• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of exposure assessment of complex mixtures toward the risk assessment

Research Project

Project/Area Number 15H05340
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Environmental risk control and evaluation
Research InstitutionNational Institute of Advanced Industrial Science and Technology

Principal Investigator

Zushi Yasuyuki  国立研究開発法人産業技術総合研究所, エネルギー・環境領域, 主任研究員 (80611780)

Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
Keywords複雑混合物 / GCxGC / 2次元GC / 物性推定 / リスク評価 / 暴露評価 / 環境運命 / 2次元ガスクロマトグラフ / LC分画 / 環境動態 / 混合物 / GCxGC / 画像分類 / 保持時間補正 / 残油 / 環境動態解析 / リスク解析 / 複雑混合物リスク評価 / GIS
Outline of Final Research Achievements

Methods for exposure assessment and risk assessment for complex mixtures have been developed in this study. Through the research activity, key technologies which use comprehensive analytical instrument GCxGC, including physico-chemical property estimation, environmental fate, and exposure assessment for technical mixture have been developed. It has also become possible to perform risk screening on bioaccumulation for non-polar substances in the mixture. A method for classifying environmental mixtures according to their detection patterns which will be useful for risk analysis have been developed. The software tool has been available via the website. Most of technologies developed in this study are built in a web platform developed in this study as well, and can easily applied to mixture assessments.

Academic Significance and Societal Importance of the Research Achievements

本課題では従来のリスク評価プロセスでは限界がある複雑混合物について新たなアプローチの構築に取り組んだ。具体的には先端分析装置であるGCxGCにLFER 理論を取り入れた物性予測手法を構築し、新たな評価アプローチを提案した。GCxGC の利用により、的確な物質の組成把握が可能となり、このGCxGCデータ解析手法を用いる事により、混合物に対して暴露評価やリスク評価を行う先行事例を示すことが出来た。この取組みの達成により、従来では科学的根拠が欠如したまま国際的な規制対象としての検討が進められている複雑混合物の取扱い現状に対して、科学的根拠を持った評価法の新たなアプローチを例示する事ができると考える。

Report

(5 results)
  • 2019 Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (44 results)

All 2020 2019 2018 2017 2016 2015 Other

All Int'l Joint Research (4 results) Journal Article (11 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 9 results,  Open Access: 4 results,  Acknowledgement Compliant: 3 results) Presentation (27 results) (of which Int'l Joint Research: 7 results,  Invited: 4 results) Book (1 results) Remarks (1 results)

  • [Int'l Joint Research] Jumeira University(アラブ首長国連邦)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] NUST(パキスタン)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] University of Nebraska/Texas A&M University(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Eawag/EPFL(スイス)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Mixture Touch: A Web Platform for the Evaluation of Complex Chemical Mixtures2020

    • Author(s)
      Zushi Yasuyuki, Hanari Nobuyasu, Nabi Deedar, Lin Bin-Le
    • Journal Title

      ACS Omega

      Volume: 5 Issue: 14 Pages: 8121-8126

    • DOI

      10.1021/acsomega.0c00340

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comprehensive two-dimensional gas-chromatography-based property estimation to assess the fate and behavior of complex mixtures: A case study of vehicle engine oil2019

    • Author(s)
      Zushi Yasuyuki、Yamatori Yuki、Nagata Jun、Nabi Deedar
    • Journal Title

      Science of The Total Environment

      Volume: 669 Pages: 739-745

    • DOI

      10.1016/j.scitotenv.2019.03.157

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 順相LCを利用した複雑混合物中成分の分画とGC×GCによる混合物評価法への応用2019

    • Author(s)
      頭士 泰之, 山取 由樹, 羽成 修康, 恒見 清孝, 永田 淳, 長尾 優, 廣岡 恵, 田中 幸樹
    • Journal Title

      島津製作所 テクニカルレポート

      Volume: C146-0387 Pages: 1-4

    • Related Report
      2018 Annual Research Report
    • Open Access
  • [Journal Article] Direct Classification of GC × GC-Analyzed Complex Mixtures Using Non-Negative Matrix Factorization-Based Feature Extraction2018

