a1)は活性化されると細胞内顆粒から細胞表面にアップレギュレーションされる:組織化学的解析.2018

    • Author(s)
      Chaw Kyi-Tha-Thu、瀧澤俊広
    • Organizer
      第70回日本産科婦人科学会学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Gene expression analysis of peripheral and decidual natural killer cells in early miscarriage using microarray analysis.2018

    • Author(s)
      Manabu Ogoyama、Akihide Ohkuchi、Tomoko Shima、Shigeru Saito、Toshihiro Takizawa
    • Organizer
      第24回 国際胎盤学会(IFPA 2018)/第26回 日本胎盤学会学術集会
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Histochemical analysis of Slc2a1 (glucose transporter type I) in uterine natural killer cells during mouse pregnancy.2018

    • Author(s)
      Chaw Kyi-Tha-Thu、Toshihiro Takizawa
    • Organizer
      第24回 国際胎盤学会(IFPA 2018)/第26回 日本胎盤学会学術集会
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Placenta-specific microRNAs: expression profile and functional implication2018

    • Author(s)
      Toshihiro Takizawa
    • Organizer
      2nd Asia Pacific Reproductive Immunology Forum
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Placental exosomes in pregnancy: past and present2018

    • Author(s)
      Toshihiro Takizawa
    • Organizer
      2nd Asia Pacific Reproductive Immunology Forum
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Glucose transporter type1(Slc2a1)is expressed in uterine natural killer cells of the mouse placenta.2017

    • Author(s)
      Chaw Kyi Tha Thu,Banyar Than Naing,瀧澤俊広
    • Organizer
      第122回日本解剖学会総会・全国学術集会
    • Place of Presentation
      長崎
    • Year and Date
      2017-03-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 明日から実践できる漢方治療ー不育症、更年期障害、婦人科癌治療の立場からー2017

    • Author(s)
      齋藤 滋
    • Organizer
      第7回漢方ネットワークミーティング
    • Place of Presentation
      神奈川
    • Year and Date
      2017-02-27
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 成人病の素因は胎児(お腹の中の赤ちゃん)から発生しています.2017

    • Author(s)
      齋藤 滋
    • Organizer
      射水市民病院診療棟耐震化整備事業完了式
    • Place of Presentation
      富山
    • Year and Date
      2017-02-25
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] RA、IBD、SLE女性患者の妊娠、出産をめざした内科、整形外科との連携.2017

    • Author(s)
      齋藤 滋
    • Organizer
      第42回富山大学附属病院地域連携研修会
    • Place of Presentation
      富山
    • Year and Date
      2017-01-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] Extremely preterm delivery(超早産)をいかにして防ぐか.2017

    • Author(s)
      齋藤 滋
    • Organizer
      第45回宮城県周産期医療懇話会・第23回宮城県委託周産期医療研修会.
    • Place of Presentation
      仙台
    • Year and Date
      2017-01-28
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Time-scale analysis of interplay between immunogenic tumor and immune response.2017

    • Author(s)
      Mojic M, Shitaoka K, Kishi H, Muraguchi A, Tahara H, Hayakawa Y.
    • Organizer
      5th Annual Meeting of the International Cytokine and Interferon Society (ICIS)2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 乳がん浸潤リンパ球の迅速・簡便TCRレパートリー解析.2017

    • Author(s)
      浜名 洋,長田拓哉,下岡清美,祐川健太,小澤龍彦,村口 篤,岸 裕幸.
    • Organizer
      第21回日本がん免疫学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 内皮細胞HLA-class II DRとアロ応答するCD4 T細胞は,anti-A/B抗体接着により抑制される.2017

    • Author(s)
      岩﨑研太,三輪祐子,打田和治,堀見孔星,松岡 裕,岡田 学,浜名 洋,岸 裕幸,村口 篤,小林孝彰.
    • Organizer
      第26回日本組織適合性学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒト妊娠子宮の脱落膜では,妊娠後期にクローナルなeffector制御性T細胞が増加する.2017

    • Author(s)
      津田さやか,岸 裕幸,島 友子,浜名 洋,牛島明美,村口 篤,齋藤 滋.
    • Organizer
      第32回日本生殖免疫学会総会・学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 関節リウマチ患者由来自己抗体が認識する非変性状態の抗原の同定と自己抗体誘導仮説.2017

