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Mechnism of genome integrity maintenance in tissue stem cell

Research Project

Project/Area Number 15H05713
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Risk sciences of radiation and chemicals
Research InstitutionOsaka University

Principal Investigator

TODO Takesshi  大阪大学, 放射線科学基盤機構附属ラジオアイソトープ総合センター, 招へい教授 (90163948)

Co-Investigator(Kenkyū-buntansha) 辻村 亨  兵庫医科大学, 医学部, 教授 (20227408)
弓場 俊輔  国立研究開発法人産業技術総合研究所, 生命工学領域, 主任研究員 (40263248)
瀬々 潤  国立研究開発法人産業技術総合研究所, 情報・人間工学領域, 招聘研究員 (40361539)
川崎 隆史  国立研究開発法人産業技術総合研究所, 生命工学領域, 主任研究員 (60356839)
吉村 崇  大阪大学, 放射線科学基盤機構附属ラジオアイソトープ総合センター, 教授 (90323336)
藤原 智子 (石川智子)  大阪大学, 医学系研究科, 助教 (70402922)
Project Period (FY) 2015-05-29 – 2020-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥199,940,000 (Direct Cost: ¥153,800,000、Indirect Cost: ¥46,140,000)
Fiscal Year 2019: ¥39,780,000 (Direct Cost: ¥30,600,000、Indirect Cost: ¥9,180,000)
Fiscal Year 2018: ¥39,130,000 (Direct Cost: ¥30,100,000、Indirect Cost: ¥9,030,000)
Fiscal Year 2017: ¥39,390,000 (Direct Cost: ¥30,300,000、Indirect Cost: ¥9,090,000)
Fiscal Year 2016: ¥41,210,000 (Direct Cost: ¥31,700,000、Indirect Cost: ¥9,510,000)
Fiscal Year 2015: ¥40,430,000 (Direct Cost: ¥31,100,000、Indirect Cost: ¥9,330,000)
Keywordsゲノム不安定性 / ゲノム構造変異 / 発がん / DNA複製酵素 / メダカ / TLS DNAポリメラーゼ / 大腸がん / 複製ストレス / 突然変異 / 損傷応答 / ゲノム変異 / ゲノム編集 / 染色体異常 / 次世代シークエンサー / 体組織幹細胞 / 組織幹細胞 / ゲノム解析 / ラット / 環境 / 遺伝子 / 間葉系幹細胞 / メダカ組織幹細胞 / 放射線
Outline of Final Research Achievements

Damage Response is a biological defense mechanism that counters various DNA damages and play an essential role in maintaining genome stability. We found that medaka mutants lacking a special DNA polymerase, which is one of the damage response mechanisms, develop intestinal tumor in all individuals in an age-dependent manner. This medaka tumorigenesis is characterized by the proliferation of stem cells in the basement membrane of the intestine in the early stage of onset. Furthermore, by performing genome analysis of the tumor cells, we found that mutations at the chromosomal level occur frequently.

Academic Significance and Societal Importance of the Research Achievements

大腸がんは、我が国に限らず世界において最も罹患率が高く、しかも肺がんに続き2番目に死亡率の高いがん疾患である。本研究では、100%の個体で、しかも特定の生育時期に大腸がんを発症するモデル動物をメダカにおいて樹立できた。更に、その分子基盤の大枠を解明することに成功した。大腸がん発症メカニズム解明の貴重なモデル系の開発であり、今後、生物学・基礎医学に限らず、臨床研究においても大きな貢献が期待できる。学術的にも社会的にも、本研究の意義は大きいと考えられる。

Assessment Rating
Verification Result (Rating)

B

Assessment Rating
Result (Rating)

A: Progress in the research is steadily towards the initial goal. Expected research results are expected.

