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Research for molecular bases relating to the development of body odor from armpits

Research Project

Project/Area Number 15H05610
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Applied anthropology
Research InstitutionThe University of Tokyo

Principal Investigator

Toyoda Yu  東京大学, 医学部附属病院, 特任研究員 (80650340)

Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥21,970,000 (Direct Cost: ¥16,900,000、Indirect Cost: ¥5,070,000)
Fiscal Year 2018: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Keywords体質 / 健康 / 腋臭症 / 膜輸送体 / トランスレーショナル研究 / トランスレーショナルリサーチ / 体質・健康 / 体臭発生機序の分子実体
Outline of Final Research Achievements

This proposal is focused on understanding molecular bases in the development of human axillary odors which may be affected by constitution and/or healthy condition of each subject. For this purpose, we researched an axillary osmidrosis risk factor, ATP-binding cassette transporter sub-family C member 11 (ABCC11). Via in vitro and in vivo experiments as well as analyses and clinical samples, we successfully obtained important findings that will contribute to accelerate future researches on human body odor and axillary osmidrosis.

Academic Significance and Societal Importance of the Research Achievements

本研究がさらに発展することで、ヒト体臭発生機序の分子生理学的理解が深まり、体臭の個人差を生みだす分子基盤が明らかになると期待される。また、本研究を通じて、我が国においても患者数が増加の一途にある生活習慣病リスクのさらなる理解に貢献することが期待される成果を得ることもできた。膜輸送体(トランスポーター)に着目したヒトの体質・疾患リスクという観点からも興味深い知見が得られたと考えられ、今後のさらなる研究の発展が期待される。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (51 results)

All 2019 2018 2017 2016 2015 Other

All Journal Article (19 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 18 results,  Open Access: 16 results,  Acknowledgement Compliant: 6 results) Presentation (28 results) (of which Int'l Joint Research: 7 results,  Invited: 3 results) Book (1 results) Remarks (3 results)

  • [Journal Article] Functional Characterization of Clinically-Relevant Rare Variants in ABCG2 Identified in a Gout and Hyperuricemia Cohort2019

    • Author(s)
      Toyoda Yu, Mancikova Andrea, Krylov Vladimir, Morimoto Keito, Pavelcova Katerina, Bohata Jona, Pavelka Karel, Pavlikova Marketa, Suzuki Hiroshi, Matsuo Hirotaka, Takada Tappei, Stiburkova Blanka
    • Journal Title

      Cells

      Volume: 8 Issue: 4 Pages: 363-363

    • DOI

      10.3390/cells8040363

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification of hepatic NPC1L1 as an NAFLD risk factor evidenced by ezetimibe-mediated steatosis prevention and recovery2019

    • Author(s)
      Toyoda Yu, Takada Tappei, Umezawa Masakazu, Tomura Fumiya, Yamanashi Yoshihide, Takeda Ken, Suzuki Hiroshi
    • Journal Title

      FASEB BioAdvances

      Volume: in press Issue: 5 Pages: 283-295

    • DOI

      10.1096/fba.2018-00044

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibitors of Human ABCG2: From Technical Background to Recent Updates With Clinical Implications.2019

    • Author(s)
      Toyoda Y, Takada T, Suzuki H.
    • Journal Title

      Front Pharmacol.

      Volume: 10 Pages: 208-208

    • DOI

      10.3389/fphar.2019.00208

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Possible association between middle ear cholesteatoma and a single nucleotide polymorphism 538G>A in ABCC11, a human earwax type determinant.2018

    • Author(s)
      Kusunoki T , Nakagawa H, Tsukamoto M, Toyoda Y, Kamiya K,Okada H, Hara S, Furukawa M,
    • Journal Title

      Journal of Molecular and Genetic Medicine

      Volume: 12:3 Issue: 3 Pages: 1000362-1000362

    • DOI

      10.4172/1747-0862.1000362

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of ABCG2 as an Exporter of Uremic Toxin Indoxyl Sulfate in Mice and as a Crucial Factor Influencing CKD Progression.2018

    • Author(s)
      Takada T, Yamamoto T, Matsuo H, Tan JK, Ooyama K, Sakiyama M, Miyata H, Yamanashi Y, Toyoda Y, Higashino T, Nakayama A, Nakashima A, Shinomiya N, Ichida K, Ooyama H, Fujimori S, Suzuki H
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 11147-11147

