| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Outline of Final Research Achievements |
Since mental health diseases have been prevalent in pregnancy and lactation period, maternal psychotropic drug usage during lactation have been common in Japan. In our research, we focused on the babies whose mothers have mental diseases, collected their samples, and followed up, in order to make clinical case series. Besides, we try to examine in vivo experiments using Oct1/2 double knock out mice to confirm the importance of Organic Cation Transporter 1 (Oct1) in the membrane transport of psychotropic drug at mammary gland. Twenty patients were recruited. Depression, schizophrenia and panic disorder were common among mothers. And 29 drugs were prescribed, mainly as the combination of several drugs, such as flunitrazepam or zolpidem. During the follow up periods, two patients showed delay in language development, but the others had developed normally. As for the in vivo experiments, due to difficulties in breeding or other unexpected troubles, it is still on going.
|
