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Analysis of multi time-scale dynamics in mechanobiological stimulation by impulsive force

Research Project

Project/Area Number 15H05352
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionThe University of Tokyo

Principal Investigator

Nakagawa Keiichi  東京大学, 大学院工学系研究科(工学部), 助教 (00737926)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥24,440,000 (Direct Cost: ¥18,800,000、Indirect Cost: ¥5,640,000)
Fiscal Year 2016: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2015: ¥21,320,000 (Direct Cost: ¥16,400,000、Indirect Cost: ¥4,920,000)
Keywordsメカノバイオロジー / メカニカルストレス / 撃力 / レーザー / カルシウムイメージング / 再生医療 / 再生医工学
Outline of Final Research Achievements

In recent years, studies that clarify the mechanical action on the living body and aim at understanding diseases and applying them to medical treatment are actively conducted. In this study, we developed an impulsive force loading system to investigate how the instantaneous mechanical stimulus affects cells. Cells are given nanometer and microsecond scale displacement by a cantilever accelerated by nanosecond laser. We also acheved observation of a cell response with calcium imaging.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • Research Products

    (4 results)

All 2017 2016

All Presentation (4 results)

  • [Presentation] 瞬間的力学刺激に対する細胞のカルシウムシグナリングの動的観察及び解析2017

    • Author(s)
      加藤拓真、中川桂一、芦葉裕、小林英津子、塚本哲、佐久間一郎
    • Organizer
      第56回生体医工学会大会
    • Place of Presentation
      東北大学(宮城県・仙台市)
    • Year and Date
      2017-05-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] 極微の衝撃に対する細胞応答の解析を目的とした刺激負荷システムの開発2017

    • Author(s)
      芦葉裕、中川桂一、加藤拓真,小林英津子、塚本哲、佐久間一郎
    • Organizer
      平成28年度衝撃波シンポジウム
    • Place of Presentation
      ヴェルクよこすか(神奈川県・横須賀市)
    • Year and Date
      2017-03-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] 細胞に対する撃力刺激負荷システムの開発2016

    • Author(s)
      芦葉裕、中川桂一、塚本哲、小林英津子、佐久間一郎
    • Organizer
      第55回生体医工学会大会
    • Place of Presentation
      富山国際会議場(富山県・富山市)
    • Year and Date
      2016-04-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] 細胞に対する撃力刺激負荷システムの開発2016

    • Author(s)
      芦葉裕,中川桂一,塚本哲,小林英津子,佐久間一郎
    • Organizer
      第55回日本生体医工学会大会
    • Place of Presentation
      富山国際会議場(富山県・富山市)
    • Year and Date
      2016-04-26
    • Related Report
      2015 Annual Research Report

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Published: 2015-04-16   Modified: 2018-03-22  

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