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Patterned Naofibers for cell culture by plasma treatment

Research Project

Project/Area Number 15H06586
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Materials/Mechanics of materials
Research InstitutionKeio University

Principal Investigator

Maeda Tomoki  慶應義塾大学, 理工学部(矢上), 助教 (00754730)

Project Period (FY) 2015-08-28 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsナノファイバ / エレクトロスピニング法 / パターニング / 表面改質 / プラズマ処理 / エレクトロスピニング / 細胞培養 / 機械材料・材料力学 / 材料加工・処理 / ナノ材料 / 高分子構造・物性
Outline of Final Research Achievements

In this study, the patterning method of electrospun nanofibers by plasma treatment was developed. Additionally, the cell culture on the patterned nanofibers was examined.
The PDMS surface was partially modified by using a mask during the plasma treatment. Then, the nanofibers were spun using the treated PDMS as a collector. As a result, the patterned nanofibers were obtained on the PDMS substrate. By adjusting the condition of plasma treatment and electrospinning, the patterned area became clearer. Furthermore, cells were cultured on the patterned nanofibers. As a result, the cell proliferation was enhanced on the patterned nanofibers as compared to the untreated surface.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • Research Products

    (20 results)

All 2017 2016 2015

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 2 results) Presentation (13 results) (of which Int'l Joint Research: 9 results) Book (5 results)

  • [Journal Article] PEG-based nanocomposite hydrogel: Thermoresponsive sol-gel transition controlled by PLGA-PEG-PLGA molecular weight and concentration2017

    • Author(s)
      M. Miyazaki, T. Maeda, K. Hirashima, N. Kurokawa, K. Nagahama and A. Hotta
    • Journal Title

      Polymer

      Volume: 115 Pages: 246-254

    • DOI

      10.1016/j.polymer.2017.03.016

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Syndiotactic polypropylene nanofibers obtained from solution electrospinning process at ambient temperature2015

    • Author(s)
      T. Maeda, K. Takaesu, and A. Hotta
    • Journal Title

      Journal of Applied Polymer Science

      Volume: 133 Issue: 13 Pages: 43238-43238

    • DOI

      10.1002/app.43238

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] SANSによる高強度ポリプロピレンゲルの構造解析2017

    • Author(s)
      遠藤冬玲,前田知貴,堀田篤
    • Organizer
      2016年度量子ビームサイエンスフェスタ
    • Place of Presentation
      つくば国際会議場(茨城県・つくば市)
    • Year and Date
      2017-03-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] Biodegradability of poly(butylene succinate-co-butylene adipate) (PBSA) controlled by temperature during the dried-gel process2017

    • Author(s)
      H. Yamazaki, T. Maeda, A. Hotta
    • Organizer
      APS March Meeting 2017
    • Place of Presentation
      New Orleans(USA)
    • Year and Date
      2017-03-13
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Controlling the biodegradability of poly(butylene succinate-co-butylene adipate) (PBSA) by solvents used in the dried-gel process2017

    • Author(s)
      H. Yamazaki, S. Kamitabira, T. Maeda, A, Hotta
    • Organizer
      APS March Meeting 2017
    • Place of Presentation
      New Orleans(USA)
    • Year and Date
      2017-03-13
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Laponite concentration optimized for the thermoresponsive gelation of PEG-rich PLGA-PEG-PLGA/laponite solution2017

    • Author(s)
      K. Tanimoto, T. Maeda, A. Hotta
    • Organizer
      APS March Meeting 2017
    • Place of Presentation
      New Orleans(USA)
    • Year and Date
      2017-03-13
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis of PEG-rich PLGA-PEG-PLGA for the PLGA-PEG-PLGA/laponite hydrogels with thermoresponsive sol-gel transitions2017

    • Author(s)
      K. Tanimoto, T. Maeda, A. Hotta
    • Organizer
      APS March Meeting 2017
    • Place of Presentation
      New Orleans(USA)
    • Year and Date
      2017-03-13
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Sol-gel transition behavior of aqueous peptide-amphiphile (C16-W3K) solutions: effects of alkyl-tail length, mechanical shear, temperature, and salt2017

    • Author(s)
      M. Yamamoto, T. Otsuka, Y. Orimo, T. Maeda, A. Hotta
    • Organizer
      APS March Meeting 2017
    • Place of Presentation
      New Orleans(USA)
    • Year and Date
      2017-03-13
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Salt effects on the sol-gel transitions of aqueous peptide-amphiphile solutions2017