    • DOI

      10.1038/s41598-018-29208-w

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 健康長寿の秘訣は糖質よりも脂肪にあり!?2018

    • Author(s)
      豊田 優
    • Journal Title

      Farumashia

      Volume: 54 Issue: 8 Pages: 814-814

    • DOI

      10.14894/faruawpsj.54.8_814

    • NAID

      130007429218

    • ISSN
      0014-8601, 2189-7026
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Are human ATP-binding cassette transporter C11 and earwax associated with the incidence of cholesteatoma?2018

    • Author(s)
      Nakagawa Hiroshi、Toyoda Yu、Albrecht Tobias、Tsukamoto Megumi、Praetorius Mark、Ishikawa Toshihisa、Kamiya Kazusaku、Kusunoki Takeshi、Ikeda Katsuhisa、Sertel Serkan
    • Journal Title

      Med. Hypotheses

      Volume: 114 Pages: 19-22

    • DOI

      10.1016/j.mehy.2018.02.030

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Investigation of the transport of xanthine dehydrogenase inhibitors by the urate transporter ABCG22018

    • Author(s)
      Nakamura Makiko、Fujita Kyoko、Toyoda Yu、Takada Tappei、Hasegawa Hiroshi、Ichida Kimiyoshi
    • Journal Title

      Drug Metabolism and Pharmacokinetics

      Volume: 33 Issue: 1 Pages: 77-81

    • DOI

      10.1016/j.dmpk.2017.11.002

    • NAID

      210000186733

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Multiple common and rare variants of ABCG2 cause gout2017

    • Author(s)
      Higashino Toshihide、Takada Tappei、Nakaoka Hirofumi、Toyoda Yu、Stiburkova Blanka、Miyata Hiroshi、Ikebuchi Yuki、Nakashima Hiroshi、Shimizu Seiko、Kawaguchi Makoto、Sakiyama Masayuki、Nakayama Akiyoshi、Akashi Airi、Tanahashi Yuki、Kawamura Yusuke、Nakamura Takahiro、Wakai Kenji、Hosomichi Kazuyoshi 他
    • Journal Title

      RMD Open

      Volume: 3 Issue: 2 Pages: e000464-e000464

    • DOI

      10.1136/rmdopen-2017-000464

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Spontaneous production of glutathione-conjugated forms of 1,2-dichloropropane: comparative study on metabolic activation processes of dihaloalkanes associated with occupational cholangiocarcinoma2017

    • Author(s)
      Yu Toyoda, Tappei Takada, and Hiroshi Suzuki
    • Journal Title

      Oxid. Med. Cell. Longev.

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Clinical and molecular evidence of ABCC11 protein expression in axillary apocrine glands of patients with axillary osmidrosis2017

    • Author(s)
      Yu Toyoda, Tappei Takada, Tuneaki Gomi, Hiroshi Nakagawa, Toshihisa Ishikawa and Hiroshi Suzuki
    • Journal Title

      Int. J. Mol. Sci.

      Volume: 18(2) Issue: 2 Pages: 417-417

    • DOI

      10.3390/ijms18020417

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes.2017

    • Author(s)
      Nakayama A, Nakaoka H, Yamamoto K, Sakiyama M, Shaukat A, Toyoda Y, Okada Y, Ohkawa Y,他39名
    • Journal Title

      Ann Rheum Dis.

      Volume: 76 Issue: 5 Pages: 869-877

    • DOI

      10.1136/annrheumdis-2016-209632

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Identification of Febuxostat as a New Strong ABCG2 Inhibitor: Potential Applications and Risks in Clinical Situations.2016

    • Author(s)
      Miyata H*, Takada T*, Toyoda Y*, Matsuo H, Ichida K, Suzuki H.
    • Journal Title

      Front Pharmacol.

      Volume: 7 Pages: 518-518

    • DOI

      10.3389/fphar.2016.00518

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Regulation of the Axillary Osmidrosis-Associated ABCC11 Protein Stability by N-linked Glycosylation: Effect of Glucose Condition2016

    • Author(s)
      Yu Toyoda, Tappei Takada, Hiroshi Miyata, Toshihisa Ishikawa, and Hiroshi Suzuki
    • Journal Title

      PLoS ONE

      Volume: 11(6) Issue: 6 Pages: e0157172-e0157172

    • DOI

      10.1371/journal.pone.0157172

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Halogenated hydrocarbon solvent-related cholangiocarcinoma risk: biliary excretion of glutathione conjugates of 1,2-dichloropropane evidenced by untargeted metabolomics analysis2016

    • Author(s)
      Yu Toyoda, Tappei Takada, and Hiroshi Suzuki
    • Journal Title

      Sci. Rep.