    • Author(s)
      Zushi Yasuyuki、Hashimoto Shunji
    • Journal Title

      Analytical Chemistry

      Volume: 90 Issue: 6 Pages: 3819-3825

    • DOI

      10.1021/acs.analchem.7b04313

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pixel-by-pixel correction of retention time shifts in chromatograms from comprehensive two-dimensional gas chromatography coupled to high resolution time-of-flight mass spectrometry2017

    • Author(s)
      Zushi, Y., Gros. J., Tao, Q., Reichenbach, S.E., Hashimoto, S., Arey, S.J.
    • Journal Title

      J.Chromatogr. A

      Volume: 1508 Pages: 121-129

    • DOI

      10.1016/j.chroma.2017.05.065

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Revaluation of stockpile amount of PFOS-containing aqueous film-forming foam in Japan: gaps and pitfalls in the stockpile survey2017

    • Author(s)
      Zushi, Y., Yamamoto, A., Tsunemi, K., Masunaga, S.
    • Journal Title

      Environ. Sci. Pollut. Res.

      Volume: 24 Issue: 7 Pages: 6736-6745

    • DOI

      10.1007/s11356-017-8374-1

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Nontarget approach for environmental monitoring by GC x GC-HRTOMFS in the Tokyo Bay basin2016

    • Author(s)
      Zushi, Y., Hashimoto, S., Tanabe, K
    • Journal Title

      Chemosphere

      Volume: 156 Pages: 398-406

    • DOI

      10.1016/j.chemosphere.2016.04.131

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Status and Trends of Perfluoroalkyl Substances in Japan with Special Emphasis on the Tokyo Bay Basin2016

    • Author(s)
      Masunaga Shigeki、Zushi Yasuyuki
    • Journal Title

      ASC Symposium Series

      Volume: 1244 Pages: 157-179

    • DOI

      10.1021/bk-2016-1244.ch007

    • ISBN
      9780841231993, 9780841231986
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 私たちの身の回りに存在する化学物質 ~東京湾流域を対象とした網羅的分析の実施事例~2016

    • Author(s)
      頭士泰之
    • Journal Title

      Safety & Sustainability News letter

      Volume: 26 Pages: 3-3

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Selective and comprehensive analysis of organohalogen compounds by GC×GC-HRTofMS and MS/MS2015

    • Author(s)
      Hashimoto S., Zushi Y., Takazawa Y., IEDA T., Fushimi A., Tanabe K., Shibata Y.
    • Journal Title

      Environmental Science and Pollution Research

      Volume: open Issue: 8 Pages: 1-12

    • DOI

      10.1007/s11356-015-5059-5

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Temporal trends for inflow of perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) to Tokyo Bay, Japan, estimated by a receptor-oriented approach2015

    • Author(s)
      ①Sakurai T, Serizawa S, Isobe T, Kobayashi J, Kodama K, Lee JH, Maki H, Zushi Y, Sevilla-Nastor JB, Imaizumi Y, Suzuki N, Horiguchi T, Shiraishi H
    • Journal Title

      Sci. Total Environ.

      Volume: 539 Pages: 277-285

    • DOI

      10.1016/j.scitotenv.2015.08.142

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Mixture Touch: 環境混合物を診るためのウェブプラットフォーム2019

    • Author(s)
      頭士泰之, 羽成修康, 林彬勒
    • Organizer
      日本環境化学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ウェブプラットフォーム(Mixture Touch)におけるデータ解析手法実装の試み2019

    • Author(s)
      頭士泰之
    • Organizer
      統計学的アプローチによる問題解決のための環境化学分析の最適化・高度化に関する研究集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Mixture Touch: A Web Platform for Assessments of Complex Mixtures Using Comprehensive Two-Dimensional Gas Chromatography Coupled with Mass Spectrometry (GC×GC-MS)2019

