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The role of HDOI in the relationship between bone and fat.

Research Project

Project/Area Number 15H05646
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field General physiology
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

Takano Haruko  国立研究開発法人国立循環器病研究センター, 研究所, 研究員 (40532891)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥24,050,000 (Direct Cost: ¥18,500,000、Indirect Cost: ¥5,550,000)
Fiscal Year 2017: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2016: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2015: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Keywords脂肪組織 / ナトリウム利尿ペプチド / 骨形成 / 機械刺激 / 骨膜 / 間葉系幹細胞 / 骨芽細胞 / 伸展刺激 / 生理学 / 運動負荷 / 肥満 / 骨 / ベージュ細胞
Outline of Final Research Achievements

Exercise-induced myokines provide systemic benefits by controlling adipose tissues. However, the relationships between bones and adipose tissues remain to be elucidated. In this study, we analyzed whether periosteum-derived HDOI regulates adipose tissues. After backcrossing to C57BL/6 for 10 generations, we didn’t find any abnormalities in adipose tissues of HDOI-KO mice compared to wild-type mice. Furthermore, HDOI-Tg mice were quite normal in their adipose tissues and showed no metabolic differences even under high-fat diet conditions. Although exercise didn’t induce HDOI directly, mechanical stimulation was required to maintain the expression of HDOI.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (16 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (1 results) Journal Article (8 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 8 results,  Open Access: 8 results,  Acknowledgement Compliant: 1 results) Presentation (4 results) (of which Int'l Joint Research: 1 results) Book (2 results) Remarks (1 results)

  • [Int'l Joint Research] KAIST(韓国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Allergic TH2 Response Governed by B-Cell Lymphoma 6 Function in Naturally Occurring Memory Phenotype CD4+ T Cells2018

    • Author(s)
      Takashi Ogasawara,Yuko Kohashi,Jun Ikari,Toshibumi Taniguchi,Nobuhide Tsuruoka,Haruko Watanabe-Takano,Lisa Fujimura,Akemi Sakamoto,Masahiko Hatano,Hirokuni Hirata,Yasutsugu Fukushima,Takeshi Fukuda,Kazuhiro Kurasawa,Koichiro Tatsumi,Takeshi Tokuhisa,Masafumi Arima
    • Journal Title

      Frontiers in Immunology

      Volume: 9 Pages: 750-750

    • DOI

      10.3389/fimmu.2018.00750

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A New Secretory Peptide of Natriuretic Peptide Family,Osteocrin, Suppresses the Progression of Congestive Heart Failure After Myocardial Infarction.2018

    • Author(s)
      Miyazaki T, Otani K, Chiba A, Nishimura H, Tokudome T, Takano-Watanabe H, Matsuo A, Ishikawa H, Shimamoto K, Fukui H, Kanai Y, Yasoda A, Ogata S, Nishimura K, Minamino N, Mochizuki N.
    • Journal Title

      Circ Res.

      Volume: 122(5) Issue: 5 Pages: 742-751

    • DOI

      10.1161/circresaha.117.312624

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cardiomyokines from the heart.2018

    • Author(s)
      Chiba A, Watanabe-Takano H, Miyazaki T, Mochizuki N.
    • Journal Title

      Cell Mol Life Sci.

      Volume: 75 Issue: 8 Pages: 1349-1362

    • DOI

      10.1007/s00018-017-2723-6

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Circulating osteocrin stimulates bone growth by limiting C-type natriuretic peptide clearance.2017

    • Author(s)
      Kanai Y, Yasoda A, Mori KP, Watanabe-Takano H, Nagai-Okatani C, Yamashita Y, Hirota K, Ueda Y, Yamauchi I, Kondo E, Yamanaka S, Sakane Y, Nakao K, Fujii T, Yokoi H, Minamino N, Mukoyama M, Mochizuki N, Inagaki N.
    • Journal Title

      Journal of Clinical Investigation

      Volume: 127 Issue: 11 Pages: 4136-4147

    • DOI

      10.1172/jci94912

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of chronic allergic responses by dampening Bcl6-mediated suppressor activity in memory T helper 2 cells.2017

    • Author(s)
      Ogasawara T, Hatano M, Satake H, Ikari J, Taniguchi T, Tsuruoka N, Watanabe-Takano H, Fujimura L, Sakamoto A, Hirata H, Sugiyama K, Fukushima Y, Nakae S, Matsumoto K, Saito H, Fukuda T, Kurasawa K, Tatsumi K, Tokuhisa T, Arima M.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 114 Issue: 5

    • DOI

      10.1073/pnas.1613528114

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Osteocrin, a secretory peptide from heart, contributes to cranial osteogenesis in zebrafish2016

    • Author(s)
      Chiba A, Watanabe-Takano H, Terai K, Fukui H, Miyazaki T, Uemura M, Hashimoto H, Hibi M, Fukuhara S, Mochizuki N
    • Journal Title

      Development

      Volume: 144 Pages: 334-344

    • DOI

      10.1242/dev.143354

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Transcriptional repression of p27 is essential for murine embryonic development.2016

    • Author(s)
      Teratake Y, Kuga C, Hasegawa Y, Sato Y, Kitahashi M, Fujimura L, Watanabe-Takano H, Sakamoto A, Arima M, Tokuhisa T, Hatano M.
    • Journal Title

      Sci Rep.

      Volume: 6 Issue: 1 Pages: 26244-26244

    • DOI

      10.1038/srep26244

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] DA-Raf-Mediated Suppression of the Ras--ERK Pathway Is Essential for TGF-β1-Induced Epithelial-Mesenchymal Transition in Alveolar Epithelial Type 2 Cells.2015

    • Author(s)
      Watanabe-Takano, H., Takano, K., Hatano, M., Tokuhisa, T. and Endo T.
    • Journal Title

      ProS One

      Volume: 10 Issue: 5 Pages: e0127888-e0127888

    • DOI

      10.1371/journal.pone.0127888

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Osteocrinは骨形態形成を制御する骨膜ホルモンである2017

    • Author(s)
      高野 晴子
    • Organizer
      第35回日本骨代謝学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Osteocrinは骨形態形成を制御する骨膜ホルモンである2017

    • Author(s)
      高野 晴子
    • Organizer
      第69回日本細胞生物学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Osteocrinは骨形態形成を制御する骨膜ホルモンである2016

    • Author(s)
      高野晴子、千葉彩乃、宮崎敬大、金井有吾、森慶太、八十田明宏、横井秀基、 望月直樹
    • Organizer
      第39回日本分子細胞生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] DA-Raf-mediated Suppression of the Ras-ERK Pathway Is Essential for TGF-b-induced Epithelial-mesenchymal Transition in Alveolar Epithelial Type 2 Cells2015

    • Author(s)
      Haruko Watanabe-Takano
    • Organizer
      The American Society for Cell Biology
    • Place of Presentation
      San Diego
    • Year and Date
      2015-12-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Book] THE LUNG perspective2015

    • Author(s)
      遠藤 剛、渡辺ー高野 晴子、高野和儀
    • Total Pages
      8
    • Publisher
      メディカルレビュー社
    • Related Report
      2015 Annual Research Report
  • [Book] 血管医学2015

    • Author(s)
      高野 晴子、千葉 彩乃、宮崎 敬大、望月 直樹
    • Total Pages
      3
    • Publisher
      メディカルレビュー社
    • Related Report
      2015 Annual Research Report
  • [Remarks] 国立循環器病研究センター研究所 細胞生物学部 高野 晴子

    • URL

      http://www.ncvc.go.jp/res/divisions/structural_analysis/takano.html

    • Related Report
      2015 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2022-08-30  

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