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Surveillance of pathogenic mycobacteria in Asian and Oceanian countries

Research Project

Project/Area Number 15H05263
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Veterinary medical science
Research InstitutionNagasaki University

Principal Investigator

WADA Takayuki  長崎大学, 熱帯医学研究所, 准教授 (70332450)

Co-Investigator(Kenkyū-buntansha) 柳井 徳磨  岐阜大学, 応用生物科学部, 教授 (10242744)
吉田 志緒美  独立行政法人国立病院機構近畿中央呼吸器センター, その他部局等, 感染症研究部 流動研究員 (40260806)
Research Collaborator SUZUKI Yasuhiko  
NAKAJIMA Chie  
MADARAME Hiroo  
IMAJO Masayuki  
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000)
Fiscal Year 2018: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2015: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Keywords細菌学 / 人獣共通感染症 / 抗酸菌 / 細菌ゲノム比較 / 動物感染症 / 抗酸菌症 / 獣医病理
Outline of Final Research Achievements

Mycobacterium is a genus including pathogenic agents, which can survive in natural environments, such as soil and water. Some species is infectious to animals and humans as zoonotic pathogens, causing tumors and granuloma on skins or various organs. In this study, we aimed to survey mycobacterial infection of animal cases in Asian countries mainly based on genomic analysis of clinical isolates. In collaboration with Taiwan, we established a convenient method for detection of Mycobacterium marinum, and reported an infection case of the species. We also analyzed various animal cases infected with some mycobacterial species, such as M. avium, M. caprae, and so on. In each study, the clinical strains were isolated and their genome sequences were determined to compare with each other and sequences retrieved from database, which could provide new information and evidences about animal infection of the genus broadly.

Academic Significance and Societal Importance of the Research Achievements

本課題の成果は,抗酸菌感染症における動物症例に関し,細菌ゲノム解析を手法的な基盤として積み重ねてきた.結果として,本課題を通して分析された症例の原因菌は人獣共通感染症の起因菌としてリスクが高い菌種も多く含まれ,ヒトの衛生保健にも寄与しうる成果となった.本結果はアジア地域を中心とした獣医師ネットワークに還元され,今後の研究展開を牽引し活用出来ると考えている.直接的な国際連携としては,台湾をカウンターパートとした動物感染症の研究体制構築を達成した.抗酸菌症に限らない感染症対策が望まれる場合にも,こうした連携を活かした国際的研究を展開できる素地になることが期待される.

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (43 results)

All 2019 2018 2017 2016 2015 Other

All Int'l Joint Research (9 results) Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 1 results) Presentation (28 results) (of which Int'l Joint Research: 13 results,  Invited: 2 results)

  • [Int'l Joint Research] 国立屏東科技大学/国立台湾大学(台湾)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] 国立屏東科技大学/国立台湾大学(台湾)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] ノッチンガム大学マレーシア分校(マレーシア)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] 国立台湾大学/国立屏東科技大学(台湾)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] ノッティンガム大学マレーシア校(マレーシア)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] アグリサーチ研究所(ニュージーランド)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] 台湾大学/屏東科技大学(台湾)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] サダト市立大学(エジプト)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] パタン医科大学(ネパール)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Disseminated nontuberculous mycobacterial disease in a cat caused by Mycobacterium sp. strain MFM0012018

    • Author(s)
      Kayanuma H, Ogihara K, Yoshida S, Yamamoto K, Wada T, Yamamoto T, Tsuyuki Y, Madarame H.
    • Journal Title

      Veterinary Microbiology

      Volume: 220 Pages: 90-96

    • DOI

      10.1016/j.vetmic.2018.05.010

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phylogenetic uniqueness of Mycobacterium avium subspecies hominissuis isolated from an abnormal pulmonary bovine case2018

    • Author(s)
      Yoshida Shiomi、Araki Tsubasa、Asai Tomohito、Tsuyuguchi Kazunari、Arikawa Kentaro、Iwamoto Tomotada、Nakajima Chie、Suzuki Yasuhiko、Ohya Kenji、Yanai Tokuma、Wada Takayuki、Yamamoto Taro
    • Journal Title

