Large scale amplification of tissue-repairing macrophages by regulation of subset differentiation and their application for tissue regeneration.
| Project/Area Number |
15H05040
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Hoshi Kazuto 東京大学, 医学部附属病院, 教授 (30344451)
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| Co-Investigator(Kenkyū-buntansha) |
藤原 夕子 東京大学, 医学部附属病院, 助教 (50466744)
疋田 温彦 東京大学, 医学部附属病院, 特任准教授 (60443397)
高戸 毅 東京大学, 医学部附属病院, 登録診療員 (90171454)
稲木 涼子 東京大学, 医学部附属病院, 特任研究員 (90632456)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2017: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Keywords | マクロファージ / 組織再生 / 創傷治癒 / 組織形成性サブセット / インビボイメージング / 遺伝子改変マウス / 2光子顕微鏡 |
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| Outline of Final Research Achievements |
This research was performed to establish the principle of the treatment for the wound by using cells called macrophage. Mice in which the state of macrophage can be detected by fluorescence were generated. Skin defects were made on the back of the mice, and the process of the wound healing was observed by microscopy. Methods to increase the macrophages, which can promote the wound healing, from the blood, and the potency of the macrophages were examined. In addition, the role of macrophages during the cartilage regeneration in the body was examined using several methods including electron microscopy by which minute structures can be observed. As a result, it was strongly suggested that macrophages affect chondrocytes directly in the early phase of the cartilage regeneration.
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Report
(4 results)
Research Products
(2 results)