      Volume: 6 Issue: 1 Pages: 24586-24586

    • DOI

      10.1038/srep24586

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 胆管がんにかかわる発がん性候補物質の胆汁排泄を発見2016

    • Author(s)
      豊田 優, 高田 龍平, 鈴木 洋史
    • Journal Title

      化学(株式会社化学同人)

      Volume: 71(6) Pages: 73-73

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Halogenated hydrocarbon solvent-related cholangiocarcinoma risk: biliary excretion of glutathione conjugates of 1,2-dichloropropane evidenced by untargeted metabolomics analysis.2016

    • Author(s)
      Yu Toyoda, Tappei Takada, and Hiroshi Suzuki.
    • Journal Title

      Sci. Rep.

      Volume: in press

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diagnosis of human axillary osmidrosis by genotyping of the human ABCC11 gene: Clinical practice and basic scientific evidence.2016

    • Author(s)
      Yu Toyoda, Tsuneaki Gomi, Hiroshi Nakagawa, Makoto Nagakura, and Toshihisa Ishikawa.
    • Journal Title

      Biomed. Res. Int.

      Volume: 2016 Pages: 7670483-7670483

    • DOI

      10.1155/2016/7670483

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Novel dysfunctional variant in ABCG2 as a cause of severe tophaceous gout: biochemical, molecular genetic and functional analysis.2016

    • Author(s)
      Blanka Stiburkova, Hiroshi Miyata, Jakub Zavada, Michal Tomcik, Karel Pavelka, Gabriela Storkanova, Yu Toyoda, Tappei Takada, and Hiroshi Suzuki.
    • Journal Title

      Rheumatology

      Volume: 55(1) Issue: 1 Pages: 191-194

    • DOI

      10.1093/rheumatology/kev350

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] ヒトABC輸送体ABCC11の遺伝子多型とアポクリン腺の性状との関連性に関する研究2018

    • Author(s)
      豊田 優, 森本 渓音, 高田 龍平, 鈴木 洋史
    • Organizer
      第3回トランスポーター研究会関東部会
    • Related Report
      2018 Annual Research Report
  • [Presentation] コレステロール輸送体Niemann-Pick C1-Like 1の肝臓における病態生理学的重要性に関する研究2018

    • Author(s)
      豊田 優, 高田 龍平, 戸村 文弥, 山梨 義英, 鈴木 洋史
    • Organizer
      第91回日本生化学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 工業用化学物質による職業性胆管がんリスクに関する研究2018

    • Author(s)
      豊田 優, 高田 龍平, 鈴木 洋史
    • Organizer
      第4回次世代を担う若手のためのレギュラトリーサイエンスフォーラム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 職業性胆管がんリスク関連物質の胆汁排泄2018

    • Author(s)
      豊田 優, 高田 龍平, 鈴木 洋史
    • Organizer
      第13回トランスポーター研究会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 職業性胆管がんリスク関連有機溶剤成分の発がん性に関する研究2018

    • Author(s)
      豊田 優, 高田 龍平, 鈴木 洋史
    • Organizer
      第45回日本毒性学会学術年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ABCC2-mediated biliary excretion of glutathione conjugates of 1,2-dichloropropane evidenced by untargeted metabolomics2017

    • Author(s)
      Yu Toyoda, Tappei Takada, and Hiroshi Suzuki
    • Organizer
      Gordon Research Conference 2017 "Multi-Drug Efflux Systems" Integrated Approaches to Understanding the Role of Multi-Drug Efflux Systems in Health and Disease
    • Place of Presentation
      Galveston, TX, USA
    • Year and Date
      2017-03-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Halogenated hydrocarbon solvent-related cholangiocarcinoma risk: ABCC2-mediated biliary excretion of glutathione conjugates of 1,2-dichloropropane evidenced by untargeted metabolomics analysis2017

    • Author(s)
      Yu Toyoda, Tappei Takada, and Hiroshi Suzuki
    • Organizer
      Gordon Research Conference 2017 “Multi-Drug Efflux Systems” Integrated Approaches to Understanding the Role of Multi-Drug Efflux Systems in Health and Disease
    • Place of Presentation
      Galveston, TX, USA
    • Year and Date
      2017-03-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Febuxostat is a newly identified strong ABCG2 inhibitor2017

    • Author(s)
      Yu Toyoda, Tappei Takada, Hiroshi Miyata, Hirotaka Matsuo, Kimiyoshi Ichida, and Hiroshi Suzuki
    • Organizer
      Gordon Research Seminar 2017 “Multi-Drug Efflux Systems” Linking Molecular Mechanisms to Biological Functions of Transporters Through Innovation and Multidisciplinary Approaches
    • Place of Presentation
      Galveston, TX, USA
    • Year and Date
      2017-03-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 生体異物およびその関連代謝物の体内動態解析:職業性胆管がん事例への応用2017

