| Budget Amount *help |
¥24,050,000 (Direct Cost: ¥18,500,000、Indirect Cost: ¥5,550,000)
Fiscal Year 2017: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2016: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2015: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
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| Outline of Final Research Achievements |
Exercise-induced myokines provide systemic benefits by controlling adipose tissues. However, the relationships between bones and adipose tissues remain to be elucidated. In this study, we analyzed whether periosteum-derived HDOI regulates adipose tissues. After backcrossing to C57BL/6 for 10 generations, we didn’t find any abnormalities in adipose tissues of HDOI-KO mice compared to wild-type mice. Furthermore, HDOI-Tg mice were quite normal in their adipose tissues and showed no metabolic differences even under high-fat diet conditions. Although exercise didn’t induce HDOI directly, mechanical stimulation was required to maintain the expression of HDOI.
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