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Development of novel diagnosis and therapeutic procedures for nasal NK/T-cell lymphoma consists of targeting EBV-associated molecules

Research Project

Project/Area Number 15H04986
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionAsahikawa Medical College

Principal Investigator

Harabuchi Yasuaki  旭川医科大学, 医学部, 教授 (80208686)

Co-Investigator(Kenkyū-buntansha) 高原 幹  旭川医科大学, 医学部, 講師 (50322904)
長門 利純  旭川医科大学, 医学部, 助教 (80431419)
岸部 幹  旭川医科大学, 医学部, 講師 (80447101)
小林 博也  旭川医科大学, 医学部, 教授 (90280867)
上田 征吾  旭川医科大学, 医学部, 助教 (90447102)
駒林 優樹  旭川医科大学, 医学部, 助教 (40548864)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Keywords頭頸部外科学 / 頭頸部外科 / 悪性腫瘍
Outline of Final Research Achievements

We generated murine xenograft models inoculated with an natural killer/T-cell lymphoma cell line and revealed that sPD-L1 could be a prognostic predictor for NNKTL and open up the pos- sibility of immunotherapy of this lymphoma using PD-1/ PD-L1 axis inhibitors.
We revealed that circulating EBV‐miRNAs, particularly miR‐BART2‐5p, may serve as potential diagnostic and prognostic biomarkers in patients with nasal natural killer/T-cell lymphoma.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (17 results)

All 2017 2016 2015

All Journal Article (7 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 6 results,  Open Access: 5 results,  Acknowledgement Compliant: 5 results) Presentation (9 results) (of which Int'l Joint Research: 5 results,  Invited: 2 results) Book (1 results)

  • [Journal Article] Novel treatment for early-stage nasal natural killer/T-cell lymphoma: intra-maxillary arterial infusion chemotherapy with concomitant radiotherapy2017

    • Author(s)
      Takahara Miki、Nagato Toshihiro、Kishibe Kan、Ueda Seigo、Komabayashi Yuki、Yamashina Masaaki、Takahashi Kouji、Harabuchi Yasuaki
    • Journal Title

      Hematological Oncology

      Volume: 35 Issue: 2 Pages: 158-162

    • DOI

      10.1002/hon.2273

    • Related Report
      2017 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Programmed death-ligand 1 and its soluble form are highly expressed in nasal natural killer/T-cell lymphoma: a potential rationale for immunotherapy2017

    • Author(s)
      Toshihiro Nagato, Takayuki Ohkuri, Kenzo Ohara, Yui Hirata, Kan Kishibe, Yuki Komabayashi, Seigo Ueda, Miki Takahara, Takumi Kumai, Kei Ishibashi, Akemi Kosaka, Naoko Aoki, Kensuke Oikawa, Yuji Uno, Naoko Akiyama, Masatoshi Sado, Hidehiro Takei, Esteban Celis, Yasuaki Harabuchi, Hiroya Kobayashi
    • Journal Title

      Cancer Immunol Immunother

      Volume: 印刷中 Issue: 7 Pages: 877-890

    • DOI

      10.1007/s00262-017-1987-x

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 鼻性NK/T細胞リンパ腫2017

    • Author(s)
      熊井琢美, 原渕保明
    • Journal Title

      耳鼻咽喉科・頭頸部外科

      Volume: 89 Pages: 1018-1028

    • NAID

      10030285840

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Circulating Epstein-Barr virus-encoded micro-RNAs as potential biomarkers for nasal natural killer/T-cell lymphoma2016

    • Author(s)
      Yuki Komabayashi
    • Journal Title

      Hematol Oncol

      Volume: on line Issue: 4 Pages: 1-9

    • DOI

      10.1002/hon.2360

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] CCL17 and CCL22/CCR4 signaling is a strong candidate for novel targeted therapy against nasal natural killer/T-cell lymphoma2015