    • Author(s)
      Zushi Yasuyuki
    • Organizer
      ICCA- LRI Workshop
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ノンターゲット分析による環境試料中の成分網羅的分析手法の検討2018

    • Author(s)
      頭士 泰之, 山取 由樹, Deedar Nabi, 永田 淳
    • Organizer
      日本水環境学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 2016 年熊本地震後の熊本市の地下水・表流水水質―バイオアッセイを用いた追跡調査2018

    • Author(s)
      黒田 啓介, 小林 淳, 高澤 嘉一, 頭士 泰之, 白石 不二雄, 山崎 美穂, 中島 大介
    • Organizer
      日本水環境学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 各種質量分析データに適用可能なNMFによるクロマトピークデコンボリューション手法2017

    • Author(s)
      頭士 泰之
    • Organizer
      統計学的アプローチによる問題解決のための環境化学分析の最適化・高度化に関する研究集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] GCxGC-based property estimation for risk assessment of complex petrochemical mixture including the generated compounds in the engine oils2017

    • Author(s)
      Zushi Yasuyuki, Nagata Jun, Deedar Nabi
    • Organizer
      SETAC North America FOcused Topic Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 2016 年熊本地震後の地下水水質と汚染:バイオアッセイによる評価2017

    • Author(s)
      黒田 啓介, 小林 淳, 高澤 嘉一, 頭士 泰之, 白石 不二雄, 山崎 美穂, 中島 大介
    • Organizer
      日本地下水学会2017年春季講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] GCxGC-HRTOFMSによるノンターゲットモニタリングのための各種ソフトウェアの改良2017

    • Author(s)
      橋本 俊次, 家田 曜世, 高澤 嘉一, 頭士 泰之, 大塚 宜寿
    • Organizer
      第26回環境化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 逆解析アプローチによる環境混合物評価手法の検討 - 混合物分析画像のパターン認識による分類と因果解析 -2017

    • Author(s)
      頭士 泰之, 橋本 俊次
    • Organizer
      第26回環境化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 酵母アッセイを用いた熊本市における地下水汚染のスクリーニング2017

    • Author(s)
      黒田 啓介, 小林 淳, 高澤 嘉一, 頭士 泰之, 白石 不二雄, 山崎 美穂, 中島 大介
    • Organizer
      第26回環境化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Rapid screening of groundwater pollution after an earthquake by recombinant yeast assays2017

    • Author(s)
      黒田 啓介, 小林 淳, 高澤 嘉一, 頭士 泰之, 白石 不二雄, 山崎 美穂, 中島 大介
    • Organizer
      10th Micropol & Ecohazard Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Passive sampling and GCGC: When two marry to give better understanding of transport behaviour and fate of micropollutants in environmental waters2017

    • Author(s)
      Nabi D., Zushi Yasuyuki.,Samanipour S., Ahmad F., Arey S., Aeppli C.
    • Organizer
      9th International Passive Sampling Workshop and Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 熊本市における地震後の地下水水質2017

    • Author(s)
      黒田啓介, 小林淳, 中島大介, 白石不二雄, 山崎美穂, 高澤嘉一, 頭士 泰之
    • Organizer
      日本水環境学会
    • Related Report
      2016 Annual Research Report
  • [Presentation] 複雑混合物のリスク評価のための手法提案2016

    • Author(s)
      頭士泰之, 山取由樹, 加茂将史, 恒見清孝
    • Organizer
      環境化学討論会
    • Related Report
      2016 Annual Research Report
  • [Presentation] 室内製品暴露評価ツール(ICET)を用いた日常生活における暴露評価 - 難燃剤を事例として -2016

    • Author(s)
      頭士泰之, 山取由樹, 恒見清孝, 梶原秀夫, 東野晴行
    • Organizer
      日本リスク研究学会
    • Related Report
      2016 Annual Research Report
  • [Presentation] 複数物質・複雑混合物への暴露に対するリスク評価手法の開発に向けて2016