    • Author(s)
      小澤龍彦,津田玲奈,浜名 洋,小林栄治,多喜博文,戸邉一之,村口 篤,岸 裕幸.
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] p38活性化はEGFR Ser-1015のリン酸化を介したエンドサイトーシスを誘導する.2017

    • Author(s)
      大賀英司,田中智大,小澤龍彦,村口 篤,櫻井宏明.
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 自己免疫性出血病XIII/13症例より作製したヒト単クローン抗体のエピトープ解析.2017

    • Author(s)
      尾崎 司,惣宇利正善,小澤龍彦,村口 篤,一瀬白帝.
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Evolution of anti-citrullinated peptide antibody (ACPA): analysis of autoantigen under native condition using a human monoclonal ACPA.2017

    • Author(s)
      Ozawa T, Tsuda R, Hamana H, Kobayashi E, Taki H, Muraguchi A, Kishi H.
    • Organizer
      第46回日本免疫学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] TCR repertoire analysis of antigen-specific T cells using immunospot array assay on a chip (T-ISAAC) technology.2017

    • Author(s)
      Kobayashi E, Ozawa T, Hamana H, Lyu F, Muraguchi A, Kishi H.
    • Organizer
      第46回日本免疫学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] T cell receptor (TCR) gene cloning from tumor infiltrating lymphocytes of breast cancer patients toward TCR gene therapy.2017

    • Author(s)
      Hamana H, Nagata T, Shitaoka K, Sukegawa K, Ozawa T, Kobayashi E, Muraguchi A, Kishi H.
    • Organizer
      第46回日本免疫学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Majority of tumor infiltrating lymphocytes in B16F10 melanoma recognized tumor-associated antigens, but not melanoma-associated antigens or neoantigens.2017

    • Author(s)
      Shitaoka K, Hamana H, Kobayashi E, Ozawa T, Hayakawa Y, Muraguchi A, Kishi H.
    • Organizer
      第46回日本免疫学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] A novel method to produce high amounts of recombinant MHC/peptide complexes for isolation of antigen-specific human TCRs.2017

    • Author(s)
      Lyu F, Ozawa T, Hamana H, Kobayashi E, Muraguchi A, Kishi H.
    • Organizer
      第46回日本免疫学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] The model of antigen detection system using yeast surface display library.2017

    • Author(s)
      Ohnuki Y, Ozawa T, Hamana H, Kobayashi E, Lyu F, Muraguchi A, Kishi H.
    • Organizer
      第46回日本免疫学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Production of Ro52/TRIM21 autoantibodies that react to PEP08 epitope in Ro52 clinically relate to the morbidity and severity of interstitial lung disease in connective tissue disease.2017

    • Author(s)
      Okumura M, Ozawa T, Taki H, Muraguchi A, Kishi H.
    • Organizer
      第46回日本免疫学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Tumor-specific CTL’s reduced clonality and proliferation index, not the inhibitory immune checkpoint expression, as hallmarks of B16 melanoma immune evasion.2017

    • Author(s)
      Mojic M, Shitaoka K, Kishi H, Muraguchi A, Tahara H, Hayakawa Y.
    • Organizer
      第46回日本免疫学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Differential response of allo-reactive CD4 T-cells against HLA class II expressed on endothelial cells in the presence of HLA and ABO antibody.2017

    • Author(s)
      Iwasaki K, Hamana H, Kishi H, Muraguchi A.
    • Organizer
      第46回日本免疫学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 羊膜由来細胞を用いた自己免疫疾患治療への試み2017

    • Author(s)
      吉田淑子.
    • Organizer
      第16回日本再生医療学会総会 シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] ハイパードライヒト乾燥羊膜の利用した先進医療2017

    • Author(s)
      岡部素典.
    • Organizer
      第16回日本再生医療学会総会 シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 羊膜間葉系幹細胞サブクラスの線維化抑制に対する効果2017

    • Author(s)
      吉田淑子、吉田 聡、周 凱旋、荒井健一、岡部素典、斎藤 滋、二階堂敏雄.
    • Organizer
      第122回日本解剖学会総会日本学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 羊膜由来細胞のkaryotypeの検討2017

    • Author(s)
      吉田 聡、吉田一晴、周 凱旋、岡部 素典、吉田 淑子.
    • Organizer
      第122回日本解剖学会総会日本学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] HD羊膜の再発翼状片への利用と羊膜バンクの設立2017