Report

(11 results)
  • 2021 Research Progress Assessment (Verification Result) ( PDF )
  • 2020 Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report   Abstract(Research Progress Assessment) ( PDF )   Research Progress Assessment (Result) ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Abstract ( PDF )   Comments on the Screening Results ( PDF )   Annual Research Report
  • Research Products

    (53 results)

All 2021 2020 2019 2018 2017 2016 2015 Other

All Journal Article (19 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 19 results,  Open Access: 17 results,  Acknowledgement Compliant: 4 results) Presentation (30 results) (of which Int'l Joint Research: 7 results,  Invited: 10 results) Book (3 results) Remarks (1 results)

  • [Journal Article] Estrogen receptor 2b is the major determinant of sex-typical mating behavior and sexual preference in medaka.2021

    • Author(s)
      Nishiike Y, Miyazoe D, Togawa R, Yokoyama K, Nakasone K, Miyata M, Kikuchi Y, Kamei Y, Todo t, Ishikawa-Fujiwara T, Ohno K, Usami T, Nagahama Y, Okubo T.
    • Journal Title

      Current Biology

      Volume: -

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of Rev1 in alkylating agent-induced loss of heterozygosity in Oryzias latipes.2020

    • Author(s)
      Fujikawa Y, Ishikawa-Fujiwara T, Kuo T, Shinkai N, Shoji T, Kawasaki T, Kamei Y, Sakuraba Y, Sato A, Kinoshita M, Gondo Y, Yuba S, Tsujimura T, Sese J, Todo T
    • Journal Title

      Genes to Cells

      Volume: 25 Issue: 2 Pages: 124-138

    • DOI

      10.1111/gtc.12746

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] reactIDR: evaluation of the statistical reproducibility of high-throughput structural analyses towards a robust RNA structure prediction2019

    • Author(s)
      Kawaguchi Risa、Kiryu Hisanori、Iwakiri Junichi、Sese Jun
    • Journal Title

      BMC Bioinformatics

      Volume: 20 Issue: 3 Pages: 130-130

    • DOI

      10.1186/s12859-019-2645-4

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Coulomb and CH-π interactions in (6-4) photolyase-DNA complex dominate DNA binding and repair abilities2018

    • Author(s)
      Terai Yuma、Sato Ryuma、Yumiba Takahiro、Harada Ryuhei、Shimizu Kohei、Toga Tatsuya、Ishikawa-Fujiwara Tomoko、Todo Takeshi、Iwai Shigenori、Shigeta Yasuteru、Yamamoto Junpei
    • Journal Title

      Nucleic Acids Research

      Volume: 46 Issue: 13 Pages: 6761-6772

    • DOI

      10.1093/nar/gky364

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A combination of MTAP and BAP1 immunohistochemistry is effective for distinguishing sarcomatoid mesothelioma from fibrous pleuritis2018

    • Author(s)
      Kinoshita Yoshiaki、Hamasaki Makoto、Yoshimura Masayo、Matsumoto Shinji、Sato Ayuko、Tsujimura Tohru、Ueda Hitoshi、Makihata Satoshi、Kato Fumiaki、Iwasaki Akinori、Nabeshima Kazuki
    • Journal Title

      Lung Cancer

      Volume: 125 Pages: 198-204

    • DOI

      10.1016/j.lungcan.2018.09.019

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pulmonary Regnase-1 orchestrates the interplay of epithelium and adaptive immune systems to protect against pneumonia2018

    • Author(s)
      Nakatsuka Yoshinari、Vandenbon Alexis、Mino Takashi、Yoshinaga Masanori、Uehata Takuya、Cui Xiaotong、Sato Ayuko、Tsujimura Tohru、Suzuki Yutaka、Sato Atsuyasu、Handa Tomohiro、Chin Kazuo、Sawa Teiji、Hirai Toyohiro、Takeuchi Osamu
    • Journal Title

      Mucosal Immunology

      Volume: AOP Issue: 4 Pages: 1203-1218

    • DOI

      10.1038/s41385-018-0024-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Integrative Molecular Characterization of Malignant Pleural Mesothelioma2018

    • Author(s)
      Hmeljak Julija、TCGA Research Network et al (他58名、48番目)
    • Journal Title

      Cancer Discovery

      Volume: 8 Issue: 12 Pages: 1548-1565

    • DOI

      10.1158/2159-8290.cd-18-0804

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] ChIP-Atlas: a data-mining suite powered by full integration of public ChIP-seq data.2018