    • Author(s)
      豊田 優, 高田 龍平, 鈴木 洋史
    • Organizer
      サーモフィッシャーサイエンティフィック質量分析フォーラム2017
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ヒトの腋窩アポクリン腺における腋臭症リスク決定因子ABCC11の発現に関する研究2017

    • Author(s)
      豊田 優, 高田 龍平, 五味 常明, 宮田 大資, 石川 智久, 鈴木 洋史
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 職業性胆管がんリスク関連有機溶剤成分の活性化に関する研究2017

    • Author(s)
      豊田 優, 高田 龍平, 鈴木 洋史
    • Organizer
      第44回日本毒性学会学術年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 腋臭症リスク決定因子:ABCC11のヒト腋窩アポクリン腺における発現2017

    • Author(s)
      豊田 優, 高田 龍平, 五味 常明, 宮田 大資, 中川 大, 石川 智久, 鈴木 洋史
    • Organizer
      第12回トランスポーター研究会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] メタボローム解析を活用した職業性胆管がんリスクに関する研究2016

    • Author(s)
      豊田 優, 高田 龍平, 鈴木 洋史
    • Organizer
      第10回メタボロームシンポジウム
    • Place of Presentation
      慶應義塾大学先端生命科学研究所(鶴岡、山形)
    • Year and Date
      2016-10-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] N-結合型糖鎖によるヒトABCC11タンパク質の安定性制御とグルコースによる影響2016

    • Author(s)
      豊田 優, 高田 龍平, 宮田 大資, 石川 智久, 鈴木 洋史
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター/東北大学(仙台、宮城)
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] 塩素系有機洗浄剤成分による胆管がんリスク:ジクロロプロパン代謝物の胆汁排泄と関連分子機構2016

    • Author(s)
      豊田 優, 高田 龍平, 鈴木 洋史
    • Organizer
      第11回トランスポーター研究会年会
    • Place of Presentation
      京都大学(宇治、京都)
    • Year and Date
      2016-07-02
    • Related Report
      2016 Annual Research Report
  • [Presentation] 有機溶剤成分1,2-ジクロロプロパンに起因する胆管がんリスクと胆汁排泄機構2016

    • Author(s)
      豊田 優, 高田 龍平, 鈴木 洋史
    • Organizer
      第43回日本毒性学会学術年会
    • Place of Presentation
      ウインクあいち(名古屋、愛知)
    • Year and Date
      2016-06-29
    • Related Report
      2016 Annual Research Report
  • [Presentation] メタボロミクスを活用した、有機溶剤成分に起因する胆管がんリスクに関する研究2016

    • Author(s)
      豊田 優, 高田 龍平, 鈴木 洋史
    • Organizer
      医療薬学フォーラム2016/第24回クリニカルファーマシーシンポジウム
    • Place of Presentation
      滋賀県立芸術劇場 びわ湖ホール(大津、滋賀)
    • Year and Date
      2016-06-25
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] メタボロミクスを活用した、トランスポーター関連疾患の研究2016

    • Author(s)
      豊田 優
    • Organizer
      生化学若い研究者の会 2016春のセミナー
    • Place of Presentation
      東京大学(本郷、東京)
    • Year and Date
      2016-04-29
    • Related Report
      2016 Annual Research Report
  • [Presentation] N-結合型糖鎖によるヒトABC輸送体ABCC11タンパク質の細胞内安定性制御.2016

    • Author(s)
      豊田 優, 高田 龍平, 宮田 大資, 石川 智久, 鈴木 洋史.
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜(神奈川、横浜)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] 有機溶剤成分に起因する胆管がんリスクに関するヒト肝細胞キメラマウスを用いた検討.2015

    • Author(s)
      豊田 優, 高田 龍平, 鈴木 洋史.
    • Organizer
      BMB2015(第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸ポートアイランド(兵庫、神戸)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Halogenated hydrocarbon solvent-related cholangiocarcinoma risk: biliary excretion of glutathione conjugates of 1,2-dichloropropane.2015

    • Author(s)
      豊田 優, 高田 龍平, 鈴木 洋史.
    • Organizer
      第9回次世代を担う若手医療薬科学シンポジウム
    • Place of Presentation
      千葉大学(千葉、千葉)
    • Year and Date
      2015-11-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] N-結合型糖鎖修飾に着眼したヒトABC輸送体ABCC11タンパク質の細胞内安定性制御機構の解析.2015

