Functional analysis of BMP signaling on tooth and limb development
| Project/Area Number |
15H06423
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
Hayano Satoru 岡山大学, 医歯薬学総合研究科, 助教 (20633712)
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| Project Period (FY) |
2015-08-28 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 細胞死 / 発生 / 歯 / 四肢 / プログラム細胞死 / 発生・分化 / 細胞・組織 / 歯学 / BMP / p53 |
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| Outline of Final Research Achievements |
In this study, we investigated the BMP signaling function on tooth and limb formation during their development. We found that BMP ligands and phospho-SMADs were expressed in the area where programed cell death occurs. Further, tooth and limb bud organ culture with p53 inhibitor revealed that p53 pathway plays important role in tooth and limb formation.
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Report
(3 results)
Research Products
(7 results)
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[Journal Article] Practical whole-tooth restoration utilizing autologous bioengineered tooth germ transplantation in a postnatal canine model2017
Author(s)
Ono M, Oshima M, Ogawa M, Sonoyama W, Hara ES, Oida Y, Shinkawa S, Nakajima R , Mine A ,Hayano S, Fukumoto S , Kasugai8 S , Yamaguchi A, Tsuji T, Kuboki T
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Journal Title
Sci Rep
Volume: 7
Issue: 1
Pages: 44522
DOI
NAID
URL
Related Report
Peer Reviewed / Open Access
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