    • Author(s)
      Shinya Oki, Tazro Ohta, Go Shioi, Hideki Hatanaka, Osamu Ogasawara, Yoshihiro Okuda, Hideya Kawaji, Ryo Nakaki, Jun Sese, Chikara Meno
    • Journal Title

      EMBO reports

      Volume: 19 Issue: 12

    • DOI

      10.15252/embr.201846255

    • NAID

      120006649027

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] EAGLE: Explicit Alternative Genome Likelihood Evaluator.2017

    • Author(s)
      Tony Kuo, Martin Frith, Jun Sese, Paul Horton
    • Journal Title

      BMC Medical Genomics

      Volume: 11 Issue: Suppl 2 Pages: 28-28

    • DOI

      10.1186/s12920-018-0342-1

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Targeted Inactivation of DNA Photolyase Genes in Medaka Fish (Oryzias latipes)2017

    • Author(s)
      Ishikawa-Fujiwara T, Shiraishi E, Fujikawa Y, Mori T, Tsujimura T, Todo T
    • Journal Title

      Photochemistry and Photobiology

      Volume: 93 Issue: 1 Pages: 315-322

    • DOI

      10.1111/php.12658

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Unfolded protein response transducer IRE1-mediated signaling independent of XBP1 mRNA splicing is not required for growth and development of medaka fish2017

    • Author(s)
      Tokiro Ishikawa, Makoto Kashima, Atsushi J Nagano, Tomoko Ishikawa-Fujiwara, Yasuhiro Kamei, Takeshi Todo, Kazutoshi Mori
    • Journal Title

      eLife

      Volume: 6:e26845 Pages: 1-29

    • DOI

      10.7554/elife.26845

    • NAID

      120006358815

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] UPR Transducer BBF2H7 Allows Export of Type II Collagen in a Cargo- and Developmental Stage-Specific Manner2017

    • Author(s)
      Tokiro Ishikawa, Takuya Toyama, Yuki Nakamura, Kentaro Tamada, Hitomi Shimizu, Satoshi Ninagawa, Tetsuya Okada, Yasuhiro Kamei, Tomoko Ishikawa-Fujiwara, Takeshi Todo, Eriko Aoyama, Masaharu Takigawa, Akihiro Harada and Kazutoshi Mori
    • Journal Title

      Journal of cell biology

      Volume: 印刷中 Issue: 6 Pages: 1761-1774

    • DOI

      10.1083/jcb.201609100

    • NAID

      120006343784

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Regnase-1 Maintains Iron Homeostasis via the Degradation of Transferrin Receptor 1 and Prolyl-Hydroxylase-Domain-Containing Protein 3 mRNAs2017

    • Author(s)
      Yoshinaga Masanori、Nakatsuka Yoshinari、Vandenbon Alexis、Ori Daisuke、Uehata Takuya、Tsujimura Tohru、Suzuki Yutaka、Mino Takashi、Takeuchi Osamu
    • Journal Title

      Cell Reports

      Volume: 19 Issue: 8 Pages: 1614-1630

    • DOI

      10.1016/j.celrep.2017.05.009

    • NAID

      120006305989

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Functional Conversion of CPD and (6-4) Photolyases by Mutation2016

    • Author(s)
      Daichi Yamada, Hisham M. Dokainish, Tatsuya Iwata, Junpei Yamamoto, Tomoko Ishikawa, Takeshi Todo, Shigenori Iwai, Elizabeth D. Getzoff, Akio Kitao, and Hideki Kandori
    • Journal Title

      Biochemistry

      Volume: 55 Issue: 30 Pages: 4173-4183

    • DOI

      10.1021/acs.biochem.6b00361

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] COSMOS: accurate detection of somatic structural variations through asymmetric comparison between tumor and normal samples.2016

    • Author(s)
      Yamagata, Koichi; Yamanishi, Ayako; Kokubu, Chikara; Takeda, Junji; Sese, Jun
    • Journal Title

      Nucleic Acids Research

      Volume: 44 (8) Issue: 8 Pages: e78-e78

    • DOI

      10.1093/nar/gkw026

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Fukushima simulation experiment: assessing the effects of chronic low-dose-rate internal 137Cs radiation exposure on litter size, sex ratio, and biokinetics in mice.2016

    • Author(s)
      Nakajima H, Yamaguchi Y, Yoshimura T, Fukumoto M, Todo T.
    • Journal Title

      J Radiat Res.