    • Author(s)
      Takumi Kumai, Toshihiro Nagato, Hiroya Kobayashi, Yuki Komabayashi, Seigo Ueda, Kan Kishibe, Takayuki Ohkuri, Miki Takahara, Esteban Celis, Yasuaki Harabuchi
    • Journal Title

      Cancer Immunology, Immunotherapy

      Volume: - Issue: 6 Pages: 697-705

    • DOI

      10.1007/s00262-015-1675-7

    • NAID

      120005774022

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Novel targets for natural killer/T-cell lymphoma immunotherapy2015

    • Author(s)
      Takumi Kumai
    • Journal Title

      Immunotherapy

      Volume: 8 Issue: 1 Pages: 45-55

    • DOI

      10.2217/imt.15.103

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] c-Met is a novel tumor associated antigen for T-cell based immunotherapy against NK/T cell lymphoma2015

    • Author(s)
      Takumi Kumai
    • Journal Title

      Oncoimmunology

      Volume: 2 Issue: 2 Pages: e976077-e976077

    • DOI

      10.4161/2162402x.2014.976077

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] The identification of nasal NK/T-cell lymphoma-associated antigens for helper T cell-based immunotherapy2017

    • Author(s)
      Kumai T, Nagato T, Takahara M, Katada A, Hayashi T, Harabuchi Y
    • Organizer
      The 53rd Korean Rhinologic Society Annual Congress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 進行性鼻壊疽から鼻性NK/T細胞リンパ腫へ2017

    • Author(s)
      原渕保明
    • Organizer
      第90回日耳鼻千葉県地方部会学術講演会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 鼻腔に発生する致死性肉芽腫の謎を解く2017

    • Author(s)
      原渕保明
    • Organizer
      第111回鹿児島県耳鼻咽喉科学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Soluble ICAM-1 secretion and its functional role as an autocrine growth factor in nasal NK/T cell lymphoma cells.2016

    • Author(s)
      Miki Takahara
    • Organizer
      The 17th International Symposium on EBV and Associated Diseases
    • Place of Presentation
      Zurich, Switzerland
    • Year and Date
      2016-08-08
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Diagnostic values of circulating Epstein-Barr virus-encoded microRNAs as potential biomarkers for nasal natural killer/T-cell lymphoma2016

    • Author(s)
      Kan Kishibe
    • Organizer
      The 17th International Symposium on EBV and Associated Diseases
    • Place of Presentation
      Zurich, Switzerland
    • Year and Date
      2016-08-08
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Regulation of CDK1 and Survivin by EBV-encoded LMP1 in nasal NK/T-cell lymphoma cells2016

    • Author(s)
      Seigo Ueda
    • Organizer
      The 17th International Symposium on EBV and Associated Diseases
    • Place of Presentation
      Zurich, Switzerland
    • Year and Date
      2016-08-08
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] CCL17 and CCL22/CCR4 signaling is a candidate for novel targeted therapy against nasal natural killer/T-cell lymphoma2016

    • Author(s)
      Toshihiro Nagato
    • Organizer
      The 17th International Symposium on EBV and Associated Diseases
    • Place of Presentation
      Zurich, Switzerland
    • Year and Date
      2016-08-08
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 宿題報告 進行性鼻壊疽から鼻性NK/T細胞リンパ腫へ2016

    • Author(s)
      原渕保明
    • Organizer
      日本耳鼻咽喉科学会
    • Place of Presentation
      名古屋
    • Year and Date
      2016-05-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] 鼻性NK/T細胞リンパ腫 臨床医の視点から行う基礎研究とその臨床応用2015

    • Author(s)
      長門利純
    • Organizer
      第54回日本鼻科学会
    • Place of Presentation
      広島
    • Year and Date
      2015-10-01
    • Related Report
      2015 Annual Research Report
  • [Book] EBウイルス2015

    • Author(s)
      原渕保明
    • Total Pages
      232
    • Publisher
      診断と治療社
    • Related Report
      2015 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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