      Infection, Genetics and Evolution

      Volume: 62 Pages: 122-129

    • DOI

      10.1016/j.meegid.2018.04.013

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mycobacterium caprae Infection in Captive Borneo Elephant, Japan2018

    • Author(s)
      Yoshida S, Suga S, Ishikawa S, Mukai Y, Tsuyuguchi K, Inoue Y, Yamamoto T, Wada T.
    • Journal Title

      Emerging Infectious Diseases

      Volume: 24 Issue: 10 Pages: 1937-1940

    • DOI

      10.3201/eid2410.180018

    • NAID

      120006987945

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ヒト,動物,環境をとりまく非結核性抗酸菌の浸淫状況と宿主適応2017

    • Author(s)
      和田崇之, 吉田志緒美, 柳井徳磨
    • Journal Title

      日本臨床微生物学雑誌

      Volume: 27(3) Pages: 1-10

    • NAID

      40021261765

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Mycolactone-producing Mycobacterium marinum infection in captive Hong Kong warty newts and pathological evidence of impaired host immune function.2017

    • Author(s)
      Li WT, Chang HW, Pang VF, Wang FI, Liu CH, Chen TY, Guo JC, Wada T, Jeng CR.
    • Journal Title

      Diseases of Aquatic Organisms

      Volume: 123 Issue: 3 Pages: 239-249

    • DOI

      10.3354/dao03092

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Characterization of Mycolic Acids in Total Fatty Acid Methyl Ester Fractions from <i>Mycobacterium</i> Species by High Resolution MALDI-TOFMS2015

    • Author(s)
      Teramoto K, Suga M, Sato T, Wada T, Yamamoto A, Fujiwara N
    • Journal Title

      Mass Spectrometry

      Volume: 4 Issue: 1 Pages: A0035-A0035

    • DOI

      10.5702/massspectrometry.A0035

    • NAID

      130005095680

    • ISSN
      2186-5116, 2187-137X
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Mycobacterium caprae infection in a captive Borneo elephant2019

    • Author(s)
      Yoshida S, Suga S, Ishikawa S, Mukai Y, Tsuyuguchi K, Inoue Y, Yamamoto T, Wada T.
    • Organizer
      The U.S.-Japan Cooperative Medical Sciences Program’s 21st International Conference on Emerging Infectious Diseases (EID) in the Pacific Rim
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 結核に罹患したボルネオゾウの原因菌はヒト結核菌ではなくMycobacterium capraeだった2019

    • Author(s)
      吉田志緒美,菅里美,石川智史,向井康彦,露口一成,井上義一,山本太郎,和田崇之.
    • Organizer
      第92回日本細菌学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Mycobacterium caprae infection in a captive Borneo elephant2018

    • Author(s)
      Yoshida S, Suga S, Ishikawa S, Mukai Y, Tsuyuguchi K, Inoue Y, Yamamoto T, Wada T.
    • Organizer
      A Joint Conference of the 11th International Meeting of Asian Society of Conservation Medicine (ASCM) and the Wildlife Disease Association Australasia (WDAA) 2018.
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ヒト―動物―環境に浸淫する抗酸菌属の実態解明2018

    • Author(s)
      吉田志緒美,露口一成,和田崇之,山本太郎,鈴木克洋.
    • Organizer
      第50回非結核性抗酸菌症研究協議会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ゾウの結核における迅速検査キットを用いた血清学的モニタリング2018

    • Author(s)
      石川智史,菅里美,吉田志緒美,向井康彦.
    • Organizer
      第24回日本野生動物医学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] イソニアジド過量投与により肝障害と風気疝を呈したゾウ結核症の一例2018

    • Author(s)
      菅里美,石川智史,吉田志緒美,向井康彦.
    • Organizer
      第24回日本野生動物医学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 動物園飼育ゾウの結核事例2018

    • Author(s)
      吉田志緒美,露口一成,菅里美,石川智史,向井康彦,和田崇之,山本太郎,鈴木克洋.
    • Organizer
      第49回結核・非定型抗酸菌症治療研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ゾウの結核の症状,その診断と治療の難しさについて2018