      Volume: Suppl 1 Issue: suppl 1 Pages: 29-35

    • DOI

      10.1093/jrr/rrv079

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Viable neuronopathic Gaucher disease model in medaka (Oryzias latipes) displays axonal accumulation of alpha-synuclein2015

    • Author(s)
      Norihito Uemura, Masato Koike, Satoshi Ansai, Masato Kinoshita, Tomoko Ishikawa-Fujiwara, Hideaki Matsui, Kiyoshi Naruse, Naoaki Sakamoto, Yasuo Uchiyama, Takeshi Todo, Shunichi Takeda, Hodaka Yamakado, Ryosuke Takahashi
    • Journal Title

      PLoS Genetics

      Volume: 11 Issue: 4 Pages: 1-14

    • DOI

      10.1371/journal.pgen.1005065

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The N-terminal acidic residue of the cytosolic helix 8 of an odorant receptor is responsible for different response dynamics via G-protein2015

    • Author(s)
      T. Kawasaki, T. Saka, S. Mine, E. Mizohata, T. Inoue, H. Matsumura, T. Sato
    • Journal Title

      FEBS Lett.

      Volume: 589 Issue: 10 Pages: 1136-1143

    • DOI

      10.1016/j.febslet.2015.03.025

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] p16/CDKN2A FISH in Differentiation of Diffuse Malignant Peritoneal Mesothelioma From Mesothelial Hyperplasia and Epithelial Ovarian Cancer.2015

    • Author(s)
      Ito T, Hamasaki M, Matsumoto S, Hiroshima K, Tsujimura T, Kawai T, Shimao Y, Marutsuka K, Moriguchi S, Maruyama R, Miyamoto S, Nabeshima K.
    • Journal Title

      Am J Clin Pathol

      Volume: 143 Issue: 6 Pages: 830-838

    • DOI

      10.1309/ajcpoatj9l4gcgda

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Genome analysis of Rev3l deficient medaka mutant2020

    • Author(s)
      Tomoko (Ishikawa) Fujiwara, Yoshihiro Fujikawa, Andres Canela, Tatsuma Shoji, Fei Sun, Jun Sese, Takeshi Todo
    • Organizer
      日本放射線影響学会第63回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] A unique phenotype of medaka rev3l mutant2019

    • Author(s)
      Yoshihiro Fujikawa, Tomoko Ishikawa-Fujiwara, Ayuko Sato, Tetsushi Sakuma,Tsutomu Shimura, Takashi Yamamoto, Seiji Kodama, Tohru Tsujimura, Takeshi Todo
    • Organizer
      16th International Congress of Radiation Research
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Characteristic feature of genomic instability in rev1 and rev3 mutants2019

    • Author(s)
      Tomoko Ishikawa-Fujiwara, Yoshihiro Fujikawa, Takeshi Todo
    • Organizer
      16th International Congress of Radiation Research
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 消化管腫瘍を高頻度に発がんするメダカrev3l変異体を用いた発がんメカニズムの解析2019

    • Author(s)
      藤川 芳宏 、藤原 智子 、佐藤 鮎子 、志村 勉 、 児玉 靖司 、辻村 亨 、藤堂 剛
    • Organizer
      第6回アジア環境変異原学会日本環境変異原学会第48回大会合同大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Acute irradiation induces testis-ova formation in OGG1 or REV1 gene deficient medaka (Oryzias latipes)2019

    • Author(s)
      Erge Sha, Kento Nagata, Takako Yasuda, Tomoko Ishikawa-Fujiwara, Takeshi Todo, Hiroshi Mitani, Shoji Oda
    • Organizer
      日本放射線影響学会第62回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Rev3l-deficent medaka provides an excellent model for studies of intestinal tumor development2019

