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Effect of oral environment on declining cognitive function of the elderly

Research Project

Project/Area Number 15H05058
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Social dentistry
Research InstitutionNippon Sport Science University

Principal Investigator

Onozuka Minoru  日本体育大学, 保健医療学部, 教授 (90084780)

Co-Investigator(Kenkyū-buntansha) 久保 金弥  名古屋女子大学, 家政学部, 教授 (00329492)
笹栗 健一  自治医科大学, 医学部, 講師 (10235286)
山本 利春  神奈川歯科大学, 大学院歯学研究科, 准教授 (50111901)
高橋 徹  福岡女子大学, 人間環境科学研究科, 准教授 (80324292)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000)
Fiscal Year 2017: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2015: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Keywords認知症 / 残存歯数 / 口腔環境 / 海馬萎縮 / MMSE / 神経科学 / 脳萎縮 / 海馬
Outline of Final Research Achievements

In the elderly who have dental treatment (group 3) with 20 or more residual teeth (group 1), no remaining dentition 20 or less (group 2), remaining number of teeth 20 or less, the extent of hippocampal atrophy and MMSE were investigated over 3 years. It was found that a group 2 had the largest extent of atrophy in the hippocampal region, followed by group 3 and group 1 in order. Similar results were seen in MMSE analysis. However, statistical analysis did not show any significant difference.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (5 results)

All 2017 2015 Other

All Journal Article (4 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 4 results,  Open Access: 4 results,  Acknowledgement Compliant: 3 results) Remarks (1 results)

  • [Journal Article] CXCL14-like Immunoreactivity Exists in Somatostatin-containing Endocrine Cells, and in the Lamina Propria and Submucosal Somatostatinergic Nervous System of Mouse Alimentary Tract2017

    • Author(s)
      Suzuki H, Yamada K, Matsuda Y, Onozuka M, Yamamoto T
    • Journal Title

      ACTA HISTOCHEMICA ET CYTOCHEMICA

      Volume: 50 Issue: 6 Pages: 149-158

    • DOI

      10.1267/ahc.17015

    • NAID

      130006285160

    • ISSN
      0044-5991, 1347-5800
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Maternal Active Mastication during Prenatal Stress Ameliorates Prenatal Stress-Induced Lower Bone Mass in Adult Mouse Offspring2017

    • Author(s)
      Azuma K, Ogura M, Kondo H, Suzuki A, Hayashi S, Iinuma M, Onozuka M, Kubo KY
    • Journal Title

      Int J Med Sci

      Volume: 14 Issue: 4 Pages: 348-355

    • DOI

      10.7150/ijms.18298

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Tooth loss early in life suppresses neurogenesis and synaptophysin expression in the hippocampus and impairs learning in mice2017

    • Author(s)
      Kubo KY, Murabayashi C, Kotachi M, Suzuki A, Mori D, Sato Y, Onozuka M, Azuma K, Iinuma M
    • Journal Title

      Arch Oral Biol

      Volume: 74 Pages: 21-27

    • DOI

      10.1016/j.archoralbio.2016.11.005

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Influence of restoration adjustment on orefrontal blood flow2015

    • Author(s)
      Sasaguri K, Otsuka T, Tsunashima H, Shimazaki T, Onozuka M
    • Journal Title

      J Stomat Occ Med

      Volume: 8 Pages: 22-28

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Remarks] 咀嚼と脳の研究所

    • URL

      http://www.imbs-mastication.org/

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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