    • Author(s)
      岡部素典、吉田淑子、周 凱旋、古市恵津子、二階堂敏雄
    • Organizer
      第122回日本解剖学会総会日本学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] スカイフルーツは、抗酸化作用を増強する。Part 22017

    • Author(s)
      吉田淑子、吉田一晴、周 凱旋、岡部素典、卞 勝人.
    • Organizer
      第17回日本抗加齢学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ハイパードライヒト乾燥羊膜の有用性と安全性の検討2017

    • Author(s)
      宮腰晃央、岡部素典、吉田淑子、二階堂敏雄、林 篤志.
    • Organizer
      第71回日本臨床眼科学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 子宮内膜癌組織に存在する CD133+CXCR4+細胞の性質。2017

    • Author(s)
      吉田淑子、孫 毅、岡部素典.
    • Organizer
      第77回日本解剖学会中部支部学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒト由来の新しい生体吸収性材料の開発における安全性・分解性の評価.2017

    • Author(s)
      岡部素典、吉田淑子.
    • Organizer
      第77回日本解剖学会中部支部学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] スカイフルーツの抗酸化作用について.2017

    • Author(s)
      周 凱旋、吉田淑子、吉田一晴、卞 勝人、岡部素典. 古市恵津子.
    • Organizer
      第76回日本解剖学会中部支部学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] マウス脱落膜ナチュラルキラー細胞はI型グルコース輸送体を発現している2017

    • Author(s)
      Kyi-Tha-Thu Chaw、瀧澤 俊広
    • Organizer
      第25回日本胎盤学会学術集会(一般講演)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 妊娠初期の脱落膜NK細胞は胎盤特異的microRNAを取り込んでいる2017

    • Author(s)
      小古山学、大口昭英、島 友子、齋藤 滋、瀧澤俊広
    • Organizer
      第25回日本胎盤学会学術集会(一般講演)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 卵胞期から黄体期にかけての母体末梢血NK細胞の変動2017

    • Author(s)
      石田 洋一、大口 昭英、鈴木 達也、高橋 宏典、瀧澤 俊広、松原 茂樹
    • Organizer
      第32回日本生殖免疫学会総会・学術集会(一般講演)
    • Related Report
      2017 Annual Research Report
  • [Presentation] マウス妊娠子宮ナチュラルキラー細胞におけるI型グルコース輸送体の組織化学的解析2017

    • Author(s)
      Kyi-Tha-Thu Chaw、瀧澤 俊広
    • Organizer
      第32回日本生殖免疫学会総会・学術集会(一般講演)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 妊娠初期流産における末梢血および脱落膜natural killer細胞のmicroRNA発現プロファイル解析2017

    • Author(s)
      小古山 学、大口 昭英、島 友子、齋藤 滋、瀧澤 俊広
    • Organizer
      第32回日本生殖免疫学会総会・学術集会(一般講演)
    • Related Report
      2017 Annual Research Report
  • [Presentation] マウス子宮ナチュラルキラー細胞に発現しているSlc2a1の組織化学的解2017

    • Author(s)
      Kyi-Tha-Thu Chaw、瀧澤 俊広
    • Organizer
      第123回日本解剖学会総会・全国学術集会(一般講演)
    • Related Report
      2017 Annual Research Report
  • [Presentation] The role of regulatory T cells for pregnancy.2016

    • Author(s)
      Saito S
    • Organizer
      The 3rd Annual meeting of Korean Society of Reproductive Immunology (KSRI)
    • Place of Presentation
      Seoul, Korea.
    • Year and Date
      2016-12-17
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] TCR repertoire of CD4+CD25+CD137+Foxp3+ tumor infiltrating lymphocytes in mice.2016

    • Author(s)
      Kishi H, Hamana H, Shitaoka K, Lyu F, Ozawa T, Muraguchi A.
    • Organizer
      第45回日本免疫学会学術集会
    • Place of Presentation
      宜野湾
    • Year and Date
      2016-12-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] Single-T-cell manipulation method using microwell array chip (T-ISAAC) allows rapid and efficient cloning of antigen-specific TCRs.2016