    • Author(s)
      豊田 優, 石川 智久, 中川 大.
    • Organizer
      第28回日本動物細胞工学会2015年度大会
    • Place of Presentation
      東北大学(宮城、仙台)
    • Year and Date
      2015-07-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] アデノウイルスベクターを介した一過性導入法によるヒトABC輸送体ABCC11のin vivo安定性評価.2015

    • Author(s)
      豊田 優, 中川 大, 高田 龍平, 五味 常明, 石川 智久, 鈴木 洋史.
    • Organizer
      第28回日本動物細胞工学会2015年度大会
    • Place of Presentation
      東北大学(宮城、仙台)
    • Year and Date
      2015-07-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 有機溶剤成分に起因する胆管癌リスク:胆管側膜輸送体を介したジクロロプロパン代謝物の胆汁排泄.2015

    • Author(s)
      豊田 優, 高田 龍平, 鈴木 洋史.
    • Organizer
      第10回トランスポーター研究会年会
    • Place of Presentation
      慶應義塾大学(東京、港区)
    • Year and Date
      2015-06-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] Untargeted metabolomics analysis in ABCC11 Tg mouse.2015

    • Author(s)
      Yu Toyoda, Tappei Takada, Hiroshi Nakagawa, Hiroshi Miyata, Tuneaki Gomi, Yoh-ichi Tagawa, Toshihisa Ishikawa, and Hiroshi Suzuki.
    • Organizer
      Gordon Research Conference 2015 “Multi-Drug Efflux Systems” A paradigm shift from fundamental mechanisms to practical applications
    • Place of Presentation
      Lucca (Barga), Italy
    • Year and Date
      2015-04-26
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Predicted crucial amino acid residues for substrate recognition by human ABCB1: in vitro analysis–based calculation using novel substrates for human ABCB1 from Pterogyne nitens and Magnolia sp.2015

    • Author(s)
      Hiroshi Nakagawa, Kazuhiro Satake, Megumi Tsukamoto, Yu Toyoda, Onat Kadioglu, Luis Octavio Regasinie, Vanderlan da Silva Bolzani, Gert Fricker, Toshihisa Ishikawa, and Thomas Efferth.
    • Organizer
      Gordon Research Conference 2015 “Multi-Drug Efflux Systems” A paradigm shift from fundamental mechanisms to practical applications
    • Place of Presentation
      Lucca (Barga), Italy
    • Year and Date
      2015-04-26
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Biomolecular characterization of human ABCC11 and its clinical implications.2015

    • Author(s)
      Yu Toyoda and Toshihisa Ishikawa.
    • Organizer
      Gordon-Kenan Research Seminar 2015 “Multi-Drug Efflux Systems” Learning from the Past to Innovate the Future
    • Place of Presentation
      Lucca (Barga), Italy
    • Year and Date
      2015-04-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Biliary excretion of glutathione-conjugates of 1, 2-dichloropropane: potential influence on the cholangiocarcinoma risk induced by the exposure to halogenated hydrocarbon solvent.2015

    • Author(s)
      Yu Toyoda, Tappei Takada, and Hiroshi Suzuki.
    • Organizer
      Gordon-Kenan Research Seminar 2015 “Multi-Drug Efflux Systems” Learning from the Past to Innovate the Future
    • Place of Presentation
      Lucca (Barga), Italy
    • Year and Date
      2015-04-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Book] ABC Transporters -40 Years on (Human ABC transporter ABCC11: Looking back pioneers’ odyssey and creating a new path toward clinical application) (doi 10.1007/978-3-319-23476-2_12)2016

    • Author(s)
      Toshihisa Ishikawa, and Yu Toyoda.
    • Total Pages
      22
    • Publisher
      Springer International Publishing
    • Related Report
      2015 Annual Research Report
  • [Remarks] 東京大学医学部附属病院薬剤部ホームページ(豊田優)

    • URL

      https://plaza.umin.ac.jp/~todaiyak/y_toyoda.php

    • Related Report
      2018 Annual Research Report
  • [Remarks] 東京大学医学部附属病院薬剤部研究室ホームページ

    • URL

      http://plaza.umin.ac.jp/~todaiyak/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 自己紹介(研究室ホームページ内、平成29年3月31日現在)

    • URL

      http://plaza.umin.ac.jp/~todaiyak/y_toyoda.php

    • Related Report
      2016 Annual Research Report

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Published: 2015-04-16   Modified: 2020-03-30  

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