    • Author(s)
      頭士 泰之, 山取 由樹, 永田 淳, 加茂 将史, 恒見 清孝
    • Organizer
      日本リスク研究学会
    • Related Report
      2016 Annual Research Report
  • [Presentation] GCxGC-HRTofMSによる環境ノンターゲット分析の試み2016

    • Author(s)
      橋本俊次, 家田曜世, 高澤嘉一, 田邊 潔, 柴田康行, 頭士 泰之
    • Organizer
      質量分析総合討論会
    • Related Report
      2016 Annual Research Report
  • [Presentation] GCxGC-HRTOFMSによるノンターゲットモニタリングのための差の解析法の検討2016

    • Author(s)
      橋本俊次, 家田曜世, 高澤嘉一, 田邊 潔, 柴田康行, 頭士 泰之
    • Organizer
      環境化学討論会
    • Related Report
      2016 Annual Research Report
  • [Presentation] GC×GC-HRTOFMSによる多成分網羅分析-ソフトウェアによる化合物の自動検出とマトリックスの影響評価-2016

    • Author(s)
      家田曜世, 橋本俊次, 高澤嘉一, 田邊 潔, 頭士 泰之, 柴田康行, 前川文彦, 佐野一広, 鈴木剛, 中山祥嗣, 磯部友彦, Tin-Tin-Win-Shwe, 川嶋貴治
    • Organizer
      環境化学討論会
    • Related Report
      2016 Annual Research Report
  • [Presentation] 日本環境化学会25周年記念パネルディスカッション2016

    • Author(s)
      頭士泰之
    • Organizer
      環境化学討論会
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] MSデータベースを利用した網羅分析事例の紹介と環境リスク解析への展望2016

    • Author(s)
      頭士泰之
    • Organizer
      日本水環境学会シンポジウム
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 2次元GC計測を用いた複雑混合物スクリーニング評価,2016

    • Author(s)
      頭士泰之
    • Organizer
      化学物質の安全管理に関するシンポジウム
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] COMPREHENSIVE ANALYSIS OF HOUSE DUST USING GC×GC-HRTOFMS AND IN-HOUSE SOFTEWARE2016

    • Author(s)
      家田曜世, 橋本俊次, 高澤嘉一, 田邊潔, 頭士泰之, 柴田康行, 前川文彦, 佐野一広, 鈴木剛, 中山祥嗣, 磯部友彦, Tin-Tin-Win-Shwe, 川嶋貴治
    • Organizer
      Dioxin 2016
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Exploring chemical markers for environmental release of perfluorooctane sulfonate in aqueous fire-fighting foams using comprehensive analysis with high resolution mass spectrometry2016

    • Author(s)
      Yasuyuki Zushi, Atsushi Yamamoto, Shiho Kitai, Shigeki Masunaga, Hideya Kawasaki, Ryuichi Arakawa
    • Organizer
      ACS 2016
    • Place of Presentation
      San Diego, USA
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ノンターゲット分析とGISを組み合わせた環境中存在物質の排出源解析2015

    • Author(s)
      頭士泰之、橋本俊次、田邊潔
    • Organizer
      第24回環境化学討論会
    • Place of Presentation
      札幌コンベンションセンター (北海道札幌市)
    • Related Report
      2015 Annual Research Report
  • [Presentation] Non-target analysis by GC × GC-HRTOFMS and its application to emission source analysis of the detected contaminants using GIS2015

    • Author(s)
      Yasuyuki Zushi, Shunji Hashimoto, Kiyoshi Tanabe
    • Organizer
      SETAC North America 2015
    • Place of Presentation
      Salt Lake city, USA
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Book] 製品含有化学物質の リスク管理、情報伝達の効率化 -規制対応/リスクアセスメント/調査・顧客対応-2017

    • Author(s)
      頭士 泰之(分担執筆)
    • Total Pages
      654
    • Publisher
      技術情報協会
    • Related Report
      2017 Annual Research Report
  • [Remarks] ウェブプラットフォーム:Mixture Touch

    • URL

      http://www.mixture-platform.net/Mixture_Touch_open/

    • Related Report
      2018 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2022-11-04  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi