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Examination of new medicine for bone metabolism by investigation of potential natural drugs in China

Research Project

Project/Area Number 15H05298
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Functional basic dentistry
Research InstitutionNagasaki University

Principal Investigator

TSUKUBA Takayuki  長崎大学, 医歯薬学総合研究科(歯学系), 教授 (30264055)

Co-Investigator(Kenkyū-buntansha) 坂井 詠子  長崎大学, 医歯薬学総合研究科(歯学系), 助教 (10176612)
岡元 邦彰  岡山大学, 医歯薬学総合研究科(歯学系), 教授 (10311846)
西下 一久  長崎大学, 医歯薬学総合研究科(歯学系), 助教 (20237697)
胡 錦萍  長崎大学, 熱帯医学研究所, 助教 (30420631)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Keywords天然薬物 / 骨代謝治療薬 / 中国
Outline of Final Research Achievements

Osteoporosis is accompanied by an increase in the population of elderly people, the number of patients in Japan has been rapidly increasing. Since bisphosphonates, currently used osteoporosis drugs, have extremely strong side effects such as necrosis of the jaw, development of drugs with low toxicity is urgent. The purpose of this research is to find bone metabolism drugs with less toxicity from natural medicines in China and Jilin Province, which is a treasure house of natural products and is known as a longevity village. As a result of various analyzes, it was revealed that Rutaecarpine and Dihydroartemisinin are less toxic and have strong osteoclast inhibitory effects. Furthermore, the detailed molecular mechanisms were also analyzed.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (53 results)

All 2018 2017 2016 2015

All Journal Article (18 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 18 results,  Open Access: 10 results,  Acknowledgement Compliant: 6 results) Presentation (34 results) (of which Invited: 4 results) Book (1 results)

  • [Journal Article] Rutaecarpine attenuates osteoclastogenesis by impairing M-CSF and RANKL-stimulated signaling pathways.2018

    • Author(s)
      Fukuma Y, Sakai E, Komaki S, Nishishita K, Okamoto K, Tsukuba T.
    • Journal Title

      Clin Exp Pharmacol Physiol.

      Volume: 印刷中 Issue: 8 Pages: 863-865

    • DOI

      10.1111/1440-1681.12941

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of gingipains prevents Porphyromonas gingivalis-induced preterm birth and fetal death in pregnant mice.2018

    • Author(s)
      Takii R, Kadowaki T, Tsukuba T, Yamamoto K.
    • Journal Title

      European Journal of Pharmacology

      Volume: 824 Pages: 48-56

    • DOI

      10.1016/j.ejphar.2018.01.028

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transcription factor EB influences invasion and migration in oral squamous cell carcinomas.2018

    • Author(s)
      Sakamoto H, Yamashita K, Okamoto K, Kadowaki T, Sakai E, Umeda M, Tsukuba T.
    • Journal Title

      Oral Dis.

      Volume: 印刷中 Issue: 5 Pages: 741-748

    • DOI

      10.1111/odi.12826

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rab44, a novel large Rab GTPase, negatively regulates osteoclast differentiation by modulating intracellular calcium levels followed by NFATc1 activation.2018

    • Author(s)
      Yu Yamaguchi, Eiko Sakai, Kuniaki Okamoto, Hiroshi Kajiya, Koji Okabe, Mariko Naito, Tomoko Kadowaki and Tsukuba T
    • Journal Title

      Cell Mol Life Sci.

      Volume: 75 Issue: 1 Pages: 33-48

    • DOI

      10.1007/s00018-017-2607-9

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Rho-specific guanine nucleotide exchange factor Plekhg5 modulates cell polarity, adhesion, migration, and podosome organization in macrophages and osteoclasts.2017

    • Author(s)
      Iwatake M, Nishishita K, Okamoto K, Tsukuba T.
    • Journal Title

      Exp Cell Res.

      Volume: 359(2) Issue: 2 Pages: 415-430

    • DOI

      10.1016/j.yexcr.2017.08.025

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of deficiency of Kelch-like ECH-associated protein 1 on skeletal organization: a mechanism for diminished nuclear factor of activated T cells cytoplasmic-1 during osteoclastogenesis2017

    • Author(s)
      Sakai E., Morita M., Ohuchi M., Kido MA., Fukuma Y., Nishishita K., Okamoto K., Itoh K., Yamamoto M, and Tsukuba T
    • Journal Title

      FASEB Journal

      Volume: 31 Issue: 9 Pages: 4011-4022

    • DOI

      10.1096/fj.201700177r

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The dental resin monomers HEMA and TEGDMA have inhibitory effects on osteoclast differentiation with low cytotoxicity2017

    • Author(s)
      Inamitsu H, Okamoto K, Sakai E, Murata H, Tsukuba T
    • Journal Title

      Journal of Applied Toxicology

      Volume: 印刷中 Issue: 7 Pages: 817-824

    • DOI

      10.1002/jat.3429

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cathepsin K modulates invasion, migration and adhesion of oral squamous cell carcinomas in vitro.2017

    • Author(s)
      Yamashita K, Iwatake M, Okamoto K, Yamada SI, Umeda M, Tsukuba T.
    • Journal Title

      Oral Dis

      Volume: 23 Issue: 4 Pages: 518-525

    • DOI

      10.1111/odi.12643

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Rab27A regulates transport of cell surface receptors modulating multinucleation and lysosome-related organelles in osteoclasts.2016

    • Author(s)
      Shimada-Sugawara M, Sakai E, Okamoto K, Fukuda M, Izumi T, Yoshida N, Tsukuba T
    • Journal Title

      Sci Rep

      Volume: 印刷中 Issue: 6 Pages: 1321-1333

    • DOI

      10.1002/jcp.25235

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Sanguiin H-6, a constituent of Rubus parvifolius L., inhibits receptor activator of nuclear factor-κB ligand-induced osteoclastogenesis and bone resorption in vitro and inhibits tumor necrosis factor-α-induced osteoclastogenesis in vivo.2016

    • Author(s)
      Sakai E, Aoki Y, Yoshimatsu M, Nishishita K, Iwatake M, Fukuma Y, Okamoto K, Tanaka T, Tsukuba T
    • Journal Title

      Phytomedicine

      Volume: 23 Issue: 8 Pages: 828-837

    • DOI

      10.1016/j.phymed.2016.04.002

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)2016

    • Author(s)
      Klionsky DJ., Abdelmohsen K., Abe A., Abedin MJ.,Inomata M., et al.
    • Journal Title

      Autophagy

      Volume: 12(1) Issue: 1 Pages: 1-222

    • DOI

      10.1080/15548627.2015.1100356

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Lipid droplets affect elimination of Porphyromonas gingivalis in HepG2 cells by altering the autophagy-lysosome system2016

    • Author(s)
      Zaitsu Y, Iwatake M, Sato K, Tsukuba T
    • Journal Title

      Microbes Infect.

      Volume: 18 Issue: 9 Pages: 565-571

    • DOI

      10.1016/j.micinf.2016.05.004

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Castalagin exerts inhibitory effects on osteoclastogenesis through blocking a broad range of signaling pathways with low cytotoxicity2015

    • Author(s)
      Iwatake, M.; Sakai, E.; Okamoto, K.; Tanaka, T.; Tsukuba, T.
    • Journal Title

      Phytotherapy Research

      Volume: 29 Issue: 6 Pages: 0-0

    • DOI

      10.1002/ptr.5333

    • NAID

      120006987044

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rab27A Regulates Transport of Cell Surface Receptors Modulating Multinucleation and Lysosome Related Organellas in osteoclasts2015

    • Author(s)
      Megumi Shimada-Sugawara,Eiko Sakai,Kuniaki Okamoto,Mitsunori Fukuda,Tetsuro Izumi,Noriaki Yoshida,Takayuki Tsukuba
    • Journal Title

      SCIENTIFIC REPORTS

      Volume: 5 Issue: 1 Pages: 9620-9620

    • DOI

      10.1038/srep09620

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Cobalt protoporphyrin represses osteoclastogenesis through blocking multiple signaling pathways2015

    • Author(s)
      Yuka Yashima, Kuniaki Okamoto, Eiko Sakai, Mayumi Iwatake, Yutaka Fukuma, Kazuhisa Nishishita, Takayuki Tsukuba
    • Journal Title

      BioMetals

      Volume: 28 Issue: 4 Pages: 725-732

    • DOI

      10.1007/s10534-015-9861-9

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Punicalagin attenuates osteoclast differentiation by impairing NFATcl expression and blocking Akt- and JNK-dependent pathways2015

    • Author(s)
      Mayumi Iwatake, Kuniaki Okamoto, Takashi Tanaka and Takayuki Tsukuba
    • Journal Title

      Molecular and Cellular Biochemistry

      Volume: 407 Issue: 1-2 Pages: 161-172

    • DOI

      10.1007/s11010-015-2466-3

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cafestol has a weaker inhibitory effect on osteoclastogenesis than kahweol and promotes osteoblast differentiation.2015

    • Author(s)
      Fukuma Y, Sakai E, Nishishita K, Okamoto K, Tsukuba T
    • Journal Title

      Biofactors

      Volume: 41 Issue: 4 Pages: 222-231

    • DOI

      10.1002/biof.1218

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Dual Effects of Liquiritigenin on the Proliferation of Bone Cells : Promotion of Osteoblasl Differentiation and Inhibition of Osteoclast Differentiation2015

    • Author(s)
      Kaho Uchino, Kuniaki Okamoto, Eiko Sakai, Erika Yoneshima, Mayumi Iwatake, Yutaka Fukuma, Kazuhisa Nishishita and Takayuki Tsukuba
    • Journal Title

      PHYTOTHERAPY RESEARCH

      Volume: 11 Issue: 11 Pages: 1714-21

    • DOI

      10.1002/ptr.5416

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Presentation] エンドソーム・リソソーム機能と骨細胞2017

    • Author(s)
      筑波隆幸
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎ブリックホール・長崎新聞文化ホール (長崎県、長崎市)
    • Year and Date
      2017-03-15
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Keap1遺伝子欠損はin vivoおよびin vitroにおいて骨の細胞分化を抑制する2017

    • Author(s)
      坂井詠子、福間裕、西下一久、岡元邦彰、筑波隆幸
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎ブリックホール・長崎新聞文化ホール (長崎県、長崎市)
    • Year and Date
      2017-03-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] Dihydroartemisininの破骨細胞分化抑制効果2017

    • Author(s)
      小巻俊介、坂井詠子、福間裕、西下一久、岡元邦彰、筑波隆幸
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎ブリックホール・長崎新聞文化ホール (長崎県、長崎市)
    • Year and Date
      2017-03-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] The dental resin monomers HEMA and TEGDMA have inhibitory effects on osteoclast differentiation with low cytotoxicity2017

    • Author(s)
      稲光宏之、岡元邦彰、坂井詠子、西下一久、村田比呂司、筑波隆幸
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎ブリックホール・長崎新聞文化ホール (長崎県、長崎市)
    • Year and Date
      2017-03-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] Rutaecarpineの破骨細胞分化抑制効果2017

    • Author(s)
      福間裕、坂井詠子、小巻俊介、西下一久、岡元邦彰、筑波隆幸
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎ブリックホール・長崎新聞文化ホール (長崎県、長崎市)
    • Year and Date
      2017-03-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] Cathepsin K regulates invasion, migration, and adhesion of oral squamous cell carcinomas2017

    • Author(s)
      山下健太郎、岩竹真弓、岡元邦彰、山田慎一、梅田正博、筑波隆幸
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎ブリックホール・長崎新聞文化ホール (長崎県、長崎市)
    • Year and Date
      2017-03-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] エンドソーム・リソソーム機能と骨細胞2017

    • Author(s)
      筑波隆幸
    • Organizer
      第90回日本薬理学会年会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Keap1遺伝子欠損はin vivoおよびin vitroにおいて骨の細胞分化を抑制する2017

    • Author(s)
      坂井詠子,福間裕,西下一久,岡元邦彰,筑波隆幸
    • Organizer
      第90回日本薬理学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Rutaecarpineの破骨細胞分化抑制効果2017

    • Author(s)
      福間裕, 坂井詠子, 小巻俊介, 西下一久, 岡元邦彰, 筑波隆幸
    • Organizer
      第90回日本薬理学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] カテプシンKは口腔扁平上皮癌の転移、遊走、接着を制御する2017

    • Author(s)
      山下健太郎, 岩竹真弓, 山田慎一, 岡元邦彰,梅田正博, 筑波隆幸
    • Organizer
      第90回日本薬理学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 歯科レジンモノマーHEMA及びTEGDMAは低い細胞毒性で破骨細胞抑制活性を持つ2017

    • Author(s)
      稲光宏之, 岡元邦彰, 坂井詠子, 西下一久, 村田比呂司, 筑波隆幸
    • Organizer
      第90回日本薬理学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Dihydroartemisininの破骨細胞分化抑制効果2017

    • Author(s)
      小巻俊介, 坂井詠子, 福間裕, 西下一久, 岡元邦彰, 筑波隆幸
    • Organizer
      第90回日本薬理学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 破骨細胞分化を制御する新規Rabタンパク質の同定と解析2017

    • Author(s)
      山口優, 坂井詠子, 岡元邦彰, 門脇知子, 筑波隆幸
    • Organizer
      第 22 回日本病態プロテアーゼ学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Actin-Binding LIM protein 1は破骨細胞における細胞骨格形成と細胞機能を制御する2017

    • Author(s)
      楢原春菜, 坂井詠子, 岡元邦彰, 吉田教明, 筑波隆幸
    • Organizer
      第59回日本歯科基礎医学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] コバルトプロトポルフィリンの破骨細胞分化および活性化に対する影2017

    • Author(s)
      岡元邦彰,坂井詠子,筑波隆幸
    • Organizer
      メタルバイオサイエンス研究会2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヘムオキシゲナーゼ1の発現抑制はカスパーゼ3の活性化、HMGB1の細胞外遊離と破骨細胞分化に必要である2017

    • Author(s)
      坂井詠子, 岡元邦彰, 筑波隆幸
    • Organizer
      第59回日本歯科基礎医学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 破骨細胞分化を制御する新規Rabタンパク質の同定と機能解析2017

    • Author(s)
      山口優,坂井詠子,岡元邦彰,鍛治屋浩,岡部幸司、門脇知子,筑波隆幸
    • Organizer
      第59回日本歯科基礎医学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Keap1遺伝子欠損はIrf8とMafBの発現上昇を介して破骨細胞分化を抑制する2017

    • Author(s)
      坂井詠子,福間裕,西下一久,岡元邦彰,筑波隆幸
    • Organizer
      第59回日本歯科基礎医学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 新規高分子量Gタンパク質Rab44はCa2+流入及びNFATc1経路を介して破骨細胞分化を負に制御する2017

    • Author(s)
      山口優,坂井詠子,岡元邦彰,鍛治屋浩,岡部幸司、門脇知子,筑波隆幸
    • Organizer
      第90回日本生化学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 扁平上皮癌細胞の増殖能・浸潤能・転移能における転写因子TFEBの役割2017

    • Author(s)
      坂元裕, 山下健太郎, 岡元邦彰, 門脇知子, 梅田正博, 筑波隆幸
    • Organizer
      第90回日本生化学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Keap1遺伝子欠損はNrf2の活性化を介して破骨細胞分化を抑制する2017

    • Author(s)
      坂井詠子, 福間裕, 西下一久, 岡元邦彰, 筑波隆幸
    • Organizer
      第90回日本生化学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 破骨細胞分化を負に制御する新規Kelchタンパク質の同定と機能解析2017

    • Author(s)
      楢原峻, 坂井詠子, 山口優, 楢原春菜, 門脇知子, 岡元邦彰, 朝比奈泉,筑波隆幸
    • Organizer
      第90回日本生化学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] tert-ButylhydroquinoneによるIrf8とMafBの発現増加を介した破骨細胞分化抑制機構2016

    • Author(s)
      坂井詠子,山口優,福間裕,西下一久,岡元邦彰,筑波隆幸
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター・東北大学川内北キャンパス(宮城県、仙台市)
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] 骨芽細胞分化における転写因子TFEBの関与2016