    • Author(s)
      Ozawa T, Kishi H, Hamana H, Tajiri K, Muraguchi A.
    • Organizer
      第45回日本免疫学会学術集会
    • Place of Presentation
      宜野湾
    • Year and Date
      2016-12-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] A rapid and easy system for cDNAs cloning of antigen specific TCRs from single human and mouse T-cells within 4 days.2016

    • Author(s)
      Hamana H, Kishi H, Shitaoka K, Ozawa T, Muraguchi A.
    • Organizer
      第45回日本免疫学会学術集会
    • Place of Presentation
      宜野湾
    • Year and Date
      2016-12-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] T cell receptor obtained from tumor-infiltrating lymphocytes without using tumor-specific antigens exhibits cytotoxicity to tumors in vitro and in vivo.2016

    • Author(s)
      Shitaoka K, Kishi H, Hamana H, Hayakawa Y, Ozawa T, Muraguchi A.
    • Organizer
      第45回日本免疫学会学術集会
    • Place of Presentation
      宜野湾
    • Year and Date
      2016-12-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] TCR repertoire analysis of OVA-specific T-cells infiltrating into OVA-expressing-melanoma during tumor progression.2016

    • Author(s)
      Lyu F, Shitaoka K, Hamana H, Hayakawa Y, Kishi H, Muraguchi A.
    • Organizer
      第45回日本免疫学会学術集会
    • Place of Presentation
      宜野湾
    • Year and Date
      2016-12-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] Ⅰ型グルコース輸送体(Slc2a1)は子宮間膜側脱落膜リンパ系集合体に発現している2016

    • Author(s)
      Chaw Kyi Tha Thu,Banyar Than Naing,瀧澤俊広
    • Organizer
      第31回日本生殖免疫学会総会・学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2016-12-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] Pathophysiology of preeclampsia from the view point of immunological maladaptation.2016

    • Author(s)
      Saito S
    • Organizer
      The 19th Congress of the Federation of Asia and Oceania Perinatal Societies (FAOPS)
    • Place of Presentation
      Taipei, Taiwan.
    • Year and Date
      2016-12-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 免疫学的妊娠機構からみた自己免疫合併妊娠管理.2016

    • Author(s)
      齋藤 滋
    • Organizer
      リウマチ合併症カンファレンス.
    • Place of Presentation
      松本
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] ISAAC法を用いた抗原特異的T細胞検出法の開発.2016

    • Author(s)
      小澤龍彦,岸 裕幸,浜名 洋,田尻和人,呂 福蓮,村口 篤
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 羊膜間葉系幹細胞サブクラスの肝線維化抑制に対する効果.2016

    • Author(s)
      吉田淑子、吉田聡、周 凱旋、荒井健一、岡部素典、斎藤 滋、二階堂敏雄.
    • Organizer
      第30回肝類洞壁細胞研究会学術集会
    • Place of Presentation
      富山
    • Year and Date
      2016-11-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] マウス胎盤におけるⅠ型グルコース輸送体の組織化学的解析2016

    • Author(s)
      Chaw Kyi Tha Thu,Banyar Than Naing,瀧澤俊広
    • Organizer
      第24回日本胎盤学会学術集会
    • Place of Presentation
      和歌山
    • Year and Date
      2016-11-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] 免疫からみた妊娠維持機構とその破綻2016

    • Author(s)
      齋藤 滋
    • Organizer
      医療パラダイムシフト推進協議会・研究会
    • Place of Presentation
      東京
    • Year and Date
      2016-11-11
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Fetomaternal and peripheral immune status in preeclamptic and normotensive oocyte donation cases.2016

    • Author(s)
      Saito S
    • Organizer
      20th World Congress meeting of the International Society for the Study of Hypertension in Pregnancy (ISSHP)
    • Place of Presentation
      Sao Paulo, Brazil
    • Year and Date
      2016-10-24
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] CD133 and CXCR4 positive endometrial cancer cells possess cancer stem-like cell characteristics.2016

    • Author(s)
      Yi Sun, Toshiko Yoshida, Motonori Okabe, Kaixuan Zhou, Fang Wang, Chika Soko, Shigeru Saitou, Toshio Nikaido.
    • Organizer
      第76回日本解剖学会中部支部学術集会
    • Place of Presentation
      松本
    • Year and Date
      2016-10-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] Anti-oxidant activity of amnion-derived cells against oxidative stress induced by X-irradiation and H2O2 stimulation.2016