    • Author(s)
      Yoshihiro Fujikawa, Tomoko Fujiwara, Ayuko Sato, Tsutomu Shimura, Seiji Kodama, Tohru Tsujimura, Takeshi Todo
    • Organizer
      日本放射線影響学会第62回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Involvement of Trans Lesion Synthesis DNA polymerase on maintenance of Genome stability2019

    • Author(s)
      Tomoko Fujiwara, Yoshihiro Fujikawa, Takeshi Todo
    • Organizer
      日本放射線影響学会第62回大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] メダカBAP1 遺伝子変異体の作製2018

    • Author(s)
      藤原 智子 、藤川 芳宏 、藤堂 剛
    • Organizer
      日本放射線影響学会第61回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 年齢・組織依存的高発がんモデル:メダカ rev3l 変異体2018

    • Author(s)
      藤川 芳宏 、藤原 智子 、佐藤 鮎子 、佐久間 哲史 、山本 卓 、 児玉 靖司 、辻村 亨 、藤堂 剛
    • Organizer
      日本放射線影響学会第61回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 137Cs 多世代経口摂取による内部被曝線量評価と子孫マウスにおける全塩基配列解析のマウス系統比較2018

    • Author(s)
      中島 裕夫、藤堂 剛、鈴木 正敏、遠藤 曉、遠藤 大二
    • Organizer
      日本放射線影響学会第61回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] メダカrev3l変異体における染色体不安定性の消化管腫瘍への関与2018

    • Author(s)
      藤川 芳宏 、藤原 智子 、佐藤 鮎子 、佐久間 哲史 、山本 卓 、 児玉 靖司 、辻村 亨 、藤堂 剛
    • Organizer
      日本環境変異原学会第47回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 多世代にわたり低線量 137Cs 内部被曝した A / J および B6 マウスにおける全ゲノム解析2018

    • Author(s)
      中島 裕夫、大野 みずき、 石原 弘、 鈴木 正敏、 遠藤 曉、 遠藤 大二、 續 輝久、 藤堂 剛
    • Organizer
      日本環境変異原学会第47回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] The role of EZH2 in the proliferation, migration, and tumorigenicity of malignant mesothelioma.2018

    • Author(s)
      Tsujimura T, Sato A, Yuki M, Abe S, Shinohara Y
    • Organizer
      14th International Conference of the International Mesothelioma Interest Group
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cryptochrome and DNA Photolyase Family,2018

    • Author(s)
      Takeshi Todo
    • Organizer
      International Symposium on Biological Rhythms“20 Years since Discovery of mammalian Clock Genes”
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] DNA 損傷修復とゲノム変異2018

    • Author(s)
      藤堂 剛
    • Organizer
      第16回日本乳癌学会近畿地方会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 中皮腫細胞診のupdate2018

    • Author(s)
      辻村 亨, 佐藤鮎子, 結城美智子, 隅田安由美, 阿部晋也, 篠原義康,
    • Organizer
      第59回日本臨床細胞学会総会春期大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 光と生命2018

    • Author(s)
      藤堂 剛
    • Organizer
      変異機構研究会第31回夏の学校
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Statistical significance of marker combinations: theory and applications2017

    • Author(s)
      瀬々潤
    • Organizer
      International workshop for systems genetics.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 高次の組み合わせの効果を見出すための多重検定補正法と生命科学データ解析への応用2017

    • Author(s)
      瀬々潤
    • Organizer
      応用数理学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] メダカにおけるrev3l変異体の紫外線誘発突然変異と消化管腫瘍の解析2017

    • Author(s)
      藤川 芳宏、藤原 智子、佐藤 鮎子、佐久間 哲史、山本 卓、辻村 亨、藤堂 剛
    • Organizer
      日本環境変異原学会第46回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] CRISPRによる光回復酵素遺伝子群ノックアウトメダカの作製2017

    • Author(s)
      藤原(石川)智子、藤川芳宏、藤堂剛
    • Organizer
      第39回日本光医学・光生物学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] rev3l 変異体メダカの生殖組織および消化管腫瘍の解析2017