    • Author(s)
      向井康彦,菅里美,石川智史,吉田志緒美.
    • Organizer
      日本動物園水族館協会主催 第28回ゾウ会議
    • Related Report
      2018 Annual Research Report
  • [Presentation] アジアにおけるOne Healthに基づいた抗酸菌症のサーベイランスネットワークについて2017

    • Author(s)
      柳井徳磨,吉田志緒美,和田崇之
    • Organizer
      第90回日本細菌学会総会
    • Place of Presentation
      仙台国際センター(宮城県・仙台市)
    • Year and Date
      2017-03-19
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Mycobacterium marinum infection in scheltopusiks (ophisaurus apodus)2017

    • Author(s)
      Yoshida S, Matsubara K, Kojima A, Wada T
    • Organizer
      10th International Meeting of Asian Society of Conservation Medicine
    • Related Report
      2017 Annual Research Report
  • [Presentation] Tuberculosis in a captive Asian elephant: the first treatment in Japan2017

    • Author(s)
      Ishikawa S, Yoshida S, Wada T, Paudel S, Suga S, Mukai Y
    • Organizer
      10th International Meeting of Asian Society of Conservation Medicine
    • Related Report
      2017 Annual Research Report
  • [Presentation] Genomic monitoring of clinical strains of Mycobacterium tuberculosis isolated from a captive Asian elephant2017

    • Author(s)
      Wada T, Yoshida S, Yamamoto K, Yamamoto T, Ishikawa S, Suga S, Mukai Y
    • Organizer
      10th International Meeting of Asian Society of Conservation Medicine
    • Related Report
      2017 Annual Research Report
  • [Presentation] 抗酸菌属における病原性とその動物症例2017

    • Author(s)
      和田崇之,吉田志緒美,柳井徳磨
    • Organizer
      環境微生物系学会合同大会2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] Molecular characterization of Mycobacterium avium subspecies hominissuis Isolated from cattle with pulmonary disease using variable number of tandem repeats analysis2016

    • Author(s)
      Wada T, Yoshida S, Yanai T, Yamamoto T.
    • Organizer
      One Health Eco Health Conference, 2016
    • Place of Presentation
      Melbourne Convention and Exhibition Centre (Melbourne, Australia)
    • Year and Date
      2016-12-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mycobacterium pseudoshottsii isolated from farmed fish in South-Western Japan2016

    • Author(s)
      Yoshida S, Tsuyuguchi K, Nonaka L, Imajoh M, Yanai T, Tamaru A, Nakajima C, Suzuki Y, Wada T, Yamamoto T.
    • Organizer
      The 9th International Meeting of ASCM in Taipei, Taiwan
    • Place of Presentation
      Taipei Zoo (Taipei, Taiwan)
    • Year and Date
      2016-10-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Genotypic characterization of Mycobacterium avium subsp. hominissuis isolated from cattle with pulmonary infection2016

    • Author(s)
      Wada T, Yoshida S, Araki T, Iwamoto T, Yamamoto T, Yanai T.
    • Organizer
      The 9th International Meeting of ASCM in Taipei, Taiwan
    • Place of Presentation
      Taipei Zoo (Taipei, Taiwan)
    • Year and Date
      2016-10-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 結核,非結核抗酸菌症の分子疫学-ヒト症例の国内事情と動物症例の解析例-2016

    • Author(s)
      和田崇之
    • Organizer
      中部地区獣医師大会・獣医学術中部地区学会
    • Place of Presentation
      名古屋国際会議場(愛知県・名古屋市)
    • Year and Date
      2016-08-28
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 滅菌水供給装置の汚染が原因と考えられたMycobacterium chimaeraの疑似アウトブレイク2016

    • Author(s)
      吉田志緒美,東桃代,露口一成,鈴木克洋,井上義一,和田崇之,山本太郎,林清二
    • Organizer
      第91回日本結核病学会総会
    • Place of Presentation
      ホテル日航金沢(石川県・金沢市)
    • Year and Date
      2016-05-26
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
  • [Presentation] 播種性病態を引き起こした新世界ザル由来Mycobacterium kansasii株の遺伝子解析及び病原性評価2016