    • Author(s)
      岡元邦彰,坂井詠子,西下一久,筑波隆幸
    • Organizer
      第58回日本歯科基礎医学会
    • Place of Presentation
      札幌コンベンションセンター(北海道、札幌市)
    • Year and Date
      2016-08-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] Keap1遺伝子欠損はIrf8の発現上昇を介して破骨細胞分化を抑制する2016

    • Author(s)
      坂井詠子,福間裕,西下一久,岡元邦彰,筑波隆幸
    • Organizer
      第58回日本歯科基礎医学会
    • Place of Presentation
      札幌コンベンションセンター(北海道、札幌市)
    • Year and Date
      2016-08-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] 破骨細胞におけるリソソーム/エンドソームに関与するタンパク質の同定とその機能解析2016

    • Author(s)
      岩竹真弓,岡元邦彰,筑波隆幸
    • Organizer
      第21回日本病態プロテアーゼ学会
    • Place of Presentation
      千里ライフサエンスセンター(大阪府、豊中市)
    • Year and Date
      2016-08-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] ヒト肝細胞内での脂肪滴はオートファジー‐リソソームシステムによる歯周病細菌排除に影響する2016

    • Author(s)
      財津有未,岩竹真弓,佐藤啓子, 筑波隆幸
    • Organizer
      第21回日本病態プロテアーゼ学会
    • Place of Presentation
      千里ライフサエンスセンター(大阪府、豊中市)
    • Year and Date
      2016-08-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] Keap1/Nrf2の破骨細胞と骨芽細胞分化における役割2015

    • Author(s)
      坂井詠子,福間 裕,山口 優,西下一久,岡元邦彰,筑波隆幸
    • Organizer
      第 38回日本分子生物学会年会、第 88回日本生化学会大会
    • Place of Presentation
      神戸市・ポートアイランド
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] リソソーム促進転写因子TFEBの骨芽細胞分化における影響2015

    • Author(s)
      米嶋枝里香,岡元邦彰,坂井詠子,西下一久,筑波隆幸,吉田教明
    • Organizer
      第74回 日本矯正歯科学会大会
    • Place of Presentation
      福岡市・福岡国際会議場
    • Year and Date
      2015-11-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] 骨系細胞におけるリソソームの新しい機能2015

    • Author(s)
      筑波隆幸
    • Organizer
      第57回歯科基礎医学会
    • Place of Presentation
      新潟市・朱鷺メッセ
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] カフェストールは、カフェオールより破骨細胞分化阻害効果が弱く、骨芽細胞の成熟を促進する2015

    • Author(s)
      福間 裕,坂井詠子,西下一久,岡元邦彰,筑波隆幸
    • Organizer
      第57回歯科基礎医学会
    • Place of Presentation
      新潟市・朱鷺メッセ
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] Keap1/Nrf2の破骨細胞分化における役割2015

    • Author(s)
      坂井詠子,福間 裕,西下一久,岡元邦彰,筑波隆幸
    • Organizer
      第57回歯科基礎医学会
    • Place of Presentation
      新潟市・朱鷺メッセ
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] 骨吸収におけるリソソーム小胞輸送に関与するタンパク質の同定とその機能解析2015

    • Author(s)
      岩竹真弓,岡元邦彰,筑波隆幸
    • Organizer
      第57回歯科基礎医学会
    • Place of Presentation
      新潟市・朱鷺メッセ
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] 口腔扁平上皮癌におけるカテプシンKの浸潤突起形成での役割2015

    • Author(s)
      山下健太郎,岩竹真弓,岡元邦彰,山田慎一,梅田正博,筑波隆幸
    • Organizer
      第20回日本病態プロテアーゼ学会学術集会
    • Place of Presentation
      名古屋市・ANA クラウンプラザホテルグランコート名古屋
    • Year and Date
      2015-08-21
    • Related Report
      2015 Annual Research Report
  • [Book] 現代歯科薬理学 第6版2018

    • Author(s)
      大谷啓一 監著/鈴木邦明・戸苅彰史・青木和広・兼松隆・筑波隆幸 編
    • Total Pages
      448
    • Publisher
      医歯薬出版
    • ISBN
      9784263458112
    • Related Report
      2017 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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