    • Author(s)
      藤川芳宏、藤原智子、佐藤鮎子、佐久間哲史、山本卓、辻村亨、藤堂剛
    • Organizer
      日本放射線影響学会第60回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Targeted inactivation of rev3l in medaka (Oryzias latipes)2016

    • Author(s)
      Yoshihiro Fujikawa, Tomoko Ishikawa-Fujiwara, Tetsushi Sakuma, Takashi Yamamoto, Tohru Tsujimura, Takeshi Todo
    • Organizer
      10th 3R International Symposium(
    • Place of Presentation
      松江市(Hotel Ichibata)
    • Year and Date
      2016-11-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Rev3L変異体メダカの放射線および紫外線感受性の解析2016

    • Author(s)
      藤川 芳宏、藤原(石川) 智子、佐久間 哲史、山本 卓、藤堂 剛
    • Organizer
      日本放射線影響学会 第59回大会
    • Place of Presentation
      広島市(JMSアステールプラザ)
    • Year and Date
      2016-10-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] メダカを用いた光回復酵素・クリプトクロームファミリーの機能解析2016

    • Author(s)
      藤堂 剛
    • Organizer
      第19回日本光生物学協会年会
    • Place of Presentation
      東京都(東京大学山上会館)
    • Year and Date
      2016-07-28
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] メダカ Rev3L 変異体の紫外線および放射線感受性の解析2016

    • Author(s)
      藤川 芳宏、藤原(石川) 智子、佐久間 哲史、山本 卓、藤堂 剛
    • Organizer
      第38回 光医学・光生物学会
    • Place of Presentation
      京都市(京都リサーチパークサイエンスホール)
    • Year and Date
      2016-07-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] 間葉系幹細胞移植による骨再生2016

    • Author(s)
      竹谷健・弓場俊輔・大串始・松崎有未
    • Organizer
      第15回日本再生医療学会総会
    • Place of Presentation
      大阪国際会議場(グランキューブ大阪)
    • Year and Date
      2016-03-17
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Targeted inactivation of DNA photolyase family genes using CRISPR system,2015

    • Author(s)
      Takeshi Todo
    • Organizer
      The 7th Asia Oceania Conference of Photobiology
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2015-11-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ゲノム編集技術(TALENs)を用いた損傷乗越えDNA合成ポリメラーゼ(Rev3L, Rev)変異体メダカの作製2015

    • Author(s)
      藤川芳宏、藤原(石川)智子、佐久間哲史、山本卓、藤堂剛
    • Organizer
      第21回小型魚類研究会
    • Place of Presentation
      吹田市(銀杏会館)
    • Year and Date
      2015-09-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] TALENを利用したメダカのRev3L, Rev7遺伝子変異体の作製2015

    • Author(s)
      藤川芳宏、藤原(石川)智子、佐久間哲史、山本卓、藤堂剛
    • Organizer
      第37回日本光医学・光生物学会
    • Place of Presentation
      宮崎市(シーガイア国際会議場)
    • Year and Date
      2015-07-16
    • Related Report
      2015 Annual Research Report
  • [Book] 光と生命の事典2016

    • Author(s)
      真嶋哲朗、飯野盛利、七田芳則、藤堂剛(編集)
    • Total Pages
      422
    • Publisher
      朝倉書店
    • Related Report
      2015 Annual Research Report
  • [Book] 光老化科学の最前線」第11章「DNA光化学と概日リズム」2015

    • Author(s)
      藤原(石川)智子、藤堂剛
    • Total Pages
      301
    • Publisher
      シーエムシー出版
    • Related Report
      2015 Annual Research Report
  • [Book] 細胞診ガイドライン4 呼吸器・胸腺・体腔液・リンパ節/2015年版2015

    • Author(s)
      辻村亨
    • Total Pages
      73
    • Publisher
      金原出版㈱
    • Related Report
      2015 Annual Research Report
  • [Remarks] 放射線基礎医学教室

    • URL

      http://www.med.osaka-u.ac.jp/pub/radbio/www/index.html

    • Related Report
      2017 Annual Research Report

URL: 

Published: 2015-06-03   Modified: 2023-10-16  

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