    • Author(s)
      和田崇之,吉田志緒美,露口一成,山本太郎
    • Organizer
      第90回日本感染症学会総会
    • Place of Presentation
      仙台国際センター(宮城県・仙台市)
    • Year and Date
      2016-04-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] 播種性病態を引き起こした新世界ザル由来Mycobacterium kansasii株の遺伝子解析及び病原性評価.2016

    • Author(s)
      和田崇之,吉田志緒美,露口一成,山本太郎
    • Organizer
      第90回日本感染症学会総会・学術講演会
    • Place of Presentation
      仙台国際センター(宮城県・仙台市)
    • Year and Date
      2016-04-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] A case of mycobacteriosis of frogs: insights into virulence and ecology of aquatic mycobacteria as a zoonotic pathogen.2016

    • Author(s)
      Wada T, Yoshida S, Yamamoto K, Tachikawa Y, Yokota S, Hattori S, Nakajima C, Suzuki Y, Tsuyuguchi K, Yanai T, Yamamoto T.
    • Organizer
      The US Japan Cooperative Medical Sciences Program
    • Place of Presentation
      Marriott North Bethesda (Washington DC, US)
    • Year and Date
      2016-01-13
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] International surveillance on Mycobacteriosis in Asian network: a challenge to unite clinical cases and bacterial information towards One Health.2015

    • Author(s)
      Wada T, Yoshida S, Nakajima C, Suzuki Y, Yanai T, Yamamoto T.
    • Organizer
      One Health Conference in Nagasaki: Connecting Knowledge, Improving Practice
    • Place of Presentation
      長崎大学良順会館(長崎県・長崎市)
    • Year and Date
      2015-11-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evaluation of the virulence between Mycobacterium kansasii isolates adapted to human or animal; using “One-health” infection model in squirrel monkeys (Saimiri sciureus).2015

    • Author(s)
      Yoshida S, Wada T, Tsuyuguchi K, Yanai T, Yamamoto T.
    • Organizer
      One Health Conference in Nagasaki: Connecting Knowledge, Improving Practice
    • Place of Presentation
      長崎大学良順会館(長崎県・長崎市)
    • Year and Date
      2015-11-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Setting up an Asian Network for “One Health” from Conservation Medicine.2015

    • Author(s)
      Yanai T, Kimura J, Wada T.
    • Organizer
      One Health Conference in Nagasaki: Connecting Knowledge, Improving Practice
    • Place of Presentation
      長崎大学良順会館(長崎県・長崎市)
    • Year and Date
      2015-11-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mycobacteriosis working group in ASCM: a challenge to unite clinical cases and bacterial information towards One Health.2015

    • Author(s)
      Wada T, Yoshida S, Nakajima C, Suzuki Y, Yanai T, Yamamoto T.
    • Organizer
      8th International Conference of Conservation Medicine “One Health in Asia-Pasific.
    • Place of Presentation
      Yangon Zoo (Yangon, Myanmar)
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evaluation of Mycobacterium kansasii as zoonosis pathogen by “One Health infectious animal model”.2015

    • Author(s)
      Yoshida S, Wada T, Yanai T, Kimura J, Tsuyuguchi K, Suzuki K, Inoue Y, Kuraishi T, Hattori S, Nakajima C, Suzuki Y, Hayashi S, Yamamoto T.
    • Organizer
      8th International Conference of Conservation Medicine “One Health in Asia-Pasific.
    • Place of Presentation
      Yangon Zoo (Yangon, Myanmar)
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Genetic feature of Mycobacterium bovis isolated from Japanese Sika Deer (Cervus nippon centralis) in zoological garden in Osaka.2015

    • Author(s)
      Tamaru A, Wada T, Yoshida S, Koriyama T, Nakajima C, Suzuki Y, Tubota T.
    • Organizer
      8th International Conference of Conservation Medicine “One Health in Asia-Pasific.
    • Place of Presentation
      Yangon Zoo (Yangon, Myanmar)
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ASCM started collaboration with global networks for wildlife disease surveillance.2015

    • Author(s)
      Yanai T, Rayamajhi N, Kimura J, Wada T.
    • Organizer
      8th International Conference of Conservation Medicine “One Health in Asia-Pasific.
    • Place of Presentation
      Yangon Zoo (Yangon, Myanmar)
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2022-08-25  

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