    • Author(s)
      Luguang Han, Takashi Kondo, Qing li Zhao, Toshiko Yoshida, Motonori Okabe, Kaixuan Zhou, Yi Sun, Shigeru Saitou, Toshio Nikaido.
    • Organizer
      第76回日本解剖学会中部支部学術集会
    • Place of Presentation
      松本
    • Year and Date
      2016-10-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] 妊娠高血圧症候群の病態におけるnon-coding RNAの関与2016

    • Author(s)
      瀧澤俊広,Banyar Than Naing,高橋宏典,大口昭英,竹下俊行,齋藤滋
    • Organizer
      第37回日本妊娠高血圧学会学術集会
    • Place of Presentation
      大宮
    • Year and Date
      2016-10-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] 腫瘍浸潤リンパ球の単一細胞解析による腫瘍特異的TCRの同定および治療への応用(担癌マウスモデル).2016

    • Author(s)
      岸 裕幸,村口 篤
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] 不妊と不育ー免疫学的トレランスの破綻からみた着床不全と流産ー.2016

    • Author(s)
      齋藤 滋
    • Organizer
      第19回日本IVF学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2016-10-02
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 関節リウマチ(RA)ならびに炎症性腸疾患(IBD)患者が妊娠・出産できる体制作り.2016

    • Author(s)
      齋藤 滋
    • Organizer
      第22回石川リウマチ薬物治療研究会.
    • Place of Presentation
      金沢
    • Year and Date
      2016-10-01
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Pathophysiology and management of hypertensive disorders of pregnancy.2016

    • Author(s)
      齋藤 滋
    • Organizer
      第39回日本高血圧学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2016-09-30
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] A step in advanced for the molecular target drug for cancer stem cells in primary endometrial cancer-identified surface marker CD133+CXCR4+.2016

    • Author(s)
      Yi Sun, Toshiko Yoshida, Motonori Okabe, Kaixuan Zhou, Fang Wang, Chika Soko, Sigeru Saito, and Toshio Nikaido
    • Organizer
      Toyama Science GALA 2016
    • Place of Presentation
      富山
    • Year and Date
      2016-09-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] Anti-oxidant activity of amnion-derived cells against oxidative stress induced by X-irradiation and H2O2 stimulation.2016

    • Author(s)
      Luguang Han, Takashi Kondo, Qing li Zhao, Toshiko Yoshida, Motonori Okabe, Kaixuan Zhou, Yi Sun, Shigeru Saitou, Toshio Nikaido.
    • Organizer
      Toyama Science GALA 2016
    • Place of Presentation
      富山
    • Year and Date
      2016-09-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 免疫学的妊娠維持機構からみた自己免疫疾患合併妊娠の治療-抗TNF抗体を中心としてー.2016

    • Author(s)
      齋藤 滋
    • Organizer
      愛媛リウマチ研究会
    • Place of Presentation
      愛媛
    • Year and Date
      2016-09-24
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 流産、妊娠高血圧症候群における母子間免疫トレランスの破綻.2016

    • Author(s)
      齋藤 滋
    • Organizer
      第44回日本臨床免疫学会総会.
    • Place of Presentation
      東京
    • Year and Date
      2016-09-08
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Cis-interaction of TCRs and antigen/MHC class I complexes on CD8+ T cells causes their activation.2016

    • Author(s)
      Kishi H, Jin A, Hamana H, Shitaoka K, Tajiri K, Kobayashi E, Kusano S, Yokoyama S, Ozawa T, Nagai T, Obata T, Hatakeyama S, Horii M, Hu Y, Zhang F, Muraguchi A.
    • Organizer
      2016 International Congress of Immunology
    • Place of Presentation
      Melbourne
    • Year and Date
      2016-08-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A rapid and efficient single-cell manipulation method using microwell array chip (ISAAC) technology for screening antigen-specific cytokines-secreting T-cells.2016

    • Author(s)
      Ozawa T, Kishi H, Hamana H, Tajiri K, Lyu F, Muraguchi A.
    • Organizer
      2016 International Congress of Immunology
    • Place of Presentation
      Melbourne
    • Year and Date
      2016-08-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A rapid and easy system for screening of antigen-specific TCRs.2016

