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Molecular surgical margin analysis by margin imprinting procedure

Research Project

Project/Area Number 15H06281
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field General surgery
Research InstitutionNagoya University

Principal Investigator

HAYASHI Masamichi  名古屋大学, 医学部附属病院, 病院助教 (70755503)

Project Period (FY) 2015-08-28 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsSurgical margin / Quantitative MSP / 肝細胞癌 / 大腸癌 / 消化器癌 / surgical margin / メチル化マーカー
Outline of Final Research Achievements

The evaluation of surgical margin status has long been diagnosed by histopathological procedure. However, some of cancer-recurrences occur from the cases with cancer cell-free surgical margin. The reason may be due to an unvisible tiny cancerous cells on the surgical margins. In order to detect these cells, we collected cells on the margin surfaces by our margin imprint methods. This procedure enables us to collect cells effectively from uneven surgical margins, and on-time measurements by cancer-specific quantitative methylation-specific PCR. We think this procedure would support the conventional histopathological diagnosis also in the intraoperative time setting.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • Research Products

    (2 results)

All 2016 2015

All Presentation (2 results)

  • [Presentation] 結腸直腸癌手術におけるMolecular surgical margin analysis2016

    • Author(s)
      林 真路,栗本景介,中山吾郎,神田光郎,山田 豪,杉本博行,小 池聖彦,藤井 努,藤原道隆,小寺泰弘
    • Organizer
      第71回日本消化器外科学会総会
    • Place of Presentation
      あわぎんホール(徳島県徳島市藍場町)
    • Year and Date
      2016-07-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] 頭頸部癌におけるmolecular surgical margin analysisとlocoregional recurrence2015

    • Author(s)
      林 真路,Wayne Koch,小寺 泰弘
    • Organizer
      第53回日本癌治療学会学術集会
    • Place of Presentation
      国立京都国際会館 (京都市左京区宝ヶ池)
    • Year and Date
      2015-10-29
    • Related Report
      2015 Annual Research Report

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Published: 2015-08-26   Modified: 2018-03-22  

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