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A study to processing of integrin alpha v subunit by autophagy in squamous cell carcinoma cell

Research Project

Project/Area Number 15H06434
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionHiroshima University

Principal Investigator

Matsuoka Mirei  広島大学, 病院(歯), 歯科診療医 (10760415)

Project Period (FY) 2015-08-28 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords歯学 / 癌 / オートファジー / P62 / 口腔癌
Outline of Final Research Achievements

The purpose of this study is to develop a novel method for treating oral cancer that inhibits the proliferation, invasion and metastasis of oral cancer. It promotes selective autophagy by p62 and induces integrin αv degradation of squamous cell carcinoma cells, thereby lowering αv expression.We investigated the posttranslational modification of integrin αv in oral cancer squamous cell carcinoma cells with the aim of developing a new oral cancer treatment method to prevent oral cancer cancer growth, invasion and metastasis.
In oral squamous cell carcinoma, the expression level of integrin αv increased due to suppression of autophagy, suggesting the possibility of post-translational modification by autophagy. It was also suggested that the expression level of integrin αv and the expression level of p62 are correlated in squamous cell carcinoma cells and that p62 is a molecule necessary for cell proliferation and survival.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • Research Products

    (4 results)

All 2016

All Presentation (4 results)

  • [Presentation] 歯科治療の周術期麻酔管理でのRett症候群患者に対する行動調整2016

    • Author(s)
      向井明里,向井友宏,高橋珠世,好中大雅,小田綾,末松美玲,吉田啓太,吉田充広,入船正浩
    • Organizer
      第33回一般社団法人日本障害者歯科学会総会学術集会
    • Place of Presentation
      埼玉県,ソニックシティ
    • Year and Date
      2016-09-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 口腔扁平上皮癌細胞の浸潤・増殖に与えるHDM2の影響2016

    • Author(s)
      津島 康司, 末松 美玲, 林堂 安貴, 岡本 哲治
    • Organizer
      第70回NPO法人日本口腔科学会学術集会
    • Place of Presentation
      福岡県,福岡国際会議場
    • Year and Date
      2016-04-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] 口腔扁平上皮癌組織におけるインテグリンαv及びβ8発現の免疫組織学的解析2016

    • Author(s)
      櫻井 繁, 林堂 安貴, 吉岡 幸男, 浜名 智昭,坂上 泰士, 末松 美玲, 岡本 哲治
    • Organizer
      第70回NPO法人日本口腔科学会学術集会
    • Place of Presentation
      福岡県,福岡国際会議場
    • Year and Date
      2016-04-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] 口腔扁平上皮癌細胞の浸潤・増殖に与えるHDM2の影響2016

    • Author(s)
      津島康司 松岡美玲 林堂安貴 岡本哲治
    • Organizer
      第70回口腔科学会総会・学術集会
    • Place of Presentation
      福岡 国際会議場
    • Year and Date
      2016-04-15
    • Related Report
      2015 Annual Research Report

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Published: 2015-08-26   Modified: 2018-03-22  

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