Epidemiological study on influenza seasonality and an association with its dynamics in school children

• Project/Area Number: 15H05281
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Epidemiology and preventive medicine
• Research Institution: Tohoku University
• Principal Investigator: Kamigaki Taro 東北大学, 医学系研究科, 助教 (80451524)
• Research Collaborator: OTOMARU HIRONO ; OKAMOTO MICHIKO ; OSHITANI HITOSHI ; Chaw Liling ; Alexander Burmaa ; Oyungerel Darmaa ; Nymadawa Pagbajab ; Alday Portia ; Tan Alvin ; Tallo Veronica
• Project Period (FY): 2015-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2017: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2016: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
• Keywords: インフルエンザ / 学童 / 季節性 / ウイルス / 公衆衛生 / 疫学 / RSウイルス / ウィルス / 感染症 / 感染症疫学

Outline of Final Research Achievements

Although disease burden of influenza in Asian developing countries is similar to that in developed countries, its epidemic characteristics (especially seasonality) is very different. In this study, we conducted epidemiological studies of influenza in two countries; the Philippines and Mongolia. In the Philippines, we calculated incidence rate by considering a fraction of health seeking and revealed that it could increase up to three times. In Mongolia, a field study was conducted in a suburb district of Ulaanbaatar, and it was revealed that the frequency of tachycardia is significantly higher in hospitalized children with influenza compared with respiratory rates and SpO2 measurement. In addition, we found that the highest number of outpatient children with influenza was 1-4 years old than that in school children.

Academic Significance and Societal Importance of the Research Achievements

本研究ではアジアにおける2つの国におけるフィールド調査によりインフルエンザの疾病負荷と季節席を明らかにしたところに意義があると考えられる。最初に設定した学童での流行動態によってインフルエンザの流行と季節性については明確な関連性を示し得なかった。更なる解析を実施する予定であるが、感染拡大を誘因する別な要因についても検討が必要であると考えられる。

Research Products

• [Int'l Joint Research] Research Institute for Topical Medicine(フィリピン)
• [Int'l Joint Research] NIC, NCCD(モンゴル)
• [Int'l Joint Research] Research Institute for Topical Medicine(フィリピン)
• [Int'l Joint Research] NIC, NCCD(モンゴル)
• [Int'l Joint Research] モンゴル国立感染症センター(モンゴル)
• [Journal Article] Transmission of Respiratory Syncytial Virus Among Children Under 5 Years in Households of Rural Communities, the Philippines. (2019)
  • Author(s): Otomaru H, Kamigaki T, Tamaki R, Okamoto M, Alday PP, Tan AG, Manalo JI, Segubre-Mercado E, Inobaya MT, Tallo V, Lupisan S, Oshitani H.
  • Journal Title: Open Forum Infect Dis. Volume: 6 Issue: 3
  • DOI: 10.1093/ofid/ofz045
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Estimates of influenza and respiratory syncytial virus incidences with fraction modeling approach in Baguio City, the Philippines, 2012-2014 (2017)
  • Author(s): Taro Kamigaki, Portia P. Aldey, Edelwisa S. Mercado, Alvin G. Tan, Jenaline B. Javier, Socorro P. Lupisan, Hitoshi Oshitani, Veronica L. Tallo
  • Journal Title: Influenza and Other Respiratory Viruses Volume: 11 Issue: 4 Pages: 311-318
  • DOI: 10.1111/irv.12453
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] インフルエンザ流行時の学級閉鎖の効果に関する疫学的検討 (2018)
  • Author(s): 神垣太郎
  • Organizer: 第92回日本感染症学会学術講演会
• [Presentation] Seasonality of Influenza and RSV and the effect of climate factors in subtropical-tropical Asia (2017)
  • Author(s): Liling Chaw
  • Organizer: Transmission of respiratory viruses: from basic science to evidence-based options for control
  • Int'l Joint Research
• [Presentation] A Bayesian approach to estimate incidence rate of influenza outpatients in Baguio, the Philippines, 2012-2014 (2016)
  • Author(s): Taro Kamigaki
  • Organizer: isirv Options IX
  • Place of Presentation: アメリカ, シカゴ
  • Year and Date: 2016-08-24
  • Int'l Joint Research
• [Presentation] Burden of influenza in outpatients and inpatients in the Philippines, 2012-2014 (2016)
  • Author(s): Taro Kamigaki
  • Organizer: Incidence, Severity, and Impact of Influenza Conference 2016
  • Place of Presentation: Paris(France)
  • Year and Date: 2016-01-21
  • Int'l Joint Research
• [Presentation] Transmission Dynamics of Influenza A In A Sub-urban Community, Mongolia, 2014-2015 (2015)
  • Author(s): Taro Kamigaki
  • Organizer: International meeting on respiratory pathogens
  • Place of Presentation: Singapore(Singapore)
  • Year and Date: 2015-09-02
  • Int'l Joint Research