| Project/Area Number |
15H05138
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 海外学術 |
|---|
| Research Field |
Biomolecular chemistry
|
|---|
| Research Institution | University of Toyama |
|---|
Principal Investigator |
Morita Hiroyuki 富山大学, 和漢医薬学総合研究所, 教授 (20416663)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
WONG CHINPIOW 富山大学, 和漢医薬学総合研究所, 助教 (10816226)
伊藤 卓也 富山大学, 和漢医薬学総合研究所, 准教授 (90517484)
|
|---|
| Project Period (FY) |
2015-04-01 – 2019-03-31
|
| Project Status |
Completed (Fiscal Year 2018)
|
| Budget Amount *help |
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2018: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
|
|---|
| Keywords | 生物活性 / 植物 / 海綿 / 放線菌 |
|---|
| Outline of Final Research Achievements |
In order to find new drug seeds, we isolated chemical constituents from natural sources collected in Indonesia, Vietnam, and Myanmar. As a result, 15, 19, and 28 new naturally occurring compounds were obtained from Indonesian, Vietnamese, and Myanmar natural sources, respectively. Further bioassays revealed strong cytotoxicity of the isolated three meroterpenoids against human cancer cell lines, stronger inhibitory activity of the isolated iridoids against multifunctional accessory protein R of HIV-1, and so on. Furthermore, we conserved genomes of 161 plants, 62 marine sponges, and 38 Actinomycetes.
|
| Academic Significance and Societal Importance of the Research Achievements |
科学技術が格段に進歩した今日にあっても医薬品の60％は未だ天然物の化学構造由来である。悪性腫瘍や神経疾患、自己免疫疾患に対する治療薬の早期開発等が求められる現代にあって、未知の天然生物活性化合物を見いだし、創薬へと展開していくことは、医薬品開発において未だ重要な位置を占める。今回我々は，多様な新規生物活性化合物を多数得ることに成功し，化学構造と生物活性の相関について多くの知見を得ることができた。これらの情報はあらたな医薬品の開発に貢献することが期待される。
|