    • Author(s)
      M. Yamamoto, T. Maeda, A. Hotta
    • Organizer
      APS March Meeting 2017
    • Place of Presentation
      New Orleans(USA)
    • Year and Date
      2017-03-13
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] LA/GA比を調整したPLGA-PEG-PLGA/ラポナイト水溶液の温度応答性ゾル-ゲル転移挙動2016

    • Author(s)
      北川みどり,前田知貴,谷本啓示,堀田篤
    • Organizer
      第6回CSJ化学フェスタ2016
    • Place of Presentation
      タワーホール船堀(東京都・江戸川区)
    • Year and Date
      2016-11-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] PLGA-PEG-PLGA/ラポナイト水溶液の温度応答性ゾル-ゲル転移挙動に疎水部PLGAの分子量が与える影響2016

    • Author(s)
      谷本啓示,前田知貴,北川みどり,平島賢治,山本真嗣,堀田篤
    • Organizer
      第65回高分子討論会
    • Place of Presentation
      神奈川大学(神奈川県・横浜市)
    • Year and Date
      2016-09-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] Controlling the laponite and PLGA-PEG-PLGA composition for the thermoresponsive sol-gel transition of an aqueous PLGA-PEG-PLGA/laponite solution2016

    • Author(s)
      T. Maeda, M. Miyazaki, A. Hotta
    • Organizer
      第65回高分子討論会
    • Place of Presentation
      神奈川大学(神奈川県・横浜市)
    • Year and Date
      2016-09-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] Electrospun PVA-nanofiber patterning on a PDMS substrate by O2 plasma treatment2015

    • Author(s)
      T. Maeda, N. Kurokawa, M. Nakadoi, Y. Ishii, N. Kobayashi, and A. Hotta
    • Organizer
      14th Pacific Polymer Conference
    • Place of Presentation
      Hawaii (USA)
    • Year and Date
      2015-12-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A newly designed controlled drug-release platform with both anti-thrombogenicity and endothelialization: micropatterned-diamond-like carbon combined with biocompatible polymer2015

    • Author(s)
      K. Bito, T. Hasebe, T. Maeda, S. Maegawa, Y. Yamato, T. Matsumoto, T. Mine, T. Suzuki, and A. Hotta
    • Organizer
      2015 MRS Fall Meeting & Exhibit
    • Place of Presentation
      Boston (USA)
    • Year and Date
      2015-11-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Basic fibroblast growth factor delivery using a micro-patterned hydrogenated amorphous carbon (a-C:H) nano-coating on the 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer2015

    • Author(s)
      K. Bito, T. Hasebe, T. Maeda, S. Maegawa, Y. Yamato, T. Matsumoto, T. Mine, T. Suzuki, and A. Hotta
    • Organizer
      2015 MRS Fall Meeting & Exhibit
    • Place of Presentation
      Boston (USA)
    • Year and Date
      2015-11-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Book] NANOSTRUCTURES FOR NOVEL THERAPY2017

    • Author(s)
      N. Kurokawa, F. Endo, T. Maeda, A. Hotta
    • Publisher
      Elsevier
    • Related Report
      2016 Annual Research Report
  • [Book] ポリプロピレンの構造制御と複合化,成形加工技術2016

    • Author(s)
      前田知貴,堀田篤
    • Publisher
      技術情報協会
    • Related Report
      2016 Annual Research Report
  • [Book] Comprehensive Guide for Nanocoatings Technology2015

    • Author(s)
      T. Maeda, K. Hagiwara, T. Hasebe, and A. Hotta
    • Total Pages
      29
    • Publisher
      Nova Science Publishers Inc.
    • Related Report
      2015 Annual Research Report
  • [Book] Poly(Ethylene Terephthalate) Based Blends, Composites and Nanocomposites2015

    • Author(s)
      T. Maeda, F. Endo, and A. Hotta
    • Total Pages
      22
    • Publisher
      Elsevier
    • Related Report
      2015 Annual Research Report
  • [Book] Printing on Polymers: Fundamentals and Applications2015

    • Author(s)
      K. Tsuji, T. Maeda, and A. Hotta
    • Total Pages
      18
    • Publisher
      Elsevier
    • Related Report
      2015 Annual Research Report

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Published: 2015-08-26   Modified: 2018-03-22  

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