    • Author(s)
      Hamana H, Kishi H, Shitaoka K, Piao X, Ozawa T, Muraguchi A.
    • Organizer
      2016 International Congress of Immunology
    • Place of Presentation
      Melbourne
    • Year and Date
      2016-08-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification of tumor-specific T cell receptors of primary tumor-infiltrating lymphocytes (TILs) from B16F10 melanoma-bearing mice at single cell levels.2016

    • Author(s)
      Shitaoka K, Hamana H, Kishi H, Ozawa T, Muraguchi A.
    • Organizer
      2016 International Congress of Immunology
    • Place of Presentation
      Melbourne
    • Year and Date
      2016-08-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Role of paternal antigens-specific Treg cells in successful implantation and pregnancy.2016

    • Author(s)
      Saito S
    • Organizer
      Reproductive Immunology Satellite Meeting 2016
    • Place of Presentation
      Cairns, Australia
    • Year and Date
      2016-08-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 流産、早産、妊娠高血圧症候群という三大産科疾患の病態解明と治療への試み.2016

    • Author(s)
      齋藤 滋
    • Organizer
      第95回未来医療セミナー
    • Place of Presentation
      大阪
    • Year and Date
      2016-07-28
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] B16F10メラノーマ浸潤リンパ球の単一細胞解析による,がん特異的T細胞の同定およびTCR遺伝子治療の試み.2016

    • Author(s)
      下岡清美,浜名 洋,呂 福蓮,小澤龍彦,早川芳弘,岸 裕幸,村口 篤.
    • Organizer
      第20回日本がん免疫学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2016-07-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] 明日の周産期医療を開拓する.2016

    • Author(s)
      齋藤 滋
    • Organizer
      第52回日本周産期・新生児医学会学術集会
    • Place of Presentation
      富山
    • Year and Date
      2016-07-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] 自己免疫疾患患者の妊娠・出産を考える.2016

    • Author(s)
      齋藤 滋
    • Organizer
      富山県膠原病患者会
    • Place of Presentation
      富山
    • Year and Date
      2016-07-02
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] The pathophysiology of preterm birth from the view point of intestinal and vaginal microbiota.2016

    • Author(s)
      Saito S
    • Organizer
      13th Congress of the International Society for Immunology of Reproduction
    • Place of Presentation
      Erfurt, Germany
    • Year and Date
      2016-06-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 膜間葉系幹細胞のサブクラスの特徴.2016

    • Author(s)
      吉田淑子、岡部素典、周 凱旋、李 華麗、斎藤 繁、二階堂敏雄.
    • Organizer
      第37回日本炎症・再生医学会
    • Place of Presentation
      京都
    • Year and Date
      2016-06-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] 着床不全、不育症の最近の話題.2016

    • Author(s)
      齋藤 滋
    • Organizer
      平成28年度第1回滋賀県産科婦人科医会.
    • Place of Presentation
      大津
    • Year and Date
      2016-06-12
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 不育症の最近の話題.2016

    • Author(s)
      齋藤 滋
    • Organizer
      第9回広島生殖医療研究会.
    • Place of Presentation
      広島
    • Year and Date
      2016-06-11
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 子宮内感染、炎症からみた早産の病態.2016

    • Author(s)
      齋藤 滋
    • Organizer
      RSV Japan Global Experts’ Meeting
    • Place of Presentation
      東京
    • Year and Date
      2016-06-11
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 免疫学的妊娠維持機構から見た自己免疫合併妊娠管理.2016

    • Author(s)
      齋藤 滋
    • Organizer
      北摂免疫フォーラム.
    • Place of Presentation
      大阪
    • Year and Date
      2016-05-20
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 羊水内病原体検出システムを確立し、見えてきたこと.2016

    • Author(s)
      齋藤 滋
    • Organizer
      妊婦の感染と早産を考える会~新たな早産予防と治療戦略の確立に向けて.
    • Place of Presentation
      福岡
    • Year and Date
      2016-05-14
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 免疫からみた妊娠維持機構.2016

    • Author(s)
      齋藤 滋
    • Organizer
      1型糖尿病の成因を考える会.
    • Place of Presentation
      東京
    • Year and Date
      2016-04-09
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 妊娠期間中の母体末梢血NK細胞におけるmiRNA-mRNAの変動解析2015

