| Project/Area Number |
15H05024
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
SAITO TAKASHI 北海道医療大学, 歯学部, 教授 (40265070)
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| Co-Investigator(Kenkyū-buntansha) |
村田 勝 北海道医療大学, 歯学部, 教授 (00260662)
伊藤 修一 北海道医療大学, 歯学部, 准教授 (50382495)
松田 康裕 北海道医療大学, 歯学部, 講師 (50431317)
別所 和久 京都大学, 医学研究科, 教授 (90229138)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2017: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Keywords | 象牙質再石灰化 / 象牙質再生誘導 / 齲蝕治療 / う蝕治療 / 修復材料 / 歯学 / 修復象牙質形成 |
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| Outline of Final Research Achievements |
In this research, we aimed to obtain knowledge that aids in the development of new caries therapy by developing and disseminating multifunctional adhesive restoration materials/technology based on hybrid technology of dentin remineralization/regeneration technology. Dentin phosphoprotein derived peptide induced proliferation, differentiation and mineralization of odontoblasts. Moreover, it was suggested that by adding fish derived collagen as a safe carrier and/or nephronectin, laminin as co-factors enhancing the action of the peptide, it becomes possible to develop multifunctional adhesive restoration material.
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