Functional analysis of BMP signaling on tooth and limb development

• Project/Area Number: 15H06423
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: Okayama University
• Principal Investigator: Hayano Satoru 岡山大学, 医歯薬学総合研究科, 助教 (20633712)
• Project Period (FY): 2015-08-28 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 細胞死 / 発生 / 歯 / 四肢 / プログラム細胞死 / 発生・分化 / 細胞・組織 / 歯学 / BMP / p53

Outline of Final Research Achievements

In this study, we investigated the BMP signaling function on tooth and limb formation during their development. We found that BMP ligands and phospho-SMADs were expressed in the area where programed cell death occurs. Further, tooth and limb bud organ culture with p53 inhibitor revealed that p53 pathway plays important role in tooth and limb formation.

Research Products

• [Journal Article] Practical whole-tooth restoration utilizing autologous bioengineered tooth germ transplantation in a postnatal canine model. (2017)
  • Author(s): Ono M, Oshima M, Ogawa M, Sonoyama W, Hara ES, Oida Y, Shinkawa S, Nakajima R , Mine A ,Hayano S, Fukumoto S , Kasugai8 S , Yamaguchi A, Tsuji T, Kuboki T
  • Journal Title: Sci Rep Volume: 7 Issue: 1 Pages: 44522-44522
  • DOI: 10.1038/srep44522
  • NAID: 120006535050
  • Peer Reviewed / Open Access
• [Journal Article] 歯科矯正用アンカースクリューおよびオクルーザルスプリントを用いて咬合再構築を行った成人開咬症例 (2016)
  • Author(s): 早野暁, 星島光博, 石川崇典, 上岡寛
  • Journal Title: 中四国矯正歯科学会誌 Volume: 28 Pages: 95-103
  • Peer Reviewed
• [Journal Article] Alternation in the gap-junctional intercellular communication capacity during the maturation of osteocytes in the embryonic chick calvaria (2016)
  • Author(s): ZiyiWang, Naoya Odagaki, Tomoyo Tanaka, Mana Hashimoto, Masahiro Nakamura, Satoru Hayano, Yoshihito Ishihara, Noriaki Kawanabe, Hiroshi Kamioka
  • Journal Title: Bone Volume: 91 Pages: 20-29
  • DOI: 10.1016/j.bone.2016.06.016
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Common mechanisms in development and disease: BMP signaling in craniofacial development (2016)
  • Author(s): Daniel Graf, Zeba Malik, Satoru Hayano, Yuji Mishina
  • Journal Title: Cytokine & Growth Factor Reviews Volume: 27 Pages: 129-139
  • DOI: 10.1016/j.cytogfr.2015.11.004
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] 下歯槽神経切断によるラット下顎切歯の形態形成と歯原性間葉系幹細胞の減少 (2016)
  • Author(s): 早野暁, 川邉紀章, 福井裕子, 上岡寛
  • Organizer: 第75回日本矯正歯科学会
  • Place of Presentation: アスティー徳島（徳島県徳島市）
  • Year and Date: 2016-11-07
• [Presentation] Augmented BMP signaling in the neural crest inhibits nasal cartilage morphogenesis by inducing p53-mediated apoptosis. (2015)
  • Author(s): Satoru Hayano
  • Organizer: International Symposium 2015 Oral and Craniofacial Development and Diseases
  • Place of Presentation: Osaka University, Osaka, Japan
  • Year and Date: 2015-12-10
  • Int'l Joint Research
• [Presentation] 神経堤におけるBMP-Smadシグナリングの亢進が顎顔面の軟骨発生に与える影響 (2015)
  • Author(s): 早野 暁 、小松 義広、藩 海春、三品 裕司
  • Organizer: 第74回日本矯正歯科学大会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2015-11-18