    • Author(s)
      石田洋一,趙東威,大口昭英,桑田知之,松原茂樹,斎藤滋,瀧澤俊広
    • Organizer
      第30回日本生殖免疫学会総会・学術集会
    • Place of Presentation
      熊本
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Assessment of T cell receptor function.2015

    • Author(s)
      Kishi H, Hamana H, Shitaoka K, Ozawa T, Muraguchi A.
    • Organizer
      第44回日本免疫学会学術集会
    • Place of Presentation
      北海道
    • Year and Date
      2015-11-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Development of an NFAT-luciferase reporter system for screening of antigen-specific TCRs using non-T cells.2015

    • Author(s)
      Hamana H, Kishi H, Shitaoka K, Piao X, Ozawa T, Muraguchi A.
    • Organizer
      第44回日本免疫学会学術集会
    • Place of Presentation
      北海道
    • Year and Date
      2015-11-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Identification of tumor-specific T cell receptors from primary tumor-infiltrating lymphocytes (TILs) obtained from B16F10 melanoma-bearing mice.2015

    • Author(s)
      Shitaoka K, Kishi H, Hamana H, Ozawa T, Muraguchi A.
    • Organizer
      第44回日本免疫学会学術集会
    • Place of Presentation
      北海道
    • Year and Date
      2015-11-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Identification of T-cell receptors of the CD8+ T cells in response to HLA-A24 restricted epitopes from hepatitis B virus.2015

    • Author(s)
      Tamai T, Kishi H, Shitaoka K, Hamana H, Ozawa T, Muraguchi A.
    • Organizer
      第44回日本免疫学会学術集会
    • Place of Presentation
      北海道
    • Year and Date
      2015-11-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] 19染色体上にクラスターを形成する胎盤特異的miRNAについて2015

    • Author(s)
      倉品隆平,神戸沙織,間瀬有里,石川源,瀧澤俊広,竹下俊行
    • Organizer
      第23回日本胎盤学会学術集会・第33回日本絨毛性疾患研究会
    • Place of Presentation
      東京
    • Year and Date
      2015-11-06
    • Related Report
      2015 Annual Research Report
  • [Presentation] プライマリー腫瘍浸潤リンパ球を用いた腫瘍特異的T細胞受容体同定の試み2015

    • Author(s)
      岸 裕幸,村口 篤.
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] 悪性リンパ腫における腫瘍浸潤CD8+Tリンパ球の解析.2015

    • Author(s)
      岸 裕幸,村橋睦了,浜名 洋,松本太一,原 周司,猪狩洋介,石塚賢治,高松 泰,田村和夫,谷憲三朗,村口 篤.
    • Organizer
      第7回血液疾患免疫療法研究会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2015-09-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] Pathophysiology of preeclampsia from the view point of immunology.2015

    • Author(s)
      Saito S.
    • Organizer
      ISSHP European Congress
    • Place of Presentation
      Hungary
    • Year and Date
      2015-09-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Direct   reprogramming of immortalized human amniotic epithelial (iHAE) cells towards insulin producing cells.2015

    • Author(s)
      Faruk Hasan, Toshiko Yoshida, Motonori Okabe, Kaixuan Zhou, Chika Soko and Toshio Nikaido.
    • Organizer
      平成27年度 富山大学若手研究者等の学術交流・発表会
    • Place of Presentation
      富山
    • Year and Date
      2015-09-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] Identification of cancer stem cells/cancer initiating cells in endometrial cancer cells.2015

    • Author(s)
      6) Yi Sun, Toshiko Yoshida, Motonori Okabe, Kaixuan Zhou, Fang Wang, Chika Soko, Sigeru Saito, and Toshio Nikaido
    • Organizer
      平成27年度 富山大学若手研究者等の学術交流・発表会
    • Place of Presentation
      富山
    • Year and Date
      2015-09-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] Cancer stem cells/cancer initiating cells in cervical cancer cells.2015

    • Author(s)
      Meijie Sang, Toshiko Yoshida, Motonori Okabe, Chika Koike, Kaixuan Zhou, Yi Sun, Fang Wang, Toshio Nikaido
    • Organizer
      平成27年度 富山大学若手研究者  等の学術交流・発表会
    • Place of Presentation
      富山
    • Year and Date
      2015-09-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] The phenotype of regulatory T (Treg) cells in normal pregnancy, miscarriage and preeclampsia.2015

