Molecular surgical margin analysis by margin imprinting procedure
| Project/Area Number |
15H06281
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2015-08-28 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | Surgical margin / Quantitative MSP / 肝細胞癌 / 大腸癌 / 消化器癌 / surgical margin / メチル化マーカー |
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| Outline of Final Research Achievements |
The evaluation of surgical margin status has long been diagnosed by histopathological procedure. However, some of cancer-recurrences occur from the cases with cancer cell-free surgical margin. The reason may be due to an unvisible tiny cancerous cells on the surgical margins. In order to detect these cells, we collected cells on the margin surfaces by our margin imprint methods. This procedure enables us to collect cells effectively from uneven surgical margins, and on-time measurements by cancer-specific quantitative methylation-specific PCR. We think this procedure would support the conventional histopathological diagnosis also in the intraoperative time setting.
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Report
(3 results)
Research Products
(2 results)