    • Author(s)
      Saito S.
    • Organizer
      14th International Symposium for Immunology of Reproduction
    • Place of Presentation
      Bulgaria
    • Year and Date
      2015-05-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Naturally occurring-functional regulatory T cells play important roles for implantation and maintenance of allogeneic pregnancy in human.2015

    • Author(s)
      Saito S
    • Organizer
      IFFS/JSRM International Meeting
    • Place of Presentation
      Yokohama
    • Year and Date
      2015-04-26
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 妊娠初期脱落膜 NK 細胞の miRNA mRNA 発現に関する統合解析2015

    • Author(s)
      趙東威,稲田貢三子,島友子,竹下俊行,齋藤滋,瀧澤俊広
    • Organizer
      第67回日本産科婦人科学会学術講演会
    • Place of Presentation
      横浜
    • Year and Date
      2015-04-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] 妊娠初期栄養膜細胞における a Disintegrin and Metalloproteinase(ADAM)ファミ リーの発現:絨毛外栄養膜細胞浸潤への ADAM 関与可能性2015

    • Author(s)
      高橋宏典、松原茂樹、大口昭英、薄井里英、桑田知之、馬場洋介、鈴木寛正、瀧澤俊広、鈴木光明
    • Organizer
      第67回日本産科婦人科学会学術講演会
    • Place of Presentation
      横浜
    • Year and Date
      2015-04-10
    • Related Report
      2015 Annual Research Report
  • [Book] 制御性T細胞研究の現在.2019

    • Author(s)
      津田さやか、齋藤滋.
    • Total Pages
      264
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2018 Annual Research Report
  • [Book] Preeclampsia2018

    • Author(s)
      Saito S, Shima T, Nakashima A.
    • Total Pages
      290
    • Publisher
      Springer
    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
  • [Book] Preeclampsia2018

    • Author(s)
      Nakashima A, Aoki A, Kusabiraki T, Shima T, Yoshino O, Cheng SB, Sharma S, Saito S.
    • Total Pages
      290
    • Publisher
      Springer
    • Related Report
      2018 Annual Research Report
  • [Book] Preeclampsia2018

    • Author(s)
      Shiozaki A, Saito S.
    • Total Pages
      290
    • Publisher
      Springer
    • Related Report
      2018 Annual Research Report
  • [Book] 医療を変えるエクソソーム2018

    • Author(s)
      瀧澤俊広
    • Total Pages
      240
    • Publisher
      化学同人
    • ISBN
      4759819789
    • Related Report
      2018 Annual Research Report
  • [Book] エクソソーム―生命現象の鍵を握る膜小胞―2018

    • Author(s)
      瀧澤俊広
    • Publisher
      化学同人
    • Related Report
      2017 Annual Research Report
  • [Book] 生体吸収性材料の開発と安全性評価2017

    • Author(s)
      岡部素典,吉田淑子,米田徳子,米田 哲,脇 博樹,塩崎有宏,富田隆浩,鈴木拓馬,古市恵津子,相古千加,野村義宏,加藤 潔,將積日出夫,齋藤 滋,二階堂敏雄.
    • Publisher
      技術情報協会
    • ISBN
      9784861046896
    • Related Report
      2017 Annual Research Report
  • [Book] 分担章:第2編 機能研究 第1章情報伝達における機能 第2節周産期における胎盤由来エクソソーム機能 図書名:パラダイムシフトをもたらすエクソソーム機能研究最前線-シグナル伝達からがん、免疫、神経疾患との関わり、創薬利用まで(監修 落谷孝広).2017

    • Author(s)
      瀧澤俊広,大口昭英,竹下俊行,齋藤滋
    • Publisher
      エヌ・ティー・エス社
    • Related Report
      2016 Annual Research Report
  • [Book] 事例から学ぶ~外科材料を利便化する原料の開発と作製/加工/評価: 14章 生体機能材料としての羊膜と被覆材への応用展望.2016

    • Author(s)
      岡部素典, 吉田淑子, 米田徳子, 富田隆浩, 鈴木拓馬, 脇 博樹, 古市恵津子, 野村義宏, 宇治義則, 加藤 潔, 將積日出夫, 齋藤 滋, 二階堂敏雄.
    • Publisher
      技術情報協会
    • Related Report
      2016 Annual Research Report

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Published: 2015-04-16   Modified: 2020-03-30  

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